1,234,325 results match your criteria sera

Characterization of arrhythmias, evaluation of cardiac biomarkers and their association with survival in calves suffering from foot-and-mouth disease.

J Vet Cardiol 2021 Apr 18;36:64-76. Epub 2021 Apr 18.

Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru, Karnataka, 560024, India.

Introduction: Foot-and-mouth disease (FMD) causes mortality in calves due to myocarditis; however, the effects of FMD virus on cardiac arrhythmogenesis and Purkinje cells are unknown. Identifying diagnostic and prognostic markers in FMD-affected calves may be useful in disease management in the endemic countries.

Materials And Methods: A total of 81 FMD-affected calves were prospectively monitored till death or recovery. Read More

View Article and Full-Text PDF

Percentile values for serum levels of vitamins A and D in Iranian children and adolescents: The CASPIAN-V study.

Nutrition 2021 Apr 30;90:111307. Epub 2021 Apr 30.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: The reference values to determine vitamin A and D deficiency may vary based on ethnicity, age, and region of residence. The aim of this study was to determine the reference interval of circulating vitamin A and D levels among Iranian children and adolescents based on sex, age, and region of residence.

Methods: This nationwide cross-sectional study was performed with 2596 students 7 to 18 y of age from the CASPIAN-V (Childhood and Adolescence Surveillance and Prevention of Adult Non- communicable disease) study. Read More

View Article and Full-Text PDF

Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion.

J Reprod Immunol 2021 Jun 5;146:103343. Epub 2021 Jun 5.

Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, 60286, Surabaya, Indonesia. Electronic address:

Objectives: Chronic inflammation and pelvic adhesion play a critical role in endometriosis-related infertility. Research studies suggest that TGF-β superfamily members, such as soluble endoglin (sEng), growth differentiation factor 15 (GDF-15) and tumor growth factor-beta (TGF-β1) contribute to the regulation of inflammation, angiogenesis and cell adhesion. The objective of this study is to investigate the association between the concentrations of these TGF-β-related members and the clinical parameters of infertile women with endometriosis. Read More

View Article and Full-Text PDF

Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria.

Int J Parasitol Drugs Drug Resist 2021 Jun 1;16:148-154. Epub 2021 Jun 1.

Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120, Halle (Saale), Germany. Electronic address:

Transdermal drug delivery avoids complications related to oral or parenteral delivery - the need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or nausea and compliance. For malaria treatment, we demonstrate successful novel transdermal delivery of artemisone (ART) and artesunate. The incorporation of ART into a microemulsion (ME) overcomes the limitations of the lipophilic drug and provides high transcutaneous bioavailability. Read More

View Article and Full-Text PDF

Copeptin combined with National Early Warning Score for predicting survival in elderly critical ill patients at emergency department.

Am J Emerg Med 2021 Jun 8;49:153-157. Epub 2021 Jun 8.

Emergency Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China. Electronic address:

Objective: Copeptin, reflecting vasopressin release, as well as the National Early Warning Score (NEWS), reflecting the severity of critical illness, might qualify for survival prediction in elderly patients with critical illness. This prospective observational study aims at assessing the predictive value of copeptin combined with NEWS on the prognosis of elderly critical ill patients at emergency department (ED).

Methods: We analyzed serum copeptin levels and the NEWS at admission to the ED in a prospective, single-center, and observational study comprising 205 elderly patients with critical illness. Read More

View Article and Full-Text PDF

Effect of dietary hempseed cake on milk performance and haemato-chemicals in lactating Alpine dairy goats.

Animal 2021 Jun 8;15(7):100255. Epub 2021 Jun 8.

Department for Animal Production and Biotechnology, Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, V. Preloga 1, 31000 Osijek, Croatia.

Owing to the high concentrations of crude protein and beneficial fatty acids, hempseed cake could be a high-quality feedstuff for ruminants. The aim of the present study was to evaluate the effects of hempseed cake on milk production and quality, as well as haemato-chemical parameters in Alpine goats. In total, 28 French Alpine dairy goats were evaluated over 45 days. Read More

View Article and Full-Text PDF

Interaction of CP levels in maternal and nursery diets, and its effect on performance, protein digestibility, and serum urea levels in piglets.

Animal 2021 Jun 8;15(7):100266. Epub 2021 Jun 8.

Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), 9090 Melle, Belgium; Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium. Electronic address:

Reduced protein levels in nursery diets have been associated with a lower risk of postweaning diarrhea, but the interaction with CP levels in maternal diet on the performance of the offspring remains unclear. The objective of this study was to determine the effect of protein content in sow gestation and piglet nursery diets on the performance of the piglets until slaughter. This was studied in a 2 × 2 factorial trial (35 sows, 209 piglets), with higher or lower (H or L) dietary CP in sow diets (168 vs 122 g CP/kg) during late gestation. Read More

View Article and Full-Text PDF

Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats.

