701 results match your criteria septic cardiomyopathy


Blurring of vision with malaise.

J R Coll Physicians Edinb 2021 Mar;51(1):49-52

General Internal Medicine, Conquest Hospital, East Sussex Healthcare NHS Trust, Hastings.

We present the case of a 56-year-old female brought to the Emergency Department via routine ambulance transport with complaints of blurred vision and malaise. She was screened by ambulance crew using the facial arm speech time (FAST) tool and a basic top-to-toe assessment as per current routine. The examining practitioner performed a thorough assessment of the patient, revisiting the initial examination findings, and establishing new clinical features of visual field deficit and pan-systolic murmur. Read More

View Article and Full-Text PDF

Inhibiting miR-22 Alleviates Cardiac Dysfunction by Regulating Sirt1 in Septic Cardiomyopathy.

Front Cell Dev Biol 2021 1;9:650666. Epub 2021 Apr 1.

Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

High morbidity and mortality are the most typical characteristics of septic cardiomyopathy. We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. miR-22 cardiac-specific knockout (miR-22) mice and miR-22 cardiac-specific transgenic (miR-22) mice were subjected to a cecal ligation and puncture (CLP) operation, while a sham operation was used in the control group. Read More

View Article and Full-Text PDF

Afterload-related cardiac performance identifies cardiac impairment and associates with outcome in patients with septic shock: a retrospective cohort study.

J Intensive Care 2021 Apr 13;9(1):33. Epub 2021 Apr 13.

Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background: Septic patients with cardiac impairment are with high mortality. Afterload-related cardiac performance (ACP), as a new tool for diagnosing septic cardiomyopathy (SCM), still needs to be evaluated for its impact on the prognosis for patients with septic shock.

Methods: In this retrospective study, 100 patients with septic shock undertaken PiCCO monitoring were included. Read More

View Article and Full-Text PDF

Extracorporeal life support for cardiogenic shock during pregnancy and postpartum: a single center experience.

Perfusion 2021 Mar 26:2676591211004369. Epub 2021 Mar 26.

INOVA Cardiac and Thoracic Surgery, INOVA Fairfax Hospital, Falls Church, VA, USA.

Background: The use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for cardiogenic shock in pregnant and postpartum patients remains limited by concerns of bleeding, hemolysis, and fetal risks. This case series examines the underlying characteristics and management strategies for this high-risk population.

Methods: All pregnant and post-partum patients who underwent VA ECMO in the cardiovascular intensive care unit between January 1, 2016 and November 1, 2019, were included in this retrospective study. Read More

View Article and Full-Text PDF

Wnt/β-Catenin Antagonist Pyrvinium Exerts Cardioprotective Effects in Polymicrobial Sepsis Model by Attenuating Calcium Dyshomeostasis and Mitochondrial Dysfunction.

Cardiovasc Toxicol 2021 Mar 15. Epub 2021 Mar 15.

Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.

Calcium dysregulation and mitochondrial dysfunction are key elements in the development of sepsis-induced cardiac dysfunction. Evidences have suggested that inhibition of Wnt/β-Catenin signalling prevents cardiac dysfunction and remodelling in surgical, hypertension and pressure overload models. The present study investigated the effects of Wnt/β-Catenin inhibitor on calcium overload and mitochondrial dysfunction in rat sepsis model of cardiomyopathy. Read More

View Article and Full-Text PDF

Fatty acid-binding protein 4 silencing protects against lipopolysaccharide-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the Toll-like receptor 4-nuclear factor-κB pathway.

J Int Med Res 2021 Mar;49(3):300060521998233

Department of Intensive Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

Objective: To explore the effects and potential mechanisms of fatty acid-binding protein 4 (FABP4) in a lipopolysaccharide (LPS)-induced septic cardiomyopathy model.

Methods: Rat cardiomyocyte H9c2 cells were transfected with small interfering RNA (siRNA) against FABP4 (siFABP4), then induced with LPS. The following parameters were measured: cell viability, lactate dehydrogenase release, cardiac hypertrophy and related marker expression, apoptosis, inflammatory cytokine release and expression, and the activation of Toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB) pathways. Read More

View Article and Full-Text PDF

The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism.

