272,655 results match your criteria series study


Clinical photographs in the assessment of adult spinal deformity: a comparison to radiographic parameters.

J Neurosurg Spine 2021 May 14:1-5. Epub 2021 May 14.

Objective: The goal of this study was to reliably predict sagittal and coronal spinal alignment with clinical photographs by using markers placed at easily localized anatomical landmarks.

Methods: A consecutive series of patients with adult spinal deformity were enrolled from a single center. Full-length standing radiographs were obtained at the baseline visit. Read More

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Patterns of brachyury expression in chordomas.

Ann Diagn Pathol 2021 May 10;53:151760. Epub 2021 May 10.

Pathology Departments, University Hospital of Saint-Etienne, France. Electronic address:

Introduction: Chordomas are rare malignant midline tumors, presumed to arise from notochordal remnants. This was further suggested by the discovery of the brachyury in chordomas pathogenesis. Its immunohistochemical expression has become the principal adjunct in the diagnosis of chordomas. Read More

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Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.

Eur J Obstet Gynecol Reprod Biol 2021 May 5;262:21-27. Epub 2021 May 5.

Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The aim of this study was to describe one of the largest series of disseminated peritoneal leiomyomatosis (DPL) and its malignant counterpart, evaluating possible risk factors for both the benign and malignant condition, and highlighting any differences between them in terms of surgical and clinical management.

Study Design: Clinical, surgical and histopathological characteristics of patients diagnosed with DPL (group 1) and malignant-DPL (group 2), between July 2010 and July 2020, were retrospectively retrieved.

Results: A total of 14 benign and 5 malignant cases were selected. Read More

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Adjunctive homeopathic treatment of hospitalized COVID-19 patients (COVIHOM): A retrospective case series.

Complement Ther Clin Pract 2021 May 11;44:101415. Epub 2021 May 11.

WissHom: Scientific Society for Homeopathy, Koethen, Germany.

Background: and purpose. COVID-19 is a novel viral disease causing worldwide pandemia. The aim of this study was to describe the effect of adjunctive individualized homeopathic treatment delivered to hospitalized patients with confirmed symptomatic SARS-CoV-2 infection. Read More

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Continuous Infusion, Therapeutic Drug Monitoring and Outpatient Parenteral Antimicrobial Therapy with Ceftazidime-Avibactam: a Retrospective Cohort Study.

J Glob Antimicrob Resist 2021 May 11. Epub 2021 May 11.

Department of Infectious Diseases and General Internal Medicine, University Hospital of Liège, Liège, Belgium. Electronic address:

Background: Based on recent PK/PD evidence, continuous infusion (CI) of β-lactam administration is increasingly recommended for serious infections. Since 2016, the combination of ceftazidime and avibactam (CAZ/AVI) is administered per manufacturer prescription as an intermittent infusion of 2.5g q8h. Read More

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Pediatric Vulvar Lichen Sclerosus: A Survey of Disease Course.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Department of Dermatology, University of North Carolina at Chapel Hill. Electronic address:

Study Objective: To assess long-term outcomes of Lichen Sclerosus (LS) in the female pediatric population, specifically in relation to patient age, treatment type and duration, and remission.

Design: Retrospective chart review was conducted to identify female pediatric patients (0-18 years of age) who were diagnosed with LS between 1/1/2015 and 1/1/2020 at the University of North Carolina Dermatology and/or OB/GYN Departments. Patients were contacted via telephone for follow-up interviews consisting of a series of questions regarding patient age, symptom onset, time of diagnosis, treatment, and current symptoms. Read More

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Peroral endoscopic myotomy: 10-year outcomes from a large, single-center U.S. series with high follow-up completion and comprehensive analysis of long-term efficacy, safety, objective GERD, and endoscopic functional luminal assessment.

Gastrointest Endosc 2021 May 11. Epub 2021 May 11.

Division of Gastroenterology, Hepatology & Nutrition, NYU-Winthrop Hospital, Mineola, NY, USA.

