32,921 results match your criteria self-reported measured

The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine.

J Affect Disord 2021 Jul 20;294:592-596. Epub 2021 Jul 20.

Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.

Method: . Read More

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The accuracy of patient-reported weight prior to total joint arthroplasty and arthroscopy of the lower extremity.

Arch Orthop Trauma Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthopaedic Surgery, Center for Hip Preservation, Orthopaedic and Rheumatologic Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Mail code A41, Cleveland, OH, 44195, USA.

Purpose: The accuracy of preoperative patient-reported weight was never evaluated in patients undergoing lower extremity procedures. The purpose of this study was to: (1) compare the disparity between patient-reported and measured weights in patients undergoing lower extremity total joint arthroplasty (LE-TJA) and arthroscopy; and (2) investigate the association between patient-specific factors (patient age, BMI, zip code, and psychiatric comorbidities) and the accuracy of patient-reported weight.

Methods: Preoperative self-reported weights were retrospectively compared to measured weights in 400 LE-TJA and 85 control arthroscopy patients. Read More

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Changes in health-related quality of life for HCV-infected people who inject drugs on opioid agonist treatment following sustained virologic response.

Clin Infect Dis 2021 Jul 31. Epub 2021 Jul 31.

Clemson University School of Health Research, Clemson, SC, USA.

Background: Although efforts to treat hepatitis C virus (HCV) in people who inject drugs (PWID) yield high rates of sustained virologic response (SVR), the relationship between successful HCV treatment and health-related quality of life (HRQOL) among PWID is poorly understood. This study examined HRQOL changes throughout HCV treatment and post-treatment for PWID achieving SVR.

Methods: Participants included 141 PWID who achieved SVR following HCV treatment onsite at three opioid agonist treatment (OAT) clinics in Bronx, NY. Read More

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The relationship between common foot problems with falls and quality of life in older people.

Int J Older People Nurs 2021 Jul 31:e12402. Epub 2021 Jul 31.

Department of Orthotics and Prosthetics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Objectives: To evaluate the relationship between a number of prevalent foot problems in older people and their history of falls and quality of life. To examine the relationship between timed up and go (TUG) test time and ankle muscles' strength.

Method: In this cross-sectional observational study on a convenient sample of 350 people 65 years and older, direct logistic and hierarchical regressions were used to assess the relation of self-reported falls and quality of life with hallux valgus, oedema, sensory loss and callus. Read More

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A systematic review and gap analysis of frailty and oral health characteristics in older adults: A call for clinical translation.

Gerodontology 2021 Jul 30. Epub 2021 Jul 30.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Objective: This systematic review updates the evidence for association between oral health characteristics and frailty status, identifying gaps in translational dental research and application of frailty assessment into clinical practice.

Background: Clinicians have little guidance on stage-appropriate dental treatment for medically complex older adults. Oral health characteristics have been associated with frailty status, determined through validated assessment tools representing a concise measure of health. Read More

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Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells.

Cancer Chemother Pharmacol 2021 Jul 31. Epub 2021 Jul 31.

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, Canada.

Purpose: Embryonal rhabdomyosarcoma (eRMS) is the most common type of rhabdomyosarcoma in children. eRMS is characterized by malignant skeletal muscle cells driven by hyperactivation of several oncogenic pathways including the MYC pathway. Targeting MYC in cancer has been extremely challenging. Read More

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Sleep and cardiovascular outcomes in relation to nocturnal hypertension: the J-HOP Nocturnal Blood Pressure Study.

Hypertens Res 2021 Jul 30. Epub 2021 Jul 30.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

There is a lack of data on how nighttime blood pressure (BP) might modify the relationship between sleep duration and cardiovascular disease (CVD) risk. Self-reported sleep duration data were available for 2253/2562 patients from the J-HOP Nocturnal BP study; of these, 2236 had complete follow-up data (mean age 63.0 years, 83% using antihypertensive drugs). Read More

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Sleep disordered breathing symptoms are associated with depressive symptoms: A longitudinal study of Chinese adolescents.

J Affect Disord 2021 Jul 27;293:492-501. Epub 2021 Jul 27.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University & Shandong University Center for Suicide Prevention Research, Jinan, Shandong, China. Electronic address:

Background: Little is known about the prospective association between sleep disordered breathing (SDB) and depressive symptoms in Chinese adolescents. This study examined the independent predictive role of SDB symptoms in depressive symptoms in a large sample of adolescents.

Methods: A total of 11831 adolescents who participated in the baseline survey of Shandong Adolescent Behavior and Health Cohort and 7072 adolescents who were resurveyed 1 year later were included for the analyses. Read More

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Influence of excessive daily sleeping and sleep quality on BDNF and NGF serum levels in adolescents.

