J Biol Chem 2021 May 21:100822. Epub 2021 May 21.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China; Institute of Ocean Research, Peking University, Beijing 100191, China. Electronic address:
The fungal cyclohexadepsipeptides destruxins (DTXs), isaridins (ISDs) and isariins (ISRs) are nonribosomal peptides whose structures include a 19-membered ring composed of five amino acid residues and one α- or β-hydroxy acid residue. These cyclohexadepsipeptides contain unusual nonproteinogenic amino acid-building blocks and possess a range of antiviral, antibacterial and other activities. The biosynthetic gene clusters for ISDs and ISRs have not been identified, and the biosynthesis of the nonproteinogenic (3S)-methyl-l-proline residue, which is found in DTXs, ISDs and many other natural products, lacks full characterization. Read More