454,041 results match your criteria sense bnp

3D bioprinted human iPSC-derived somatosensory constructs with functional and highly purified sensory neuron networks.

Biofabrication 2021 May 7. Epub 2021 May 7.

Medicine, Harvard Medical School, 65 Landsdowne Street, Rm. 252, PRB-252, Cambridge, Massachusetts, 02139, UNITED STATES.

Engineering three-dimensional (3D) sensible tissue constructs, along with the complex microarchitecture wiring of the sensory nervous system, has been an ongoing challenge in the tissue engineering field. By combining 3D bioprinting and human pluripotent stem cell (hPSC) technologies, sensible tissue constructs could be engineered in a rapid, precise, and controllable manner to replicate 3D microarchitectures and mechanosensory functionalities of the native sensory tissue (e.g. Read More

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Somatosensory versus cerebellar contributions to proprioceptive changes associated with motor skill learning: A theta burst stimulation study.

Cortex 2021 Apr 15;140:98-109. Epub 2021 Apr 15.

Program in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Kinesiology, Indiana University, Bloomington, IN, USA. Electronic address:

Background: It is well established that proprioception (position sense) is important for motor control, yet its role in motor learning and associated plasticity is not well understood. We previously demonstrated that motor skill learning is associated with enhanced proprioception and changes in sensorimotor neurophysiology. However, the neural substrates mediating these effects are unclear. Read More

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A complex fracture of the hyoid bone and the larynx after a bicycle accident - Case report and review of literature.

Int J Surg Case Rep 2021 Apr 27;82:105922. Epub 2021 Apr 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

Introduction And Importance: Reports about laryngeal trauma and fractures of the hyoid bone are rare in the literature. Most cases are forensic cases and the results of postmortem analysis. Traumatic larynx and hyoid bone fractures represent a rare but important differential diagnosis of the common symptom hoarseness. Read More

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A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing.

Mol Metab 2021 May 4:101240. Epub 2021 May 4.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

Objective: The area postrema (AP) and the nucleus tractus solitaris (NTS), located in the hindbrain, are key nuclei that sense and integrate peripheral nutritional signals and, consequently, regulate feeding behaviour. While single cell transcriptomics have been used in mice to reveal the gene expression profile and heterogeneity of key hypothalamic populations, similar in-depth studies have not yet been performed in the hindbrain.

Methods: Using single-nucleus RNA sequencing, we provide a detailed survey of 16,034 cells within the AP and NTS of the mouse, in the fed and fasted state. Read More

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Map-like use of Earth's magnetic field in sharks.

Curr Biol 2021 May 3. Epub 2021 May 3.

Florida State University, National High Magnetic Field Laboratory, 1800 E. Paul Dirac Drive, Tallahassee, FL 32310, USA.

Migration is common in marine animals, and use of the map-like information of Earth's magnetic field appears to play an important role. While sharks are iconic migrants and well known for their sensitivity to electromagnetic fields, whether this ability is used for navigation is unresolved. We conducted magnetic displacement experiments on wild-caught bonnetheads (Sphyrna tiburo) and show that magnetic map cues can elicit homeward orientation. Read More

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Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production.

Neuromodulation 2021 May 7. Epub 2021 May 7.

Department of Medical Physiology, Kyorin University School of Medicine, Tokyo, Japan.

Objectives: Time awareness may change depending on the mental state or disease conditions, although each individual perceives his/her own sense of time as stable and accurate. Nevertheless, the processes that consolidate altered duration production remain unclear. The present study aimed to manipulate the subjective duration production via memory consolidation through the modulation of neural plasticity. Read More

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Visual Analytics of Smartphone-Sensed Human Behavior and Health.

IEEE Comput Graph Appl 2021 May-Jun;41(3):96-104

Smartphone health sensing tools, which analyze passively gathered human behavior data, can provide clinicians with a longitudinal view of their patients' ailments in natural settings. In this Visualization Viewpoints article, we postulate that interactive visual analytics (IVA) can assist data scientists during the development of such tools by facilitating the discovery and correction of wrong or missing user-provided ground-truth health annotations. IVA can also assist clinicians in making sense of their patients' behaviors by providing additional contextual and semantic information. Read More

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COVID-19 Is a Crisis in Planetary Health and Politics of Expertise: Time to Think Critically and Innovate Both.

Marco Boschele

OMICS 2021 May;25(5):279-284

Department of Political Science and Public Administration, Kocaeli University, İzmit, Turkey.

