Neuroimage Clin 2021 Mar 22;30:102638. Epub 2021 Mar 22.
Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent University, Belgium; Department of Rehabilitation Medicine, Maastricht University, Maastricht, Netherlands; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, United States. Electronic address:
Background: Chronic neck pain is a leading cause of disability worldwide, affecting the lives of millions of people. Research investigating functional brain alterations in relation to somatosensory function is necessary to better understand mechanisms underlying pain development and maintenance in individuals with chronic neck pain, yet remains scarce. This case-control study aimed to examine resting-state functional connectivity alterations and associations with pain outcomes, self-reported central sensitization-related symptoms and quantitative sensory testing (QST) measures in patients with chronic non-traumatic (idiopathic/CINP) neck pain and chronic traumatic (whiplash associated/CWAD) neck pain compared to pain-free controls. Read More