Background And Aims: Peroral endoscopic myotomy (POEM) is becoming the treatment of choice for achalasia. Data beyond 3 years are emerging but limited. We herein report our 10-year experience, focusing on long-term efficacy and safety including the prevalence, management, and sequelae of postoperative reflux. Read More

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Estimation of the Effective Doses from Typical Fluoroscopic Examinations with Barium Contrast.

Radiat Prot Dosimetry 2021 May 15. Epub 2021 May 15.

Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Inga-Marie Nilssons gata 49, Malmö 205 02, Sweden.

The current study aimed to estimate the effective doses and conversion coefficients (CCs) for typical barium swallow (BS), barium meal (BM) and barium enema (BE) protocols and to evaluate the impact of different examination parameters on the resulting CCs. Data were collected in surgical and therapy departments in St. Petersburg Urban Mariinsky Hospital. Read More

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Postmarket American Experience With Woven EndoBridge Device: Adjudicated Multicenter Case Series.

Neurosurgery 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.

Background: The Woven EndoBridge (WEB) device was granted premarket approval in the United States following results of the Woven EndoBridge Intrasaccular Therapy (WEB-IT) study. WEB-IT reported excellent adequate angiographic occlusion of treated aneurysms with a high safety profile. These results were achieved, however, in the context of a prospective study with strict inclusion criteria and rigorous training support. Read More

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Effects of osmotic pressure on the irreversible electroporation in giant lipid vesicles.

PLoS One 2021 14;16(5):e0251690. Epub 2021 May 14.

Department of Basic Science, Primeasia University, Dhaka, Bangladesh.

Irreversible electroporation (IRE) is a nonthermal tumor/cell ablation technique in which a series of high-voltage short pulses are used. As a new approach, we aimed to investigate the rupture of giant unilamellar vesicles (GUVs) using the IRE technique under different osmotic pressures (Π), and estimated the membrane tension due to Π. Two categories of GUVs were used in this study. Read More

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Characterizing and predicting person-specific, day-to-day, fluctuations in walking behavior.

PLoS One 2021 14;16(5):e0251659. Epub 2021 May 14.

Center for Wireless & Population Health Systems, The Qualcomm Institute and the Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, United States of America.

Despite the positive health effect of physical activity, one third of the world's population is estimated to be insufficiently active. Prior research has mainly investigated physical activity on an aggregate level over short periods of time, e.g. Read More

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National estimates from the Youth '19 Rangatahi smart survey: A survey calibration approach.

PLoS One 2021 14;16(5):e0251177. Epub 2021 May 14.

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Background: Significant progress has been made addressing adolescent health needs in New Zealand, but some areas, such as mental health issues remain, particularly for rangatahi Māori (indigenous Māori young people). Little is known about how contemporary Māori whānau (families) and communities influence health outcomes, health literacy and access to services. Previous nationally representative secondary school surveys were conducted in New Zealand in 2001, 2007 and 2012, as part of the Youth2000 survey series. Read More

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Time series models for prediction of leptospirosis in different climate zones in Sri Lanka.

PLoS One 2021 14;16(5):e0248032. Epub 2021 May 14.

Postgraduate Institute of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka.

In tropical countries such as Sri Lanka, where leptospirosis-a deadly disease with a high mortality rate-is endemic, prediction is required for public health planning and resource allocation. Routinely collected meteorological data may offer an effective means of making such predictions. This study included monthly leptospirosis and meteorological data from January 2007 to April 2019 from Sri Lanka. Read More

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Effect of cations on the removal rate of chloride ions and mechanism analysis in high-salt wastewater.

Water Sci Technol 2021 May;83(9):2232-2241

College of Environmental Science and Engineering, State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry, Donghua University, Shanghai 201620, China E-mail:

Precipitation dechlorination has the advantage of being a simple process with a low cost. However, there are few reports on the effect of cations on dechlorination. In this study, we investigated the effect of cations in high-salt wastewater on the removal of chlorine ions by cuprous chloride precipitation and analysed the corresponding mechanism. Read More

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Systematic Video Analysis of Anterior Cruciate Ligament Injuries in Professional Female Soccer Players.

