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The Utility of Real-Time Remote Auscultation Using a Bluetooth-Connected Electronic Stethoscope: Open-Label Randomized Controlled Pilot Trial.

JMIR Mhealth Uhealth 2021 Jul 27;9(7):e23109. Epub 2021 Jul 27.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, Japan.

Background: The urgent need for telemedicine has become clear in the COVID-19 pandemic. To facilitate telemedicine, the development and improvement of remote examination systems are required. A system combining an electronic stethoscope and Bluetooth connectivity is a promising option for remote auscultation in clinics and hospitals. Read More

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Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions.

Brain Pathol 2021 Jul 23:e13003. Epub 2021 Jul 23.

Brain Endowment Bank, University of Miami, Miami, FL, USA.

Schizophrenia (SCZ) is a psychiatric disorder that can include symptoms of disorganized speech and thoughts with uncertain underlying mechanisms possibly linked to over-activated microglia. In this study, we used brain samples from sixteen donors with SCZ and thirteen control donors to assess the differential activation of microglia by quantifying density and 3D reconstruction of microglia stained with ionized calcium-binding adaptor molecule-1 (Iba1). Our samples consisted of sections from the frontal, temporal, and cingulate cortical gray matter, subcortical white matter regions (SCWM), and included the anterior corpus callosum. Read More

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Risk factor analysis and outcomes of airway management in antenatally diagnosed cervical masses.

Int J Pediatr Otorhinolaryngol 2021 Jul 21;149:110851. Epub 2021 Jul 21.

Division of Otolaryngology, Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. Electronic address:

Purpose: To investigate antenatally-determined imaging characteristics associated with invasive airway management at birth in patients with cervical masses, as well as to describe postnatal management and outcomes.

Study Design: A retrospective analysis of 52 patients with antenatally diagnosed neck masses was performed using single-center data from January 2008 to January 2019. Antenatal imaging, method of delivery, management, and outcomes data were abstracted from the medical record and analyzed. Read More

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Characterisation of anal intraepithelial neoplasia and anal cancer in HIV-positive men by immunohistochemical markers p16, Ki-67, HPV-E4, and DNA methylation markers.

Int J Cancer 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Cancer Center Amsterdam CCA, Amsterdam University Medical Centers (Amsterdam UMC), Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

Human papillomavirus (HPV)-induced anal intraepithelial neoplasia (AIN, graded 1-3) is highly prevalent in HIV-positive (HIV+) men-who-have-sex-with-men (MSM), but only a minority of lesions progresses to cancer. This study aimed to characterise comprehensively anal tissue samples from a cross-sectional series (n = 104) of HIV + MSM and longitudinal series (n = 40) of AIN2/3 progressing to cancer using different biomarkers. The cross-sectional series consisted of 8 normal, 26 AIN1, 45 AIN2, 15 AIN3 and 10 anal squamous cell carcinoma. Read More

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Improving Accuracy of American Society of Anesthesiologists Physical Status Using Audit-Feedback and Artificial Intelligence: A Time Series Analysis.

Int J Qual Health Care 2021 Jul 26. Epub 2021 Jul 26.

Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, MA 02111, USA.

Background: While the American Society of Anesthesiologists (ASA) Physical Status (PS) is used to adjust for greater mortality risk with higher ASA PS classification, inaccurate classification can lead to inaccurate comparison of institutions. The purpose of this study was to assess the effect of audit and feedback with a rule-based artificial intelligence algorithm on the accuracy of ASA PS classification.

Methods: We reviewed 78,121 anesthetic records from January 1, 2017 to February 19, 2020. Read More

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Conservative Treatment of Avulsion Injuries of the Lesser Trochanter in Adolescent Athletes.

Cureus 2021 Jun 14;13(6):e15638. Epub 2021 Jun 14.

Orthopaedic Surgery, Lenox Hill Hospital, New York, USA.

