730 results match your criteria sera arctic

Serum N-Glycome Diversity in Teleost and Chondrostrean Fishes.

Front Mol Biosci 2021 10;8:778383. Epub 2021 Nov 10.

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.

Recent advances in carbohydrate chemistry, chemical biology, and mass spectrometric techniques have opened the door to rapid progress in uncovering the function and diversity of glycan structures associated with human health and disease. These strategies can be equally well applied to advance non-human health care research. To date, the glycomes of only a handful of non-human, non-domesticated vertebrates have been analyzed in depth due to the logistic complications associated with obtaining or handling wild-caught or farm-raised specimens. Read More

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November 2021

Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations.

Biomedicines 2021 Oct 22;9(11). Epub 2021 Oct 22.

School of Public Health, Imperial College London, London SW7 2AZ, UK.

A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Read More

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October 2021

Deterioration of Lipid Metabolism Despite Fitness Improvements in Wildland Firefighters.

J Occup Environ Med 2021 Nov 23. Epub 2021 Nov 23.

Montana Center for Work Physiology and Exercise Metabolism, The University of Montana, Missoula, MT (Rosales, Dodds, Hailes, Ruby), Cardio Protection Laboratory, The University of Montana, Missoula, MT (Quindry), Integrative Physiology Laboratory, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK (Coker), National Technology and Development Program, United States Department of Agriculture Forest Service, Missoula, MT (Sol).

Objective: Determine serum lipid and general health/fitness alterations following a 5-month wildfire suppression season.

Methods: We recruited 100 wildland firefighters (WLFFs) to a 5-month pre- to post-season observational study. Nude body mass, blood pressure (BP), grip strength, and step-test heart rate (HR) were recorded. Read More

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November 2021

Evidence of Arctic Fox Survival following Exposure to Rabies Virus.

J Wildl Dis 2021 Nov 23. Epub 2021 Nov 23.

US Department of Agriculture, National Wildlife Research Center, 4101 Laporte Avenue, Fort Collins, Colorado 80521, USA.

The arctic fox variant of the rabies virus (RABV) is enzootic in the circumpolar north. Reports of abortive RABV exposures motivated a retrospective analysis of sera from 41 arctic foxes captured at Karrak Lake in Nunavut, Canada, during 2011-2015. Estimated RABV antibody prevalence among foxes was 14% (95% confidence interval, 7-28%). Read More

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November 2021

Influences of spent coffee grounds on skin mucosal and serum immunities, disease resistance, and growth rate of Nile tilapia (Oreochromis niloticus) reared under biofloc system.

Fish Shellfish Immunol 2021 Nov 11;120:67-74. Epub 2021 Nov 11.

University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Institute of Aquaculture and Protection of Waters, Na Sádkách 1780, 370 05, České Budějovice, Czech Republic.

The study was executed to find out the potential effects spent coffee ground (SCG) on Nile tilapia's skin mucosal and serum immunities, disease prevention, and growth rate reared in a biofloc system. Nile tilapia fingerlings (average weight 15.25 ± 0. Read More

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November 2021

Smoking associates with increased BAFF and decreased interferon-γ levels in patients with systemic lupus erythematosus.

Lupus Sci Med 2021 Oct;8(1)

Rheumatology Section, Medical School, University of Western Australia Faculty of Medicine, Dentistry and Health Sciences, Crawley, Western Australia, Australia.

Objective: In SLE, smoking increases the burden of cutaneous disease and organ damage, and leads to premature mortality. However, the effect of smoking on disease manifestations and cytokine levels of patients with SLE is unclear. This study compared characteristics of patients with SLE across smoking status, and determined the association of smoking with serum cytokine levels. Read More

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October 2021

M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.

Arch Dis Child 2021 Oct 22. Epub 2021 Oct 22.

Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALL) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALL from JIA. The secondary aims were to compare the protein levels at baseline and follow-up in a paired number of children with ALL and to examine the correlation with haematology counts, erythrocyte sedimentation reaction (ESR), C-reactive protein (CRP), blasts, relapse and death. Read More

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October 2021

Bacterial Membrane-Derived Vesicles Attenuate Vancomycin Activity against Methicillin-Resistant .

