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[Infections in patients colonized with carbapenem-resistant Gram-negative bacteria in a medium Spanish city].

Rev Esp Quimioter 2021 Jun 8. Epub 2021 Jun 8.

José Gutiérrez-Fernández. Laboratorio de Microbiología. Hospital Universitario Virgen de las Nieves. Avenida de las Fuerzas Armadas, 2, E-18014, Granada, Spain.

Objective: Because there are few studies on the clinical implications of colonization by carbapenem-resistant gram-negative bacteria (CRB) this was analyzed in rectal smears (RS) and pharyngeals (PS) and its ability to predict infection/colonization.

Methods: A cross-sectional, retrospective study from adult inpatients between January 2016 and December 2019 was conducted. The isolates were characterized by MicroScan and spectrometry of masses applying EUCAST 2018 cutoff points. Read More

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Comparative analysis of different PCR-based strategies for HPV detection and genotyping from cervical samples.

J Med Virol 2021 Jun 1. Epub 2021 Jun 1.

Laboratory of Molecular Genetics and Biotechnology (GMBio), Department of Biology, Center for Biological and Health Sciences, Federal University of Sergipe, São Cristóvão, Brazil.

Background: Human papillomavirus (HPV) is the main cause of cervical cancer. Polymerase chain reaction (PCR)-based techniques are associated with accurate results with respect to HPV detection and genotyping, being able to identify viral DNA at low levels. However, differences in primer design influence their sensibility and specificity, depending on the HPV type assessed. Read More

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Light Emitted Diode on Detecting Thin-Film Transistor through Line-Scan Photosensor.

Micromachines (Basel) 2021 Apr 14;12(4). Epub 2021 Apr 14.

Department of Electrical Engineering, Feng Chia University, Taichung 40724, Taiwan.

This paper explores the effectiveness of the white, red, green, and blue light emitted diodes (LEDs) light sources to detect the third layer of the electrode pixel and the fourth layer of the via-hole passivation on thin-film transistors. The time-delay-integration charge-coupled device and a reflective spectrometer were implemented in this experiment. The optical conditions are the same, as each light source and the digital image's binary method also recognize the sharpness and contrast in the task. Read More

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Sensitivity of the Molecular Test in Saliva for Detection of COVID-19 in Pediatric Patients With Concurrent Conditions.

Front Pediatr 2021 12;9:642781. Epub 2021 Apr 12.

Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

The reference standard for the molecular diagnostic testing for COVID-19 is the use of nasopharyngeal or combined nasopharyngeal and oropharyngeal (NP/OP) swabs. Saliva has been proposed as a minimally invasive specimen whose collection reduces the risks for health care personnel. To assess the suitability of saliva for COVID-19 diagnosis as a replacement of the reference standard NP/OP swab in the setting of a tertiary care pediatric unit. Read More

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Three-Dimensional Evaluation of Soft Tissue Malar Modifications after Zygomatic Valgization Osteotomy via Geometrical Descriptors.

J Pers Med 2021 Mar 13;11(3). Epub 2021 Mar 13.

Department of Surgical Sciences, Division of Maxillofacial Surgery, University of Turin, Città della Salute e della Scienza HOSPITAL, 10129 Turin, Italy.

Patients with severe facial deformities present serious dysfunctionalities along with an unsatisfactory aesthetic facial appearance. Several methods have been proposed to specifically plan the interventions on the patient's needs, but none of these seem to achieve a sufficient level of accuracy in predicting the resulting facial appearance. In this context, a deep knowledge of what occurs in the face after bony movements in specific surgeries would give the possibility to develop more reliable systems. Read More

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Kidney Injury Molecule-1 in the detection of early kidney injury in dogs with leptospirosis.

Comp Immunol Microbiol Infect Dis 2021 Jun 1;76:101637. Epub 2021 Mar 1.

Bacterial Disease Laboratory, Federal University of Bahia, 500 Adhemar de Barros Av., Salvador, BA 40170-110, Brazil. Electronic address:

Renal damage, a common feature in canine leptospirosis, ranges from a subclinical affection to kidney dysfunction and death. Chances of recovery can be improved by early intervention. However, traditional biomarkers (serum urea and creatinine) have limited relevance for precocity. Read More

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Helically Intersected Conductive Network Design for Wearable Electronic Devices: From Theory to Application.

