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Diagnostic accuracy of stroke volume variation for predicting fluid responsiveness in children undergoing cardiac surgery: a systematic review and meta-analysis.

Paediatr Anaesth 2021 Apr 21. Epub 2021 Apr 21.

Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Dong Lake District, Nanchang, 330000, Jiangxi Province, China.

Background: Stroke volume variation (SVV) appears to be reliable for predicting fluid responsiveness (FR) in adults and its predictive value in paediatric patients has been recently reported. However, its predictive value in children undergoing cardiac surgery is unclear.

Methods: A review and meta-analysis were performed on the diagnostic utility of SVV for predicting FR in children undergoing cardiac surgery. Read More

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Reproducibility of the Edinburgh Postnatal Depression Scale during the Postpartum Period.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Amarillo, Texas.

Objective:  This study was aimed to evaluate the efficacy of the Edinburgh Postnatal Depression Scale (EPDS) in the immediate postpartum period, which we defined as between 3 and 24 hours postpartum for the purpose of this research. This is such that if it can predict scores obtained at the postpartum visit, it will be an opportunity to access psychiatric services for the patient that may otherwise be more difficult to access in the outpatient setting.

Study Design:  Longitudinal observational study, which included an analysis of 848 consecutive participants screened with the EPDS in the hospital and at the 6-week postpartum visit. Read More

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Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients.

J Clin Virol 2021 Apr 18;139:104821. Epub 2021 Apr 18.

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, University of Amsterdam and VU University Amsterdam, the Netherlands.

Background: Detecting SARS-CoV-2 antibodies may help to diagnose COVID-19. Head-to-head validation of different types of immunoassays in well-characterized cohorts of hospitalized patients remains needed.

Methods: We validated three chemiluminescence immunoassays (CLIAs) (Liaison, Elecsys, and Abbott) and one single molecule array assay (SIMOA) (Quanterix) for automated analyzers, one rapid immunoassay RIA (AllTest), and one ELISA (Wantai) in parallel in first samples from 126 PCR confirmed COVID-19 hospitalized patients and 158 pre-COVID-19 patients. Read More

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Performance characteristics of five antigen-detecting rapid diagnostic test (Ag-RDT) for SARS-CoV-2 asymptomatic infection: a head-to-head benchmark comparison.

J Infect 2021 Apr 18. Epub 2021 Apr 18.

Fight AIDS and Infectious Diseases Foundation, Badalona, Spain; Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Lihir Medical Centre - InternationalSOS, Lihir Island, Papua New Guinea.

Background: Mass testing for early identification and isolation of infectious COVID-19 individuals is efficacious for reducing disease spread. Antigen-detecting rapid diagnostic tests (Ag-RDT) may be suitable for testing strategies; however, benchmark comparisons are scarce.

Methods: We used 286 nasopharyngeal specimens from unexposed asymptomatic individuals collected between December 2020 and January 2021 to assess five Ag-RDTs marketed by Abbott, Siemens, Roche Diagnostics, Lepu Medical, and Surescreen. Read More

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Evaluation of the diagnostic performance of an oral fluid screening test device for substance abuse at traffic controls.

Clin Biochem 2021 Apr 18. Epub 2021 Apr 18.

Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Introduction: The aim of this study was to evaluate the analytical performance of the Kite Biotechnology Oral fluid (OF) screening test device, which is used for roadside screening of cannabis, opiates, amphetamines, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), cocaine and benzodiazepines by comparing samples with matched plasma samples, analysed via liquid chromatography-tandem mass spectrometry (LC-MS/MS) for confirmation.

Methods: OF and plasma samples were obtained simultaneously from a total of 100 subjects. OF samples were analysed by OF screening test based on immunochromatography. Read More

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MRI-based radiomics as response predictor to radiochemotherapy for metastatic cervical lymph node in nasopharyngeal carcinoma.

Br J Radiol 2021 Apr 21:20201212. Epub 2021 Apr 21.

Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Objective: To establish and substantiate MRI-based radiomic models to predict the treatment response of metastatic cervical lymph node to radiochemotherapy in patients with nasopharyngeal carcinoma (NPC).

