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[New aspects in Fournier's gangrene - a rapid review].

Aktuelle Urol 2021 Apr 21. Epub 2021 Apr 21.

Universitätsmedizin Rostock, Urologische Klinik und Poliklinik, Rostock.

Fournier's gangrene (FG) is a sporadic, life-threatening, necrotising infection affecting the perineum, perineal region and genitals. Published literature provides hints that the outcome of this disease has failed to improve in recent years. We have therefore performed a rapid evidence synthesis by searching the database MEDLINE. Read More

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Esthetic Outcomes of Implant-Supported Single Crowns Related to Abutment Type and Material: A Systematic Review.

Int J Prosthodont 2021 Mar-Apr;34(2):229-249

Purpose: To systematically review the influence of abutment material and configuration on the soft tissue esthetic outcomes of implant-supported single crowns (iSCs) after 3 years.

Materials And Methods: An electronic search on MEDLINE (PubMed) from January 2000 to July 2019 was conducted for clinical trials with no language restrictions. The focus question was: In partially edentulous patients with iSCs, does the abutment material (metal vs ceramic) or the configuration (standardized vs customized) have an effect on the soft tissue esthetic outcomes? Randomized controlled trials, controlled clinical trials, and prospective or retrospective case series with at least 10 patients and a minimum of 3 years of follow-up were included. Read More

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Salvage Radiosurgery for Recurrent Supratentorial Primitive Neuroectodermal Tumors: A Single Institutional Series and Review of the Literature.

Stereotact Funct Neurosurg 2021 Apr 21:1-7. Epub 2021 Apr 21.

Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Supratentorial primitive neuroectodermal tumor is a rare, aggressive intrinsic brain tumor with limited treatment options for recurrent disease. SRS as a treatment modality in the recurrent setting was investigated.

Methods: A retrospective review of 8 patients treated with SRS for local or distant recurrence of supratentorial PNET from 1999 to 2014 was conducted. Read More

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Visceral Mycoses as a Cause of Severe HIV Infection and Death.

Int Arch Allergy Immunol 2021 Apr 21:1-7. Epub 2021 Apr 21.

Department of Pathology, Central City Clinical Hospital, Veliky Novgorod, Russian Federation.

Introduction: In recent years, there has been an increase in the number of systemic fungal infections among HIV-infected individuals. The article aimed to examine the frequency of invasive mycoses among the HIV-infected patients at the time of their urgent and/or planned admission to a specialized hospital.

Methods: The diagnostic methods used in this study involved physical examination, laboratory testing, bacteriological examination, immunological examination, molecular genetic testing, and radiological imaging. Read More

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Genetics of HLA peptide presentation, and impact on outcomes in HLA-matched allo-HCT.

Transplant Cell Ther 2021 Apr 18. Epub 2021 Apr 18.

Internal Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Background: Minor histocompatibility antigens (mHA), which are recipient derived peptide epitopes presented on the cell surface, are known to mediate GVHD; however, there are no current methods to associate mHA features with GVHD risk. This deficiency is due in part to the lack of technological means to accurately predict, let alone confirm, the tremendous number of potential mHA in each individual transplant. Prior studies have shown that different HLA molecules present varying fractions of candidate peptide epitopes; however, the genetic "distance" between HLA matched donors and recipients is relatively constrained. Read More

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"Blepharophimosis-plus" syndromes: Frequency of systemic genetic disorders that also include blepharophimosis.

Clin Exp Ophthalmol 2021 Apr 21. Epub 2021 Apr 21.

Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Background: To determine the frequency of isolated blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) vs. systemic genetic disorders in patients presenting with blepharophimosis.

Methods: Retrospective clinical records review. Read More

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Patch test results in patients with suspected contact allergy to shoes - retrospective IVDK data analysis 2009-2018.

Contact Dermatitis 2021 Apr 21. Epub 2021 Apr 21.

Information Network of Departments of Dermatology, University Medical Centre Göttingen, Göttingen, Germany.

Background: Allergic contact dermatitis caused by shoes is common and new relevant allergens have been identified.

Objectives: To investigate the pattern of type IV sensitization in patients with suspected allergic contact dermatitis of the feet related to shoes as presumed culprit trigger.

Methods: Retrospective analysis of data of the Information Network of Departments of Dermatology (IVDK), 2009-2018. Read More

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COVID-19 and telehealth: Applying telehealth and telemedicine in a pandemic.