This expert review offers an analysis of the global governance of the COVID-19 pandemic. The pandemic is not only a health crisis but also a crisis of global governance. For example, the nation states in dealing with the crises of the pandemic have turned inwards, toward native and national solutions, and therefore away from the much-needed global cooperation to respond to the pandemic. Read More

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Surface Chirality Influences Molecular Rotation upon Desorption.

Phys Rev Lett 2021 Apr;126(16):166101

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Chiral surfaces offer great potential as a medium for enantioselective synthesis or separation, yet their dynamic enantiospecific interactions with adsorbates are not well understood. Here, the influence of chiral surfaces on the molecular rotations of desorbing molecules is investigated. Formic acid desorption from Cu{531} and Cu{110} serve as model systems for desorption processes of an achiral adsorbate from a chiral and an achiral surface. Read More

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Improving Caregiver Self-Efficacy and Children's Behavioral Outcomes via a Brief Strength-Based Video Coaching Intervention: Results from a Randomized Controlled Trial.

Prev Sci 2021 May 7. Epub 2021 May 7.

Department of Psychology and Center for Translational Neuroscience, University of Oregon, Eugene, OR, USA.

Many existing preventive intervention programs focus on promoting responsive parenting practices. However, these parenting programs are often long in duration and expensive, and meta-analytic evidence indicates that families facing high levels of adversity typically benefit less. Moreover, due to a lack of specification and evaluation of conceptual models, the mechanisms underlying program-related changes in caregivers and their children often remain unclear. Read More

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Current understanding on molecular drug targets and emerging treatment strategy for novel coronavirus-19.

Naunyn Schmiedebergs Arch Pharmacol 2021 May 7. Epub 2021 May 7.

Neuroscience Division, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India.

SARS-CoV-2 is an enveloped positive-sense RNA virus, contain crown-like spikes on its surface, exceptional of large RNA genome, and a special replication machinery. Common symptoms of SARS-CoV-2 include cough, common cold, fever, sore throat, and a variety of severe acute respiratory disease (SARD) such as pneumonia. SARS-CoV-2 infects epithelial cells, T-cells, macrophages, and dendritic cells and also influences the production and implantation of pro-inflammatory cytokines and chemokines. Read More

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Plate Positioning Affects the Pressure on the Axillary Nerve Following a Deltopectoral Approach.

Acta Chir Orthop Traumatol Cech 2021 ;88(2):153-157

Istanbul Medeniyet University, Department of Orthopaedic Surgery and Traumatology, Istanbul, Turkey.

PURPOSE OF THE STUDY To investigate the pressure levels on the axillary nerve at different plate positions after plate fixation of a proximal humerus fracture. MATERIAL AND METHODS Eight fresh-frozen cadaveric specimens were used. The plates were applied on the lateral side of the humerus. Read More

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January 2021

Programming living sensors for environment, health and biomanufacturing.

Microb Biotechnol 2021 May 7. Epub 2021 May 7.

Centre for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3FF, UK.

Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purposes including environmental monitoring, disease diagnosis and adaptive biomanufacturing. Despite demonstrated proof-of-concept success in the laboratory, the real-world applications of microbial sensors have been restricted due to certain technical and societal limitations. Read More

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Understanding the illness representations of young people with anxiety and depression: A qualitative study.

Psychol Psychother 2021 May 7. Epub 2021 May 7.

Evidence-Based Practice Unit (EBPU), University College London and Anna Freud National Centre for Children and Families, UK.

Background: Many young people with anxiety or depression drop out of treatment early, and/or leave treatment without showing measurably improved symptom levels. To enhance treatment engagement and effectiveness, it is critical to better understand how young people's perceptions of the symptoms, causes, consequences, treatability, and course of their anxiety and depression influence engagement.

Aim: This study aimed to provide a qualitative account of illness perceptions among youth with anxiety and depression by applying the Common Sense Model of Self-Regulation (CSM), which was developed in physical health contexts. Read More

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Eshelby untwisting.

Chem Commun (Camb) 2021 May 7. Epub 2021 May 7.

Department of Chemistry and the Molecular Design Institute, New York University, 100 Washington Square East, New York, NY 10003-6688, USA.

