9,546 results match your criteria sers


Protein capture and SERS detection on multiwavelength rainbow-trapping width-graded nano-gratings.

Nanotechnology 2021 Sep 20. Epub 2021 Sep 20.

University of Toronto, 10 KINGS COLLEGE ROAD, toronto, Toronto, Ontario, M5S 1A1, CANADA.

Multiwavelength surface-enhanced Raman scattering (SERS) on substrates with rainbow-trapping properties hold the potential for a one-size-fits-all platform for rapid and multiplexed disease detection. We present the first report on the utilization of rainbow-trapping width-graded nano-gratings, a new class of chirped metamaterials, to detect protein biomarkers. Using cytochrome c (Cc), a challenging analyte with the inherent difficulty to adsorb onto silver films due to repulsive Coulombic forces, we investigated methods of binding Cc on the silver nano-grating in order to improve the SERS signal strength at both 532 nm and 638 nm excitation and hence enhance reliability of detection. Read More

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September 2021

Raman, SERS and DFT analysis of the natural red dyes of Japanese origin alkannin and shikonin.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 9;265:120382. Epub 2021 Sep 9.

Department of Scientific Research, The Metropolitan Museum of Art, 1000 Fifth Avenue, New York, NY 10028, United States.

Alkannin is the main coloring matter of Alkanet, a natural red dye extracted from the root of Alkanna tinctoria L. Shikonin, the optical isomer of alkannin, is extracted from Lithospermum erythrorhizon. As both red dyes are only slightly soluble in water, the application of ordinary Raman spectroscopy is limited. Read More

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September 2021

In Situ Raman Observation of Oxygen Activation and Reaction at Platinum-Ceria Interfaces during CO Oxidation.

J Am Chem Soc 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory of Physical Chemistry of Solid Surfaces, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, College of Chemistry and Chemical Engineering, College of Materials, iChEM, Fujian Key Laboratory of Advanced Materials, College of Energy, Xiamen University, Xiamen 361005, China.

Understanding the fundamental insights of oxygen activation and reaction at metal-oxide interfaces is of significant importance yet remains a major challenge due to the difficulty in in situ characterization of active oxygen species. Herein, the activation and reaction of molecular oxygen during CO oxidation at platinum-ceria interfaces has been in situ explored using surface-enhanced Raman spectroscopy (SERS) via a borrowing strategy, and different active oxygen species and their evolution during CO oxidation at platinum-ceria interfaces have been directly observed. In situ Raman spectroscopic evidence with isotopic exchange experiments demonstrate that oxygen is efficiently dissociated to chemisorbed O on Pt and lattice Ce-O species simultaneously at interfacial Ce defect sites under CO oxidation, leading to a much higher activity at platinum-ceria interfaces compared to that at Pt alone. Read More

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September 2021

Using Raman Spectroscopy and SERS for in-situ studies of rhizosphere bacteria.

Proc SPIE Int Soc Opt Eng 2015 Aug 21;9550. Epub 2015 Aug 21.

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556.

Bacteria colonize plant roots to form a symbiotic relationship with the plant and can play in important role in promoting plant growth. Raman spectroscopy is a useful technique to study these bacterial systems and the chemical signals they utilize to interact with the plant. We present a Raman study of YR343 that was isolated from the rhizosphere of (Eastern Cottonwood). Read More

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Development of [email protected] nanoparticles coupled to [email protected] core-shell nanoparticles for the sensitive detection of zearalenone.

Anal Chim Acta 2021 Oct 27;1180:338888. Epub 2021 Jul 27.

Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Tianjin Institute of Environmental and Operational Medicine, Tianjin, 300050, China. Electronic address:

Agricultural products are frequently contaminated by mycotoxins; thus, the accurate detection of mycotoxins is important to food safety. Zearalenone (ZEN), a mycotoxin produced by certain Fusarium and Gibberella species, is a group III carcinogen. We developed a universal surface-enhanced Raman scattering (SERS) aptasensor for the detection of ZEN. Read More

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October 2021

Heterodimers of metal nanoparticles: synthesis, properties, and biological applications.

Mikrochim Acta 2021 09 19;188(10):345. Epub 2021 Sep 19.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Heterodimers of metal nanoparticles consist of two metals, come in many sizes and adopt various shapes. They offer unique properties due to the presence of two metals and have the extraordinary flexibility needed to serve as a multipurpose platform for diverse applications in areas including photonics, sensing, and catalysis. Heterodimer nanoparticles contain different metals that contribute to extraordinary surface plasmon resonance (SPR), surface-enhanced Raman scattering (SERS), and catalytic properties. Read More

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September 2021

Trapping analytes into dynamic hot spots using Tyramine-medicated crosslinking chemistry for designing versatile sensor.