Background:  Avulsion injuries of the lesser trochanter apophysis are relatively uncommon injuries and there have been no peer-reviewed case series dedicated to the evaluation and treatment of this injury. The purpose of this study is to characterize avulsion injuries of the lesser trochanter apophysis, review treatment protocols, and time to return to sport.  Methods: We reviewed 30 confirmed avulsion fractures of the lesser trochanter. Read More

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Comparison of Outcomes for Laser Trabeculoplasty after Kahook Dual Blade Goniotomy Versus in Goniotomy-Naive Eyes.

Ophthalmol Ther 2021 Jul 24. Epub 2021 Jul 24.

University of Missouri School of Medicine, Columbia, MO, USA.

Introduction: This was a comparison of laser trabeculoplasty (LTP) outcomes in eyes with prior Kahook Dual Blade (KDB) goniotomy versus in goniotomy-naive control eyes.

Methods: This was a retrospective matched comparative case series. We identified a cohort of patients undergoing LTP between February 2017 and July 2020 at University of Missouri. Read More

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Influence of frosted haptics on rotational stability of toric intraocular lenses.

Sci Rep 2021 Jul 23;11(1):15099. Epub 2021 Jul 23.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

We investigated the unfolding property and rotational stability of a new toric intraocular lens (IOL); TECNIS toric II (toric-II, ZCW, Johnson & Johnson) that is an improved version of TECNIS toric IOL (toric-I, ZCV). Both IOLs are based on an identical platform, except for the frosted haptics with toric-II IOL. The study consisted of two parts; experimental study and clinical, retrospective, case series. Read More

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Development of an Entrustment-Supervision Assessment Tool for Pharmacy Experiential Education via Sequential Stakeholder Focus Groups.

Am J Pharm Educ 2021 Jul 22:8523. Epub 2021 Jul 22.

The Ohio State University, College of Pharmacy, Columbus, Ohio.

To devise a pharmacy-specific, expanded Entrustable Professional Activities (EPA) entrustment-supervision scale, which frames preceptor ratings of entrustment in a prospective and retrospective manner for use in experiential learning settings. A series of focus group sessions were conducted to solicit expert opinion to develop and refine two entrustment-supervision scales. Purposive sampling was used to identify experts from different professional groups (physicians, pharmacy experiential administrators, and pharmacy practice faculty) and who had extensive knowledge regarding EPAs and at least one publication related to EPAs. Read More

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Self-report instruments for assessing adherence to warfarin therapy: a systematic review.

Eur J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.

Background: The assessment of adherence to warfarin therapy is useful in clinical practice due to its wide variability in dose-response and risks of complications. The aim of this study was to investigate validated instruments used to assess adherence to warfarin therapy.

Methods: Information was collected from the MEDLINE (PubMed), LILACS, EMBASE, and Cochrane Library databases. Read More

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The role of philosophy in the development and practice of nursing: Past, present and future.

Nurs Philos 2021 Jul 19:e12363. Epub 2021 Jul 19.

University of Alberta, Edmonton, Alberta, Canada.

This article summarizes a virtual live-streamed panel event that occurred in August 2020 and was cosponsored by the International Philosophy of Nursing Society (IPONS) and the University of California, Irvine's Center for Nursing Philosophy. The event consisted of a series of three self-contained panel discussions focusing on the past, present and future of IPONS and was moderated by the current Chair of IPONS, Catherine Green. The first panel discussion explored the history of IPONS and the journal Nursing Philosophy. Read More

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Outcomes of pre- heart transplantation desensitization in a series of highly sensitized patients bridged with left ventricular assist devices.

J Heart Lung Transplant 2021 May 31. Epub 2021 May 31.

Department of Pharmacy, Advocate Christ Medical Center Oak Lawn, Illinois.

Desensitization therapy for heart transplantation (HT) candidates can shorten transplant wait times and broaden the donor pool. Specific evidence-based recommendations on both protocols and indications are lacking. We retrospectively assessed left ventricular assist devices-bridged candidates who received pre-HT desensitization therapy. Read More

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Delayed post-extraction implants placed using a modified Summers technique: Preliminary results of a single cohort study.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2 Suppl. 1):117-129

University of Milano, Department of Biomedical, Surgical and Dental Sciences, Milan, Italy.