The concept of Eshelby untwisting, the effect of an axial screw dislocation driving an intrinsically twisted nanocrystal towards a straighter configuration more consistent with long-range translational symmetry, is introduced here. Force-field simulations of nanorods built from the enantiomorphous (space groups, P3121 and P3221) crystal structures of benzil (C6H5-C(O)-C(O)-C6H5) were previously shown to twist in opposite directions, even in the absence of dislocations. Here, both right- and left-handed screw dislocations were introduced into benzil nanorods in silico. Read More

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Nursing assistant's perceptions of the good work environment in municipal elderly care in Sweden -a focus group study.

J Health Organ Manag 2021 Apr;35(9):163-177

University of Gothenburg, Gothenburg, Sweden.

Purpose: The purpose of this paper is to investigate aspects related to difficulty to retain nursing assistants at nursing homes in Sweden related to perceived work environment characteristics.

Design/methodology/approach: To reveal aspects related to difficulty to retain nursing assistants, the paper uses the BIKVA model, sense of coherence and New Public Management (NPM). In total, three focus groups with nursing assistants at three nursing homes are interviewed with corresponding individual interviews with their senior managers and users. Read More

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Dying as an issue of public concern: cultural scripts on palliative care in Sweden.

Med Health Care Philos 2021 May 6. Epub 2021 May 6.

Department of Health, Medicine and Caring Sciences (HMV), Linköping University, Linköping, Sweden.

In Sweden, palliative care has, over the past decades, been object to policies and guidelines with focus on how to achieve "good palliative care". The aim of this study has been to analyse how experts make sense of the development and the current state of palliative care. Departing from this aim, focus has been on identifying how personal experiences of 'the self' are intertwined with culturally available meta-level concepts and how experts contribute to construct new scripts on palliative care. Read More

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Uvular Necrosis After Shoulder Surgery: A Report of Three Cases.

Cureus 2021 Mar 31;13(3):e14233. Epub 2021 Mar 31.

Orthopaedic Surgery, Stanford University School of Medicine, Stanford, USA.

Uvular necrosis is a rare postoperative complication that can manifest from endotracheal tube intubation or laryngeal mask airway placement resulting in compression and restriction of blood flow to the uvula. This report describes three patients who underwent outpatient shoulder surgery under general anesthesia and were subsequently diagnosed with uvular necrosis. Their symptoms included persistent sore throat, dysphagia, odynophagia, and foreign body sensation, with swelling and white exudate on the uvular tip. Read More

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A new fossil mantis shrimp and the convergent evolution of a lobster-like morphotype.

PeerJ 2021 16;9:e11124. Epub 2021 Apr 16.

Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.

Eumalacostracan crustaceans all have a more or less stereotypic body organisation in the sense of tagmosis. Originally, this included a head with six segments (ocular segment plus five appendage-bearing segments), a thorax region with eight segments, and a pleon with six segments. Interestingly, despite these restrictions in variability in terms of tagmosis, the morphological diversity within Eumalacostraca is rather high. Read More

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Increase of Collectivistic Expression in China During the COVID-19 Outbreak: An Empirical Study on Online Social Networks.

Front Psychol 2021 20;12:632204. Epub 2021 Apr 20.

CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

The pathogen-prevalence hypothesis postulates that collectivism would be strengthened in the long term in tandem with recurrent attacks of infectious diseases. However, it is unclear whether a one-time pathogen epidemic would elevate collectivism. The outbreak of COVID-19 and the widespread prevalence of online social networks have provided researchers an opportunity to explore this issue. Read More

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Putting Stress in Historical Context: Why It Is Important That Being Stressed Out Was Not a Way to Be a Person 2,000 Years Ago.

Fabian Hutmacher

Front Psychol 2021 20;12:539799. Epub 2021 Apr 20.

Department of Psychology, University of Regensburg, Regensburg, Germany.

It was not until the middle of the twentieth century that scientists and Western societies began to label the combination of physiological and psychological responses that people display when things are getting too much and out of balance as "stress." However, stress is commonly understood as a universal mechanism that exists across times and cultures. In a certain sense, this universality claim is correct: the physiological and endocrinological mechanisms underlying the stress response are not a modern invention of our body. Read More

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The Relationship of Fear of Death Between Neuroticism and Anxiety During the Covid-19 Pandemic.

Front Psychiatry 2021 20;12:648498. Epub 2021 Apr 20.

Faculty of Psychology, Universidad Católica de Valencia San Vicente Mártir, València, Spain.

After a lockdown, particularly one where human life is at risk, there are expected to be psychological consequences. The examination of personality traits, where different adaptative and non-adaptative behaviors in the face of adversity are expected, is our interest. The aim of this research was to analyze the role fear of personal death played during the Covid-19 outbreak in relation to personality and anxiety. Read More

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Caring for People With Dementia Under COVID-19 Restrictions: A Pilot Study on Family Caregivers.