Methods: A total of 145 consecutive patients with NPC were enrolled including 102 in primary cohort and 43 in validation cohort. Metastatic lymph nodes were diagnosed according to radiologic criteria and treatment response was evaluated according to the Response Evaluation Criteria in Solid Tumors. Read More

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eNose-TB: A trial study protocol of electronic nose for tuberculosis screening in Indonesia.

PLoS One 2021 21;16(4):e0249689. Epub 2021 Apr 21.

Faculty of Medicine, Public Health and Nursing, Center for Tropical Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background: Even though conceptually, Tuberculosis (TB) is almost always curable, it is currently the world's leading infectious killer. Patients with pulmonary TB are the source of transmission. Approximately 23% of the world's population is believed to be latently infected with TB bacteria, and 5-15% of them will progress at any point in time to develop the disease. Read More

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Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients.

PLoS One 2021 21;16(4):e0240200. Epub 2021 Apr 21.

Department of Internal Medicine, University Hospital of Salamanca-IBSAL, University of Salamanca, Salamanca, Spain.

Background: Efficient and early triage of hospitalized Covid-19 patients to detect those with higher risk of severe disease is essential for appropriate case management.

Methods: We trained, validated, and externally tested a machine-learning model to early identify patients who will die or require mechanical ventilation during hospitalization from clinical and laboratory features obtained at admission. A development cohort with 918 Covid-19 patients was used for training and internal validation, and 352 patients from another hospital were used for external testing. Read More

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Usability and Clinical Evaluation of Self-Sampling for SARS-CoV-2 Diagnostic Testing Using Nasal and Saliva Specimens in South Africa: Study Protocol.

JMIR Res Protoc 2021 Mar 9. Epub 2021 Mar 9.

Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington DC, USA, Washington, US.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus novel discovered in December 2019 and is currently the cause of a global pandemic. A critical aspect of fighting this pandemic is by obtaining accurate and timeous test results so that positive identified cases can be isolated to reduce the spread. Research has shown that saliva is a promising candidate for SARS-CoV-2 diagnostics because collection is minimally invasive and can reliably be self-administered. Read More

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CT-based radiomics for predicting the rapid progression of coronavirus disease 2019 (COVID-19) pneumonia lesions.

Br J Radiol 2021 Apr 21:20201007. Epub 2021 Apr 21.

Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Objectives: To develop and validate a radiomic model to predict the rapid progression (defined as volume growth of pneumonia lesions > 50% within seven days) in patients with coronavirus disease 2019 (COVID-19).

Methods: Patients with laboratory-confirmed COVID-19 who underwent longitudinal chest CT between January 01 and February 18, 2020 were included. A total of 1316 radiomic features were extracted from the lung parenchyma window for each CT. Read More

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MRI characteristics of syringomyelia associated with foramen magnum arachnoiditis: differentiation from Chiari malformation.

Acta Neurochir (Wien) 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosurgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: It is important to distinguish foramen magnum arachnoiditis (FMA) from Chiari malformation (CM) before surgery because the operative strategies for these diseases differ. In the current study, we compared pretreatment magnetic resonance imaging (MRI) of FMA with CM and investigated the MRI findings useful to differentiate between these diseases.

Methods: We retrospectively reviewed patients with FMA or CM aged ≥ 18 years who underwent surgeries at our institution between 2007 and 2019. Read More

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Ultrasound lymphatic imaging for the diagnosis of metastatic central lymph nodes in papillary thyroid cancer.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 2nd Ruijin Road 197, Shanghai, 200025, People's Republic of China.

Objectives: Up to 40% of papillary thyroid cancer (PTC) patients have lymph node metastasis, a condition that implies persistent, recurrent, or progressive disease. However, the American Joint Committee on Cancer Manual states that there is no reliable examination for adequate lymph node staging. Therefore, our aim is to develop a lymphatic imaging technique using ultrasonography to address this challenge. Read More

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Validation of functional liver imaging scores (FLIS) derived from gadoxetic acid-enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Child-Pugh score and FLIS.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Radiology, Biomedical Research Institute, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea.