Horm Behav 2021 Jun 8;133:105005. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan. Electronic address:

Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. Read More

View Article and Full-Text PDF

Evaluation of IGF-1 as a novel theranostic biomarker for schizophrenia.

J Psychiatr Res 2021 Jun 2;140:172-179. Epub 2021 Jun 2.

Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.

Objective: In the current study, we aimed to investigate fasting plasma levels of glucose, insulin, growth hormone, IGF-1, and lipid profile in remission schizophrenia patients, treatment resistant schizophrenia patients and healthy controls and to determine whether IGF-1 levels can be used as a theranostic biomarker in schizophrenia.

Methods: Sixty-two patients under remission from schizophrenia, sixty-five treatment-resistant patients with schizophrenia and sixty-two healthy controls were included in the study. All patients were recruited and evaluated over 11 months. Read More

View Article and Full-Text PDF

Altered neuroaxonal integrity in schizophrenia and major depressive disorder assessed with neurofilament light chain in serum.

J Psychiatr Res 2021 Jun 2;140:141-148. Epub 2021 Jun 2.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zürich, University of Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.

Background: Schizophrenia (SZ) and major depressive disorders (MDD) have been frequently linked to anatomical brain alterations. However, the relationship between brain pathology, inflammation and clinical symptoms in these disorders is still unclear. Thus, by applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL), we can now address main issues in psychiatric research and potentially offer innovative diagnostic tools toward better clinical characterizations and monitoring in both SZ and MDD. Read More

View Article and Full-Text PDF

Interactions between cattle breed type and anabolic implant strategy impact circulating serum metabolites, feedlot performance, feeding behavior, carcass characteristics, and economic return in beef steers.

Domest Anim Endocrinol 2021 May 1;77:106633. Epub 2021 May 1.

Department of Animal, Dairy and Veterinary Science, Utah State University, 4815 Old Main Hill, Logan, Utah, 84322, USA. Electronic address:

Introducing Bos indicus (BI) genetics into a beef herd has the potential to increase environmental sustainability. When introducing BI genetics, there are concerns regarding negative impacts on temperament, growth, and carcass characteristics. Implants are routinely used in the United States, with majority of cattle on feed receiving an anabolic implant to improve growth and efficiency, however research regarding the interaction between cattle breed type and anabolic implants is limited. Read More

View Article and Full-Text PDF

Label-free surface-enhanced Raman spectroscopy for diagnosis and analysis of serum samples with different types lung cancer.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 26;261:120021. Epub 2021 May 26.

School of Physics, Dalian University of Technology, Dalian, 116023, People's Republic of China.

Screening and detection of early lung cancer is important for diagnosis and prognosis. Intervention in early stage of lung cancer can significantly improve the cure and survival of patients. Surface-enhanced Raman spectroscopy (SERS) is an increasingly popular method of diagnosing cancer. Read More

View Article and Full-Text PDF

Vitamin D supplementation reduces serum lipids of children with hypertriacylglycerolemia: A randomized, triple-masked, placebo-controlled crossover trial.

Nutrition 2021 Apr 28;89:111296. Epub 2021 Apr 28.

Laboratory of Physiology, Nutrition and Health, Faculty of Physical Education and Dance, Federal University of Goiás, Samambaia Campus, Goiânia, Goiás, Brazil.

Objectives: This study aimed to evaluate the effect of cholecalciferol supplementation on the body composition and metabolic profile of children with hypertriacylglycerolemia.

Methods: This is a randomized, triple-masked, placebo-controlled, crossover trial of 44 Brazilian children with hypertriacylglycerolemia, age 4 to 11 y. The sample included eutrophic and overweight/obese children according to body mass index for age, with sufficient and insufficient vitamin D basal levels. Read More

View Article and Full-Text PDF

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.

Environ Int 2021 Jun 8;155:106666. Epub 2021 Jun 8.

Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, United States.

Background: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.

Objective: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth. Read More

View Article and Full-Text PDF

Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma.

Biochem Biophys Res Commun 2021 Jun 8;566:36-44. Epub 2021 Jun 8.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. Electronic address:

The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. The melanocortin 4 receptor-deficient (Mc4r-KO) mice were divided into four groups with or without a high-fat diet (HFD) and with or without dextran sulfate sodium (DSS) to induce colitis, and the differences in liver damage and occurrence of HCC were analyzed. Read More

View Article and Full-Text PDF

High fat induces activation of the tryptophan-ERK-CREB pathway and promotes bone absorption in cage layers.

Poult Sci 2021 Mar 22;100(7):101149. Epub 2021 Mar 22.