Am J Sports Med 2021 May 14:3635465211008169. Epub 2021 May 14.

Education and Research Department, Isokinetic Medical Group, Bologna, Italy.

Background: Female soccer players are particularly susceptible to anterior cruciate ligament (ACL) injuries, accounting for 16% to 43% of the injury burden during the season. Despite the advancements in injury prevention programs, the rate of ACL injuries continues to rise.

Purpose: To provide a comprehensive description of the mechanisms, situational pattern, and biomechanics of ACL injuries in women's soccer. Read More

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Mesyl Phosphoramidate Oligonucleotides as Potential Splice-Switching Agents: Impact of Backbone Structure on Activity and Intracellular Localization.

Nucleic Acid Ther 2021 May 14. Epub 2021 May 14.

Department of Paediatrics, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

A series of 2'-deoxy and novel 2'--methyl and 2'--(2-methoxyethyl) (2'-MOE) oligonucleotides with internucleotide methanesulfonyl (mesyl, μ) or 1-butanesulfonyl (busyl, β) phosphoramidate groups has been synthesized for evaluation as potential splice-switching oligonucleotides. Evaluation of their splice-switching activity in spinal muscular atrophy patient-derived fibroblasts revealed no significant difference in splice-switching efficacy between 2'-MOE mesyl oligonucleotide and the corresponding phosphorothioate (nusinersen). Yet, a survival study with model neonatal mice has shown the antisense 2'-MOE mesyl oligonucleotide to be inferior to nusinersen at the highest dose of 40 mg/kg. Read More

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Cluster Size Dependent Interaction of Free Manganese Oxide Clusters with Acetic Acid and Methyl Acetate.

J Phys Chem A 2021 May 14. Epub 2021 May 14.

School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332-0430, United States.

We have employed infrared multiple-photon dissociation (IR-MPD) spectroscopy together with density functional theory (DFT) calculations to study the interaction of series of subnanometer sized manganese oxide clusters, MnO ( = 1-6, = 0-9) with acetic acid (HOAc) and methyl acetate (MeOAc). Reaction with HOAc leads to strongly cluster size and composition dependent IR-MPD spectra, indicating molecular adsorption on MnO clusters and thermodynamically favorable but kinetically hampered HOAc dissociation (deprotonation) on MnO and MnO. Other cluster sizes exhibit the preferred formation of a dissociative bidentate chelating structure. Read More

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The Treatment of Bone Marrow Lesions Associated with Advanced Knee Osteoarthritis: Comparing Intraosseous and Intraarticular Injections with Bone Marrow Concentrate and Platelet Products.

Pain Physician 2021 May;24(3):E279-E288

Regenexx, LLC, Des Moines, IA.

Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated with advanced osteoarthritis of the adjacent joint. Injection of autologous orthobiologic products, including bone marrow concentrate and platelet-rich plasma, have demonstrated safety and efficacy in treating both advanced osteoarthritis (via intraarticular injection) and associated bone marrow lesions (via intraosseous injection). The relative efficacy of intraarticular versus intraosseous injection of orthobiologics has not been evaluated at the present time. Read More

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Use of Bone Marrow Concentrate to Treat Pain and Musculoskeletal Disorders: An Academic Delphi Investigation.

Pain Physician 2021 May;24(3):263-273

Research & Development, Regenexx, LLC.

Background: Acute and degenerative musculoskeletal disorders are among the most common etiologies of disability worldwide. Recently, there has been interest in the field of regenerative medicine to bridge the gap between conservative and surgical management of these conditions. Autologous bone marrow concentrate is one type of injectate that has increased in popularity over the last few decades. Read More

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The Electrophilicities of XCF and XCl (X=H, Cl, Br, I) and the Propensity of These Molecules To Form Hydrogen and Halogen Bonds with Lewis Bases: An Ab Initio Study.

Authors:
I Alkorta A C Legon

Chempluschem 2021 Apr 30;86(5):778-784. Epub 2021 Apr 30.

School of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, United Kingdom.