The aim of this retrospective case series was to evaluate the clinical and radiographic outcomes of the patients that underwent implant surgery with a modification of the sinus lift summers protocol. Forty healthy patients in need for oral rehabilitation with dental implants were included in this study. Inclusion criterion was the need for extraction of one compromised tooth due to persistent abscess/ periodontitis/cyst in the atrophic posterior maxilla region. Read More

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Accurate population-based model for individual prediction of colon cancer recurrence.

Acta Oncol 2021 Jul 19:1-9. Epub 2021 Jul 19.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Background: Prediction models are useful tools in the clinical management of colon cancer patients, particularly when estimating the recurrence rate and, thus, the need for adjuvant treatment. However, the most used models (MSKCC, ACCENT) are based on several decades-old patient series from clinical trials, likely overestimating the current risk of recurrence, especially in low-risk groups, as outcomes have improved over time. The aim was to develop and validate an updated model for the prediction of recurrence within 5 years after surgery using routinely collected clinicopathologic variables. Read More

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3D laparoscopic salvage radical prostatectomy: mini-series report and review of the literature.

J BUON 2021 May-Jun;26(3):964-969

The Oncology Institute "Prof. Dr. Ion Chiricuţă", Cluj-Napoca, Romania.

Purpose: Salvage therapy represents a rescue therapy, given after the first line of treatment had failed.The purpose of this study was to review the outcomes of patients who underwent salvage laparoscopic radical prostatectomy (sLRP) in our department and to review current published studies.

Methods: Our mini-series consisted of 6 patients with recurrent prostate cancer(PCa) after non-surgical primary treatment. Read More

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The Effect of Shame and Self-Efficacy on Gambling Behaviour.

J Gambl Stud 2021 Jul 15. Epub 2021 Jul 15.

The Cairnmillar Institute, Melbourne, Australia.

Previous research has identified the benefits of increasing self-efficacy in problem gamblers, while other research has identified higher levels of shame and dysfunctional coping in problem gamblers. The primary aim of the present study was to examine the relationships between problem gambling behaviour, shame (as both a personality trait and an emotional state), gambling-related self-efficacy, and dysfunctional coping mechanisms. The sample consisted of 235 participants (172 male; mean age = 30. Read More

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The impacts of government reimbursement negotiation on targeted anticancer medication price, volume and spending in China.

BMJ Glob Health 2021 Jul;6(7)

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Introduction: New targeted therapies have changed cancer treatment in the past decades. However, high prices of targeted anticancer medications have increased economic burden for both patients and health insurance systems. In July 2017, China implemented combined medication price negotiation and mandatory reimbursement policies for 15 targeted anticancer medications. Read More

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Integrated Battery-Capacitor Electrodes: Pyridinic N-Doped Porous Carbon-Coated Abundant Oxygen Vacancy Mn-Ni-Layered Double Oxide for Hybrid Supercapacitors.

ACS Appl Mater Interfaces 2021 Jul 14;13(29):34374-34384. Epub 2021 Jul 14.

Key Laboratory for Magnetism and Materials of MOE, School of Physical Science and Technology, Lanzhou University, 730000 Lanzhou, China.

Integrating the battery behavior and supercapacitor behavior in a single electrode to obtain better electrochemical performance has been widely researched. However, there is still a lack of research studies on an integrated battery-capacitor supercapacitor electrode (BatCap electrode). In this work, an integrated BatCap electrode porous carbon-coated Mn-Ni-layered double oxide (Mn-Ni LDO-C) was fabricated successfully using controllable heat treatment of polypyrrole-precoated Mn-Ni-layered double hydroxide (Mn-Ni [email protected]). Read More

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Trend and factors associated with Tuberculosis-Diabetes Mellitus comorbidity in a Northeastern Brazilian municipality.