Sleep Med 2021 Jun 26;84:415-423. Epub 2021 Jun 26.

Public Health Department, Federal University of Maranhão, São Luís, MA, Brazil.

Introduction: The brain-derived neurotrophic factor (BDNF) and neural growth factor (NGF) are widely expressed in the brain and play an important role in neuroplasticity, neurogenesis, and increased neuronal connections. Previous studies have shown that reduced serum levels of these proteins are associated with disorders in human sleep.

Objective: Current study evaluates the prevalence in adolescents of excessive daytime sleepiness (EDS) and sleep quality, and analyzes the influence of these factors on BDNF and NGF serum levels. Read More

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Diagnostic accuracy of monitoring tests of fellow eyes in patients with unilateral neovascular age related macular degeneration (EDNA study).

Ophthalmology 2021 Jul 27. Epub 2021 Jul 27.

Centre for Public Health, Queen's University Belfast, Belfast BT12 6BA. Electronic address:

Objective: To evaluate the diagnostic accuracy of routinely used tests of visual function and retinal morphology compared to fundus fluorescein angiography (FFA) to detect onset of active macular neovascularisation in unaffected fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD).

Design: Prospective diagnostic accuracy cohort study conducted in 24 eye clinics in the UK over 3 years.

Participants: Older adults (>50y) with recently diagnosed unilateral nAMD with a fellow (study) eye free of nAMD. Read More

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Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.

Lancet Respir Med 2021 Jul 27. Epub 2021 Jul 27.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.

Methods: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. Read More

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Hebbian Learning on Small Data Enables Experimental Discovery of High Polyimides.

J Phys Chem A 2021 Jul 30. Epub 2021 Jul 30.

IBM Research, Almaden Research Center, 650 Harry Road, San Jose, California 95120, United States.

We report a study combining computational design and experimental evaluation of polyimides with high glass transition temperatures: between 220 °C and 500 °C. The computational approach is based on the recently introduced competitive learning algorithm, supervised self-organizing maps (SUSI), which we recast as an ensemble method, e-SUSI. We use e-SUSI to solve both unsupervised and supervised/semisupervised learning tasks capturing structure-property relationships of high- polyimides historically studied at Almaden Research Center. Read More

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Private groundwater management and risk awareness: A cross-sectional analysis of two age-related subsets in the Republic of Ireland.

Sci Total Environ 2021 Jul 16;796:148844. Epub 2021 Jul 16.

Environmental Sustainability & Health Institute, Technological University Dublin, Dublin, Ireland; Irish Centre for Research in Applied Geosciences (iCRAG), University College Dublin, Dublin, Ireland. Electronic address:

Risk communication represents the optimal instrument for decreasing the incidence of private groundwater contamination and associated waterborne illnesses. However, despite attempts to promote voluntary well maintenance in high groundwater-reliant regions such as the Republic of Ireland, awareness levels of supply status (e.g. Read More

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Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: a randomized clinical trial.

Breast Cancer 2021 Jul 30. Epub 2021 Jul 30.

Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Among breast cancer populations, exercise interventions resulted in positive but relatively small improvements on fatigue, which may be due to insensitive measures of global fatigue. Perceived fatigability-whole-body tiredness anchored to standardized tasks/activities of a specific intensity and duration-may help to detect effective exercise interventions reducing fatigue in oncology. We examined whether perceived physical fatigability improved after an exercise intervention. Read More

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Validity arguments for patient-reported outcomes: justifying the intended interpretation and use of data.

J Patient Rep Outcomes 2021 Jul 30;5(1):64. Epub 2021 Jul 30.

Swinburne University of Technology, Centre for Global Health and Equity, School of Health Sciences, PO Box 218, Hawthorn, Melbourne, Victoria, 3122, Australia.

Background: Contrary to common usage in the health sciences, the term "valid" refers not to the properties of a measurement instrument but to the extent to which data-derived inferences are appropriate, meaningful, and useful for intended decision making. The aim of this study was to determine how validity testing theory (the Standards for Educational and Psychological Testing) and methodology (Kane's argument-based approach to validation) from education and psychology can be applied to validation practices for patient-reported outcomes that are measured by instruments that assess theoretical constructs in health.

Methods: The Health Literacy Questionnaire (HLQ) was used as an example of a theory-based self-report assessment for the purposes of this study. Read More

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Association of Long Working Hours with Marital Status Changes in South Korea: A Cohort Study.