Equilibrium dissociation energies, D , of four series of halogen- and hydrogen-bonded complexes B⋅⋅⋅XCF (X=H, Cl, Br and I) are calculated ab initio at the CCSD(T)(F12c)/cc-pVDZ-F12 level. The Lewis bases B involved are N , CO, PH , C H , C H , H S, HCN, H O and NH . Plots of D versus N , where the N are the nucleophilicities assigned to the Lewis bases previously, are good straight lines through the origin, as are those for the corresponding set of complexes B⋅⋅⋅XCl. Read More

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Characterization of Gene Expression Signatures for the Identification of Cellular Heterogeneity in the Developing Mammary Gland.

J Mammary Gland Biol Neoplasia 2021 May 14. Epub 2021 May 14.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, US.

The developing mammary gland depends on several transcription-dependent networks to define cellular identities and differentiation trajectories. Recent technological advancements that allow for single-cell profiling of gene expression have provided an initial picture into the epithelial cellular heterogeneity across the diverse stages of gland maturation. Still, a deeper dive into expanded molecular signatures would improve our understanding of the diversity of mammary epithelial and non-epithelial cellular populations across different tissue developmental stages, mouse strains and mammalian species. Read More

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Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

Lasers Med Sci 2021 May 14. Epub 2021 May 14.

Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1 Street, 91-151, Łódź, Poland.

The purpose of this study was to assess skin elasticity, the reduction in the number and the depth of wrinkles and changes in the other skin defects (bags under the eyes, dark circles under the eyes, skin hyperpigmentation in the ageing eye area following the use of non-ablative fractional laser, bipolar radiofrequency and intense pulsed light). Moreover, the study was also comparison which device brought better results than the others. This study included 71 patients (66 women, 5 men), aged 33-63 years (the average age was 45. Read More

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Phosphorus-nitrogen compounds: part 53-synthesis, characterization, cytotoxic and antimicrobial activity, DNA interaction and molecular docking studies of new mono- and dispirocyclotriphosphazenes with pendant arm(s).

Mol Divers 2021 May 14. Epub 2021 May 14.

Department of Physics, Hacettepe University, 06800, Ankara, Turkey.

Mono-/dispirocyclotriphosphazenes with pendant arm(s) are robust, but they are less investigated inorganic ring systems. In this study, a series of mono (3 and 4)- and dispirocyclotriphosphazenes with 4-chloro-benzyl pendant arm(s) (13-16) was obtained from the Cl exchange reactions of hexachlorocyclotriphosphazene with sodium (N-benzyl)aminopropanoxides (1 and 2). When compound (3) reacted with excess pyrrolidine, morpholine, tetra-1,4-dioxa-8-azaspiro[4,5]decane (DASD) and piperidine, the fully substituted monospirocyclotriphosphazenes (7, 9, 10 and 12) occurred. Read More

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Hydrological processing of salinity and nitrate in the Salinas Valley agricultural watershed.

Environ Monit Assess 2021 May 14;193(Suppl 1):272. Epub 2021 May 14.

Department of Land, Air, and Water Resources & Biological and Agricultural Engineering, University of California, Davis, One Shield Avenue, Davis, CA, USA.

Regime shifts of major salinity constituents (Ca, Mg, Na, K, SO, Cl, HCO, and NO) in the lower Salinas River, an agricultural ecosystem, can have major impacts on ecosystem services central to continued agricultural production in the region. Regime shifts are large, persistent, and often abrupt changes in the structure and dynamics of social-ecological systems that occur when there is a reorganization of the dominant feedbacks in the system. Monitoring information on changes in the system state, controlling variables, and feedbacks is a crucial contributor to applying sustainability and ecosystem resilience at an operational level. Read More

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A novel technique for superficial complicated stomas using the Dacron vascular prosthesis.

Langenbecks Arch Surg 2021 May 14. Epub 2021 May 14.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, 14048-900, Brazil.

