Lipids Health Dis 2018 Jul 21;17(1):165. Epub 2018 Jul 21.
Department of Toxicology, Tianjin Centers for Disease Control and Prevention, No. 6, Huayue Road, Hedong District, Tianjin, 300011, People's Republic of China.
Background: Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, the effects of Se supplementation, in combination with supplemental magnesium, on high fat-induced hyperlipidemia have not been studied. This study was designed to elucidate the effects of oral selenium and magnesium co-supplementation on antihyperlipidemic and hepatoprotective, antioxidative activities, and related gene expression in a hyperlipidemic rat model.
Methods: Forty male Sprague Dawley rats were divided into 4 groups: one group served as control group (CT), provided control diet; The other groups were made hyperlipidemic with high-fat diet; specifically, a high-fat diet group (HF); low-dose selenium (0. Read More