Microorganisms 2021 Sep 29;9(10). Epub 2021 Sep 29.

Research Group for Host-Microbe Interactions, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.

Methicillin-resistant (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. Read More

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September 2021

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Theranostics 2021 3;11(19):9217-9233. Epub 2021 Sep 3.

DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required. The combination of LC-MS/MS with chemical isobaric labeling enabled the simultaneous quantitative comparison of Trp and its amino group-bearing metabolites in multiple samples. Read More

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September 2021

Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up.

Sci Rep 2021 Oct 7;11(1):19936. Epub 2021 Oct 7.

Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, P.O. Box 5400, 90014, Oulu, Finland.

The aim of this study was to cross-sectionally and longitudinally examine whether higher hemoglobin (Hb) levels within the normal variation associate with key components of metabolic syndrome and total and cardiovascular mortality. The study included 967 Finnish subjects (age 40-59 years) followed for ≥ 20 years. The focus was on Hb levels, cardiovascular diseases (CVDs) and mortality rates. Read More

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October 2021

Adaptation to a High Iodine Intake in Greenland Inuit Suggested by Thyroid Disease Pattern.

Thyroid 2021 Nov 1. Epub 2021 Nov 1.

Department of Clinical Medicine, Arctic Health Research Centre, Aalborg University, Aalborg, Denmark.

Arctic living is influenced by cold winters, short summers, and excessive iodine intake from the traditional Inuit diet providing for habitation of the Arctic for centuries. This is changing and we surveyed thyroid function in populations living in Greenland. Population-based cross-sectional study. Read More

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November 2021

A New Pipeline for the Normalization and Pooling of Metabolomics Data.

Metabolites 2021 Sep 17;11(9). Epub 2021 Sep 17.

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e. Read More

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September 2021

Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes.

Biomed Res Int 2021 2;2021:7086108. Epub 2021 Sep 2.

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Arkhangelsk, Russia.

The paper presents the results of studying the immunological parameters of 369 people who were practically healthy at the time of the survey, 298 women and 71 men, of which 216 people are living in the European North of the Russian Federation (173 women and 43 men) and 153 are residents of the Arctic (125 women and 28 men). The study was carried out in the morning (08:00-10:00 am). The study included the determination of the aggregation of erythrocytes, platelets, neutrophilic granulocytes, lymphocytes, hemogram study, hematological analysis, enzyme immunoassay, and flow cytometry. Read More

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September 2021

Long-Term Survival, Causes of Death, and Trends in 5-Year Mortality After Intracerebral Hemorrhage: The Tromsø Study.

Stroke 2021 Dec 9;52(12):3883-3890. Epub 2021 Sep 9.

Department of Clinical Medicine (M.C., S.H.J., L.-H.J., E.B.M.), UiT The Arctic University of Norway, Tromsø.

Background And Purpose: Data on long-term survival after intracerebral hemorrhage (ICH) are scarce. In a population-based nested case-control study, we compared long-term survival and causes of death within 5 years in 30-day survivors of first-ever ICH and controls, assessed the impact of cardiovascular risk factors on 5-year mortality, and analyzed time trend in 5-year mortality in ICH patients over 2 decades.

Methods: We included 219 participants from the population-based Tromsø Study, who after the baseline participation had a first-ever ICH between 1994 to 2013 and 1095 age- and sex-matched participants without ICH. Read More

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December 2021

Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples collected from Northern Norwegian women: The MISA cohort study.

Environ Res 2022 Mar 30;204(Pt A):111980. Epub 2021 Aug 30.

Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, 7491, Norway; Department of General Hygiene I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119992, Russia. Electronic address:

The ubiquitous presence of legacy and emerging persistent organic pollutants (POPs) in the environmental matrices poses a potential hazard to the humans and creating public health concerns. The present study aimed to evaluate dioxins, dioxin-like polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and chlorinated paraffins (CPs) concentrations in serum of women (postpartum, pregnant and non-pregnant) from Northern Norway to better understand their exposure and contamination status as well as temporal trends across 2007-2009 (MISA 1) to 2019 (MISA 2). Sixty-two blood samples from the MISA 1 cohort and 38 samples from MISA 2 were randomly selected in this study (n = 100). Read More

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Change in cardiovascular risk assessment tool and updated Norwegian guidelines for cardiovascular disease in primary prevention increase the population proportion at risk: the Tromsø Study 2015-2016.

Open Heart 2021 08;8(2)

Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

Aims: To compare the population proportion at high risk of cardiovascular disease (CVD) using the Norwegian NORRISK 1 that predicts 10-year risk of CVD mortality and the Norwegian national guidelines from 2009, with the updated NORRISK 2 that predicts 10-year risk of both fatal and non-fatal risk of CVD and the Norwegian national guidelines from 2017.

Methods: We included participants from the Norwegian population-based Tromsø Study (2015-2016) aged 40-69 years without a history of CVD (n=16 566). The total proportion eligible for intervention was identified by NORRISK 1 and the 2009 guidelines (serum total cholesterol ≥8 mmol/L, systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥100 mm Hg) and NORRISK 2 and the 2017 guidelines (serum total cholesterol ≥7 mmol/L, low density lipoprotein (LDL) cholesterol ≥5 mmol/L, systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥100 mm Hg). Read More

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Serum biochemistry and haematology in wild and captive bearded seals (Erignathus barbatus) from Svalbard, Norway.

Acta Vet Scand 2021 Aug 26;63(1):33. Epub 2021 Aug 26.

Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1432, Ås, Norway.

Background: Health assessment of seals in captivity include haematology and serum biochemistry measurements. Because such parameters differ between species, it is crucial to have species-specific reference values for the interpretation of clinical samples. Furthermore, differences in nutrition and environment, life cycles as well as seasonal/annual cycles and varying physiological conditions can potentially affect serum chemistry and haematology parameters. Read More

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Serum Matrix Metalloproteinase 7 and accelerated GFR decline in a general non-diabetic population.

Nephrol Dial Transplant 2021 Aug 26. Epub 2021 Aug 26.

Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Background: Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with GFR decline in a general nondiabetic population.

Methods: In the Renal Iohexol Clearance Survey (RENIS), we measured GFR using iohexol clearance in 1627 subjects aged 50-64 without self-reported diabetes, kidney or cardiovascular disease. Read More

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Zoonotic pathogens in wild muskoxen (Ovibos moschatus) and domestic sheep (Ovis aries) from Greenland.

Vet Med Sci 2021 Nov 14;7(6):2290-2302. Epub 2021 Aug 14.

Department of Plant and Environmental Sciences, University of Copenhagen, Denmark.

The present study aimed to estimate the prevalence of zoonotic pathogens Giardia duodenalis, Cryptosporidium spp., Toxoplasma gondii and Erysipelothrix in muskoxen (Ovibos moschatus) and sheep (Ovis aries) from Greenland. In 2017 and 2018, faecal samples were collected from wild muskoxen from three distinct populations (Zackenberg, Kangerlussuaq, and Ivittuut) and from domestic sheep from southwest Greenland. Read More

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November 2021

Age-related changes in the parameters of carbohydrate metabolism and supply of vitamins B1, B2 in residents of two northern regions.

Klin Lab Diagn 2021 Aug;66(8):465-471

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FCIAR UrB RAS).

A great deal of research was being done in studying of the age-related characteristics of carbohydrate metabolism and the provision of vitamins B1, B2 among the population of the Subarctic (SR) and Arctic (AR) regions, differing in the extreme natural and climatic-geographic living conditions. The surveyed population was divided into five age groups: 16-21, 22-35, 36-45, 46-60 and 61-74 years old. The parameters of carbohydrate metabolism (glucose, lactate, pyruvate) were determined in the blood serum, the content of thiamine (thiamin diphosphate effect) and riboflavin - in hemolysates, and the values of the lactate/pyruvate ratio (Lac/Pyr) were calculated. Read More

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A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity.