Objectives: To validate the functional liver imaging score (FLIS) for prediction of hepatic function in gadoxetic acid-enhanced MRI.

Methods: We retrospectively identified 134 patients (88 men, 46 women; mean age, 58.8 years) between January 2015 and December 2018 with the following inclusion criteria: patients diagnosed with liver cirrhosis or chronic liver disease (CLD) who underwent gadoxetic acid-enhanced MRI. Read More

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Joint segmentation and classification of hepatic lesions in ultrasound images using deep learning.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, Republic of Korea.

Objectives: To develop a convolutional neural network system to jointly segment and classify a hepatic lesion selected by user clicks in ultrasound images.

Methods: In total, 4309 anonymized ultrasound images of 3873 patients with hepatic cyst (n = 1214), hemangioma (n = 1220), metastasis (n = 1001), or hepatocellular carcinoma (HCC) (n = 874) were collected and annotated. The images were divided into 3909 training and 400 test images. Read More

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Accuracy of 18-F Fluorodeoxyglucose Positron Emission Tomographic/Computed Tomographic Imaging in Primary Staging of Squamous Cell Carcinoma of the Oral Cavity.

JAMA Netw Open 2021 Apr 1;4(4):e217083. Epub 2021 Apr 1.

Department of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.

Importance: Squamous cell carcinoma (SCC) of the oral cavity is one of the most common tumor entities worldwide. Precise initial staging is necessary to determine a diagnosis, treatment, and prognosis.

Objective: To examine the diagnostic accuracy of preoperative 18-F fluorodeoxyglucose (FDG) positron emission tomographic/computed tomographic (PET/CT) imaging in detecting cervical lymph node metastases. Read More

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[Rapid SARS-CoV-2 antigenic test: definition, legislation of use, technological principles, analytical and clinical performance comparison].

Ann Biol Clin (Paris) 2021 Apr 20. Epub 2021 Apr 20.

Service de virologie, Hôpitaux Universitaires Pitié-Salpêtrière - Charles-Foix, APHP, Paris, France, Université de Paris, Inserm UMR-S U1139 3PHM, Paris, France, Laboratoire de microbiologie, Université de Paris, Faculté de pharmacie, Paris, France.

The SARS-CoV-2 has emerged in China at the end of 2019. In order to meet the growing demand in laboratories for RT-PCR testing for viral genome detection, rapid tests detecting a SARS-CoV-2 protein (antigenic rapid test) have been developed. In this review, we present for different SARS-CoV-2 antigenic rapid tests authorized in France: legislation, technological principle, and analytical and clinical performances. Read More

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Rapid identification of pufferfish in roast fish fillet by real-time PCR.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2021 Apr 21:1-6. Epub 2021 Apr 21.

National Health Commission Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, China.

The purpose of this study was to develop a rapid method based on a real-time PCR assay designed to identify the presence of pufferfish in roasted fish fillet. Specific primers and probes were designed targeting . and . Read More

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Vitamin B status in health and disease: a critical review. Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls.

Crit Rev Clin Lab Sci 2021 Apr 21:1-31. Epub 2021 Apr 21.

The Nutristasis Unit, Viapath, St. Thomas' Hospital, London, UK.

Vitamin B (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained principally from food of animal origin. Cobalamin becomes bioavailable through a series of steps pertaining to its release from dietary protein, intrinsic factor-mediated absorption, haptocorrin or transcobalamin-mediated transport, cellular uptake, and two enzymatic conversions ( methionine synthase and methylmalonyl-CoA-mutase) into cofactor forms: methylcobalamin and adenosylcobalamin. Read More

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The relationship between dual antiplatelet treatment (DAPT) score and saphenous venous grafts patency after coronary artery bypass grafting surgery.

Acta Cardiol 2021 Apr 21:1-7. Epub 2021 Apr 21.

Depertament of Cardiology, Kartal Kosuyolu High Specialty Training and Research Hospital, University of Medical Sciences, İstanbul, Turkey.