Department of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.

Cage layer fatigue is a common metabolic disease associated with a calcium and phosphorus imbalance, but recently we found this disease can be led by high fat diet. In order to elucidate the pathogenesis induced by a high fat diet, we randomly divided 88 White Shell Roman layers into 2 groups. There were 44 layers in each group. Read More

View Article and Full-Text PDF

Evaluation of serum antioxidative status, immune status and intestinal condition of Linwu duck challenged by lipopolysaccharide with various dosages and replications.

Poult Sci 2021 Apr 20;100(7):101199. Epub 2021 Apr 20.

Hunan Institute of Animal and Veterinary Science, Changsha 410131, China. Electronic address:

The present study investigated the dosage and replication effects of lipopolysaccharide challenges on the serum oxidative and immune status, and the intestinal morphology and permeability of Linwu ducks at the growing stage. A total of 500 54-day-old Linwu ducks were randomly assigned into 10 treatments, which included a factorial arrangement of 2 levels of LPS challenge replications (1 and 2 times) × 5 levels of lipopolysaccharide challenging dosages (0, 0.1, 0. Read More

View Article and Full-Text PDF

Serum Inhibin-A and PAPP-A2 in the prediction of pre-eclampsia during the first and second trimesters in high-risk women.

Pregnancy Hypertens 2021 Jun 2;25:116-122. Epub 2021 Jun 2.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

Objectives: Maternal serum inhibin-A, pregnancy associated plasma protein-A (PAPP-A) and PAPP-A2 together with placental growth factor (PlGF), maternal risk factors and uterine artery pulsatility index (UtA PI) were analysed to study their ability to predict pre-eclampsia (PE).

Study Design: Serial serum samples for the nested case-control study were collected prospectively at 12-14, 18-20 and 26-28 weeks of gestation from 11 women who later developed early-onset PE (EO PE, diagnosis < 34 + 0 weeks of gestation), 34 women who developed late-onset PE (LO PE, diagnosis ≥ 34 + 0 weeks) and 89 controls.

Main Outcome Measures: Gestational age -adjusted multiples of the median (MoM) values were calculated for biomarker concentrations. Read More

View Article and Full-Text PDF

Detection of SARS-CoV-2 IgG antibodies in dried blood spots.

Diagn Microbiol Infect Dis 2021 May 13;101(1):115425. Epub 2021 May 13.

Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The COVID-19 pandemic led to development of numerous serologic tests. To obviate the need for phlebotomy services, we validated dried blood spots (DBS) for anti-SARS-CoV-2 serologic testing. Immunoglobulins were extracted from 3 mm DBS punches and the extracts were analyzed using the Euroimmun anti-SARS-CoV-2 IgG ELISA. Read More

View Article and Full-Text PDF

In vitro and in vivo study on angiogenesis of porcine induced pluripotent stem cell-derived endothelial cells.

Differentiation 2021 Jun 4;120:10-18. Epub 2021 Jun 4.

College of Life Science, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address:

Pluripotent stem cells (PSCs) are a promising source of endothelial cells (ECs) for the treatment of cardiovascular diseases. Since clinical application of embryo stem cells (ESCs) involves issues of medical ethics and risk of immune rejection, induced pluripotent stem cells (iPSCs) will facilitate cell transplantation therapy for the cardiovascular diseases. Swine is identified as an ideal large-animal model for human, because of its similar organ size and physiological characteristics. Read More

View Article and Full-Text PDF

Study of the correlation between the noncanonical pathway of pyroptosis and idiopathic inflammatory myopathy.

Int Immunopharmacol 2021 Jun 8;98:107810. Epub 2021 Jun 8.

Qinghai University, 251 Ningda Road, Chengbei District, Xining City, Qinghai Province 810000, China.

Background: The pathogenesis of idiopathic inflammatory myopathy (IIM) is complex and unclear. The purpose of this study was to investigate whether the noncanonical pathway of pyroptosis is involved in the pathogenesis of IIM, and the intervention effect of drugs glyburide and bright blue G (BBG).

Methods: After the drug intervention, we detected the expression of the caspase-4, caspase-5, caspase-11, GSDMD, pannexin-1, NLRP3 and P2X7R proteins in skeletal muscle tissues from the six groups using Western blotting. Read More

View Article and Full-Text PDF

Conjugated linoleic acid improves meiotic spindle morphology and developmental competence of heat-stressed bovine oocyte.

Theriogenology 2021 May 27;172:67-72. Epub 2021 May 27.

Pasargad Institute for Advanced Innovative Solutions (PIAIS), Khatam University, Tehran 1991633356, Iran.