ACS Appl Mater Interfaces 2021 Mar 24;13(9):11480-11488. Epub 2021 Feb 24.

College of Material Science and Engineering, Sichuan University of Science and Engineering; Material Corrosion and Protection Key Laboratory of Sichuan province, Zigong 643000, China.

Flexible and stretchable strain sensors are crucial components for wearable electronics that can detect and quantify the stimuli from the environment and thus realize the rapid feedback and control of smart devices. However, reconciliation of the conflict between resourceful design of conductive networks and large-scale production in the industry still faces a huge challenge. Herein, we present a new flow-manipulated strategy to prepare a wearable strain sensor featuring a helically intersected conductive network, which exhibited easy integration, multidimensional sensibility, and robust mechanical properties. Read More

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Feature-sensitive Deep Convolutional Neural Network for Multi-instance Breast Cancer Detection.

IEEE/ACM Trans Comput Biol Bioinform 2021 Feb 18;PP. Epub 2021 Feb 18.

To obtain a well-performed computer-aided detection model for detecting breast cancer, it is usually needed to design an effective and efficient algorithm and a well-labeled dataset to train it. In this paper, firstly, a multi-instance mammography clinic dataset was constructed. Each case in the dataset includes a different number of instances captured from different views, it is labeled according to the pathological report, and all the instances of one case share one label. Read More

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February 2021

Gender Brain Structural Differences and Interoception.

Front Neurosci 2020 6;14:586860. Epub 2021 Jan 6.

IRCCS SDN, Naples, Italy.

Interoception, the ability to perceive inner body sensations, has been demonstrated to be different among genders, with a stronger female attention toward interoceptive information. No study correlated this capability with brain differences between males and females. This study aims to detect behavioral variances and structural neuroimaging interoception correlates in a sample of healthy volunteers matched for age. Read More

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January 2021

BIONOTE as an Innovative Biosensor for Measuring Endocannabinoid Levels.

Sensors (Basel) 2021 Jan 12;21(2). Epub 2021 Jan 12.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

In this study, a novel approach was developed to quantify endocannabinoids (eCBs), and was based on the liquid biosensor BIONOTE. This device is composed of a probe that can be immersed in a solution, and an electronic interface that can record a current related to the oxy-reductive reactions occurring in the sample. The two most representative members of eCBs have been analysed in vitro by BIONOTE: anandamide (-arachidonoylethanolamine, AEA) and 2-arachidonoylglycerol (2-AG). Read More

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January 2021

Role of BRCA Mutation and HE4 in Predicting Chemotherapy Response in Ovarian Cancer: A Retrospective Pilot Study.

Biomedicines 2021 Jan 8;9(1). Epub 2021 Jan 8.

Department of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.

Even though 80% of patients with High-Grade Serous Ovarian Cancer respond to standard first-line chemotherapy, a majority of them could relapse in the following five years due to a resistance to platinum. Human Epididymis protein 4 (HE4) is one of the most promising markers in predicting platinum therapy response. This pilot study aims to evaluate the potential role of HE4 value in predicting chemotherapy response in mutated patients and in wild-type (non-mutated) ones. Read More

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January 2021

First-Hand Accounts of Interoceptive Difficulties in Autistic Adults.

J Autism Dev Disord 2021 Jan 3. Epub 2021 Jan 3.

Child Study Center, Yale University, 230 S. Frontage Rd, New Haven, CT, 06511, USA.

Interoceptive awareness refers to one's ability to detect, discriminate, and regulate internal bodily and mental processes. Interoceptive challenges in ASD remain under researched and poorly understood. In this study, we analyzed texts of adults who self-identify as autistic describing their interoceptive challenges. Read More

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January 2021

Umbilical cord lactate compared with pH as predictors of intrapartum asphyxia.

Exp Ther Med 2021 Jan 26;21(1):80. Epub 2020 Nov 26.

Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Despite advances in fetal monitoring during labor, one of the most critical causes of neonatal death and neurologic injuries remains intrapartum asphyxia. Umbilical cord gases can be used to detect acidosis and fetal distress. We conducted a retrospective, multicenter study to evaluate umbilical cord blood pH and lactate as a mean of evaluating the degree of intrapartum hypoxia and also to establish which of the two is more reliable in predicting morbidity in term neonates. Read More

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January 2021

Complexity Analysis of Surface Electromyography for Assessing the Myoelectric Manifestation of Muscle Fatigue: A Review.

Entropy (Basel) 2020 May 7;22(5). Epub 2020 May 7.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.

The surface electromyography (sEMG) records the electrical activity of muscle fibers during contraction: one of its uses is to assess changes taking place within muscles in the course of a fatiguing contraction to provide insights into our understanding of muscle fatigue in training protocols and rehabilitation medicine. Until recently, these myoelectric manifestations of muscle fatigue (MMF) have been assessed essentially by linear sEMG analyses. However, sEMG shows a complex behavior, due to many concurrent factors. Read More

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A Novel Capacitive Step Sensor to Trigger Stimulation on Functional Electrical Stimulators Devices for Drop Foot.

IEEE Trans Neural Syst Rehabil Eng 2020 12 28;28(12):3083-3088. Epub 2021 Jan 28.

Drop foot is a typical clinical condition associated with stroke. According to the World Health Organization, fifteen million people suffer a stroke per year, and one of three people's survival gets drop foot. Functional Electrical Stimulation systems are applied over the peroneal motor nerve to achieve the drop foot problem's dorsiflexion. Read More

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December 2020

[Update on precursors of vulvar carcinoma].

Gynecol Obstet Fertil Senol 2021 Jun 6;49(6):538-546. Epub 2020 Nov 6.

Institut Curie Saint-Cloud, 35, rue Dailly, 92210 Saint-Cloud, France; Université de Versailles-Saint-Quentin-en-Yvelines, UFR sciences de la santé, Versailles, France. Electronic address:

Vulvar carcinomas represent 4% of all gynaecological cancers with 838 new cases in France in 2018. The precursor lesions of vulvar carcinomas are differentiated vulvar intraepithelial lesion (dVIN) in a context of lichen sclerosus and vulvar high-grade squamous intraepithelial lesion (HSIL) link to human papillomavirus (HPV) infection. Three typical clinical forms of HSIL are described: the Bowenoid papulosis, the Bowen's disease and the confluent VIN. Read More

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[Quality evaluation of different Berberidis Cortex species based on ~1H-NMR metabolomics and anti-diabetic activity].

Zhongguo Zhong Yao Za Zhi 2020 Oct;45(19):4677-4685

College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.

To evaluate the quality differences of four mainstream species of Berberidis Cortex,~1H-NMR metabolomics was applied to detect its primary and secondary metabolites, and the partial least squares discriminant analysis and analysis of variance were integrated to screen differential metabolites between species. Furthermore, diabetic rat model was established by high fat diet and streptozotocin to assess differences in antidiabetic activities among the four species. Sixteen compounds were simultaneously detected and identified, including alkaloids, organic acids, carbohydrates and amino acids. Read More

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October 2020

Hypertryptasemia and Mast Cell-Related Disorders in Severe Osteoporotic Patients.

Mediators Inflamm 2020 20;2020:5785378. Epub 2020 Oct 20.

Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Purpose: Systemic mastocytosis (SM) is characterized by a clonal proliferation of neoplastic mast cells (MCs) in one or more extracutaneous organs including the bone marrow (BM). SM is often associated with osteoporosis (OP) and fractures. Hypertryptasemia usually occurs in SM. Read More

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October 2020

Two Measures of Interoceptive Sensibility and the Relationship With Introversion and Neuroticism in an Adult Population.

Psychol Rep 2020 Oct 28:33294120965461. Epub 2020 Oct 28.

Leeds School of Social Sciences, Leeds Beckett University, Leeds, UK.