Background And Purpose: Despite the advances achieved in surgical techniques in recent years, an intestinal stoma is still needed in many patients undergoing colorectal surgery. However, the intestinal stoma may be associated with serious complications and the need for a second surgical procedure. In extreme cases, when it is not possible to access the abdominal cavity, the management of a complicated stoma is challenging. Read More

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Sentinel Lymph Node Biopsy in High-Risk Cutaneous Squamous Cell Carcinoma: Analysis of a Large Size Retrospective Series.

Dermatol Surg 2021 May 11. Epub 2021 May 11.

All authors are affiliated with the Departments of dermatology, head and neck surgery, dermatologic surgery, and dermatopathology, CHU de Québec-Université Laval, Québec, Canada.

Background: One of the most important prognostic factors for mortality in cutaneous squamous cell carcinoma (cSCC) is the development of nodal metastasis. There is no consensus regarding which patient with cSCC should be offered sentinel lymph node biopsy (SLNB).

Objective: This study aimed to establish the rate of positive SLNBs among patients with high-risk cSCCs and to identify which high-risk features are associated with a positive SLNB. Read More

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Comparing the Effectiveness of Education Versus Digital Cognitive Behavioral Therapy for Adults With Sickle Cell Disease: Protocol for the Cognitive Behavioral Therapy and Real-time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA) Study.

JMIR Res Protoc 2021 May 14;10(5):e29014. Epub 2021 May 14.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Background: Patients with sickle cell disease (SCD) experience significant medical and psychological stressors that affect their mental health, well-being, and disease outcomes. Digital cognitive behavioral therapy (CBT) has been used in other patient populations and has demonstrated clinical benefits. Although evidence-based, nonpharmacological interventions for pain management are widely used in other populations, these treatments have not been well studied in SCD. Read More

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Cross-linguistic influence of phonological awareness and phonological recoding skills in Chinese reading acquisition among early adolescent students.

J Gen Psychol 2021 May 14:1-22. Epub 2021 May 14.

East China Normal University.

This study investigated crosslinguistic phonological awareness and phonological recoding skills in Chinese reading acquisition among early Chinese adolescent students. 76 Chinese children participated in this study and finished a series of reading measurements over 1 year (from Grade 5 to Grade 6). In Grade 5, they were assessed by Chinese phonological awareness (syllable, onset, rhyme, phoneme, and tone awareness), English phonological awareness (syllable, onset, and rime, phoneme awareness) as well as English and Chinese phonological recoding skills. Read More

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Advanced Glass Fiber Polymer Composite Laminate Operating as a Thermoelectric Generator: A Structural Device for Micropower Generation and Potential Large-Scale Thermal Energy Harvesting.

ACS Appl Mater Interfaces 2021 May 14. Epub 2021 May 14.

Department of Materials Science & Engineering, University of Ioannina, GR-45110 Ioannina, Greece.

This study demonstrates for the first time a structural glass fiber-reinforced polymer (GFRP) composite laminate with efficient thermal energy harvesting properties as a thermoelectric generator (TEG). This TEG laminate was fabricated by stacking unidirectional glass fiber (GF) laminae coated with p- and n-type single-wall carbon nanotube (SWCNT) inks via a blade coating technique. According to their thermoelectric (TE) response, the p- and n-type GF-SWCNT fabrics exhibited Seebeck coefficients of +23 and -29 μV/K with 60 and 118 μW/m·K power factor values, respectively. Read More

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Angiotensin II Type 1 Receptor Antibody Mediated Rejection Following Orthotopic Heart Transplant: A Single Center Experience.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1Division of Cardiology, Department of Medicine 2Department of Pathology & Immunology 3Department of Developmental Biology Washington University in St. Louis, St. Louis, MO, 63130.

Background: Antibody mediated rejection (AMR) following orthotopic heart transplant (OHT) causes significant morbidity and mortality. There is limited data on antibodies to the angiotensin II type 1 receptor (AT1R-Ab) causing rejection following OHT.

Methods: This is a retrospective, single center study that presents our 2-year experience with a series of 11 patients with evidence of nonspecific graft dysfunction and pathologic levels of AT1R-Ab. Read More

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February 2021