Ann Transl Med 2021 Feb;9(3):259

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100730, China.

Background: Mitochondrial dysfunction plays an important role in the development of septic cardiomyopathy. This study aimed to reveal the protective role of uncoupling protein 2 (UCP2) in mitochondria through AMP-activated protein kinase (AMPK) on autophagy during septic cardiomyopathy.

Methods: UCP2 knockout mice via a cecal ligation and puncture (CLP) model and the H9C2 cardiomyocyte cell line in response to lipopolysaccharide (LPS) were used to study the effect. Read More

View Article and Full-Text PDF
February 2021

Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury.

Free Radic Biol Med 2021 Apr 9;166:348-357. Epub 2021 Mar 9.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. Electronic address:

Sepsis rapidly contributed to multiorgan failure affecting most commonly of the cardiovascular and respiratory systems and yet there were no effective therapies. The current study aimed at providing evidence on the cardioprotection of suppression of 5-Lipoxygenase (5-Lox) and identifying the possible mechanism in the mouse model of sepsis. The cecal ligation-perforation (CLP) model was applied to C57BL/6 wild-type (WT) and 5-Lox deficient (5-Lox) mice to induce sepsis. Read More

View Article and Full-Text PDF

Case Report: Takotsubo Syndrome Associated With Novel Coronavirus Disease 2019.

Front Cardiovasc Med 2021 22;8:614562. Epub 2021 Feb 22.

Assistance Publique - Hôpitaux de Paris, Centre Cochin University Hospital, Intensive Care Medicine Department, Paris, France.

Takotsubo cardiomyopathy is triggered by emotional or physical stress. It is defined as a reversible myocardial dysfunction, usually with apical ballooning aspect due to apical akinesia associated with hyperkinetic basal left ventricular contraction. Described in cases of viral infections such as influenza, only few have been reported associated with novel coronavirus disease 2019 (COVID-19) in the recent pandemic. Read More

View Article and Full-Text PDF
February 2021

Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease.

Oxid Med Cell Longev 2021 20;2021:6669075. Epub 2021 Feb 20.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Mitochondria maintain mitochondrial homeostasis through continuous fusion and fission, that is, mitochondrial dynamics, which is precisely mediated by mitochondrial fission and fusion proteins, including dynamin-related protein 1 (Drp1), mitofusin 1 and 2 (Mfn1/2), and optic atrophy 1 (OPA1). When the mitochondrial fission and fusion of cardiomyocytes are out of balance, they will cause their own morphology and function disorders, which damage the structure and function of the heart, are involved in the occurrence and progression of cardiovascular disease such as ischemia-reperfusion injury (IRI), septic cardiomyopathy, and diabetic cardiomyopathy. In this paper, we focus on the latest findings regarding the molecular features and regulatory mechanisms of mitochondrial dynamic disorder in cardiovascular pathologies. Read More

View Article and Full-Text PDF
February 2021

LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.

Inflammation 2021 Mar 4. Epub 2021 Mar 4.

Department of Intensive Care Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong Province, People's Republic of China.

Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is still unknown. Read More

View Article and Full-Text PDF

Bilateral acute renal cortical necrosis after a dog bite: case report.

BMC Infect Dis 2021 Feb 27;21(1):231. Epub 2021 Feb 27.

Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.

Background: Capnocytophaga canimorsus is a Gram-negative capnophilic rod and part of dogs/cats' normal oral flora. It can be transmitted by bites, scratches, or even by contact of saliva with injured skin. Asplenic patients and patients with alcohol abuse are at particular risk for fulminant C. Read More

View Article and Full-Text PDF
February 2021

Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis.

Crit Care Med 2021 04;49(4):e444-e453

Division of Pulmonary, Department of Medicine, Intermountain Medical Center, Salt Lake City, UT.