J Colloid Interface Sci 2021 Sep 8;607(Pt 1):782-790. Epub 2021 Sep 8.

Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University Chuncheon 24341, Republic of Korea; Kangwon Radiation Convergence Research Support Center, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Hypothesis: Due to the intrinsic nature of the surface-enhanced Raman scattering (SERS), the detection of molecules with weak binding affinities toward metal substrates is critical for development of a universal SERS sensing platform. We hypothesized the physical trapping of small pesticide molecules for active hot spot generation using tyramine-mediated crosslinking chemistry and silver nanoparticles (Ag NPs) enhances SERS detection sensitivity.

Experiments: Tyramine-mediated crosslinking chemistry for sensor application was validated by ultraviolet-visible absorption spectroscopy, scanning electron microscopy, dynamic light scattering, and Raman spectroscopy. Read More

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September 2021

Study on degranulation of mast cells under C48/80 treatment by electroporation-assisted and ultrasound-assisted surface-enhanced Raman spectrascopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 27;265:120331. Epub 2021 Aug 27.

MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, Fujian, China; School of opto-electronic and Communication Engineering, Xiamen University of Technology, Xiamen, Fujian, China. Electronic address:

Both electroporation-assisted and ultrasound-assisted delivery methods can rapidly deliver nanoparticles into living cells for surface-enhanced Raman scattering (SERS) detection, but these two methods have never been compared. In this study, electroporation-assisted SERS and ultrasound-assisted SERS were employed to detect the biochemical changes of degranulated mast cells induced by mast cell stimulator (C48/80). The results showed that the cell damage of electroporation based on controllable electric pulse was smaller than that of ultrasound based on cavitation. Read More

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Facile fabrication of PS/CuS/Ag sandwich structure as SERS substrate for ultra-sensitive detection.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120370. Epub 2021 Sep 10.

Key Laboratory of Preparation and Applications of Environmental Friendly Materials (Jilin Normal University), Ministry of Education, Changchun 130103, China. Electronic address:

In this work, a serials of PS(polystyrene)/CuS/Ag sandwich substrates were successfully constructed using the magnetic sputtering method by adjusting the Ag sputtering time (0 min, 2 min, 4 min, 6 min, 8 min and 10 min) and used as the surface-enhanced Raman scattering (SERS) substrates. When the Ag sputtering time was 6 min, the strongest SERS signal was observed. The optimized SERS substrate has strong SERS activity on 4-mercaptobenzoic acid (4-MBA), the minimum detection limit was 10 M and the enhancement factor was as high as 4. Read More

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September 2021

Site-Selective Deposition of Metal-Organic Frameworks on Gold Nanobipyramids for Surface-Enhanced Raman Scattering.

Nano Lett 2021 Sep 17. Epub 2021 Sep 17.

Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR , People's Republic of China.

Site-selective deposition of metal-organic frameworks (MOFs) on metal nanocrystals has remained challenging because of the difficult control of the nucleation and growth of MOFs. Herein we report on a facile wet-chemistry approach for the selective deposition of zeolitic imidazolate framework-8 (ZIF-8) on anisotropic Au nanobipyramids (NBPs) and nanorods. ZIF-8 is selectively deposited at the ends and waist and around the entire surface of the elongated Au nanocrystals. Read More

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September 2021

Correction: SERS-based nanostrategy for rapid anemia diagnosis.

Nanoscale 2021 Sep 17. Epub 2021 Sep 17.

Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences Henan University Kaifeng, Henan 475004, China.

Correction for 'SERS-based nanostrategy for rapid anemia diagnosis' by Pir Muhammad , , 2020, , 1948-1957, DOI: 10.1039/C9NR09152A. Read More

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September 2021

Macroscopical monolayer films of ordered arrays of gold nanoparticles as SERS substrates for quantitative detection in aqueous solutions.

Nanoscale 2021 Sep 17;13(35):14925-14934. Epub 2021 Sep 17.

