1,244 results match your criteria self-reported influenza

Factors associated with influenza vaccination acceptance in Mexican healthcare workers: A multicenter cross-sectional study.

Prev Med 2021 Apr 14:106560. Epub 2021 Apr 14.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Col. Belisario Domínguez Sección XVI, Tlalpan, Mexico City 14080, Mexico.

Adherence of healthcare workers (HCWs) to influenza vaccination is far from optimal despite its being the most effective intervention for preventing influenza. In order to evaluate factors associated with influenza vaccination acceptance among Mexican HCWs during the 2017-2018 influenza season, a multicenter cross-sectional study spanning public and private hospitals was conducted. Participants were consecutively invited to answer a self-administered questionnaire. Read More

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Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.

Nat Commun 2021 Apr 16;12(1):2283. Epub 2021 Apr 16.

Clinicum, University of Helsinki, Helsinki, Finland.

Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among children or adolescents vaccinated with AS03 adjuvant-supplemented pandemic H1N1 influenza A vaccine, Pandemrix. Here we show that pediatric Pandemrix-associated NT1 patients have enhanced T-cell immunity against the viral epitopes, neuraminidase 175-189 (NA) and nucleoprotein 214-228 (NP), but also respond to a NA-mimic, brain self-epitope, protein-O-mannosyltransferase 1 (POMT1). Read More

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COVID-19 and vaccine hesitancy: A longitudinal study.

PLoS One 2021 16;16(4):e0250123. Epub 2021 Apr 16.

Rady School of Management, University of California San Diego, La Jolla, California, United States of America.

How do attitudes toward vaccination change over the course of a public health crisis? We report results from a longitudinal survey of United States residents during six months (March 16 -August 16, 2020) of the COVID-19 pandemic. Contrary to past research suggesting that the increased salience of a disease threat should improve attitudes toward vaccines, we observed a decrease in intentions of getting a COVID-19 vaccine when one becomes available. We further found a decline in general vaccine attitudes and intentions of getting the influenza vaccine. Read More

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Attitudes towards influenza and uptake of the flu vaccine: A survey of pharmacy staff working in English hospitals.

Vaccine 2021 Apr 9. Epub 2021 Apr 9.

Pharmacy Department, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, United Kingdom.

Objectives: Pharmacy staff working in hospitals are at risk of contracting and disseminating influenza. Previous research focuses on community pharmacists' attitudes towards influenza and vaccination. This survey investigates the beliefs and attitudes of pharmacists and other pharmacy staff working in English Hospitals regarding influenza and the vaccine and how this relates to vaccine uptake. Read More

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Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.

Lancet Respir Med 2021 Apr 9. Epub 2021 Apr 9.

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre, Oxford, UK. Electronic address:

Background: Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.

Methods: We performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. Read More

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Attitudes and Knowledge of European Medical Students and Early Graduates about Vaccination and Self-Reported Vaccination Coverage-Multinational Cross-Sectional Survey.

Int J Environ Res Public Health 2021 Mar 30;18(7). Epub 2021 Mar 30.

European Medical Students' Association (EMSA), Rue Guimard 15, 1040 Brussels, Belgium.

Vaccination is one of the most useful preventive interventions in healthcare. The purpose of our study was to gain overview of the opinions, knowledge, and engagement in vaccination practices among medical students (MS) and junior doctors (JD) in Europe. The survey was distributed from March 2016 until August 2016 via the e-mail and social media of the European Medical Students' Association. Read More

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Influenza vaccination rates and location for receiving the influenza vaccination among older adult Medicare beneficiaries.

J Am Pharm Assoc (2003) 2021 Feb 27. Epub 2021 Feb 27.

Objectives: The objectives of this study were to (1) assess the trends in older adult influenza vaccination rates and (2) locations at which U.S. older adults received influenza vaccinations for the 2008-2009 to 2017-2018 influenza seasons, and (3) compare the estimates of influenza vaccination rates and locations with the estimates from other sources reported previously. Read More

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February 2021

The coverage of influenza and pneumococcal vaccinations among people living with HIV in Denmark: A single-center cross-sectional survey.

Hum Vaccin Immunother 2021 Mar 24:1-6. Epub 2021 Mar 24.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Annual influenza vaccination is recommended for all people living with HIV (PLWH), and so is pneumococcal vaccination at least once. This is due to higher incidence rates for both infections among PLWH, compared to HIV negative, even in the later highly active antiretroviral therapy era. To clarify the uptake of and attitude toward both vaccines among PLWH in Denmark, a survey on self-reported vaccine uptake was performed during 2017. Read More

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Influenza and other respiratory viral infections associated with absence from school among schoolchildren in Pittsburgh, Pennsylvania, USA: a cohort study.