Interoception, the ability to detect internal bodily signals, is vital for an individual's well-being and is increasingly connected to mental health disorders. Research investigating relationships between individual differences in interoception and personality types is limited, and mixed results are reported across a variety of interoceptive tasks, measures, and conceptualisations. Guided by biological theories, this study contributed further to the understanding of the relationship between interoception and personality by utilising two interoceptive measures. Read More

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October 2020

Analysis of Intraoperative Seizures During Bipolar Brain Mapping in Eloquent Areas: Intraoperative Seizures in brain mapping.

Clin Neurol Neurosurg 2020 12 13;199:106304. Epub 2020 Oct 13.

Department of Surgical Neuro-Oncology, National Institute of Neurology and Neurosurgery, South Insurgentes Avenue 3877, Tlalpan, 14269 Mexico City, Mexico; Department of Radiosurgery, National Institute of Neurology and Neurosurgery, South Insurgentes Avenue 3877, Tlalpan, 14269 Mexico City, Mexico.

Objectives: Awake Craniotomy (AC) is a very well described technique that is performed to make an adequate tumor resection preserving the functionality of the patient. Intraoperative Seizures (IS) are reported as a failure of such procedure. We analyze the incidence and risk factor during AC. Read More

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December 2020

A novel real-time PCR to detect Cetacean morbillivirus in Atlantic cetaceans.

J Virol Methods 2020 11 2;285:113964. Epub 2020 Sep 2.

Division of Histology and Animal Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran Canaria, Arucas, Canary Islands, Spain.

Cetacean morbillivirus (CeMV, family Paramyxoviridae) is a re-emergent pathogen associated with severe epizootic outbreaks causing high mortality among cetaceans worldwide. Recently, CeMV caused an unusual mortality event of Guiana dolphins (Sotalia guianensis) in Brazil. Partial sequence of the viral phosphoprotein (P) gene showed that the Guiana dolphin morbillivirus (GDMV) might represent a new lineage of CeMV. Read More

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November 2020

Perfusion speed of indocyanine green in the stomach before tubulization is an objective and useful parameter to evaluate gastric microcirculation during Ivor-Lewis esophagectomy.

Surg Endosc 2020 12 27;34(12):5649-5659. Epub 2020 Aug 27.

Department of Surgery, San Raffaele Hospital, Vita-Salute San Raffaele University, Via Olgettina Milano, 60, 20132, Milan, MI, Italy.

Background: Anastomotic leakage (AL) during Ivor-Lewis esophagectomy (ILE), owing to gastric conduit (GC) ischemia, is a serious complication. Measurement parameters during intraoperative ICG fluorescence angiography (ICG-FA) are unclear. We aimed to identify objective ICG-FA parameters associated with AL. Read More

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December 2020

Multilayer myocardial strain improves the diagnosis of heart failure with preserved ejection fraction.

ESC Heart Fail 2020 10 21;7(5):3240-3245. Epub 2020 Jun 21.

Department of Internal Medicine/Cardiology, German Heart Center Berlin, Berlin, 13353, Germany.

Aims: The diagnostic and treatment of patients with heart failure with preserved ejection fraction (HFpEF) are both hampered by an incomplete understanding of the pathophysiology of the disease. Novel imaging tools to adequately identify these patients from individuals with a normal cardiac function and respectively patients with HF with reduced EF are warranted. Computing multilayer myocardial strain with feature tracking is a fast and accurate method to assess cardiac deformation. Read More

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October 2020

Intraoral Somatosensory Alterations Impact Pulp Sensibility Testing in Patients with Symptomatic Irreversible Pulpitis.

J Endod 2020 Jun 25;46(6):786-793. Epub 2020 Apr 25.

Section of Head and Face Physiology, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Introduction: This case-control study aimed to compare trigeminal somatosensory sensitivity between patients with a clinical diagnosis of symptomatic irreversible pulpitis (n = 33) and healthy participants (n = 33) and to evaluate the impact of somatosensory stratification of symptomatic irreversible pulpitis on pulp sensibility testing.