This study was conducted to elucidate the effects of introducing conjugated linoleic acid (CLA) on meiotic spindle organization of heat stressed (HS) matured oocytes and the resulting blastocysts DNA methylation as well as the expression of the genes involved in DNA methylation (DNMT3a, DNMT3b and DNMT1). Immature bovine oocytes were cultured at 41 °C for the first 12 h and 38.5 °C for the second 12 h of maturation time in the presence of 0 and 50 μM of CLA (HS and HS + CLA groups, respectively). Read More

View Article and Full-Text PDF

Characterization and prediction of viral loads of Hepatitis B serum samples by using surface-enhance Raman spectroscopy (SERS).

Photodiagnosis Photodyn Ther 2021 Jun 8:102386. Epub 2021 Jun 8.

PCR Laboratory, PINUM Hospital, Faisalabad, Pakistan.

Background: Raman spectroscopy is a promising technique to analyze the body fluids for the purpose of non-invasive disease diagnosis.

Objectives: To develop a surface-enhanced Raman spectroscopy (SERS) based method for qualitative and quantitative analysis of hepatitis B viral (HBV) infection from blood serum samples.

Methods: Clinically diagnosed hepatitis B virus (HBV) infected serum samples of patients of different levels of viral loads have been subjected for SERS analysis in comparison with the healthy ones by using silver nanoparticles (Ag NPs) based SERS substrates. Read More

View Article and Full-Text PDF


J Thorac Oncol 2021 Jun 8. Epub 2021 Jun 8.

Cancer Research UK Beatson Institute, Glasgow, UK.

Introduction: Malignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate blood biomarker could prompt specialist referral or be deployed in future screening. In earlier retrospective studies, SOMAscan® proteomics and Fibulin-3 appeared highly accurate, but SOMAscan® has not been validated prospectively and subsequent Fibulin-3 data have been contradictory. Read More

View Article and Full-Text PDF

Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins.

J Ethnopharmacol 2021 Jun 8:114315. Epub 2021 Jun 8.

Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address:

Ethnopharmacological Relevance: Dalbergia sissoo DC. (Indian rosewood or Sheesham) is a traditional medicinal plant, reported since time immemorial for its analgesic, anti-nociceptive, anti-inflammatory, and immuno-modulatory properties. D. Read More

View Article and Full-Text PDF

Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity.

J Ethnopharmacol 2021 Jun 8:114304. Epub 2021 Jun 8.

Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, China. Electronic address:

Ethnopharmacological Relevance: Anneslea fragrans Wall. is traditionally used as a folk medicine in treating indigestion, fever, dysentery, diarrhea, and liver inflammation in China, Vietnam and Cambodia. However, its anti-inflammatory activity and mechanism under a safety therapeutic dose as well as the main chemical components have not yet been fully investigated. Read More

View Article and Full-Text PDF

Selenium mitigated aflatoxin B1-induced cardiotoxicity with potential regulation of 4 selenoproteins and ferroptosis signaling in chicks.

Food Chem Toxicol 2021 Jun 8:112320. Epub 2021 Jun 8.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

The aim of the present study was to explore the underlying mechanism of selenium (Se)-mediated detoxification of aflatoxin B (AFB)-induced cardiotoxicity in chicks. A Se-deficient, corn-soybean meal-basal diet (36 μg Se/kg, BD) and three test diets (BD+1.0 mg AFB/kg, 0. Read More

View Article and Full-Text PDF

Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation.

Am J Med Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China. Electronic address:

Background: Fluid therapy is indispensable in treating patients with hemorrhagic shock. However, fluid overload correlates with kidney injury in patients with hemorrhagic shock. We hypothesized that hemodilution after fluid treatment contributes to the kidney injury. Read More

View Article and Full-Text PDF

Recombinant antithrombin attenuates acute respiratory distress syndrome in experimental endotoxemia.

Am J Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Sepsis-induced endothelial acute respiratory distress syndrome (ARDS) is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocalyx from septic vasculitis; however, the underlying mechanism remains unknown. Here, we investigated the effect of rAT administration on vascular endothelial injury under endotoxemia. Read More

View Article and Full-Text PDF

Lack of Effects of the Genetic Polymorphisms of Interleukin-10 in Clinical Outcomes of COVID-19.

Viral Immunol 2021 Jun 11. Epub 2021 Jun 11.

Hospital General de Culiacán, "Bernardo J Gastélum," Secretaria de Salud de Sinaloa (Z.C: 80230), Culiacán, México.

Interleukin-10 () gene polymorphisms have been associated with severity and outcomes in patients with respiratory and nonrespiratory viral infections. The aim of this study was to assess whether rs1800871 and rs1800872 polymorphisms of gene are associated with the clinical outcomes of COVID-19 in a Mexican population. Study subjects were 193 COVID-19 patients. Read More

View Article and Full-Text PDF