775 results match your criteria sensitivity salbutamol


Salbutamol and salt-sensitive hypertension.

Authors:
Matthew A Bailey

Kidney Int 2021 08;100(2):272-275

British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK. Electronic address:

Salbutamol activates the NaCl cotransporter of the distal convoluted tubule. Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phosphoproteomics identified protein phosphatase 1/inhibitor 1 as a distinct regulatory node for NaCl cotransporter activation by salbutamol, which did not activate the transporter in inhibitor 1 knockout mice. Read More

View Article and Full-Text PDF

Immunochromatographic Assay Based on Polydopamine-Decorated Iridium Oxide Nanoparticles for the Rapid Detection of Salbutamol in Food Samples.

ACS Appl Mater Interfaces 2021 Jun 9;13(24):28899-28907. Epub 2021 Jun 9.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, P. R. China.

Salbutamol (SAL), a β-2 adrenoreceptor agonist, is an unpopular addition to livestock and poultry, causing several side effects to human health. Thus, it is very important to develop a simple and rapid analytical method to screen SAL in the field of food safety. Here, we present an immunochromatographic assay (ICA) method for sensitively detecting SAL with polydopamine-decorated iridium oxide nanoparticles ([email protected] NPs) as a signal tag. Read More

View Article and Full-Text PDF

Obesity modifies the implantation window and disrupts intrauterine embryo positioning in rats.

Reproduction 2021 05 31;162(1):61-72. Epub 2021 May 31.

Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina.

Obesity is a chronic disease that impairs female reproduction. When gestation is achieved, maternal obesity can cause offspring's health complications. We intended to evaluate the effects of maternal pre-conceptional obesity on uterine contractile activity, embryo implantation and offspring development. Read More

View Article and Full-Text PDF

Rapid Detection of Ractopamine and Salbutamol in Swine Urine by Immunochromatography Based on Selenium Nanoparticles.

Int J Nanomedicine 2021 9;16:2059-2070. Epub 2021 Mar 9.

Joint National Laboratory for Antibody Drug Engineering, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, People's Republic of China.

Purpose: The purpose of this study was to establish a lateral flow immunoassay using selenium nanoparticles (Se-NPs) as a probe to detect ractopamine (RAC) and salbutamol (SAL) in swine urine.

Methods: SDS and PEG were used as templates to prepare Se-NPs; anti-RAC monoclonal antibodies or anti-SAL monoclonal antibodies were labelled with Se-NPs; and rapid detection kits were prepared. The sensitivity, specificity, and stability were measured, and actual samples were analysed. Read More

View Article and Full-Text PDF

The Strategy of Dimercaptothiol as Self-assembled Monolayers Enhance The Sensitivity of SPR Immunosensor for Detection of Salbutamol.

Anal Sci 2021 Mar 5. Epub 2021 Mar 5.

Institution of Quality Standard and Testing Technology for Agro-Product, Shandong Academy of Agricultural Science.

View Article and Full-Text PDF

Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.

Invest Ophthalmol Vis Sci 2021 02;62(2):15

Section of Ophthalmology, School of Life Course Sciences, King's College London, United Kingdom.

Purpose: Refractive errors, particularly myopia, are common and a leading cause of blindness. This study aimed to explore associations between medications and refractive error in an aging adult cohort and to determine whether childhood-onset refractive errors predict future medication use to provide novel insights into disease mechanisms.

Methods: The study compared the spherical equivalent values measured in 102,318 UK Biobank participants taking the 960 most commonly used medications. Read More

View Article and Full-Text PDF
February 2021

Bismuth telluride decorated on graphitic carbon nitrides based binary nanosheets: Its application in electrochemical determination of salbutamol (feed additive) in meat samples.

J Hazard Mater 2021 07 29;413:125265. Epub 2021 Jan 29.

Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address:

The design and fabrication of effective electrochemical sensor for ultrasensitive detection of feed additive and multidrug are highly significant in food analysis. In this work, we explored to develop the possibility for rapid detection of feed additive drug using bismuth telluride (BiTe) decorated graphitic carbon nitrides (GCN) nanostructures as a modified electrode for electrochemical sensing. Herein, the modified electrode was focused on the development of electrocatalytic performances for the determination of salbutamol in food products. Read More

View Article and Full-Text PDF

Green spectrofluorimetric determination of salmeterol xinafoate in its pure forms, medicinal commercial formula, and human plasma: Application for stability studies.