Objectives: Septic cardiomyopathy develops frequently in patients with sepsis and likely increases short-term mortality. However, whether septic cardiomyopathy is associated with long-term outcomes after sepsis is unknown. We investigated whether septic patients with septic cardiomyopathy have worse long-term outcomes than septic patients without septic cardiomyopathy. Read More

View Article and Full-Text PDF

SARS-CoV-2 Infection and CMV Dissemination in Transplant Recipients as a Treatment for Chagas Cardiomyopathy: A Case Report.

Trop Med Infect Dis 2021 Feb 10;6(1). Epub 2021 Feb 10.

Laboratory of Dermatology and Immunodeficiencies (LIM-56), Institute of Tropical Medicine of School of Medicine of São Paulo (FMUSP), 05403-000 São Paulo, Brazil.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it is considered a pandemic. SARS-CoV-2 infection can lead to severe pneumonia, acute respiratory distress syndrome (ARDS), septic shock, and/or organ failure. Read More

View Article and Full-Text PDF
February 2021

Berberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-κB signalling in rats.

Pharm Biol 2021 Dec;59(1):121-128

Department of Critical Care Medicine, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.

Context: Berberine (Ber) can increase the survival rate of septic mice and inhibit inflammation, but whether it has a protective effect on septic cardiomyopathy (SCM) is unclear.

Objective: To investigate whether Ber ameliorates SCM in a rat model and its potential mechanism.

Materials And Methods: Male SD rats were randomly divided into three groups: control (Con,  = 6) (DD HO, 2 mL/100 g, ig, qd × 3 d, then saline, 10 mg/kg, ip); sepsis [LPS (lipopolysaccharide),  = 18] (LPS 10 mg/kg instead of saline, ip); and berberine intervention (Ber,  = 18) (Ber, 50 mg/kg instead of DD HO, ig, qd × 3 d, LPS instead of saline, ip). Read More

View Article and Full-Text PDF
December 2021

Pathophysiology of sepsis-induced cardiomyopathy.

Nat Rev Cardiol 2021 Jan 20. Epub 2021 Jan 20.

Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, UK.

Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to infection and is the leading cause of death in intensive care units. Cardiac dysfunction caused by sepsis, usually termed sepsis-induced cardiomyopathy, is common and has long been a subject of interest. In this Review, we explore the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, with an emphasis on how best to interpret this condition in the clinical context. Read More

View Article and Full-Text PDF
January 2021

[Heart rate control in patients with sepsis and septic cardiomyopathy: the role of Ivabradine].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Nov;32(11):1393-1398

Department of Critical Care Medicine, the Affiliated Bao'an Hospital of Shenzhen, Southern Medical University, Shenzhen 518101, Guangdong, China. Corresponding author: Wang Lijun, Email:

Tachycardia is an independent risk factor for mortality of patients with sepsis and multiple organ dysfunction syndrome (MODS), and has attracted extensive attention in recent years. Ivabradine, a specific blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel in sinoatrial node, is capable of inducing heart rate reduction (HRR) via binding specific sites of the channel and promotes ventricular filling because of prolongation of the diastolic period. Ivabradine has no negative effect on inotropic contractility, conductivity, and systemic vascular resistance. Read More

View Article and Full-Text PDF
November 2020

Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction.

Clin Transl Med 2021 Jan;11(1):e266

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.

Background: As a pattern recognition receptor, Toll-like receptor 7 (TLR7) widely presented in the endosomal membrane of various cells. However, the precise role and mechanism of TLR7 in septic cardiomyopathy remain unknown. This study aims to determine the role of TLR7 in cardiac dysfunction during sepsis and explore the mechanism of TLR7 in septic cardiomyopathy. Read More

View Article and Full-Text PDF
January 2021

Systolic dysfunction as evaluated by tissue Doppler imaging echocardiography and mortality in septic patients: A systematic review and meta-analysis.

J Crit Care 2021 Apr 31;62:256-264. Epub 2020 Dec 31.

Department of Anesthesia and Intensive Care, Policlinico - San Marco University Hospital, Catania, Italy; Department of General Surgery and Medical-Surgical Specialties, Section of Anesthesia and Intensive Care, University of Catania, Catania, Italy.