Background: Coronary artery bypass grafting (CABG) remains the gold standard treatment for mutivessel and left main coronary artery disease (CAD). Saphenous vein graft (SVG) patency is still a problem in CAD patients after CABG surgery. The Dual Antiplatelet Treatment (DAPT) score is a clinical prediction tool that predicts ischaemic and bleeding risk in CAD patients. Read More

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Cortical involvement determines impairment 30 years after a clinically isolated syndrome.

Brain 2021 Apr 21. Epub 2021 Apr 21.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, UK.

Many studies report an overlap of MRI and clinical findings between patients with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), which in part is reflective of inclusion of subjects with variable disease duration and short periods of follow-up. To overcome these limitations, we examined the differences between RRMS and SPMS and the relationship between MRI measures and clinical outcomes 30 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis. Sixty-three patients were studied 30 years after their initial presentation with a clinically isolated syndrome; only 14% received a disease modifying treatment at any time point. Read More

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Differential Performance of CoronaCHEK SARS-CoV-2 Lateral Flow Antibody Assay by Geographic Origin of Samples.

medRxiv 2021 Apr 19. Epub 2021 Apr 19.

Background: We assessed the performance of CoronaCHEK lateral flow assay on samples from Uganda and Baltimore to determine the impact of geographic origin on assay performance.

Methods: Serum samples from SARS-CoV-2 PCR+ individuals (Uganda: 78 samples from 78 individuals and Baltimore: 266 samples from 38 individuals) and from pre-pandemic individuals (Uganda 1077 and Baltimore 532) were evaluated. Prevalence ratios (PR) were calculated to identify factors associated with a false-positive test. Read More

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Rapid Identification of Druggable Targets and the Power of the PHENotype SIMulator for Effective Drug Repurposing in COVID-19.

Res Sq 2021 Apr 14. Epub 2021 Apr 14.

The current, rapidly diversifying pandemic has accelerated the need for efficient and effective identification of potential drug candidates for COVID-19. Knowledge on host-immune response to SARS-CoV-2 infection, however, remains limited with very few drugs approved to date. Viable strategies and tools are rapidly arising to address this, especially with repurposing of existing drugs offering significant promise. Read More

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Multiparameter Analysis Using F-FDG PET/CT in the Differential Diagnosis of Pancreatic Cystic Neoplasms.

Contrast Media Mol Imaging 2021 7;2021:6658644. Epub 2021 Apr 7.

Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Fuxing Road 28, Beijing 100853, China.

Purpose: To evaluate multiparametric analysis in differential diagnosis between pancreatic serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) as well as the differentiation of the benign and malignant MCNs with F-FDG (18-fluorodeoxyglucose) PET/CT (positron emission tomography).

Methods: Forty patients with total of 41 lesions (SCNs: 27/41; MCNs: 14/41), who were preoperatively examined with F-FDG PET/CT, were retrospectively analyzed. Multiple quantitative parameters using conventional and texture features were included. Read More

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Evaluation of Multimode Color Doppler Flow Imaging in the Diagnosis of Solid Renal Tumor.

Contrast Media Mol Imaging 2021 1;2021:6656877. Epub 2021 Apr 1.

Department of Medical Ultrasound, Pudong Gongli Hospital, Shanghai 200135, China.

Background: Renal cell carcinoma is one of the most common malignant tumors in urinary system, seriously affecting people's health and life. This study aimed to evaluate the clinical value of multi-mode color Doppler flow imaging for diagnosis of solid renal tumor.

Methods: Sixty-six renal solid tumors from 63 patients were examined by color Doppler flow imaging (CDFI), power Doppler flow imaging (PDFI), superb microvascular imaging (SMI), and contrast-enhanced ultrasound (CEUS) before surgery. Read More

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Development of in-house ELISAs for the detection of anti-SARS‑CoV‑2 RBD and N IgG and IgM antibodies in biological samples.

J King Saud Univ Sci 2021 Apr 15:101439. Epub 2021 Apr 15.