BMC Infect Dis 2021 Mar 22;21(1):291. Epub 2021 Mar 22.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Information on the etiology and age-specific burden of respiratory viral infections among school-aged children remains limited. Though school aged children are often recognized as driving the transmission of influenza as well as other respiratory viruses, little detailed information is available on the distribution of respiratory infections among children of different ages within this group. Factors other than age including gender and time spent in school may also be important in determining risk of infection but have been little studied in this age group. Read More

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Management and outcome of benign acute childhood myositis in pediatric emergency department.

Ital J Pediatr 2021 Mar 9;47(1):57. Epub 2021 Mar 9.

Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Benign acute childhood myositis (BACM) is a self-limited syndrome associated with viral infections characterized by symmetric lower extremity pain typically affecting school-aged children. Evolution in rhabdomyolysis and kidney damage is rarely reported. Despite this, the acute presentation commonly concerns both parents and health care providers, often leading to unnecessary workup. Read More

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Insurance status predicts self-reported influenza vaccine coverage among pregnant women in the United States: A cross-sectional analysis of the National Health Interview Study Data from 2012 to 2018.

Vaccine 2021 Apr 18;39(15):2068-2073. Epub 2021 Mar 18.

UCLA Fielding School of Public Health, Department of Health Policy and Management, 650 Charles E Young Drive, CHS 31-235B, United States.

While the influenza vaccine is recommended for all pregnant women, influenza vaccine coverage among this high-risk population remains inadequate. Factors associated with vaccine coverage among pregnant women, including insurance status, are poorly understood. In a cross-sectional study of the National Health Interview Survey (NHIS) data from 2012 to 2018, we evaluated predictors of self-reported influenza vaccine coverage in pregnant women. Read More

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Concurrent Influenza A and Pulmonary Melioidosis in pregnancy.

W F Tan H G Lee

Med J Malaysia 2021 03;76(2):245-247

Queen Elizabeth Hospital, Department of Medicine, Kota Kinabalu, Sabah, Malaysia.

Melioidosis is endemic in Sabah. It causes significant morbidity and mortality if diagnosis and treatment is delayed. Important risk factors include diabetes, chronic kidney diseases, chronic lung diseases, thalassaemia, immunosuppressive therapy, and hazardous alcohol consumption. Read More

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US Hospital Capacity Managers' Experiences and Concerns Regarding Preparedness for Seasonal Influenza and Influenza-like Illness.

JAMA Netw Open 2021 03 1;4(3):e212382. Epub 2021 Mar 1.

Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Importance: The 2017-2018 influenza season in the US was marked by a high severity of illness, wide geographic spread, and prolonged duration compared with recent previous seasons, resulting in increased strain throughout acute care hospital systems.

Objective: To characterize self-reported experiences and views of hospital capacity managers regarding the 2017-2018 influenza season in the US.

Design, Setting, And Participants: In this qualitative study, semistructured telephone interviews were conducted between April 2018 and January 2019 with a random sample of capacity management administrators responsible for throughput and hospital capacity at short-term, acute care hospitals throughout the US. Read More

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Mental associations with COVID-19 and how they relate with self-reported protective behaviors: A national survey in the United States.

Soc Sci Med 2021 04 7;275:113825. Epub 2021 Mar 7.

RAND Corporation, USA.

Rationale: To understand novel diseases, patients may draw comparisons to other diseases.

Objective: We examined whether mentally associating specific diseases with COVID-19 was related to self-reported protective behaviors early in the pandemic.

Methods: In March 2020, a national sample of 6534 U. Read More

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Hepatitis B core-based virus-like particles: A platform for vaccine development in plants.

Biotechnol Rep (Amst) 2021 Mar 28;29:e00605. Epub 2021 Feb 28.

Institute of Biotechnology, College of Agriculture, Shiraz University, Shiraz, Iran.

Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Read More

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The Hepatitis C Continuum of Care Among HIV-Positive Persons with Heavy Alcohol Use in St. Petersburg, Russia.

AIDS Behav 2021 Mar 17. Epub 2021 Mar 17.

