147,089 results match your criteria sequential

Stepped care for the treatment of depression: a systematic review and meta-analysis.

J Affect Disord 2021 Jul 18;294:391-409. Epub 2021 Jul 18.

Health Services Research on Chronic Patients Network (REDISSEC). Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Background: The Stepped Care Model (SCM) proposes a sequential approach in the treatment of depression, applying interventions of increasing intensity according to the level of severity of the individual.

Methods: A systematic review was carried out until January 2020 in eight electronic databases. We included randomized (RCT) and non-randomized controlled trials comparing the SCM to usual non-sequential care. Read More

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Source apportionment of potentially toxic elements in soils of the Yellow River Delta Nature Reserve, China: The application of three receptor models and geostatistical independent simulation.

Environ Pollut 2021 Jul 22;289:117834. Epub 2021 Jul 22.

College of Geography and Environment, Shandong Normal University, Ji'nan, 250014, China. Electronic address:

The Yellow River Delta (YRD) wetland, the most important estuary wetland in eastern China, has an important ecosystem service function. Rapid and intensive development has inevitably led to the accumulation of potentially toxic elements (PTEs) in soils. Therefore, identifying quantitative sources and spatial distributions of PTEs is essential for soil environmental protection in the YRD. Read More

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Rationale and Design of a Randomized Study Comparing the Agent Drug Coated Balloon to Plain Old Balloon Angioplasty in Patients with In-Stent Restenosis.

Am Heart J 2021 Jul 24. Epub 2021 Jul 24.

Columbia University Irving Medical Center/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY, USA.

Background: Drug-coated balloon (DCB) technology was developed as an alternative treatment for obstructive coronary artery disease (CAD) and in-stent restenosis (ISR). Management of coronary ISR is clinically challenging and frequently encountered in practice. The Agent DCB uses an inactive excipient to effectively deliver a targeted, therapeutic dose of paclitaxel to the vessel wall. Read More

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Sequential oncogenic mutations influence cell competition.

Curr Biol 2021 Jul 16. Epub 2021 Jul 16.

Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University Graduate School of Chemical Sciences and Engineering, Sapporo, Japan. Electronic address:

At the initial stage of carcinogenesis, newly emerging transformed cells are often eliminated from epithelial layers via cell competition with the surrounding normal cells. For instance, when surrounded by normal cells, oncoprotein RasV12-transformed cells are extruded into the apical lumen of epithelia. During cancer development, multiple oncogenic mutations accumulate within epithelial tissues. Read More

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The impact of increasing karyotypic complexity and evolution on survival in CLL patients treated with ibrutinib.

Blood 2021 Jul 27. Epub 2021 Jul 27.

The Ohio State University, Columbus, Ohio, United States.

Complex karyotype defined as ≥3 cytogenetic abnormalities is prognostic of survival in patients treated with ibrutinib or venetoclax in relapsed/refractory (RR) chronic lymphocytic leukemia (CLL). Recent studies re-evaluating this dichotomous variable have shown that higher numbers of cytogenetic abnormalities (i.e. Read More

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COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction.

JCI Insight 2021 Jul 27. Epub 2021 Jul 27.

Molecular Medicine, University of Utah, Salt Lake CIty, United States of America.

Vascular injury has emerged as a complication contributing to morbidity in coronavirus disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component of the glycocalyx, a protective layer of glycoconjugates that lines the vascular lumen and regulates key endothelial cell functions. During critical illness as in the case of sepsis, enzymes degrade the glycocalyx, releasing fragments with pathologic activities into circulation and thereby exacerbate disease. Read More

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A Multitask Learning Approach to Personalised Blood Glucose Prediction.

IEEE J Biomed Health Inform 2021 Jul 27;PP. Epub 2021 Jul 27.

Blood glucose prediction algorithms are key tools in the development of decision support systems and closed-loop insulin delivery systems for blood glucose control in diabetes. Deep learning models have provided leading results among machine learning algorithms to date in glucose prediction. However these models typically require large amounts of data to obtain best personalised glucose prediction results. Read More

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Coping under a COVID-19 lockdown: patterns of daily coping and individual differences in coping repertoires.

Anxiety Stress Coping 2021 Jul 27:1-19. Epub 2021 Jul 27.

Department of Psychology, University of Koblenz-Landau, Landau, Germany.

Background: Polyregulation-the concurrent or sequential use of multiple strategies to regulate affect or cope with stressors-is a frequent but understudied phenomenon.

Objectives: We aimed to identify patterns of daily coping and individuals' coping repertoires (i.e. Read More

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Sequential Ring-Opening and Ring-Closing Reactions for Converting -Substituted Pyridines into -Substituted Anilines.