State Key Laboratory of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

In this work, macroscopical monolayer films of ordered arrays of gold nanoparticles (MMF-OA-Au NPs) are successfully prepared at the interfaces of toluene-diethylene glycol (DEG) with a water volume fraction of 10% (no more than 25%), which can greatly reduce the electrostatic repulsion among NPs during the self-assembly due to the quick transfer of the remaining citrate ions into the DEG solutions containing water. Thanks to the uniformity in the intensity of SERS signals, the as-prepared MMF-OA-Au NPs transferred onto polydimethylsiloxane (PDMS) as SERS substrates (MMF-OA-Au [email protected]) can achieve quantitative detection of the analytes (such as crystal violet and malachite green) in aqueous solutions. Moreover, MMF-OA-Au [email protected] as SERS-based pH sensors can directly determine the pH value of the aqueous solution in the range of 3 to 10 by means of the established well-defined linear relationship with the intensity of the peak of COO without any calibration, instead of the intensity ratio of the Raman peaks of COO to 8a with further calculation. Read More

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September 2021

Comparative Analysis of Machine Learning Algorithms on Surface Enhanced Raman Spectra of Clinical Species.

Front Microbiol 2021 31;12:696921. Epub 2021 Aug 31.

Department of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou, China.

Raman spectroscopy (RS) is a widely used analytical technique based on the detection of molecular vibrations in a defined system, which generates Raman spectra that contain unique and highly resolved fingerprints of the system. However, the low intensity of normal Raman scattering effect greatly hinders its application. Recently, the newly emerged surface enhanced Raman spectroscopy (SERS) technique overcomes the problem by mixing metal nanoparticles such as gold and silver with samples, which greatly enhances signal intensity of Raman effects by orders of magnitudes when compared with regular RS. Read More

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Drug-resistant Staphylococcus aureus bacteria detection by combining surface-enhanced Raman spectroscopy (SERS) and deep learning techniques.

Sci Rep 2021 09 16;11(1):18444. Epub 2021 Sep 16.

Department of Biomedical Engineering, Erciyes University, 38039, Kayseri, Turkey.

Over the past year, the world's attention has focused on combating COVID-19 disease, but the other threat waiting at the door-antimicrobial resistance should not be forgotten. Although making the diagnosis rapidly and accurately is crucial in preventing antibiotic resistance development, bacterial identification techniques include some challenging processes. To address this challenge, we proposed a deep neural network (DNN) that can discriminate antibiotic-resistant bacteria using surface-enhanced Raman spectroscopy (SERS). Read More

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September 2021

Nanostructure-based surface-enhanced Raman scattering for diagnosis of cancer.

Nanomedicine (Lond) 2021 Sep 17. Epub 2021 Sep 17.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.

Cancer is a malignant disease that seriously affects human health and life. Early diagnosis and timely treatment can significantly improve the survival rate of cancer patients. Surface-enhanced Raman scattering (SERS) is an optical technology that can detect and image samples at the single-molecule level. Read More

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September 2021

A Novel Multiplex Mycotoxin Surface-Enhanced Raman Spectroscopy Immunoassay Using Functional Gold Nanotags on a Silica Photonic Crystal Microsphere Biochip.

J Agric Food Chem 2021 Sep 16. Epub 2021 Sep 16.

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

A novel multiplex mycotoxin surface-enhanced Raman spectroscopy (SERS) immunoassay was established for the first time on different artificial antigen-modified silica photonic crystal microspheres (SPCMs), which can be integrated into a biochip array to achieve multiplex detection using corresponding antibody-functionalized gold nanoparticles (AuNPs) as the SERS nanotag. The unique optical structure of SPCMs is helpful to find the detection spots easily, accommodate a large amount of probe molecules, and enhance the Raman signal intensity. Such enhancement was confirmed by the simulation result, showing the electric field enhancing effect in SPCMs with AuNPs being 7 times. Read More

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September 2021

Shape and Deposition Angle Control of Silver Film-over-Nanosphere SERS Substrates.

Nanotechnology 2021 Sep 16. Epub 2021 Sep 16.

Physics, Middle East Technical University, Dumlupinar Blvd 1, Ankara, 06800, TURKEY.