Nurse Pract 2021 May;46(5):34-43

Abstract: In this second article of a three-part series, we explore how stakeholders can be educated on the use of telehealth technology and telemedicine. We address the need for staff and patient support for the transition to telehealth and offer suggestions to NPs for appropriate presentation and interaction with interdisciplinary teams and patients regarding telehealth. Read More

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Neuroimaging Findings of Hospitalized Covid-19 Patients: A Canadian Retrospective Observational Study.

Can Assoc Radiol J 2021 Apr 21:8465371211002815. Epub 2021 Apr 21.

University of Toronto, Toronto, Ontario, Canada.

Purpose: Coronavirus disease (COVID-19) has been associated with neurologic sequelae and neuroimaging abnormalities in several case series previously. In this study, the neuroimaging findings and clinical course of adult patients admitted with COVID-19 to a tertiary care hospital network in Canada were characterized.

Methods: This is a retrospective observational study conducted at a tertiary hospital network in Ontario, Canada. Read More

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Olfactory Cleft Opacification in COVID-19 Related Smell Loss: CT Findings and Correlation With Objective Testing.

Ear Nose Throat J 2021 Apr 21:1455613211011285. Epub 2021 Apr 21.

Department of Otorhinolaryngology, 534521Afyonkarahisar Healty Science University Hospital, Afyonkarahisar, Turkey.

Objectives: Besides the common symptoms of the coronavirus disease 2019 (COVID-19) including fever, shortness of breath, and cough, a "sudden loss of smell" has recently been added as a diagnostic symptom. The relationship between paranasal sinus computed tomography (PNS CT) and sudden loss of smell in COVID-19 was examined.

Materials And Methods: Two groups were selected for the study, the COVID-19 and the control groups. Read More

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Role of Anterior Segment OCT for Descemet Membrane Stripping During Descemet Membrane Endothelial Keratoplasty in Eyes With Congenital Hereditary Endothelial Dystrophy.

Authors:
Rajesh Fogla

Cornea 2021 Apr;40(4):458-461

Cornea Clinic, Eye Department, Apollo Hospitals, Jubilee Hills, Hyderabad, India.

Purpose: To report the utility of preoperative anterior segment optical coherence tomography (ASOCT) in decision-making for stripping of the Descemet membrane (DM) during Descemet membrane endothelial keratoplasty (DMEK) in eyes with congenital hereditary endothelial dystrophy (CHED).

Methods: ASOCT was performed in eyes with CHED undergoing DMEK. Host DM was retained if the DM appearance was normal on ASOCT. Read More

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Efficacy of polyester bands placed under the transverse vertebral process for the correction of adolescent idiopathic scoliosis : A case series of 105 patients with a minimum of 24 months follow-up.

Eur Spine J 2021 Apr 21. Epub 2021 Apr 21.

Service de Chirurgie Orthopédique Pédiatrique, Hôpital Gatien de Clocheville, CHRU de Tours, Tours, 37044 Tours Cedex 9, France.

Purpose: To report an original technique for the surgical correction of adolescent idiopathic scoliosis (AIS) based on hybrid construct using polyester bands placed under the thoracic transverse processes.

Methods: We reviewed 105 patients operated between 2013 to 2017 for AIS with a minimum of 2 years follow-up. Clinical and radiological data, including 2D measurements of scoliosis parameters preoperatively, and at 3- and 24-months postoperatively were analyzed. Read More

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Surgical volume reduction and the announcement of triage during the 1st wave of the COVID-19 pandemic in Japan: a cohort study using an interrupted time series analysis.

Surg Today 2021 Apr 21. Epub 2021 Apr 21.

Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.

Purpose: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for surgical staffs to minimize exposure to COVID-19 or save medical resources without harmful patient outcomes, in accordance with the statement of each surgical society. No research has empirically validated declines in surgical volume in Japan, based on the usage of surgical triage. We aimed to identify whether the announcement of surgical priorities by each Japanese surgical society may have affected the surgical volume decline during the 1st wave of this pandemic. Read More

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TREM2 expression in the brain and biological fluids in prion diseases.

Acta Neuropathol 2021 Apr 21. Epub 2021 Apr 21.

Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), L'Hospitalet de Llobregat, Spain.

Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases. Its soluble form (sTREM2) results from shedding of the TREM2 ectodomain. The role of TREM2 in prion diseases, a group of rapidly progressive dementias remains to be elucidated. Read More

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Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch.

JAMA Dermatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, University of California, San Francisco.

Importance: Air pollution is a worldwide public health issue that has been exacerbated by recent wildfires, but the relationship between wildfire-associated air pollution and inflammatory skin diseases is unknown.