Rev Bras Enferm 2021 9;74(3):e20201238. Epub 2021 Jul 9.

Universidade Federal do Maranhão. São Luís, Maranhão, Brazil.

Objectives: to identify the trend and factors associated with Tuberculosis-Diabetes Mellitus comorbidity in Imperatriz, Maranhão.

Methods: epidemiological temporal-series study, conducted in a Northeastern Brazilian municipality. The population consisted of Tuberculosis cases with Diabetes Mellitus-associated aggravation notified in the Notifiable Diseases Information System (SINAN) between 2009 and 2018. Read More

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A national study of choanal atresia in tertiary care centers in Canada - part II: clinical management.

J Otolaryngol Head Neck Surg 2021 Jul 13;50(1):46. Epub 2021 Jul 13.

Department of Paediatric Otolaryngology- Head and Neck Surgery, Children's Hospital at London Health Sciences Centre, London, ON, Canada.

Background: To evaluate the clinical management of choanal atresia (CA) in tertiary centers across Canada.

Methods: Multi-centre case series involving six tertiary care pediatric hospitals across Canada. Retrospective chart review of patients born between 1980 and 2010 diagnosed with choanal atresia to a participating center. Read More

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Feline cystadenomatosis affecting the ears and skin of 57 cats (2011-2019).

J Feline Med Surg 2021 Jul 13:1098612X211024498. Epub 2021 Jul 13.

Department of Immunology, Harvard Medical School, Boston, MA, USA.

Objectives: This study aimed to understand epidemiological factors associated with feline cystadenomatosis, including signalment and papillomavirus PCR status. Cystadenomatosis is an uncommon condition primarily involving the ceruminous and apocrine skin and ear glands.

Methods: This was a retrospective case series. Read More

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Acute plate fixation of displaced midshaft clavicular fractures is not associated with earlier return of normal shoulder function when union is achieved.

Bone Jt Open 2021 Jul;2(7):522-529

Department of Orthopaedic Surgery, University of Edinburgh, Edinburgh, UK.

Aims: It is unclear whether acute plate fixation facilitates earlier return of normal shoulder function following a displaced mid-shaft clavicular fracture compared with nonoperative management when union occurs. The primary aim of this study was to establish whether acute plate fixation was associated with a greater return of normal shoulder function when compared with nonoperative management in patients who unite their fractures. The secondary aim was to investigate whether there were identifiable predictors associated with return of normal shoulder function in patients who achieve union with nonoperative management. Read More

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Prognostic interplay of kidney function with sarcopenia, anemia, disability and cognitive impairment. The GLISTEN study.

Eur J Intern Med 2021 Jul 10. Epub 2021 Jul 10.

Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of the Sacred Heart, Rome, Italy.

Background: Interactions between chronic kidney disease (CKD) and several comorbidities may potentially affect prognosis of older hospitalized patients. This study aims at evaluating the prognostic interactions between estimated glomerular filtration rate (eGFR), anemia, sarcopenia, functional and cognitive dysfunction, and 3-year mortality among older patients discharged from acute care hospitals.

Methods: Our series consisted of 504 older adults enrolled in a multicenter observational study carried out in twelve Acute Geriatric and Internal Medicine wards throughout Italy. Read More

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Disease-modifying therapy usage in patients with multiple sclerosis in France: A 6-year population-based study.

Rev Neurol (Paris) 2021 Jul 9. Epub 2021 Jul 9.

Univ Rennes, EHESP, REPERES (Pharmacoepidemiology and health services research) - EA 7449, 15, avenue du Professeur Léon Bernard, CS 74312, 35000 Rennes, France; Inserm CIC-P 1414, Rennes University Hospital, Rennes University, 2, rue Henri le Guilloux, 35000 Rennes, France.

Background: Most data regarding the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) comes from clinical series or regional databases that have a risk of recruitment bias. French health administrative data offers the significant advantage of being extensive in regards to both MS population coverage and DMT prescriptions.