J Occup Environ Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: This study investigated the relationship between long working hours and the incidence of divorce or separation among Korean female and male workers.

Methods: A cohort study was conducted in 125,108 Korean workers, married at baseline, who attended health examinations between 2012 and 2017 and had been followed annually or biennially until December 31, 2018. The weekly working hours and marital status changes were measured using self-administered questionnaires. Read More

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A Psychological-Behavioral Intervention to Improve Physical Activity in Midlife Adults With Low Baseline Physical Activity.

Prim Care Companion CNS Disord 2021 Jul 29;23(4). Epub 2021 Jul 29.

Harvard Medical School, Boston, Massachusetts.

Many midlife adults (aged 45-64 years) struggle to become physically active in the context of diminished psychological well-being and multiple concurrent stressors, despite the clear association of low physical activity with the development of chronic medical conditions.

To assess the feasibility (rates of session completion) and acceptability (participant 0-10 ratings of weekly session ease and utility) of a novel 12-week, phone-delivered, midlife-adapted positive psychology-motivational interviewing (PP-MI) intervention to promote physical activity. Secondary aims were pre-post changes in accelerometer-measured physical activity and self-reported psychological and functional measures. Read More

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Strength and physical activity in osteoarthritis: the mediating role of kinesiophobia.

J Orthop Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Kinesiology and Nutrition, University of Illinois at Chicago, University of Illinois at Chicago, 1919 W Taylor St., 650 AHSB, Chicago, IL, 60612, USA.

The aim of this study was to investigate the association between muscle strength and physical activity level in people with knee osteoarthritis (OA), and determine whether this association is mediated by pain-related fear of movement (kinesiophobia) and self-reported pain. Cross-sectional data from 37 subjects (age 58.8 ± 8. Read More

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Perceived daily sleep need and sleep debt in adolescents: associations with daily affect over school and vacation periods.

Sleep 2021 Jul 29. Epub 2021 Jul 29.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.

Study Objectives: To describe trajectories of perceived daily sleep need and sleep debt, and examine if cumulative perceived sleep debt predicts next-day affect.

Methods: Daily sleep and affect were measured over 2 school weeks and 2 vacation weeks (N=205, 54.1% females, M±SDage = 16. Read More

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Psychological Responses of the Patients in Cabin Hospital to the COVID-19 Outbreak: A Comparative Epidemiologic Analysis.

Front Psychol 2021 12;12:641167. Epub 2021 Jul 12.

Department of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The building of cabin hospitals in Wuhan has been proven to be clinically successful in curing mild-symptom COVID-19 patients shortly after the outbreak of COVID-19 in late 2019. At the same time, the psychological effect of patients being treated in cabin hospitals and the features of the psychological status of the whole society remained ambiguous. This study adopted a self-administrated questionnaire to investigate the stress, depression, and anxiety status of patients in cabin hospitals ( = 212) and healthy participants outside of Hubei province ( = 221) in a population level from February 29 to March 01, 2020. Read More

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Impact of Gravity on the Perception of Linear Motion.

J Neurophysiol 2021 07 28. Epub 2021 Jul 28.

Otolaryngology-Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Accurate perception of gravity and translation is fundamental for balance, navigation, motor control, etc.. Previous studies have reported that perceptual thresholds for earth-vertical (i. Read More

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Diet Quality and the Risk of Impaired Speech Reception Threshold in Noise: The UK Biobank cohort.

Ear Hear 2021 Jul 27. Epub 2021 Jul 27.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-IdiPaz and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France IMDEA-Food Institute. CEI UAM+CSIC, Madrid, Spain.

Objective: Previous studies have examined the association between several diet quality indexes and risk of hearing loss, based on self-reported information or on audiometry test, with inconsistent results. However, the impact of healthy diets on the capacity to listening in noise, a proxy of disability due to hearing loss, is unknown. This research assessed the prospective association between five diet quality indexes and the speech reception threshold in noise in the UK Biobank study. Read More

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Seroprevalence of Measles and Mumps Antibodies Among Individuals With Cancer.

JAMA Netw Open 2021 Jul 1;4(7):e2118508. Epub 2021 Jul 1.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Importance: Although patients with cancer are at an increased risk of infection-related complications, few studies have characterized their vulnerability to measles and mumps. Given the recent outbreaks and increased community vaccine hesitancy, understanding measles and mumps immunity within this population is vital.

Objectives: To identify a point prevalence estimate of protective measles and mumps antibodies among ambulatory patients with cancer. Read More

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The influence of perceived discrimination in healthcare settings on psychological distress among a diverse sample of older Asian Americans.