Purpose: Septic induced cardiomyopathy has a wide spectrum of presentation, being associated with systolic and/or diastolic dysfunction. There is currently no evidence of association between left ventricular (LV) systolic dysfunction and mortality in septic patients.

Methods: We conducted a systematic review and meta-analysis to investigate the association between systolic wave (s') obtained with Tissue Doppler Imaging (TDI) and mortality in septic patients. Read More

View Article and Full-Text PDF

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms.

J Int Med Res 2021 Jan;49(1):300060520986369

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, P.R. China.

Objective: This study aimed to investigate the protective effects of naringin on myocardial deformation and oxidative responses in rats with sepsis-induced myocardial dysfunction (SIMD).

Methods: Global and segmental layer-specific longitudinal strain (LS) was assessed by speckle tracking echocardiography. Serum levels of creatine kinase, lactate dehydrogenase, superoxide dismutase, and malondialdehyde were measured. Read More

View Article and Full-Text PDF
January 2021

Point-of-Care Echocardiography and Hemodynamic Monitoring in Cirrhosis and Acute-on-Chronic Liver Failure in the COVID-19 Era.

J Intensive Care Med 2021 Jan 13:885066620988281. Epub 2021 Jan 13.

Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Point-of-Care (POC) transthoracic echocardiography (TTE) is transforming the management of patients with cirrhosis presenting with septic shock, acute kidney injury, hepatorenal syndrome and acute-on-chronic liver failure (ACLF) by correctly assessing the hemodynamic and volume status at the bedside using combined echocardiography and POC ultrasound (POCUS). When POC TTE is performed by the hepatologist or intensivist in the intensive care unit (ICU), and interpreted remotely by a cardiologist, it can rule out cardiovascular conditions that may be contributing to undifferentiated shock, such as diastolic dysfunction, myocardial infarction, myocarditis, regional wall motion abnormalities and pulmonary embolism. The COVID-19 pandemic has led to a delay in seeking medical treatment, reduced invasive interventions and deferment in referrals leading to "collateral damage" in critically ill patients with liver disease. Read More

View Article and Full-Text PDF
January 2021

Role of Complement and Histones in Sepsis.

Front Med (Lausanne) 2020 23;7:616957. Epub 2020 Dec 23.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, United States.

The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans. Nearly 100 clinical trials in humans with sepsis have been completed, yet there is no FDA-approved drug. Our studies of polymicrobial sepsis have highlighted the role of complement activation products (especially C5a anaphylatoxin and its receptors C5aR1 and C5aR2) in adverse effects of sepsis. Read More

View Article and Full-Text PDF
December 2020

Syphilis-associated septic cardiomyopathy: case report and review of the literature.

Authors:
Shiqi Guo Qiang Guo

BMC Infect Dis 2021 Jan 7;21(1):33. Epub 2021 Jan 7.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Septic cardiomyopathy has been observed in association with influenza, indicating that not only bacteria but also other infective agents can cause this condition. There has been no systematic study as to whether Treponema pallidum infection induces septic cardiomyopathy, and we are the first to report this possibility.

Case Presentation: We report two cases of a 48-year-old man and a 57-year-old man who were diagnosed with syphilis-related septic cardiomyopathy. Read More

View Article and Full-Text PDF
January 2021

Septic Cardiomyopathy: From Basics to Management Choices.