Thin metallic films on dielectric nanospheres are demonstrated to have a high potential for fabrication of cost-effective SERS substrates. In addition to the morphological advantages that nanospheres offer for attaining a high density of hot-spots, possessing shape adjustability by uncomplicated thermal treatment make them an attractive platform for tuneable SERS substrates. Furthermore, when combined with oblique angle metal deposition technique, adjustable gaps at a high density and adjustable shape of metal films, such as Ag films, can be achieved on nanospheres. Read More

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September 2021

Two orders of magnitude extra SERS enhancement on silver nanoparticle-based substrate induced by laser irradiation in nitrogen ambient.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 8;265:120372. Epub 2021 Sep 8.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, and Collaborative Innovation Centre of Advanced Microstructures, Nanjing University, Nanjing 210093, China. Electronic address:

Photo-reduction of silver oxide and light-induced Ag nanoparticle (NP) generations have been applied for Surface-enhanced Raman spectroscopy (SERS) substrate fabricated for years. In this paper, we demonstrate a general method to enhance the SERS activity of conventional Ag NPs-based SERS substrates by performing Raman scattering measurement in a nitrogen ambient after a period of laser irradiation (photoactivation). The Raman characteristic peak intensity of carbonaceous impurities adsorbed on the surfaces of Ag NPs display an additional enhancement of 93 times after photoactivation in nitrogen ambient. Read More

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September 2021

Suppressing Sulfite Dimerization at a Polarized Gold Electrode/Water Solution Interface for High-Quality Gold Electrodeposition.

Langmuir 2021 Sep 16. Epub 2021 Sep 16.

State Key Laboratory of Physical Chemistry of the Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China.

Solid/liquid interfacial structure occupies great importance in chemistry, biology, and materials. In this paper, by combining EC-SERS study and DFT calculation, we reveal the adsorption and dimerization of sulfite (SO) at a gold electrode/water solution interface, and establish an adsorption displacement strategy to suppress the dimerization of sulfite. At the gold electrode/sodium sulfite solution interface, at least two layers of SO anions are adsorbed on the electrode surface. Read More

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September 2021

Dual Functions of a [email protected] Nanocomposite Desalination Membrane with an Enhanced Antifouling Property and Fouling Detection Via Surface-Enhanced Raman Spectroscopy.

ACS Appl Mater Interfaces 2021 Sep 16. Epub 2021 Sep 16.

CSIRO Manufacturing, Private Bag 10, Clayton South, Melbourne 3169, Victoria, Australia.

Membrane fouling has remained a major challenge limiting the wide application of membrane technology because it reduces the efficiency and shortens the lifespan of the membrane, thus increasing the operation cost. Herein we report a novel dual-function nanocomposite membrane incorporating silver-coated gold nanoparticles ([email protected]) into a sulfosuccinic acid (SSA) cross-linked poly(vinyl alcohol) (PVA) membrane for a pervaporation desalination. Compared with the control PVA membrane and PVA/SSA membrane, the [email protected]/PVA/SSA membrane demonstrated a higher water flux and better salt rejection as well as an enhanced antifouling property. Read More

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September 2021

Implications of the Coffee-Ring Effect on Virus Infectivity.

Langmuir 2021 Sep 15. Epub 2021 Sep 15.

Civil and Environmental Engineering and Institute of Critical Technology and Applied Science (ICTAS) Sustainable Nanotechnology, Virginia Tech, Blacksburg, Virginia 24061, United States.

The factors contributing to the survival of enveloped viruses (e.g., influenza and SARS-CoV-2) on fomite surfaces are of societal interest. Read More

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September 2021

Bio-inspired Nanoenzyme Synthesis and Its Application in A Portable Immunoassay for Food Allergy Proteins.

J Agric Food Chem 2021 Sep 15. Epub 2021 Sep 15.

School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi 710021, People's Republic of China.

Nanozymes as a cost-effective and robust enzyme mimic have attracted widespread attention in the development of novel analytical methods. Herein, a new nanozyme-enhanced surface-enhanced Raman scattering (SERS) immunoassay platform was successfully developed using a peroxidase-mimicking nanozyme to replace the natural enzymes as a catalytic label of the enzyme-linked immunosorbent assay for the detection of allergy proteins. In this platform, the peroxidase-mimicking nanozymes as a catalytic label could catalyze the oxidation of the Raman-inactive reporter [i. Read More

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September 2021

Fabrication of a honeycomb-like bimetallic SERS substrate for the detection of triphenyltin chloride.

Analyst 2021 Sep 15. Epub 2021 Sep 15.

Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, P. R. China.

Triphenyltin chloride (TPhT) is an organotin compound that causes intensive toxicological risk to the environment and humans. A detection method with high sensitivity and stability is therefore desired to better detect TPhT. In this study, a novel SERS substrate was prepared by sputtering an ultra-thin Au layer on a honeycomb-like silver nanoarray fabricated the nanosphere lithography method. Read More

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September 2021

Functionalized Gold Nanorod Probes: A Sophisticated Design of SERS Immunoassay for Biodetection in Complex Media.