Luminescence 2021 Jun 4;36(4):937-942. Epub 2021 Feb 4.

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.

A natural, accurate, extremely rapid, and precise spectrofluorometric method has been developed and validated for determination of salmeterol (SAL) xinafoate in its medicinal commercial form and spiked human plasma. The native SAL fluorescence has been measured at 415 nm (after 340 nm as excitation) in distilled water. Different factors affecting the native fluorescence consistency of SAL were surveyed and optimized. Read More

View Article and Full-Text PDF

High-Performance Liquid Chromatography Method for Simultaneous Determination of Guaifenesin, Salbutamol Sulfate and Guaifenesin Impurity (Guaiacol).

J Chromatogr Sci 2021 Apr;59(5):419-424

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, 62111 Beni-Suef, Egypt.

A simple and reliable HPLC method is developed for isocratic separation of a ternary mixture of Salbutamol Sulfate (SAL), Guaifenesin (GUI) and its impurity Guaiacol (GUA) either in pure powder or in pharmaceutical formulation. Chromatographic separation was applied on a Hypersil GOLD CN column with a mobile phase consisting of 0.05 M KH2PO4 (containing 0. Read More

View Article and Full-Text PDF

Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program.

JAMA 2020 12;324(22):2301-2317

Department of Allergy, Kaiser Permanente Medical Center, San Diego, California.

Importance: Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.

Objective: To report updated recommendations for 6 topics for clinical management of adolescents and adults with asthma: (1) intermittent inhaled corticosteroids (ICSs); (2) add-on long-acting muscarinic antagonists; (3) fractional exhaled nitric oxide; (4) indoor allergen mitigation; (5) immunotherapy; and (6) bronchial thermoplasty. Read More

View Article and Full-Text PDF
December 2020

Pharmacokinetics of salmeterol and its main metabolite α-hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance-trained men: Implications for doping control.

Drug Test Anal 2021 Apr 23;13(4):747-761. Epub 2020 Nov 23.

Section of Integrative Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

As of 2020, use of beta -agonist salmeterol is restricted by the World Anti-Doping Agency (WADA) and is only permitted by inhalation at therapeutic doses not exceeding 200 μg in 24 h. In contrast to beta -agonists salbutamol and formoterol, WADA has not established a urine threshold for salmeterol despite its muscle hypertrophic actions observed in animals. Herein, we investigated plasma (0-4 h) and urine (0-24 h) concentrations (by ultra-high-performance liquid chromatography-tandem mass spectrometry [UHPLC-MS/MS]) of salmeterol and α-hydroxysalmeterol after dry powder inhalation at supratherapeutic (400 μg) and high therapeutic (200 μg) doses, and after seven consecutive days of therapeutic inhalation (200 μg × day ) in 11 healthy endurance-trained men. Read More

View Article and Full-Text PDF

Complete antigen-bridged DNA strand displacement amplification immuno-PCR assay for ultrasensitive detection of salbutamol.

Sci Total Environ 2020 Dec 9;748:142330. Epub 2020 Sep 9.

Tianjin Institute Environmental and Operational Medicine, Tianjin 300050, China. Electronic address:

Monitoring of low-level analytes are typical examples for analytical challenges. Salbutamol (SAL), a phenol-β2-agonist, has a very low residual content in the environment. Here, we present an ultrasensitive complete antigen-bridged PCR assay for detecting salbutamol (SAL). Read More

View Article and Full-Text PDF
December 2020

Diagnostic value of volumetric capnography in patients with chronic cough variant asthma.

Clinics (Sao Paulo) 2020 19;75:e1662. Epub 2020 Oct 19.

Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine, Shanghai 200433, China.

Objectives: To evaluate the quantitative changes and diagnostic performance of volumetric capnography (VCap) parameters in patients with cough variant asthma.