J Immunol 2021 09 11;207(6):1641-1651. Epub 2021 Aug 11.

Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway;

Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin as an activator of native C5 by analyzing complement activation and C5 cleavage in human whole blood anticoagulated with Gly-Pro-Arg-Pro (GPRP), a peptide targeting fibrin polymerization downstream of thrombin, allowing complete endogenous thrombin generation. Read More

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September 2021

Seroprevalence and Risk Factors Associated with Infection in Camels in the Puntland State of Somalia.

Vet Sci 2021 Jul 19;8(7). Epub 2021 Jul 19.

Department of Disease Control, School of Veterinary Medicine, The University of Zambia, Lusaka P.O. Box 32379, Zambia.

Brucellosis is an important zoonotic disease caused by members of the genus . Camel brucellosis has been reported in almost all camel-rearing countries in Africa and Asia. A cross-sectional study was conducted between February 2020 and February 2021 in Galkayo, Garowe, and Bosaso districts in the Puntland State of Somalia to investigate the seroprevalence and risk factors of brucellosis in camels. Read More

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Assessment of kidney function: clinical indications for measured GFR.

Clin Kidney J 2021 Aug 22;14(8):1861-1870. Epub 2021 Feb 22.

Institute of Public Health, Charité Universitätsmedizin Berlin, Berlin, Germany.

In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. Read More

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Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study.

Environ Res 2022 01 31;203:111712. Epub 2021 Jul 31.

Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Previous studies have shown immunotoxic effects of environmental chemicals, and the European Food Safety Authority (EFSA) recently identified a need for more studies on PFAS immunotoxicity in different populations. In the Arctic, populations are exposed to several environmental chemicals through marine diet, and the objective of this study was therefore to examine the association between Greenlandic children's exposure to major environmental chemicals and their concentrations of diphtheria and tetanus vaccine antibodies after vaccination. The study includes cross-sectional data from Greenlandic children aged 7-12 years examined during 2012-2015. Read More

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January 2022

Serum miR371 in testicular germ cell cancer before and after orchiectomy, assessed by digital-droplet PCR in a prospective study.

Sci Rep 2021 08 2;11(1):15582. Epub 2021 Aug 2.

Mohn Cancer Research Laboratory, Department of Oncology and Medical Physics, Haukeland University Hospital, Jonas Lies vei 91B, 5021, Bergen, Norway.

MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCG). Overall, 180 patients were prospectively enrolled in the study, with serum samples collected before and after orchiectomy. Read More

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Long-term increases in pathogen seroprevalence in polar bears (Ursus maritimus) influenced by climate change.

Glob Chang Biol 2021 10 22;27(19):4481-4497. Epub 2021 Jul 22.

Wildlife Research Division, Science and Technology Branch, Environment and Climate Change Canada, Edmonton, AB, Canada.

The influence of climate change on wildlife disease dynamics is a burgeoning conservation and human health issue, but few long-term studies empirically link climate to pathogen prevalence. Polar bears (Ursus maritimus) are vulnerable to the negative impacts of sea ice loss as a result of accelerated Arctic warming. While studies have associated changes in polar bear body condition, reproductive output, survival, and abundance to reductions in sea ice, no long-term studies have documented the impact of climate change on pathogen exposure. Read More

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October 2021

Impact of cinnamaldehyde on innate immunity and immune gene expression in Channa striatus against Aphanomyces invadans.

Fish Shellfish Immunol 2021 Oct 16;117:1-16. Epub 2021 Jul 16.

Norwegian College of Fishery Science, Faculty of Bioscience, Fisheries and Economics, UiT The Arctic University of Norway, Tromsø, Norway.

The effect of cinnamaldehyde (CM) enriched diet on immunity and cytokine gene expression in Channa striatus against Aphanomyces invadans is reported. C. striatus was uniformly divided into eight groups (n = 25 fish each) and fed with formulated diets with 0, 5, 10, and 15 mg kg CM enriched diet. Read More

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October 2021