Anal Chem 2021 Sep 14. Epub 2021 Sep 14.

School of Chemistry, University of New South Wales, Sydney, New South Wales 2052, Australia.

Surface-enhanced Raman scattering (SERS) probes offer considerable opportunities in label-based biosensing and analysis. However, achieving specific and reproducible performance, where low detection limits are needed in complex media, remains a challenge. Herein, we present a general strategy employing gold nanorod SERS probes and rationally designed surface chemistry involving protein resistant layers and antibodies to allow for the selective detection of species in complex media. Read More

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September 2021

Investigating Lysosomal Autophagy Surface-Enhanced Raman Scattering Spectroscopy.

Anal Chem 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Autophagy plays a critical role in many vitally important physiological and pathological processes, such as the removal of damaged and aged organelles and redundant proteins. Although autophagy is mainly a protective process for cells, it can also cause cell death. In this study, we employed and surface-enhanced Raman scattering (SERS) spectroscopies to obtain chemical information of lysosomes of HepG2 cells. Read More

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September 2021

Comparison of SERS pH probe responses after microencapsulation within hydrogel matrices.

J Biomed Opt 2021 Sep;26(9)

Texas A&M Univ., United States.

Significance: Personalized medicine requires the tracking of an individual's metabolite levels over time to detect anomalies and evaluate the body's response to medications. Implanted sensors offer effective means to continuously monitor specific metabolite levels, provided they are accurate, stable over long time periods, and do no harm.

Aim: Four types of hydrogel embedded with pH-sensitive sensors were evaluated for their accuracy, sensitivity, reversibility, longevity, dynamic response, and consistency in static versus dynamic conditions and long-term storage. Read More

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September 2021

SERS-based copper-mediated signal amplification strategy for simple and sensitive detection of telomerase activity.

Talanta 2021 Dec 19;235:122814. Epub 2021 Aug 19.

Department of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China.

Simple and sensitive detection of telomerase activity is of vital importance for both early diagnosis and therapy of malignant tumors. Inspired by DNA-biobarcode amplification reported by Chad A. Mirkin, we developed a facile DNA-biobarcode-like SERS-based copper-mediated signal amplification strategy for sensitive detection of telomerase activity. Read More

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December 2021

Adenine shares the plane with G-quartet detected by surface-enhanced Raman spectroscopy.

Talanta 2021 Dec 31;235:122777. Epub 2021 Jul 31.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, PR China; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun, 130012, PR China. Electronic address:

DNA G-quadruplexes (G4s) formed by guanine(G)-rich sequences show diversity of structural topologies. The detection of structural details is of great significance for understanding of their functions and for the target drug design, but is very challenging. Herein, we demonstrate that the surface-enhanced Raman spectroscopy (SERS) via Ag IANPs as substrates is able to identify the numbers of Adenine (A) located on the G-quartet of the G4s. Read More

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December 2021

Aptamer/derivatization-based surface-enhanced Raman scattering membrane assembly for selective analysis of melamine and formaldehyde in migration of melamine kitchenware.

Talanta 2021 Dec 28;235:122743. Epub 2021 Jul 28.

School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China. Electronic address:

The analysis of contaminants in migration of food contact material (FCMs) is an urgent demand for food safety. In this study, melamine and formaldehyde in melamine kitchenware were selectively analyzed by surface-enhanced Raman scattering (SERS) via aptamer/derivatization-based membrane assembly. The membrane assembly was designed by simple filtration of Ag nanoparticles-decorated "stellate" silicon dioxide (SiO/Ag) and composites of reduced graphene oxide and Ag nanoparticles (rGO/Ag) functioned with specific reagents. Read More

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December 2021

Iodide-modified Ag nanoparticles coupled with DSN-Assisted cycling amplification for label-free and ultrasensitive SERS detection of MicroRNA-21.

Talanta 2021 Dec 22;235:122728. Epub 2021 Jul 22.

Department of Chemistry, Shanghai Stomatological Hospital, Institute of Biomedical Sciences, State Key Lab of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China. Electronic address:

With the emergence of microRNA (miRNA) as a key player in early clinical disease diagnosis, development of rapidly sensitive and quantitative miRNA detection methods are imperative. Herein, a label-free SERS assay coupled with duplex-specific nuclease (DSN) signal amplification strategy was proposed for facilely ultrasensitive and quantitative analysis of miRNA-21. Firstly, magnetic beads assembled with excessive capture DNA were utilized to hybridize the target miRNA-21. Read More

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December 2021