Methods: This cross-sectional study enrolled 31 patients with cough variant asthma and 30 patients with chronic cough without asthma between November 2010 and March 2012. VCap measurements were recorded at baseline, during the five steps of the histamine challenge, and after bronchodilation with salbutamol. Read More

View Article and Full-Text PDF

Cost-effectiveness analysis of phenotypic-guided versus guidelines-guided bronchodilator therapy in viral bronchiolitis.

Pediatr Pulmonol 2021 01 20;56(1):187-195. Epub 2020 Oct 20.

Department of Pharmacology and Toxicology, School of Medicine, Research Group in Pharmacology and Toxicology (INFARTO), Universidad de Antioquia, Medellín, Colombia.

Objectives: Although recent evidence suggests that management of viral bronchiolitis requires something other than guidelines-guided therapy, there is a lack of evidence supporting the economic benefits of phenotypic-guided bronchodilator therapy for treating this disease. The aim of the present study was to compare the cost-effectiveness of phenotypic-guided versus guidelines-guided bronchodilator therapy in infants with viral bronchiolitis.

Methods: A decision analysis model was developed to compare the cost-effectiveness of phenotypic-guided versus guidelines-guided bronchodilator therapy in infants with viral bronchiolitis. Read More

View Article and Full-Text PDF
January 2021

Derivatization and deep eutectic solvent-based air-assisted liquid-liquid microextraction of salbutamol in exhaled breath condensate samples followed by gas chromatography-mass spectrometry.

J Pharm Biomed Anal 2020 Nov 23;191:113572. Epub 2020 Aug 23.

Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

A microwave-induced air-assisted liquid-liquid microextraction method has been proposed for the pretreatment/quantization of salbutamol in exhaled breath condensate (EBC) samples prior to gas chromatography-mass spectrometry. In this procedure, 1-fluoro-2,4-dinitrobenzene and N,N-diethylethanolammonium chloride: dichloroacetic acid: octanoic acid deep eutectic solvent were exploited as derivatization reagent and extraction solvent, respectively. A mixture of the sample solution and pyridine was transferred into a test tube. Read More

View Article and Full-Text PDF
November 2020

An in vitro bioassay for evaluating the effect of inhaled bronchodilators on airway smooth muscle.

Pulm Pharmacol Ther 2020 08 2;63:101943. Epub 2020 Sep 2.

Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, London, SE1 9NH, UK.

Purpose: The development of inhaled drug products is expensive and involves time-consuming pharmacokinetic (PK) and pharmacodynamic (PD) studies. There are few in vitro cell-based assays to evaluate the disposition and action of orally inhaled drugs to guide early product development and minimise risk. The aim of the present study was to develop a co-culture bioassay, combining an airway epithelial cell line (Calu-3) with cultured human primary airway smooth muscle cells (ASM), integrated with apparatus to deliver pharmaceutical aerosols. Read More

View Article and Full-Text PDF

Comparison of Vibrating Mesh, Jet, and Breath-Enhanced Nebulizers During Mechanical Ventilation.

Respir Care 2020 Oct 21;65(10):1419-1426. Epub 2020 Jul 21.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York.

Background: This study compared 3 nebulizer technologies for inter- and intradevice reproducibility, humidification, and fill volume sensitivity during mechanical ventilation: a breath-enhanced jet nebulizer, a vibrating mesh nebulizer, and a jet nebulizer. The breath-enhanced jet nebulizer featured a new design located on the wet side of the humidifier to reduce aerosol loss and potential humidifier contamination. The vibrating mesh nebulizer and the jet nebulizer were placed on the dry side. Read More

View Article and Full-Text PDF
October 2020

Relationship between age and bronchodilator response at diagnosis in adult-onset asthma.

Respir Res 2020 Jul 13;21(1):179. Epub 2020 Jul 13.

Department of Respiratory Medicine, Seinäjoki Central Hospital, Hanneksenrinne 7, FIN-60220, Seinäjoki, Finland.

Background: Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like reversibility in asthma-COPD overlap (ACO).

Methods: A total of 1030 patients with adult-onset asthma were included; 245 from SAAS (Seinäjoki Adult Asthma Study, Finland) and 785 from COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) cohorts. Read More

View Article and Full-Text PDF

Electrospray ionization rapid screening sans liquid chromatography column: A sensitive method for detection and quantification of chemicals in animal tissues and urine.