Curr Probl Cardiol 2021 Apr 11;46(4):100767. Epub 2020 Dec 11.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK; Department of Congenital Cardiac Surgery, Alder Hey Children Hospital, Liverpool, UK; Liverpool Centre for Cardiovascular Science, University of Liverpool and Livepool Heart and Chest Hospital, Liverpool, UK; School of Medicine, Faculty of Health and life Science, University of Liverpool, Liverpool, UK. Electronic address:

Septic cardiomyopathy (SCM) is increasingly recognized as a potential complication of septic shock; it is understood to be a reversible left ventricular systolic dysfunction. The presence of SCM in septic shock, in previous studies, infer a poorer prognosis as it significantly increases the mortality rate of patients to 70%-90% and its incidence varies from 18% to 40% of septic shock patients. The pathogenesis is unclear, but believed to be a combination of bacterial toxins, cytokines, nitric oxide, and cardiac mitochondrial dysfunction, that depresses intrinsic cardiac contractility. Read More

View Article and Full-Text PDF

Helium Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction in Mice Suppressing Toll-Like Receptor 4-Nuclear Factor κB-Tumor Necrosis Factor-Alpha/ Interleukin-18 Signaling.

Chin J Physiol 2020 Nov-Dec;63(6):276-285

Department of Traditional Chinese Medicine, The Third Affiliated Hospital; Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University, Guangzhou, China.

The nonanesthetic noble gas helium (He) can protect many organs against ischemia and reperfusion injury, such as liver and heart. However, the role of He on cardiac dysfunction during sepsis is not clear. In this study, we established a lipopolysaccharide (LPS)-induced cardiac dysfunction mouse model to examine the influence of He on the impaired cardiac function, and further investigated the possible innate immune mechanisms that may be involved. Read More

View Article and Full-Text PDF
February 2021

A Case of CIED-Associated Endocarditis and Septic Emboli Requiring Lead Extraction, AngioVac Suction, and Pulmonary Endarterectomy.

Cureus 2020 Nov 20;12(11):e11601. Epub 2020 Nov 20.

Cardiothoracic Surgery, University of California San Diego School of Medicine, La Jolla, USA.

Cardiac Implantable Electronic Devices (CIED)-associated infective endocarditis complicated by septic emboli and acute on chronic pulmonary hypertension is rare. We present a case where pulmonary thromboendarterectomy was required for treatment. A 55 year-old man with a history of myocardial infarction and ischemic cardiomyopathy status-post ICD placement 8 years prior presented with bacteremia, infected ICD, and tricuspid valve vegetation. Read More

View Article and Full-Text PDF
November 2020

Impact of Right Ventricular Dysfunction on Short- and Long-Term Mortality in Sepsis: A Meta-Analysis of 1,373 Patients.

Chest 2021 Feb 27. Epub 2021 Feb 27.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Right ventricular (RV) dysfunction in sepsis and septic shock has been infrequently studied and has uncertain prognostic significance.

Research Question: Does RV function impact mortality in sepsis and septic shock?

Study Design And Methods: We reviewed the published literature from January 1999 to April 2020 for studies evaluating adult patients with sepsis and septic shock. Study definition of RV dysfunction was used to classify patients. Read More

View Article and Full-Text PDF
February 2021

Pediatric extracorporeal cardiopulmonary resuscitation: single-center study.

Turk J Med Sci 2020 Dec 22. Epub 2020 Dec 22.

Background/aim: Extracorporeal cardiopulmonary resuscitation (ECPR) is defined as the veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support in a patient who experienced a sudden pulseless condition attributable to cessation of cardiac mechanical activity and circulation. We aimed to evaluate the clinical outcomes of our ECPR experience in a pediatric patient population.

Materials And Methods: Between September 2014 and November 2017, fifteen children were supported with ECPR following in-hospital cardiac arrest (IHCA) in our hospitals. Read More

View Article and Full-Text PDF
December 2020

COVID-19-associated takotsubo cardiomyopathy.

BMJ Case Rep 2020 Dec 12;13(12). Epub 2020 Dec 12.

Cardiology, Rush University Medical Center, Chicago, Illinois, USA.

The novel COVID-19 has had an unprecedented and devastating spread internationally. COVID-19 infection can lead to a number of cardiovascular sequelae, including heart failure, which may portend worse clinical outcomes. Here, we report a rare case of a 57-year-old woman who developed acute left ventricular systolic dysfunction with apical ballooning consistent with takotsubo cardiomyopathy (TCM), and mixed cardiogenic and septic shock in the setting of COVID-19 disease. Read More

View Article and Full-Text PDF
December 2020