Front Aging Neurosci 2021 20;13:652833. Epub 2021 Apr 20.

Department of General Psychology, University of Padova, Padova, Italy.

Introduction: The present pilot study examined to what extent the COVID-19 lockdown affected the behavioral and psychological symptoms of dementia (BPSD) in people with dementia and worsened their family caregivers' distress. The associations between changes in the BPSD of relatives with dementia (RwD) and in their caregivers' distress, and sense of social and emotional loneliness, and resilience were also investigated.

Materials And Methods: Thirty-five caregivers of RwD attending formal healthcare services before the COVID-19 lockdown volunteered for the study, and were interviewed by phone during the lockdown. Read More

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Pathophysiological Bases of Comorbidity in Migraine.

Front Hum Neurosci 2021 20;15:640574. Epub 2021 Apr 20.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. Read More

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Belonging: A Review of Conceptual Issues, an Integrative Framework, and Directions for Future Research.

Aust J Psychol 2021 Mar 30;73(1):87-102. Epub 2021 Apr 30.

Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, U.S.A.

Objective: A sense of belonging-the subjective feeling of deep connection with social groups, physical places, and individual and collective experiences-is a fundamental human need that predicts numerous mental, physical, social, economic, and behavioural outcomes. However, varying perspectives on how belonging should be conceptualised, assessed, and cultivated has hampered much-needed progress on this timely and important topic. To address these critical issues, we conducted a narrative review that summarizes existing perspectives on belonging, describes a new integrative framework for understanding and studying belonging, and identifies several key avenues for future research and practice. Read More

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Making sense of dinosaurs and birds.

Science 2021 May;372(6542):575-576

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

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Neuron replating - a powerful and versatile approach to study early aspects of neuron differentiation.

eNeuro 2021 May 6. Epub 2021 May 6.

Molecular Neurobiology Group, Institute of Physiological Chemistry, University of Marburg, 35032 Marburg, Germany

Neuron differentiation includes formation and outgrowth of neurites that differentiate into axons or dendrites. Directed neurite outgrowth is controlled by growth cones that protrude and retract actin-rich structures to sense environmental cues. These cues control local actin filament dynamics, steer growth cones towards attractants and away from repellents and navigate neurites through the developing brain. Read More

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Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy.

Stem Cell Res Ther 2021 May 6;12(1):275. Epub 2021 May 6.

Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

Background: Glaucomatous optic neuropathy (GON) is an anatomofunctional impairment of the optic nerve triggered by glaucoma. Recently, growth factors (GFs) have been shown to produce retinal neuroenhancement. The suprachoroidal autograft of mesenchymal stem cells (MSCs) by the Limoli retinal restoration technique (LRRT) has proven to achieve retinal neuroenhancement by producing GF directly into the choroidal space. Read More

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A qualitative investigation into the impact of hemophagocytic lymphohistiocytosis on children and their caregivers.

Orphanet J Rare Dis 2021 May 6;16(1):205. Epub 2021 May 6.

Chilli Consultancy, The Old Fire Station, 2 Salt Lane, Salisbury, SP1 1JS, UK.

Background: Primary hemophagocytic lymphohistiocytosis (pHLH) is a rare and life-threatening disorder, which usually occurs during infancy or early childhood and is characterized by abnormal activation of the immune system. However, the burden of pHLH on children and their families has not been previously evaluated. This qualitative study investigated the impact of pHLH and its treatment on the physical, emotional, and social well-being of patients and caregivers in the USA and UK using interviews to provide a comprehensive insight from the perspective of the caregivers and young survivors. Read More

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Safety review of current systemic treatments for severe chronic rhinosinusitis with nasal polyps and future directions.

Expert Opin Drug Saf 2021 May 7. Epub 2021 May 7.

Guy's and St Thomas NHS Foundation Trust.

Introduction: Chronic rhinosinusitis is a common condition characterised by inflammation of the nasal and sinus linings, rhinorrhoea, nasal blockage, facial pain and loss of sense of smell for longer than 12 weeks. CRS can occur with or without nasal polyps.Areas covered: First line treatment in chronic rhinosinusitis with nasal polyps is long-term intranasal corticosteroids, which have few adverse events associated with their use, as second-generation intranasal corticosteroids having a bioavailability of <0. Read More

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