Org Lett 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.

Herein we report a method for converting -substituted pyridine rings into -dialkylamino-substituted benzene rings through sequential ring-opening and ring-closing reactions. The nitrogen atom in the pyridine rings was replaced with a methine group, and a dialkylamino substituent was introduced onto the original unsubstituted carbon atom in the pyridine rings. This process can be formally regarded as a hybrid of the skeletal editing and C-H amination of pyridine rings. Read More

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Tissue N-Glycan Analysis Using LC-MS, MS/MS, and MS.

Noriko Suzuki

Curr Protoc 2021 Jul;1(7):e200

Graduate School of Science and Technology, Niigata University, Niigata, Japan.

Tissue glycans usually contain various structures, from simple to highly complicated, in different quantities. N-Glycans are particularly heterogeneous, with up to pentaantennary structures, different branch sequences, and several isomeric structures. 2-Aminopyridine (PA) tagging on released N-glycans is useful for separating isomers and to quantitatively analyze both the major and minor glycan structures in tissues using reversed-phase liquid chromatography (LC)-mass spectrometry (MS) and MS/MS analysis. Read More

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Designable Assembly of Aluminum Molecular Rings for Sequential Confinement of Iodine Molecules.

Angew Chem Int Ed Engl 2021 Jul 27. Epub 2021 Jul 27.

Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter, State key laboratory of structural chemistry, 350002, Fuzhou, CHINA.

Although numerous adsorbent materials have been reported for radioactive iodine capture, demands for the development of new absorbents that are economically viable and featured with reliable synthetic protocols still exist. Herein, in this paper, a coordination-driven self-assembly strategy towards adsorbents for sequential confinement of iodine molecules is reported. It should be noticed that these adsorbents are versatile heterometallic frameworks constructed from aluminum molecular rings of varying size, flexible copper ions and conjugated carboxylate ligands. Read More

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The dynamics of quantitative SARS-CoV-2 anti-spike IgG response to BNT162b2 vaccination.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.

Background: The vaccination for SARS-CoV-2 is necessary to overcome coronavirus disease 2019 (COVID-19). However, the time-dependent vaccine-induced immune response is not well known. This study aimed to investigate the dynamics of SARS-CoV-2 anti-spike IgG response. Read More

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Therapeutic strategies, including allogeneic stem cell transplantation, to overcome relapsed/refractory adult T-cell acute lymphoblastic leukemia.

Expert Rev Hematol 2021 Jul 27. Epub 2021 Jul 27.

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.

Introduction: The long-term survival of relapsed/refractory (R/R) adult T-cell acute lymphoblastic leukemia (T-ALL) is quite poor, and early T-cell precursor (ETP) ALL has recently been described as a high-risk T-ALL subgroup. However, the optimal therapeutic approach to R/R adult T-ALL remains poorly established.

Areas Covered: At present, cytoreductive therapy followed by allogeneic stem cell transplantation (allo-SCT) is considered to be the most clinically relevant and curative modality for R/R T-ALL. Read More

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Nitrogen removal performance and microbiological characteristics of a three-stage series of vertical flow constructed wetlands.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2578-2588

Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China.

In this study, the treatment performance and underlying molecular mechanisms of nitrogen transformation in a three-stage series of vertical flow constructed wetlands (T-VFCWs) treating rural domestic sewage were investigated at three different hydraulic loading rates (HLRs). Specifi-cally, the T-VFCWs composed of three sequential vertical flow constructed wetlands (termed V-1, V-2 and V-3), which were built according to the topography. The results showed that high pollutant removal rates could be achieved when the T-VFCWs was operated to treat rural domestic sewage, even though the HLR increased from 0. Read More

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The residential environment impact scale: Benefits and barriers to implementation in the Australian residential aged care facility context.

Aust Occup Ther J 2021 Jul 26. Epub 2021 Jul 26.

Ageing and Health, NHMRC Boosting Dementia Leadership Fellow, Head of Discipline of Behavioural and Social Sciences in Health, Faculty of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia.

The organisational, physical and social environment within residential aged care settings greatly influence its residents' sense of autonomy, choice and control and their ability to engage in meaningful occupations. Identifying to what extent these environmental contexts are supportive and well-coordinated could assist with promoting meaningful engagement of residents. The Residential Environment Impact Scale (REIS) was developed to measure the impact of the physical and social environment on residents. Read More

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Host preference and invasiveness of commensal bacteria in the Lotus and Arabidopsis root microbiota.

Nat Microbiol 2021 Jul 26. Epub 2021 Jul 26.

Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.