Methods: A standardized battery of qualitative sensory assessment measured intra- and extraoral sensitivity to touch, cold, and pinprick stimuli. Dental pain intensity (0-100, numeric rating scale) and duration (seconds) evoked by cold stimuli (refrigerant spray) were applied to, respectively, the nonaffected and affected tooth (cases) and the upper right and left premolars (controls); z score transformation, analysis of variance (ANOVA), and chi-square tests were applied to the data (P = . Read More

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Production of Mycobacterium bovis Antigens Included in Recombinant Occlusion Bodies of Baculovirus.

J Mol Microbiol Biotechnol 2019 7;29(1-6):83-90. Epub 2020 Apr 7.

Institute of Biotechnology, National Institute of Agricultural Technology (INTA, Instituto de Biotecnología, Instituto Nacional de Tecnología Agropecuaria) and IABIMO-National Scientific and Technical Research Council (CONICET, Consejo Nacional de Investigaciones Científicas y Tecnológicas), Buenos Aires, Argentina,

Bovine tuberculosis (bTB) is a disease produced by Mycobacterium bovis that affects livestock, wild animals, and humans. The classical diagnostic method to detect bTB is measuring the response induced with the intradermal injection of purified protein derivative of M. bovis (PPDb). Read More

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Metal-polymer hybrid nanomaterial for impedimetric detection of human papillomavirus in cervical specimens.

J Pharm Biomed Anal 2020 Jun 9;185:113249. Epub 2020 Mar 9.

Programa de Pós-Graduação em Inovação Terapêutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil; Laboratório de Biodispositivos Nanoestruturados, Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil. Electronic address:

The human papillomavirus (HPV) is one of the main sexually transmitted pathogens that infect the anogenital epithelium and mucous membranes. HPV genotypes can be classified as high and low oncogenic risk, with infection by the former resulting in cervical cancer in approximately 100 % of the cases. In this work, we developed an ultrasensitive electrochemical biosensor for the detection and identification of different HPV genotypes. Read More

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Current Applications of Gas Sensor Based on 2-D Nanomaterial: A Mini Review.

Front Chem 2019 10;7:839. Epub 2019 Dec 10.

Electrical and Mechanical Engineering Department, Southwest Petroleum University, Chengdu, China.

Gas sensor, as one of the most important devices to detect noxious gases, provides a vital way to monitor the concentration and environmental information of gas in order to guarantee the safety of production. Therefore, researches on high sensitivity, high selectivity, and high stability have become hot issues. Since the discovery of the nanomaterial, it has been increasingly applied to the gas sensor for its distinguishing surface performances. Read More

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December 2019

RhB-Embedded Zirconium-Naphthalene-Based Metal-Organic Framework Composite as a Luminescent Self-Calibrating Platform for the Selective Detection of Inorganic Ions.

Chemistry 2020 Feb 24;26(7):1661-1667. Epub 2020 Jan 24.

Provincial Key Laboratory of Advanced Energy Materials, College of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.

A series of [email protected] composites were synthesized through in situ encapsulation of luminous rhodamine B (RhB) molecules into a blue-emissive zirconium-naphthalene-based metal-organic framework (Zr-MOF). The fabricated [email protected] composites exhibit tunable dual-emissive characteristics due to the process of resonant energy transfer from Zr-MOF to RhB. Notably, one of the [email protected] composites ([email protected]) exhibited a weak emission at 420 nm and a strong emission at 607 nm, for which the two emissions possess large distinctions in location and intensity and can be referenced with each other in sensing analytes. Read More

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February 2020

Early ischemia identification employing 2D speckle tracking selective layers analysis during dobutamine stress echocardiography.

Echocardiography 2019 12 19;36(12):2202-2208. Epub 2019 Nov 19.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Purpose: Two-dimensional (2D) strain derived from speckle tracking proved to be feasible and accurate in the quantitative evaluation of myocardial ischemia during stress echocardiography. We compared the accuracy in detecting myocardial ischemia of the transmural segmental analysis with an endocardial specific evaluation in 20 patients undergoing dobutamine stress echocardiography (DSE) and coronary angiography.

Methods: Peak systolic global strain (G-ε) and at the subendocardial level (Endo-ε) were measured off-line at rest, a low dose, and peak stress; then, we compared the results with wall-motion analysis and significant coronary artery disease (CAD > 70% diameter stenosis). Read More

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December 2019