Objective: To assess the associations between wildfire-associated air pollution and clinic visits for atopic dermatitis (AD) or itch and prescribed medications for AD management.

Design, Setting, And Participants: This cross-sectional time-series study assessed the associations of air pollution resulting from the California Camp Fire in November 2018 and 8049 dermatology clinic visits (4147 patients) at an academic tertiary care hospital system in San Francisco, 175 miles from the wildfire source. Read More

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Clinical Characterization of Mogamulizumab-Associated Rash During Treatment of Mycosis Fungoides or Sézary Syndrome.

JAMA Dermatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, Stanford University School of Medicine, Palo Alto, California.

Importance: Mogamulizumab is a monoclonal antibody against CCR4 approved for treatment for mycosis fungoides (MF) and Sézary syndrome (SS). Mogamulizumab-associated rash (MAR) is difficult to differentiate from cutaneous MF or SS, which can lead to unnecessary discontinuation of drug use because of concern for severe drug reaction or incorrect presumption of disease relapse or progression in the skin.

Objective: To examine the most common clinical presentations of MAR in patients with MF or SS and the diagnostic and management challenges. Read More

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Facile antibacterial materials with turbine-like structure for infected scald wound healing.

Biomater Sci 2021 Apr 21. Epub 2021 Apr 21.

School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, P.R. China.

Pseudomonas aeruginosa (P. aeruginosa) is a popular hospital pathogen and the major cause of morbidity and mortality in patients with cystic fibrosis (CF) and impaired immune system. Herein, we designed and synthesized a series of organic molecules MTEBT-n (n = 1, 2, 3) to specifically and effectively kill P. Read More

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Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer.

Mol Omics 2021 Apr 20. Epub 2021 Apr 20.

The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.

Metabolic reprogramming is a hallmark of cancer, which is still far from being fully understood in colorectal cancer. In order to characterize the metabolic changes in colorectal cancer, we performed metabolomics analysis of paired colon tissues from colorectal cancer patients by using a liquid chromatography-mass spectrometry (LC-MS)-based method. Bioinformation analysis was used to define important metabolites and metabolic pathways, as well as the prognosis significance and expression levels of the key molecules. Read More

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Limited Flexor Sheath Incision and Drainage in the Emergency Department in the Management of Early Pyogenic Flexor Tenosynovitis.

Hand (N Y) 2021 Apr 21:1558944721999729. Epub 2021 Apr 21.

The Warren Alpert Medical School of Brown University, Providence, RI, USA.

Background: Pyogenic flexor tenosynovitis (PFT) has been considered a surgical emergency. Varying operative approaches have been described, but there are limited data on the method, safety, and efficacy of nonoperative or bedside management. We present a case series where patients with early flexor tenosynovitis are managed using a limited flexor sheath incision and drainage (I&D) in the emergency department (ED) to both confirm purulence within the flexor sheath and as definitive treatment. Read More

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Efficacy of bleb-independent penetrating canaloplasty in primary angle-closure glaucoma: one-year results.

Acta Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

The Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, Zhejiang, China.

Purpose: To report the efficacy and safety of bleb-independent penetrating canaloplasty in the management of primary angle-closure glaucoma (PACG).

Methods: This single-centre prospective interventional case series enrolled 57 eyes from 53 PACG patients with medically uncontrolled intraocular pressure (IOP) and peripheral anterior synechiae of over 270°. Penetrating canaloplasty, mainly consisted of tensioning suture-aided Schlemm's canal dilation and a trabeculectomy, was performed to create a direct communication between the anterior chamber and the Schlemm's canal. Read More

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Primary esophageal non-Hodgkin's lymphoma: demographics, clinical characteristics, histopathologic types, and survival in 179 patients from the SEER program and systematic review of the literature.

Esophagus 2021 Apr 20. Epub 2021 Apr 20.

Public Health and Epidemiological Studies Group, Cardiovascular Foundation of Colombia, Floridablanca, Colombia.

Background: The most frequent site for the extranodal appearance of primary non-Hodgkin's lymphomas (NHL) is the gastrointestinal (G.I.) tract. Read More

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Macular holes following vitrectomy for rhegmatogenous retinal detachment: epiretinal proliferation and spontaneous closure of macular holes.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan.

Purpose: To describe the characteristics and management of full-thickness macular holes (MHs) that develop after pars plana vitrectomy for rhegmatogenous retinal detachment (RD).

Methods: Retrospective, interventional, consecutive case series. Patients who developed secondary full-thickness MHs after prior pars plana vitrectomy for RD over a 6-year period were included. Read More

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Geospatial analysis of multiple cancers in individuals in the US, 2004-2014.