Objectives: To describe patterns of DMTs usage at the level of the entire French population of MS patients from 2010 to 2015. Read More

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Hymen Restoration: An Experience From a Moroccan Center.

Aesthet Surg J 2021 Jul 12. Epub 2021 Jul 12.

Department of Plastic, Reconstructive, Aesthetic and Maxillofacial Surgery, Henri Mondor Hospital, Créteil, France.

Background: Hymenoplasty is one of the least described vulvovaginal procedures in plastic surgery without any surgical standard that attempts to restore the hymen's ability to bleed during sexual intercourse on a couple's wedding night.

Objectives: The objective of this study is to report outcomes from a Moroccan retrospective study of a series of 529 patients who underwent either a hymenorrhaphy or a hymenoplasty.

Methods: This was a retrospective study of 529 patients who underwent hymen restoration at a center in Morocco between April 2010 and April 2019. Read More

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A Novel Medial Malleolar Osteotomy Technique for the Treatment of Osteochondral Lesions of the Talus.

Orthop J Sports Med 2021 Mar 23;9(3):2325967121989988. Epub 2021 Mar 23.

Department of Foot and Ankle Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: The current techniques for medial malleolar osteotomy may lead to posterior tibial tendon injury and have a high rate of malunion.

Purpose: To describe a novel partial step-cut medial malleolar osteotomy technique and evaluate its technical feasibility and its advantages compared with traditional methods.

Study Design: Case series; Level of evidence, 4. Read More

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Synchronization in populations of electrochemical bursting oscillators with chaotic slow dynamics.

Chaos 2021 May;31(5):053125

Department of Chemistry, Saint Louis University, 3501 Laclede Ave., St Louis, Missouri 63103, USA.

We investigate the synchronization of coupled electrochemical bursting oscillators using the electrodissolution of iron in sulfuric acid. The dynamics of a single oscillator consisted of slow chaotic oscillations interrupted by a burst of fast spiking, generating a multiple time-scale dynamical system. A wavelet analysis first decomposed the time series data from each oscillator into a fast and a slow component, and the corresponding phases were also obtained. Read More

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"Fistula Zero" Project After Total Laryngectomy: The Candiolo Cancer Institute Experience.

Front Oncol 2021 22;11:690703. Epub 2021 Jun 22.

Head and Neck Oncology Unit, Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia - IRCCS (FPO-IRCCS), Candiolo, Italy.

Objectives: Pharyngocutaneous fistula (PCF) is a troublesome complication after total laryngectomy. The "Fistula zero" project aims to reduce the number of PCF by following a detailed protocol based on three fundamental key points.

Materials And Methods: The Fistula zero project included 77 patients who underwent total laryngectomy in the period from January 2019 to December 2020. Read More

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Electrodiagnostic Testing Characteristics of Diabetic People with Carpal Tunnel Syndrome.

Rev Bras Ortop (Sao Paulo) 2021 Jun 10;56(3):356-359. Epub 2021 Feb 10.

Cirurgia do Pé, Serviço de Ortopedia e Traumatologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.

 The present study aimed to correlate electroneuromyography (ENMG) findings in diabetic and nondiabetic subjects with carpal tunnel syndrome (CTS).  In total, 154 patients were evaluated in a hand surgery outpatient clinic. All ENMG tests were bilaterally performed by a single neurologist. Read More

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The efficacy and tolerability of ultra-hypofractionated radiotherapy in low-intermediate risk prostate cancer patients: single center experience.

Aging Male 2021 Dec;24(1):50-57

Department of Radiation Oncology, University of Health Science Prof. Dr. CemilTascioglu City Hospital, Istanbul, Turkey.

Background: We aimed to investigate the efficacy and tolerability of ultra-hypofractionated radiotherapy (UHRT) in the treatment of low and intermediate-risk prostate cancer patients.

Methods: This retrospective study was conducted using data derived from 44 patients who underwent UHRT, and toxicity assessment and clinical response were investigated. Treatment consisted of 35-36. Read More

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December 2021