Research Center for Advanced Materials Science (RCAMS), King Khalid University,P.O. Box 9004, Abha 61413, Saudi Arabia.

By the end of year 2019, the new virus SARS-CoV-2 appeared, causing the Coronavirus Disease 2019 (COVID-19), and spread very fast globally. A continuing need for diagnostic tools is a must to contain its spread. Till now, the gold standard method, the reverse transcription polymerase chain reaction (RT-PCR), is the precise procedure to detect the virus. Read More

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[Accuracy of Xpert MTB/RIF for the detection of tuberculosis and rifampicin-resistance tuberculosis in China: A systematic review and meta-analysis].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Oct;53(2):320-326

Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.

Objective: To systematically review the diagnostic accuracy of Xpert/rifampicin (Xpert MTB/RIF) for the detection of active tuberculosis (TB) and rifampicin-resistance TB in Chinese patients.

Methods: Four Chinese databases (SinoMed, CNKI, WanFang database, and VIP) and three English databases (PubMed, Embase, and The Cochrane Library) were searched from January 1, 2000 to September 15, 2017, to identify diagnostic tests about the accuracy of Xpert MTB/RIF in Chinese patients. Two investigators screened the articles and extracted the information independently, and then the quality of each included study was evaluated by Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2. Read More

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October 2020

Super-resolution vibrational microscopy by stimulated Raman excited fluorescence.

Light Sci Appl 2021 Apr 20;10(1):87. Epub 2021 Apr 20.

Department of Chemistry, Columbia University, New York, NY, 10027, USA.

Inspired by the revolutionary impact of super-resolution fluorescence microscopy, super-resolution Raman imaging has been long pursued because of its much higher chemical specificity than the fluorescence counterpart. However, vibrational contrasts are intrinsically less sensitive compared with fluorescence, resulting in only mild resolution enhancement beyond the diffraction limit even with strong laser excitation power. As such, it is still a great challenge to achieve biocompatible super-resolution vibrational imaging in the optical far-field. Read More

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The value of automated breast volume scanner combined with virtual touch tissue quantification in the differential diagnosis of benign and malignant breast lesions: A comparative study with mammography.

Medicine (Baltimore) 2021 Apr;100(16):e25568

Department of Ultrasound, Wuhu No. 2 People's Hospital, Wuhu, Anhui 241001.

Abstract: This study aimed to evaluate the diagnostic value of automated breast volume scanner (ABVS) combined with virtual touch tissue quantification (VTQ) in the differential diagnosis of breast lesions.In this retrospective study, 183 patients (mean age, 49.8 ± 8. Read More

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Clinical significance of immunohistochemistry to detect BRAF V600E mutant protein in thyroid tissues.

Medicine (Baltimore) 2021 Apr;100(16):e25566

Department of Pathology, The Second Hospital of Dalian Medical University.

Abstract: This study investigated the feasibility of using immunohistochemistry (IHC) instead of PCR to detect BRAF V600E mutant protein in papillary thyroid carcinoma (PTC), and to determine the value of using preoperative BRAF V600E mutant protein by IHC to assist in the diagnosis of thyroid nodule patients with Hashimoto's thyroiditis (HT).The expression of BRAFV600E mutant protein was measured in 23 cases of HT+PTC, 31 cases of PTC, and 28 cases of HT by IHC, followed by PCR in the same samples for validation. SPSS 19. Read More

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The predictive value of serum procalcitonin for non-invasive positive pressure ventilation in the patients with acute exacerbation of chronic obstructive pulmonary disease.

Medicine (Baltimore) 2021 Apr;100(16):e25547

Department of Respiratory and Critical Care Medicine.

Abstract: This study aimed to estimate the value of serum procalcitonin (PCT) for non-invasive positive pressure ventilation (NIPPV) prediction in the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).A total of 220 AECOPD patients were divided into NIPPV group (n = 121) and control group (routine treatment, n = 99) based on the routine standards and physicians' experience. Logistic regression analysis was performed to identify the independent factors for NIPPV treatment. Read More

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