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

This study describes the self-reported prevalence of hepatitis C virus (HCV) coinfection and the HCV care continuum among persons enrolled in the St PETER HIV Study, a randomized controlled trial of medications for smoking and alcohol cessation in HIV-positive heavy drinkers and smokers in St. Petersburg, Russia. Baseline health questionnaire data were used to calculate proportions and 95% confidence intervals for self-reported steps along the HCV continuum of care. Read More

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A review: Mechanism of action of antiviral drugs.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211002621

Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.

Antiviral drugs are a class of medicines particularly used for the treatment of viral infections. Drugs that combat viral infections are called antiviral drugs. Viruses are among the major pathogenic agents that cause number of serious diseases in humans, animals and plants. Read More

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Adherence to Public Health Measures Mitigates the Risk of COVID-19 Infection in Older Adults: A Community-Based Study.

Mayo Clin Proc 2021 04 28;96(4):912-920. Epub 2020 Dec 28.

Division of Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To assess the prevalence and characteristics of coronavirus disease 2019 (COVID-19) cases during the reopening period in older adults, given that little is known about the prevalence of COVID-19 after the stay-at-home order was lifted in the United States, nor the actual effects of adherence to recommended public health measures (RPHM) on the risk of COVID-19.

Patients And Methods: This was a cross-sectional study nested in a parent prospective cohort study, which followed a population-based sample of 2325 adults 50 years and older residing in southeast Minnesota to assess the incidence of viral infections. Participants were instructed to self-collect both nasal and oropharyngeal swabs, which were tested by reverse transcription polymerase chain reaction-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay between May 8, 2020, and June, 30, 2020. Read More

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Impact of funding on influenza vaccine uptake in Australian children.

Public Health Res Pract 2021 03 10;31(1). Epub 2021 Mar 10.

Population Health, Hunter New England Local Health District, Newcastle, NSW, Australia; School of Medicine and Public Health, University of Newcastle, NSW, Australia.

Objectives and importance of study: Young children are at higher risk for serious influenza outcomes but, historically, Australian children aged less than 5 years have had low seasonal influenza vaccine uptake. In 2018, most Australian jurisdictions implemented funded influenza vaccine programs targeted at improving vaccine uptake in this age group. Our aim was to determine how successful these programs were at improving self-reported seasonal influenza vaccine uptake at the community level by comparing vaccination rates in each Australian jurisdiction before and after the introduction of funded vaccines for children aged 6 months to less than 5 years, as well as other age groups. Read More

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Psychological distress in the academic population and its association with socio-demographic and lifestyle characteristics during COVID-19 pandemic lockdown: Results from a large multicenter Italian study.

PLoS One 2021 10;16(3):e0248370. Epub 2021 Mar 10.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Measures implemented in many countries to contain the COVID-19 pandemic resulted in a change in lifestyle with unpredictable consequences on physical and mental health. We aimed at identifying the variables associated with psychological distress during the lockdown between April and May 2020 in the Italian academic population. We conducted a multicenter cross-sectional online survey (IO CONTO 2020) within five Italian universities. Read More

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A validated modification of the vaccine hesitancy scale for childhood, influenza and HPV vaccines.

Vaccine 2021 Mar 4;39(13):1831-1839. Epub 2021 Mar 4.

Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, United States; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address:

Introduction: Vaccine hesitancy contributes to outbreaks of preventable disease worldwide. The Vaccine Hesitancy Scale (VHS), developed by the international WHO SAGE Working Group, has been validated previously for measuring hesitancy towards childhood vaccines; some psychometric properties were suboptimal.

Methods: We collected data using large, nationally-representative samples of parents in the U. Read More

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Disparities in influenza vaccination: Arab Americans in California.

BMC Public Health 2021 Mar 5;21(1):443. Epub 2021 Mar 5.

William F. Connell School of Nursing, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA, 02467, USA.

Background: Influenza vaccination among minoritized groups remains below federal benchmarks in the United States (US). We used data from the 2004-2016 California Health Interview Surveys (CHIS) to characterize influenza vaccination patterns among Arab Americans in California.

Methods: Influenza vaccination was self-reported by Arab American adults (N = 1163) and non-Hispanic Whites (NHW, N = 166,955). Read More

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Increased influenza vaccination rates in patients with autoimmune rheumatic diseases during the Covid-19 pandemic: a cross-sectional study.

Rheumatol Int 2021 05 4;41(5):895-902. Epub 2021 Mar 4.

Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Laiko General Hospital, MikrasAsias 75 Street, 11527, Athens, Greece.

To assess non-compliance and potential changes in seasonal flu vaccination coverage before and during the Covid-19 pandemic in patients with autoimmune rheumatic diseases (ARDs). Consecutive patients with ARDs followed-up in 2 tertiary hospitals were telephone-interviewed (December 12-30, 2020) regarding seasonal flu vaccination during the 2019/20 and 2020/21 time periods. Self-reported disease flares that occurred after flu vaccination, as well as reasons for non-vaccination were recorded. Read More

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Barriers and facilitators to influenza-like illness absenteeism among healthcare workers in a tertiary-care healthcare system, 2017-2018 influenza season.

Infect Control Hosp Epidemiol 2021 Mar 2:1-8. Epub 2021 Mar 2.

Division of Infection Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Objective: Influenza can be introduced and propagated in healthcare settings by healthcare workers (HCWs) working while ill with influenza. However, reasons driving this behavior are unclear. In this study, we examined barriers to and facilitators of absenteeism during the influenza season. Read More

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HLA binding of self-peptides is biased towards proteins with specific molecular functions.

bioRxiv 2021 Feb 17. Epub 2021 Feb 17.

Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune responses by presenting foreign and self peptides to T cells. Each HLA variant selects a minor fraction of peptides that match a certain motif required for optimal interaction with the peptide-binding groove. These restriction rules define the landscape of peptides presented to T cells. Read More

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February 2021

Support among healthcare workers for the new mandatory seasonal influenza vaccination policy and its effects on vaccination coverage.

Ann Med 2021 12;53(1):384-390

Department of Medicine, Kuopio University Hospital, Kuopio, Finland.

Introduction: Finland was the first European country to introduce a nation-wide mandatory seasonal influenza vaccination policy for healthcare workers (HCWs) by mandating that administrators of health care institutions only employ vaccinated HCWs. In this study, we examine the effects of the new policy and the view of HCWs on the new policy.

Methods: A cross-sectional observational study was conducted in Kuopio University Hospital among HCWs working in close patient contact. Read More

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December 2021

Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021.

JMIR Public Health Surveill 2021 02 19;7(2):e24341. Epub 2021 Feb 19.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Background: The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) and Public Health England (PHE) are commencing their 54th season of collaboration at a time when SARS-CoV-2 infections are likely to be cocirculating with the usual winter infections.

Objective: The aim of this study is to conduct surveillance of influenza and other monitored respiratory conditions and to report on vaccine uptake and effectiveness using nationally representative surveillance data extracted from primary care computerized medical records systems. We also aim to have general practices collect virology and serology specimens and to participate in trials and other interventional research. Read More

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February 2021

What are the barriers and facilitators of volunteering among healthcare students during the COVID-19 pandemic? A Saudi-based cross-sectional study.

BMJ Open 2021 02 18;11(2):e042910. Epub 2021 Feb 18.

Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives: The objectives of this study were to assess the volunteering of undergraduate health students and interns in the Ministry of Health (MOH) services in the Kingdom of Saudi Arabia (KSA) during the COVID-19 pandemic, its motivational factors and barriers, as well as their risk perception of COVID-19.

Design: A cross-sectional study.

Participants: From 12 to 21 May 2020, an online survey was sent to all undergraduate health students and interns in the KSA. Read More

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February 2021

Using the health belief model to identify barriers to seasonal influenza vaccination among Australian adults in 2019.

Influenza Other Respir Viruses 2021 Feb 15. Epub 2021 Feb 15.

Biosecurity Program, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.

Background: Each year tens of thousands of Australians become ill with influenza, resulting in thousands of severe infections that require hospitalisation. However, only 40% of adults receive the annual influenza vaccine. We surveyed Australian adults to provide up to date, population-specific data on the predictors and barriers of seasonal influenza vaccination. Read More

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February 2021

Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs.

Front Immunol 2020 28;11:622385. Epub 2021 Jan 28.

The Institute of Virology and Immunology IVI, Mittelhäusern, Switzerland.

Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever virus (CSFV) targets monocytes and dendritic cells (DCs), potentially promoting prolonged antigen expression in the DCs, contrasting with cytopathogenic RepRNA. We engineered pestivirus RepRNA constructs encoding influenza virus H5N1 (A/chicken/Yamaguchi/7/2004) nucleoprotein (Rep-NP) or hemagglutinin (Rep-HA). Read More

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February 2021