99 results match your criteria sensitivities headaches

Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study.

Trials 2021 Apr 2;22(1):245. Epub 2021 Apr 2.

Kaleido Biosciences, Inc, Lexington, MA, USA.

Objectives: These 2 parallel studies (K031 and K032) aim to evaluate the safety of KB109 in addition to supportive self-care (SSC) compared with SSC alone in outpatients with mild to moderate coronavirus disease 2019 (COVID-19). KB109 is a novel synthetic glycan that was formulated to modulate the gut microbiome composition and metabolic output in order to increase beneficial short-chain fatty acid (SCFA) production in the gut. The K031 study is designed to evaluate the safety of KB109 and characterize its impact on the natural progression of COVID-19 in patients with mild to moderate disease. Read More

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Georgian Med News 2021 Jan(310):36-39

Ivane Javakhishvili Tbilisi State University, Georgia.

Bruxism has become more and more debatable and pressing issue all over the world last years. the etiology of bruxism has been changing diverse definitions, over the years, however recently it is defined as a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and by bracing or thrusting of the mandible. This literature review discusses the possible risk factors of bruxism in children and adolescence, among which behavioral abnormalities and sleep disturbances predominates. Read More

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January 2021

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.

Cochrane Database Syst Rev 2021 02 23;2:CD013665. Epub 2021 Feb 23.

NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.

Background: The clinical implications of SARS-CoV-2 infection are highly variable. Some people with SARS-CoV-2 infection remain asymptomatic, whilst the infection can cause mild to moderate COVID-19 and COVID-19 pneumonia in others. This can lead to some people requiring intensive care support and, in some cases, to death, especially in older adults. Read More

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February 2021

Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain.

Mol Neurobiol 2021 Jan 29. Epub 2021 Jan 29.

Department of Neurology, Duke University, Durham, NC, 27710, USA.

Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of Americans each year with significant population health impact. Despite the existence of a large body of information on the subject, the molecular underpinnings of orofacial pain remain elusive. Two decades of research has identified that transient receptor potential (TRP) ion channels play a crucial role in pathological pain. Read More

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January 2021

The migraine postdrome: Spontaneous and triggered phenotypes.

Cephalalgia 2021 May 10;41(6):721-730. Epub 2021 Jan 10.

Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background: Non-painful symptoms in migraine following headache resolution can last up to days. Studying the postdrome is important to appreciate the morbidity associated with migraine.

Methods: Fifty-three subjects ( = 53) with migraine were studied in an experimental setting, collecting historical phenotypic information on the postdrome in their spontaneous attacks, and also associated with nitroglycerin-triggered attacks, while being observed prospectively. Read More

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Stratifying Brain Tumour Histological Sub-Types: The Application of ATR-FTIR Serum Spectroscopy in Secondary Care.

Cancers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George St, Glasgow G1 1RD, UK.

Patients living with brain tumours have the highest average years of life lost of any cancer, ultimately reducing average life expectancy by 20 years. Diagnosis depends on brain imaging and most often confirmatory tissue biopsy for histology. The majority of patients experience non-specific symptoms, such as headache, and may be reviewed in primary care on multiple occasions before diagnosis is made. Read More

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Headache in the Older Population: Causes, Diagnoses, and Treatments.

Curr Pain Headache Rep 2020 May 29;24(7):34. Epub 2020 May 29.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.

Purpose Of Review: Primary headaches are less common and differ in presentation in older versus younger individuals. Secondary headaches become more common among older patients.

Recent Findings: Diagnosis and management of headaches in those > 65 years are discussed. Read More

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Overview of COVID-19 testing and implications for otolaryngologists.

Head Neck 2020 Jul 12;42(7):1629-1633. Epub 2020 May 12.

Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, USA.

Background: Testing for SARS-CoV-2 is important for decision making prior to surgery in otolaryngology. An understanding of current and developing testing methods is important for interpreting test results.

Methods: We performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. Read More

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Self-perceived attention difficulties are associated with sensory hypersensitivity in migraine.

Rev Neurol (Paris) 2020 Dec 17;176(10):829-838. Epub 2020 Apr 17.

Inserm UMRS 1028, CNRS UMR 5292, Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France; Functional Neurology and Epilepsy Department, Université Claude Bernard Lyon 1, Université de Lyon, Hospices Civils de Lyon, Neurological Hospital Pierre Wertheimer, Lyon, France.