Ann Cancer Epidemiol 2021 Mar 30;5. Epub 2021 Mar 30.

Mobley Consulting, LLC, Atlanta, GA, USA.

Background: There is a projected rapid increase in cancer survivors in the US population, from 15.5 million in 2016 to 26.1 million by 2040. Read More

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The advantage of chimeric antigen receptor T cell therapy in pediatric acute lymphoblastic leukemia with E2A-HLF fusion gene positivity: a case series.

Transl Pediatr 2021 Mar;10(3):686-691

Department of Hematology & Oncology, Children's Hospital of Soochow University, Suzhou, China.

The E2A-HLF fusion gene is a very poor biomarker in acute lymphoblastic leukemia (ALL) because of its high relapse risk, even with the most intensive chemotherapy and hematopoietic stem cell transplantation (HSCT). Here, we analyzed four cases diagnosed with E2A-HLF fusion gene-positive B-ALL and treated with the CCCG-ALL-2015 protocol based on high-risk stratification from Jun 2017 to May 2020 retrospectively. Three cases (Case 1, 2, 3) were insensitive to conventional therapy and inhibitors with high-level MRD on days 19 and 46, but they all achieved complete remission at the molecular level with Chimeric Antigen Receptor (CAR) T cell therapy regardless of primary resistance or recurrence. Read More

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Prediction of covid-19 growth and trend using machine learning approach.

Mater Today Proc 2021 Apr 15. Epub 2021 Apr 15.

Department of Computer Science Engineering, Kongu Engineering College, India.

The Covid-19 Corona Virus, also known as SARS-CoV-2, has wreaked havoc around the world, and the condition is only getting worse.It is a pandemic disease spreading from person-to-person every day. Therefore, it is important to keep track the number of patients being affected. Read More

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Tuberculous Arthritis of the Ankle Joint Mimicking Pigmented Villonodular Synovitis.

Cureus 2021 Mar 18;13(3):e13962. Epub 2021 Mar 18.

Orthopedic Surgery, King Abdullah Medical City, Mecca, SAU.

Osteoarticular tuberculosis (TB) of the ankle joint is rare, and there is a delay in diagnosis in most cases. All patients with the disease complained of swelling and pain in the affected ankle. Ankle TB is a disorder that can be simply misdiagnosed. Read More

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Effect of Perioperative Tranexamic Acid on Allogeneic Blood Transfusions for Total Knee Arthroplasty Patients at a Community Hospital.

Cureus 2021 Mar 17;13(3):e13951. Epub 2021 Mar 17.

Orthopedics, Lake Placid Sports Medicine, Lake Placid, USA.

Introduction Tranexamic acid (TXA) has been shown to be a cost-effective method for reducing blood loss and postoperative transfusions in patients undergoing total knee arthroplasty (TKA) at tertiary care centers. However, the efficacy of TXA has not been studied in community hospitals, and the potential cost savings may be especially beneficial for these institutions. The purpose of this study was to assess the effectiveness of TXA in reducing postoperative transfusions and blood loss following TKA at a community hospital. Read More

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Thromboembolic Disease in COVID-19.

J Clin Imaging Sci 2021 26;11:16. Epub 2021 Mar 26.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States.

Coronavirus disease 2019 (COVID-19) was initially recognized in late December 2019 and has quickly spread globally with over 114 million reported cases worldwide at the time of this publication. For the majority of patients infected with COVID-19, the clinical manifestations are absent or mild. In more advanced cases, severe respiratory dysfunction is the leading cause of morbidity and mortality. Read More

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Surgical management of cerebral venous sinus thrombosis: Case series and literature review.

Surg Neurol Int 2021 30;12:133. Epub 2021 Mar 30.

Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt.

Background: Cerebral venous sinus thrombosis (CVST) is not a common type of stroke (5%) but still hazardous to be misdiagnosed or mistreated. Aggressive medical treatment is usually failed to hinder increase intracranial tension. Therefore, decompressive craniectomy (DC) is the final measure to mitigate the deleterious effect of supratentorial herniation. Read More

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Hydrocephalus in Mexican children with Coccidioidal Meningitis: Clinical, serological, and neuroimaging findings.

Surg Neurol Int 2021 24;12:119. Epub 2021 Mar 24.

Department of Pediatric Infectious Disease, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, Mexico.

Background: Coccidioidal meningitis (CM) is a fungal infectious disease that rarely affects children. Even in endemic areas, coccidiomycosis rarely affects the pediatric population. However, 40% of affected children develop hydrocephalus. Read More

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