Rapid Commun Mass Spectrom 2020 Oct;34(20):e8876

USDA-Agricultural Research Service, Edward T. Schafer Agricultural Research Center, Biosciences Research Laboratory, 1616 Albrecht Blvd, Fargo, ND, 58102, USA.

Rationale: Electrospray ionization mass spectrometry (ESI-MS) in conjunction with liquid chromatography (LC) can provide accurate quantitative data, but it is not well-suited for the rapid screening (RS) of analytes incurred into complex matrices. This study was designed to determine the usefulness of ESI for rapid detection and quantitation of veterinary drugs from complex biological matrices under near real-time conditions.

Methods: Nine veterinary drugs or metabolites, clenbuterol, erythromycin, flunixin, 5-hydroxyflunixin, meloxicam, ractopamine, salbutamol, tylosin and zilpaterol, present in cow urine, sheep urine, sheep tissues (kidney, muscle, liver and lung) or pig kidney, were simultaneously analyzed. Read More

View Article and Full-Text PDF
October 2020

Hyperkalemia mimicking brugada pattern in electrocardiogram: A rare case report from Nepal.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):524-527

Department of Cardiology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Hyperkalemia is one of the dangerous complications of renal impairment (acute kidney injury or chronic kidney disease). Hyperkalemia may present with the electrocardiogram (ECG) changes as nonspecific repolarization abnormalities. Here, we report a case of AKI with hyperkalemia and the Brugada pattern of ECG, which reverted to normal after effective management of hyperkalemia. Read More

View Article and Full-Text PDF

Lower Ca2+ enhances the K+-induced force depression in normal and HyperKPP mouse muscles.

J Gen Physiol 2020 07;152(7)

University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada.

Hyperkalemic periodic paralysis (HyperKPP) manifests as stiffness or subclinical myotonic discharges before or during periods of episodic muscle weakness or paralysis. Ingestion of Ca2+ alleviates HyperKPP symptoms, but the mechanism is unknown because lowering extracellular [Ca2+] ([Ca2+]e) has no effect on force development in normal muscles under normal conditions. Lowering [Ca2+]e, however, is known to increase the inactivation of voltage-gated cation channels, especially when the membrane is depolarized. Read More

View Article and Full-Text PDF

Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial.

Lancet Respir Med 2020 07 11;8(7):671-680. Epub 2020 Mar 11.

Medical Research Institute of New Zealand, Wellington, New Zealand; Capital and Coast District Health Board, Wellington, New Zealand.

Background: Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are associated with important outcomes in mild asthma is unclear. In this prespecified subgroup analysis of a previously published open-label clinical trial, we aimed to assess associations between blood eosinophil counts and FeNO with outcomes and response to asthma treatment.

Methods: In the previously reported 52-week, open-label, randomised controlled trial, people with mild asthma receiving only β agonist reliever inhalers were enrolled at one of 16 clinical trials units in New Zealand, the UK, Italy, or Australia. Read More

View Article and Full-Text PDF

Label-Free Impedimetric Immunosensors Modulated by Protein A/Bovine Serum Albumin Layer for Ultrasensitive Detection of Salbutamol.

Sensors (Basel) 2020 Jan 31;20(3). Epub 2020 Jan 31.

Department of Bio-industrial Mechatronics Engineering, National Chung Hsing University, No. 145, Xingda Rd., South Dist., Taichung City 402, Taiwan.

The sensing properties of immunosensors are determined not only by the amount of immobilized antibodies but also by the number of effective antigen-binding sites of the immobilized antibody. Protein A (PA) exhibits a high degree of affinity with the Fc part of IgG antibody to feasibly produce oriented antibody immobilization. This work proposes a simple method to control the PA surface density on gold nanostructure (AuNS)-deposited screen-printed carbon electrodes (SPCEs) by mixing concentration-varied PA and bovine serum albumin (BSA), and to explore the effect of PA density on the affinity attachment of anti-salbutamol (SAL) antibodies by electrochemical impedance spectroscopy. Read More

View Article and Full-Text PDF
January 2020

Bronchodilator Response Assessed by the Forced Oscillation Technique Identifies Poor Asthma Control With Greater Sensitivity Than Spirometry.