Background: Attention is the process which enables to preferentially select salient or relevant stimuli and to attenuate the response to irrelevant incoming stimuli. Migraine is characterized by both attentional alterations and an abnormal sensory processing to external stimulations. The aim of the study was to investigate potential interactions between self-perceived attentional difficulties and sensory hypersensitivity in migraine patients. Read More

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December 2020

Imaging the Premonitory Phase of Migraine.

Front Neurol 2020 25;11:140. Epub 2020 Mar 25.

NIHR-Wellcome Trust King's Clinical Research Facility and SLaM Biomedical Research Centre, King's College London, London, United Kingdom.

Migraine is a common and disabling brain disorder with a broad and heterogeneous phenotype, involving both pain and painless symptoms. Over recent years, more clinical and research attention has been focused toward the premonitory phase of the migraine attack, which can start up to days before the onset of head pain. This early phase can involve symptomatology, such as cognitive and mood change, yawning, thirst and urinary frequency and sensory sensitivities, such as photophobia and phonophobia. Read More

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Association of diet and headache.

J Headache Pain 2019 Nov 14;20(1):106. Epub 2019 Nov 14.

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in the world. Read More

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November 2019

The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature Review.

Curr Pain Headache Rep 2019 Aug 27;23(11):79. Epub 2019 Aug 27.

Department of Health and Movement Science, Graceland University, 1 University Pl., Lamoni, IA, 50140, USA.

Purpose Of Review: This literature review describes the relationship between IgG food sensitivities and their relation to migraine headaches.

Recent Findings: IgG food sensitivities have been linked to various symptoms and disorders. While food sensitivities and intolerances are recognized within the clinical medicine community, diagnosing these sensitivities and intolerances can be challenging because symptoms are usually delayed hours to days and may not occur after every exposure to the allergen. Read More

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Region-Specific Effects of Trigeminal Capsaicin Stimulation.

J Oral Facial Pain Headache 2019 12;33(3):318–330. Epub 2019 Apr 12.

Aims: To investigate the region-specific effects of painful trigeminal capsaicin stimulation in healthy participants.

Methods: Twenty healthy participants (10 men and 10 women) participated in four sessions in which they received application of 0.05 mL Vaseline (placebo) or capsaicin cream (0. Read More

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November 2019

Neural network and logistic regression diagnostic prediction models for giant cell arteritis: development and validation.

Clin Ophthalmol 2019 21;13:421-430. Epub 2019 Feb 21.

Statistics, University of Waterloo, Waterloo, ON, Canada.

Purpose: To develop and validate neural network (NN) vs logistic regression (LR) diagnostic prediction models in patients with suspected giant cell arteritis (GCA). Design: Multicenter retrospective chart review.

Methods: An audit of consecutive patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at 14 international medical centers. Read More

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February 2019

Validation and modification of the Ottawa subarachnoid haemorrhage rule in risk stratification of Asian Chinese patients with acute headache.

Hong Kong Med J 2018 Dec 9;24(6):584-592. Epub 2018 Nov 9.

Accident and Emergency, Pok Oi Hospital, Yuen Long, Hong Kong.

Objective: To validate the Ottawa subarachnoid haemorrhage (SAH) rule in an Asian Chinese cohort and to explore the roles of blood pressure and vomiting in prediction of SAH in patients with nontraumatic acute headache.

Methods: A retrospective cohort study was conducted in two regional hospitals. All patients aged ≥16 years who presented with non-traumatic acute headache to the study centres from July 2013 to June 2016 were included. Read More

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December 2018

Acute Bacterial Meningitis.

Larry E Davis

Continuum (Minneap Minn) 2018 Oct;24(5, Neuroinfectious Disease):1264-1283

Purpose Of Review: While acute bacterial meningitis is becoming less common in developed countries because of the widespread use of vaccines against Streptococcus pneumoniae, Neisseria meningitides, and Haemophilus influenzae, bacterial meningitis still occurs worldwide, with peak incidence in young children and the elderly. Bacterial meningitis is usually lethal unless appropriate antibiotics that cross the blood-brain barrier are given. Clinical suspicion of bacterial meningitis begins when patients present with the abrupt onset of fever, headache, and meningismus. Read More

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October 2018

Modeling the Structure of Acute Sport-Related Concussion Symptoms: A Bifactor Approach.

J Int Neuropsychol Soc 2018 09 6;24(8):793-804. Epub 2018 Aug 6.

1Department of Neurosurgery,Medical College of Wisconsin,Milwaukee,Wisconsin.

