Transplant Cell Ther 2021 Apr 18. Epub 2021 Apr 18.
Internal Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address:
Background: Minor histocompatibility antigens (mHA), which are recipient derived peptide epitopes presented on the cell surface, are known to mediate GVHD; however, there are no current methods to associate mHA features with GVHD risk. This deficiency is due in part to the lack of technological means to accurately predict, let alone confirm, the tremendous number of potential mHA in each individual transplant. Prior studies have shown that different HLA molecules present varying fractions of candidate peptide epitopes; however, the genetic "distance" between HLA matched donors and recipients is relatively constrained. Read More