Aging Ment Health 2021 Jul 28:1-8. Epub 2021 Jul 28.

Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey, USA.

Objectives: The purpose of this study was to determine the relationship between discrimination in healthcare settings and psychological distress.

Method: This study utilized a retrospective cross-sectional study design. The dataset was obtained from 2015-2017 California Health Interview Survey (CHIS). Read More

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The Ferric-Superoxo Intermediate of the TxtE Nitration Pathway Resists Reduction, Facilitating Its Reaction with Nitric Oxide.

Biochemistry 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, University of Central Florida, 4111 Libra Drive, Room 255, Orlando, Florida 32816, United States.

TxtE is a cytochrome P450 (CYP) homologue that mediates the nitric oxide (NO)-dependent direct nitration of l-tryptophan (Trp) to form 4-nitro-l-tryptophan (4-NO-Trp). A recent report showed evidence that TxtE activity requires NO to react with a ferric-superoxo intermediate. Given this minimal mechanism, it is not clear how TxtE avoids Trp hydroxylation, a mechanism that also traverses the ferric-superoxo intermediate. Read More

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SYMPERHEART: an intervention to support symptom perception in persons with heart failure and their informal caregiver: a feasibility quasi-experimental study protocol.

BMJ Open 2021 Jul 27;11(7):e052208. Epub 2021 Jul 27.

School of Health Sciences Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland.

Introduction: Symptom perception in heart failure (HF) has been identified as crucial for effective self-care, and is related to patient and health system outcomes. There is uncertainty regarding the feasibility and acceptability of symptom perception support and doubts regarding how to include informal caregivers. This study aims to test the feasibility, acceptability and outcome responsiveness of an intervention supporting symptom perception in persons with HF and their informal caregiver. Read More

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Primary care physicians' views on the factors for enhancing patients' trust in rural areas of Zhejiang province, China: a cross-sectional study.

BMJ Open 2021 Jul 27;11(7):e049114. Epub 2021 Jul 27.

The Institute of Social and Family Medicine, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China

Objectives: To examine primary care physicians' (PCPs) perception of patients' trust and associated factors for enhancing perceived trust in rural China.

Design: A cross-sectional questionnaire study.

Setting: All township health centres (primary care facilities in rural areas of China) in both developed and less developed counties of Zhejiang province, China, were chosen as the study sites. Read More

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Perceptions of Vocal Performance Impairment in Singers with and without Hearing Loss.

J Voice 2021 Jul 24. Epub 2021 Jul 24.

Department of Otolaryngology - Head and Neck Surgery, USC Voice Center, Tina and Rick Caruso, University of Southern California, Los Angeles, California. Electronic address:

Introduction: It is well understood that hearing plays an important role in accurate vocal production. Singers in particular rely on auditory cues and auditory feedback to reproduce specific pitch contours. Therefore, even mild hearing loss may have a detrimental effect on a singer's ability to perform. Read More

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Patient-Reported Outcomes and Patient-Reported Experience of Patients With Atrial Fibrillation in the IMPACT-AF Clinical Trial.

J Am Heart Assoc 2021 Jul 28:e019783. Epub 2021 Jul 28.

Department of Health Research Methods, Evidence and Impact McMaster University Hamilton ON Canada.

Background The IMPACT-AF (Integrated Management Program Advancing Community Treatment of Atrial Fibrillation) trial is a prospective, randomized, cluster design trial comparing atrial fibrillation management with a computerized clinical decision support system with usual care (control) in the primary care setting of Nova Scotia, Canada. The objective of this analysis was to assess and compare patient-reported health-related quality of life and patient-reported experience with atrial fibrillation care between clinical decision support and control groups. Methods and Results Health-related quality of life was measured using the EuroQol 5-dimensional 5-level scale, whereas patient-reported experience was assessed using a self-administered satisfaction questionnaire, both assessed at baseline and 12 months. Read More

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Examining the association of alcohol use and psychotropic medication adherence among women with severe mental illness in South Africa.

Psychiatry Res 2021 Jul 19;304:114127. Epub 2021 Jul 19.

HIV Mental Health Research Unit, Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, South Africa.

Women with severe mental illness (SMI) in South Africa face numerous psychosocial challenges and alcohol use is widely used in this population as a coping strategy. Although hazardous alcohol use has a documented negative effect on medication adherence or chronic illness, research has mostly ignored the role of alcohol on psychotropic medication adherence in women with SMI. The primary aim of this study was to explore the association of hazardous alcohol use on psychotropic medication adherence in adult women living with SMI (N = 119), attending a psychiatric clinic for treatment in Cape Town. Read More

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