Objectives: Concussions cause diverse symptoms that are often measured through a single symptom severity score. Researchers have postulated distinct dimensions of concussion symptoms, raising the possibility that total scores may not accurately represent their multidimensional nature. This study examined to what degree concussion symptoms, assessed by the Sport Concussion Assessment Tool 3 (SCAT3), reflect a unidimensional versus multidimensional construct to inform how the SCAT3 should be scored and advance efforts to identify distinct phenotypes of concussion. Read More

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September 2018

Prevalence and effects of multiple chemical sensitivities in Australia.

Anne Steinemann

Prev Med Rep 2018 Jun 10;10:191-194. Epub 2018 Mar 10.

Department of Infrastructure Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, Victoria 3010, Australia.

Multiple chemical sensitivities (MCS) is a medical condition associated with exposure to common chemical pollutants. The aims of this study are to assess the prevalence of MCS, its overlaps with asthma and fragrance sensitivity, and its health and societal effects in Australia. Data were collected in June 2016 using an on-line survey with a representative national sample (N = 1098) of adults (ages 18-65) in Australia. Read More

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Referred Pain and Sensations Evoked by Standardized Palpation of the Masseter Muscle in Healthy Participants.

J Oral Facial Pain Headache 2018 03 21;32(2):159–166. Epub 2018 Mar 21.

Aims: To determine if standardized palpation of the masseter muscle can evoke referred pain and/or sensations in healthy individuals and to compare the mechanical sensitivities in response to three different levels of palpation force.

Methods: A total of 32 pain-free individuals participated. The right masseter muscle was divided into 15 test sites. Read More

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National Prevalence and Effects of Multiple Chemical Sensitivities.

Anne Steinemann

J Occup Environ Med 2018 03;60(3):e152-e156

Department of Infrastructure Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, Victoria, Australia; College of Science and Engineering, James Cook University, Townsville, Queensland, Australia; and Climate, Atmospheric Sciences, and Physical Oceanography, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California.

Objective: The aim of this study was to assess the prevalence of multiple chemical sensitivities (MCS), its co-occurrence with asthma and fragrance sensitivity, and effects from exposure to fragranced consumer products.

Methods: A nationally representative cross-sectional population-based sample of adult Americans (n = 1137) was surveyed in June 2016.

Results: Among the population, 12. Read More

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Harefuah 2017 Dec;156(12):767-771

Department of Neurology, Soroka University Medical Center, Beer Sheba.

Background: Primary headaches such as migraine and tension type headaches are extremely common and present a significant clinical challenge. These conditions involve a complex interaction between biological and psychological processes. As part of a "vicious cycle" effect, primary headaches can be deleterious to patients, causing stress, anxiety and catastrophization, while at the same time becoming exacerbated by those very same cognitive and emotional states. Read More

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December 2017

Urodynamic characteristics might be variable in bladder pain syndrome/interstitial cystitis patients with different non-bladder co-morbid conditions.

J Chin Med Assoc 2018 03 6;81(3):248-254. Epub 2017 Dec 6.

Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Shu-Tien Urological Science Research Center, Taipei, Taiwan, ROC.

Background: The aim of the study was to identify the impact of non-bladder co-morbid conditions on the urodynamic characteristics of patients with bladder pain syndrome/interstitial cystitis.

Methods: Patients with bladder pain syndrome/interstitial cystitis completed the screening questionnaires for chronic fatigue syndrome, irritable bowel syndrome, fibromyalgia, temporo-mandibular disorders, multiple chemical sensitivities, tension/migraine headache, and localized myofascial pain disorder. They underwent either conventional pressure-flow urodynamic studies or video-urodynamic studies. Read More

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Tumor Necrosis Factor Alpha Signaling in Trigeminal Ganglion Contributes to Mechanical Hypersensitivity in Masseter Muscle During Temporomandibular Joint Inflammation.

J Oral Facial Pain Headache Winter 2018;32(1):75–83. Epub 2017 Nov 16.

Aims: To determine the involvement of tumor necrosis factor alpha (TNFα) signaling in the trigeminal ganglion (TG) in the mechanical hypersensitivity of the masseter muscle during temporomandibular joint (TMJ) inflammation.

Methods: A total of 55 male Sprague-Dawley rats were used. Following injection of Complete Freund's Adjuvant into the TMJ, the mechanical sensitivities of the masseter muscle and the overlying facial skin were measured. Read More

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Application of the 2016 diagnostic approach for autoimmune encephalitis from Lancet Neurology to Chinese patients.