Roots of different plant species are colonized by bacterial communities, that are distinct even when hosts share the same habitat. It remains unclear to what extent the host actively selects these communities and whether commensals are adapted to a specific plant species. To address this question, we assembled a sequence-indexed bacterial culture collection from roots and nodules of Lotus japonicus that contains representatives of most species previously identified using metagenomics. Read More

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AC conductivity and correlation effects in nano-granular Pt/C.

Sci Rep 2021 Jul 26;11(1):15163. Epub 2021 Jul 26.

Physikalisches Institut, Goethe Universität, Frankfurt am Main, 60438, Germany.

Nano-granular metals are materials that fall into the general class of granular electronic systems in which the interplay of electronic correlations, disorder and finite size effects can be studied. The charge transport in nano-granular metals is dominated by thermally-assisted, sequential and correlated tunneling over a temperature-dependent number of metallic grains. Here we study the frequency-dependent conductivity (AC conductivity) of nano-granular Platinum with Pt nano-grains embedded into amorphous carbon (C). Read More

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Combining repetition suppression and pattern analysis provides new insights into the role of M1 and parietal areas in skilled sequential actions.

J Neurosci 2021 Jul 26. Epub 2021 Jul 26.

The Brain and Mind Institute, University of Western Ontario, London, ON N6A 5B7, Canada

How does the brain change during learning? In functional magnetic resonance imaging studies, both multivariate pattern analysis and repetition suppression (RS) have been used to detect changes in neuronal representations. In the context of motor sequence learning, the two techniques have provided discrepant findings: pattern analysis showed that only premotor and parietal regions, but not primary motor cortex (M1), develop a representation of trained sequences. In contrast, RS suggested trained sequence representations in all these regions. Read More

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How to talk with the family of a dying patient: anger to understanding, rage to compassion, loss to acceptance.

BMJ Support Palliat Care 2021 Jul 26. Epub 2021 Jul 26.

Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, Technion Israel Institute of Technology, Haifa, Israel

Informing families about the impending or actual death of their relatives is one of the most challenging and complex tasks a physician may face. The following article describes goal setting and provides five roles/recommendations for conducting the encounter with patient families regarding the imminent or actual death of their relatives. Importantly, the encounter should be family-centred, and the physician should be highly attentive to family needs. Read More

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One-pot production of maltoheptaose (DP7) from starch by sequential addition of cyclodextrin glucotransferase and cyclomaltodextrinase.

Enzyme Microb Technol 2021 Sep 8;149:109847. Epub 2021 Jun 8.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China; International Joint Laboratory of Food Science and Safety, Jiangnan University, Wuxi, Jiangsu, 214122, China.

Maltodextrins (dextrins) are glucose chains normally produced by starch hydrolysis. Maltodextrins are characterized by their degree of polymerization (DP), which indicates the average number of glucose units per chain. Maltoheptaose (DP7), also known as amyloheptaose, is one of the maltodextrin mixtures widely used in foods, cosmetics, and pharmaceutical industries. Read More

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September 2021

Gait Disorders.

Prim Care 2021 Sep 8;48(3):395-415. Epub 2021 Jul 8.

Department of Orthopaedics and Musculoskeletal Medicine, Childrens Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; Orthopaedic Surgery, University of Missouri-Kansas City School of Kansas City, Kansas City, MO, USA.

As a child matures so does the child's gait pattern. Gait changes in pediatric patients will be expected and sequential as developmental milestones. Gait changes may also represent normal variations along an appropriate spectrum. Read More

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September 2021

Usage Patterns of Minimally Invasive Glaucoma Surgery (MIGS) Differ by Glaucoma Type: IRIS Registry Analysis 2013-2018.

Ophthalmic Epidemiol 2021 Jul 26:1-9. Epub 2021 Jul 26.

Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

: To examine patterns of standard (trabeculectomy or glaucoma drainage devices, GDDs) vs novel (minimally invasive glaucoma surgery, MIGS) surgical techniques in the US.: We used the American Academy of Ophthalmology (AAO) IRIS® Registry (Intelligent Research in Sight) queried between 2013 and 2018 (inclusive) to calculate the cumulative proportion of stand-alone, concurrent (same day) or sequential (subsequent day) glaucoma surgical techniques performed in each glaucoma diagnosis type. Secondary analyses of adjusted proportions of concurrent and sequential surgeries stratified by glaucoma diagnosis were also performed. Read More

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Initial investigation of test-retest reliability of home-to-home teleneuropsychological assessment in healthy, English-speaking adults.

Clin Neuropsychol 2021 Jul 26:1-15. Epub 2021 Jul 26.

Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Prior teleneuropsychological research has assessed the reliability between in-person and remote administration of cognitive assessments. Few, if any, studies have examined the test-retest reliability of cognitive assessments conducted in sequential clinic-to-home or home-to-home teleneuropsychological evaluations - a critical issue given the state of clinical practice during the COVID-19 pandemic. This study examined this key psychometric question for several cognitive tests administered over repeated videoconferencing visits 4-6 months apart in a sample of healthy English-speaking adults. Read More

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Mixed-method study of women's assessment and experience of childbirth care.

J Adv Nurs 2021 Jul 23. Epub 2021 Jul 23.

Servicio de Psiquiatría del Hospital General Universitario de Ciudad Real, Calle Obispo Rafael Torija, Ciudad Real, Spain.

Aim: To examine women's evaluations of quality of care from their perspectives.

Background: Assessing women's satisfaction with the quality of care they receive during childbirth is an important component of care quality that should be analysed. Evidence suggests that childbirth experience has an important impact on women's health. Read More

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Swelling-Assisted Sequential Infiltration Synthesis of Nanoporous ZnO Films with Highly Accessible Pores and Their Sensing Potential for Ethanol.

ACS Appl Mater Interfaces 2021 Jul 23. Epub 2021 Jul 23.

Materials Science and Engineering Department and Advanced Materials and Manufacturing Processes Institute, University of North Texas, 1155 Union Circle, Denton, Texas 76203, United States.

Here, we report a swelling-assisted sequential infiltration synthesis (SIS) approach for the design of highly porous zinc oxide (ZnO) films by infiltration of block copolymer templates such as polystyrene--polyvinyl pyridine with inorganic precursors followed by UV ozone-assisted removal of the polymer template. We show that porous ZnO coatings with the thickness in the range between 140 and 420 nm can be obtained using only five cycles of SIS. The pores in ZnO fabricated via swelling-assisted SIS are highly accessible, and up to 98% of pores are available for solvent penetration. Read More

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APASL guidance on stopping nucleos(t)ide analogues in chronic hepatitis B patients.

Hepatol Int 2021 Jul 23. Epub 2021 Jul 23.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.

Chronic hepatitis B virus (HBV) infection is currently incurable. Long-term treatment with potent and safe nucleos(t)ide analogs (NAs) can reduce hepatocellular carcinoma (HCC) and cirrhosis-related complications through profound viral suppression. However, indefinite therapy raises several crucial issues with pros and cons. Read More

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Psychological Mechanisms of Interactions between Improvements in Exercise and Healthy Eating Behaviors (Coaction) within a Community-Based Obesity Treatment Setting.

James J Annesi

Behav Med 2021 Jul 23:1-6. Epub 2021 Jul 23.

School of Health Professions, University of Alabama at Birmingham.

Coaction refers to positive change in one behavior increasing the probability of positive change in a second behavior. Because mechanisms of coaction have not been well studied, and its improved comprehension might optimize architectures of multi-component behavioral obesity interventions, this research aimed to incorporate theory to assess whether treatment-associated changes in self-regulation and self-efficacy sequentially mediate an association between increased exercise and improved eating. Women with obesity ( age = 47. Read More

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Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes.

J Neurosci Res 2021 Jul 23. Epub 2021 Jul 23.

Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is typically transmitted upon tick bite and can cause meningitis and encephalitis in humans. In TBEV-infected mice, mitochondrial antiviral-signaling protein (MAVS), the downstream adaptor of retinoic acid-inducible gene-I (RIG-I)-like receptor (RLR) signaling, is needed to induce early type I interferon (IFN) responses and to confer protection. To characterize the brain-resident cell subset that produces protective IFN-β in TBEV-infected mice, we isolated neurons, astrocytes, and microglia from mice and exposed these cell types to TBEV in vitro. Read More

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Sequential C-H activation enabled expedient delivery of polyfunctional arenes.

Chem Commun (Camb) 2021 Jul 23. Epub 2021 Jul 23.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China.

Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C-H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol. Read More

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Examining the influence of health on employment and work ability of Saudi haemodialysis patients: A mixed-methods study.

Int J Nurs Pract 2021 Jul 22:e12993. Epub 2021 Jul 22.

School of Health and Society, University of Salford, Salford, UK.

Aims: To explore the employment, work productivity, activity impairment, and sustainability of work of Saudi patients with chronic kidney disease (CKD) on haemodialysis (HD).

Background: Failure to address CKD-related challenges may cause HD patients to lose their job, create a lack of compassion from co-workers and receive discrimination hindering progress in their profession.

Design: This is a cross-sectional explanatory sequential mixed-methods study. Read More

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