Chest 2020 06 23;157(6):1435-1441. Epub 2020 Jan 23.

Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, Glebe, NSW, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW, Australia.

Background: Persistent bronchodilator response (BDR) following diagnosis of asthma is an underrecognized treatable trait, associated with worse lung function and asthma control. The forced oscillation technique (FOT) measures respiratory system impedance, and BDR cutoffs have been proposed for healthy adults; however, the relevance in asthma is unknown. We compared BDR cutoffs, using FOT and spirometry, in asthma and the relationship with asthma control. Read More

View Article and Full-Text PDF

Phase I, Dose-Escalating Study of the Safety and Pharmacokinetics of Inhaled Dry-Powder Vancomycin (AeroVanc) in Volunteers and Patients with Cystic Fibrosis: a New Approach to Therapy for Methicillin-Resistant Staphylococcus aureus.

Antimicrob Agents Chemother 2020 02 21;64(3). Epub 2020 Feb 21.

Savara, Inc., Austin, Texas, USA.

Methicillin-resistant (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administration of vancomycin would overcome these limitations, we developed a dry powder formulation suitable for inhalation (AeroVanc). Read More

View Article and Full-Text PDF
February 2020

"In-House" Data on the Outside-A Mobile Health Approach.

Clin Pharmacol Ther 2020 04 7;107(4):948-956. Epub 2020 Mar 7.

Merck & Co., Inc, Kenilworth, New Jersey, USA.

Mobile health (mHealth) technologies have the potential to capture dense patient data on the background of real-life behavior. Merck & Co., Inc. Read More

View Article and Full-Text PDF

Comparative Safety and Effectiveness of Inhaled Corticosteroid and Long-Acting β-Agonist Combinations in Patients With COPD.

Chest 2020 05 28;157(5):1117-1129. Epub 2019 Dec 28.

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: The differential risk of pneumonia among inhaled corticosteroid (ICS) use in patients with COPD requires more investigation, especially regarding beclomethasone-containing inhalers. The goal of this study was to compare the risk and benefit profile of different ICS/long-acting β-agonist (LABA) combinations in patients with COPD.

Methods: This retrospective cohort study was conducted by using national health insurance claims data from the years 2009 to 2015 in Taiwan and included patients with COPD with new ICS/LABA use. Read More

View Article and Full-Text PDF

The sensitivity and specificity of the forced oscillation technique in the diagnosis of bronchoconstriction in children.

J Asthma 2021 Mar 23;58(3):334-339. Epub 2019 Dec 23.

Department of Trauma and Orthopaedics, District Trauma and Orthopaedic Hospital, Piekary Sląskie, Poland.

Objective: The forced oscillation technique (FOT) is a useful diagnostic respiratory system for children. However, the final value of the FOT in the diagnosis of bronchoconstriction is still open. The aim of the study was to evaluate the sensitivity and specificity of the FOT vs. Read More

View Article and Full-Text PDF

Diagnostic values of bronchodilator response versus 9-question questionnaire for asthma.

Adv Respir Med 2019 ;87(5):269-275

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Several studies have investigated different tools for asthma diagnosis in order to reduce the cost and improve its early recognition. The goal of this study is to establish ashort questionnaire to be used in practice for asthma screening and compare diagnostic values between this method and spirometric response to bronchodilators.

Material And Method: 208 patients presenting with chronic stable dyspnea (> 6 months) and definite clinical diagnosis of chronic obstructive pulmonary disease, bronchiectasis, pulmonary fibrosis or asthma, were enrolled. Read More

View Article and Full-Text PDF

[Peak expiratory flow vs. spirometry for the diagnosis of asthma in adults].

Rev Alerg Mex 2019 Jul-Sep;66(3):308-313

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Ciudad de México, México.

Background: The diagnosis of asthma is confirmed with a spirometry: FEV1 ratio (forced expiratory volume in one second)/FVC (forced vital capacity) <80% with reversibility (FEV1 >12% or 200 mL) after using salbutamol. The peak expiratory flow is cheap and easy to use; it measures the forced expiratory flow, of which reversibility > 20% suggests asthma.

Objective: To know the sensitivity, specificity, and the positive and negative predictive values of the flowmeter. Read More

View Article and Full-Text PDF