BMC Neurol 2017 Nov 6;17(1):195. Epub 2017 Nov 6.

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.

Background: A unified clinical approach to diagnose autoimmune encephalitis was published in Lancet Neurology in 2016. Purpose of our study is to examine the feasibility and reasonability of the 2016 "A clinical approach to diagnosis of autoimmune encephalitis" in China with a retrospective study.

Methods: We retrospectively collected 95 cases of autoimmune encephalitis and non autoimmune encephalitis cases with detailed clinical data from Beijing Tongren Hospital and the China National Knowledge Infrastructure (CNKI). Read More

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November 2017

Systematic Mapping of Pressure Pain Thresholds of the Masseter and Temporalis Muscles and Assessment of Their Diversity Through the Novel Application of Entropy.

J Oral Facial Pain Headache 2017 10;31(4):362–371. Epub 2017 Oct 10.

Aims: To assess the diversity of pressure pain thresholds (PPTs) within the masseter and temporalis muscles by using the novel concept of entropy and to assess the differences in PPT scores between different sites of the masseter and temporalis muscles.

Methods: In this randomized, single-blinded study, the left and right masseter and temporalis muscles of 14 healthy volunteers were divided into 15 sites each, and the PPT was assessed for each of these sites. PPT assessments were performed in two different sessions. Read More

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October 2017

Self-report and subjective history in the diagnosis of painful neck conditions: A systematic review of diagnostic accuracy studies.

Musculoskelet Sci Pract 2017 10 8;31:30-44. Epub 2017 Jun 8.

Walsh University, School of Behavioral and Health Sciences, Physical Therapy Program, 2020 East Maple Street NW, North Canton, OH 44720, United States. Electronic address:

Rising healthcare costs and inherent risks with over-utilizing diagnostic imaging require a quality subjective examination to improve effectiveness and time management of physical examinations. This systematic review investigates the diagnostic accuracy of subjective history and self-report items to determine if there is significant alteration in the probability of identifying specific painful neck conditions. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Read More

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October 2017

Urgent referral for suspected CNS cancer: which clinical features are associated with a positive predictive value of 3 % or more?

BMC Neurol 2016 Aug 26;16(1):152. Epub 2016 Aug 26.

Department of Neurology, Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston, PR2 9HT, UK.

Background: Urgent referral for suspected central nervous system (CNS) cancer is recommended, but little analysis of the referral criteria diagnostic performance has been conducted. New 2015 NICE guidance recommends direct brain imaging for patients with symptoms with positive predictive values (PPV) of 3 %, but further guidance is needed.

Methods: A 12-month retrospective evaluation of 393 patients referred under previous 2005 NICE 2-week rule criteria was conducted. Read More

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Chronic Rhinosinusitis and Irritable Bowel Syndrome: A Case Report.

Integr Med (Encinitas) 2016 Jun;15(3):44-54

Mikhail Kogan, md , is medical director at George Washington University, G. W. Center for Integrative Medicine, in Washington, DC. Carlos Cuellar Castillo, ms , is a graduate of the physiology master of science program and complementary and alternative medicine at Georgetown University, in Washington, DC. Melissa S. Barber, ms , is at Helfgott Research Institute, National University of Natural Medicine, in Portland, Oregon.

Introduction: Chronic rhinosinusitis (CRS) and irritable bowel syndrome (IBS) can be comorbidities that are difficult to treat. In this patient, an evidence-informed treatment pathway guided by laboratory biomarkers was used to address both conditions.

Case Presentation: A 69-y-old female patient presented with a 50-y history of sinusitis that was worse in the winter, postnasal drip, frequent sore throats, gastrointestinal complaints, headaches, and yeast infections. Read More

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The Detection of Small-Fiber Neuropathies in Burning Mouth Syndrome and Iatrogenic Lingual Nerve Injuries: Use of Quantitative Sensory Testing.

J Oral Facial Pain Headache 2016 ;30(2):87-98

Aims: To assess thermal pain perception in patients with burning mouth syndrome (BMS) and lingual nerve injury (LNI) by using a quantitative sensory testing (QST) protocol.

Methods: QST was used to assess cool, warm, cold pain, and heat pain thresholds in healthy control subjects (n = 17) and in patients with BMS (n = 22) and LNI (n = 47). Capsaicin (10 μg/mL) and ethyl chloride-evoked hypersensitivities at the anterior two-thirds of the tongue were measured using a visual analog scale. Read More

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