3,322 results match your criteria selectively involving

Stimulus value gates multisensory integration.

Eur J Neurosci 2021 May 22;53(9):3142-3159. Epub 2021 Mar 22.

Wake Forest School of Medicine, Winston-Salem, NC, USA.

The brain enhances its perceptual and behavioral decisions by integrating information from its multiple senses in what are believed to be optimal ways. This phenomenon of "multisensory integration" appears to be pre-conscious, effortless, and highly efficient. The present experiments examined whether experience could modify this seemingly automatic process. Read More

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Age at symptom onset influences cortical thinning distribution and survival in amyotrophic lateral sclerosis.

Neuroradiology 2021 Mar 4. Epub 2021 Mar 4.

Department of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: The lifetime risk of developing amyotrophic lateral sclerosis (ALS) increases in the elderly, and greater age at symptom onset has been identified as a negative prognostic factor in the disease. However, the underlying neurobiological mechanisms are still poorly investigated. We hypothesized that older age at symptom onset would have been associated with greater extra-motor cortical damage contributing to worse prognosis, so we explored the relationship between age at symptom onset, cortical thinning (CT) distribution, and clinical markers of disease progression. Read More

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Ratchet mechanism selectively causing idiopathic macrodislodgement of an active-fixation coronary sinus lead: a case report.

Eur Heart J Case Rep 2020 Dec 28;4(6):1-6. Epub 2020 Dec 28.

Division of Cardiology, Department of Internal Medicine, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino and University of Turin, corso Bramante 88-10126 Turin, Italy.

Background : 'Idiopathic' lead macrodislodgement may be due to Twiddler's syndrome depending on active twisting of pulse generator within subcutaneous pocket. All leads are involved, at any time from implantation, and frequently damaged. In the past few years, a reel syndrome was also observed: retraction of pacemaker leads into pocket without patient manipulation, owing to lead circling the generator. Read More

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December 2020

Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy.

Ageing Res Rev 2021 05 20;67:101307. Epub 2021 Feb 20.

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Norway. Electronic address:

The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal component of this memory system since it serves as the interface between the neocortex and the hippocampus. Read More

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Formation of Single Double-Layered Coacervate of Poly(-diethylacrylamide) in Water by a Laser Tweezer.

Langmuir 2021 Mar 22;37(9):2874-2883. Epub 2021 Feb 22.

Division of Molecular Materials Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan.

We demonstrate liquid-liquid phase separation involving both coacervation and coil-to-globule phase transition of a thermoresponsive polymer. By focusing a near-infrared laser beam into an aqueous solution of poly(-isopropylacrylamide) (PNIPAM), a single phase-separated polymer microdroplet can be formed and stably trapped at the focal point. Such droplet formation is induced by a local elevation in temperature (induced by a photothermal effect) and an optical force. Read More

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Oriented immobilization of antibodies through different surface regions containing amino groups: Selective immobilization through the bottom of the Fc region.

Int J Biol Macromol 2021 Apr 17;177:19-28. Epub 2021 Feb 17.

Department of Biocatalysis, Institute of Catalysis and Petrochemistry (ICP) CSIC, Campus UAM, Cantoblanco, 28049 Madrid, Spain. Electronic address:

Amino groups on the antibody surface (amino terminus and Lys) are very interesting conjugation targets due to their substantial quantities and selectivity toward various reactive groups. Oriented immobilization of antibodies via amino moieties on the Fc region instead of the antigen-binding fragment (Fab) is highly appreciated to conserve antigen-binding capacity. In this paper, targeting amino moieties on distinct regions, three antibody immobilization strategies were compared with the recognition ability of corresponding adsorbents. Read More

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Comparison of the '4-item assessment test' and 'nursing delirium screening scale' delirium screening tools on nonintensive care unit wards: A prospective mixed-method approach.

Eur J Anaesthesiol 2021 Feb 16. Epub 2021 Feb 16.

From the Department of Patient and Care Management (IZ, BV, MF), Department of Intensive Care Medicine (PT, AW) and Department of Anaesthesiology (TL, MB, RK, CO), Centre of Anaesthesiology and Intensive Care Medicine, University Medical Centre, Hamburg, Germany.

Background: In elderly patients following surgery, postoperative delirium (POD) is the most frequent complication and is associated with negative outcomes. The 2017 European Society of Anaesthesiology guideline on POD aims to improve patient care by implementing structured delirium prevention, diagnosis and treatment. However, these recommendations, especially systematic delirium screening, are still incompletely adopted in clinical practice. Read More

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February 2021

Link between temperament traits, brain neurochemistry and response to SSRI: insights from animal model of social behavior.

J Affect Disord 2021 03 5;282:1055-1066. Epub 2020 Nov 5.

Department of Molecular Biology, Ariel University, Ariel 4070000, Israel; Adelson School of Medicine, Ariel University, Ariel 4070000, Israel. Electronic address:

Background: Dominant-submissive relationships depend upon functionality of the neural circuits involving monoaminergic neurotransmission. Behavioral profiles of selectively bred dominant (Dom) and submissive (Sub) mice have been proposed to mimic hyperthymic- or depressive-like temperaments observed in patients with affective disorders. These mice differentially respond to psychotropic agents and stressful stimuli, however, the mechanisms underlying these differences remain unclear. Read More

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Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia.

J Cell Mol Med 2021 Mar 17;25(6):3124-3135. Epub 2021 Feb 17.

Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Acute myeloid leukaemia (AML) with chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukaemia (MLL) is an aggressive subtype with low overall survival. Bortezomib (Bort) is first applied in multiple myeloma. However, whether bort possesses anti-self-renewal and leukemogenesis of leukaemia stem cell (LSC) in AML with MLL rearrangements is still unclear. Read More

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Electrochemical immunoplatform to assist in the diagnosis and classification of breast cancer through the determination of matrix-metalloproteinase-9.

Talanta 2021 Apr 27;225:122054. Epub 2020 Dec 27.

Analytical Chemistry Dept., Faculty of Chemistry, Complutense University of Madrid, E-28040, Madrid, Spain.

Matrix metalloproteinase 9 (MMP-9) is a zinc-dependent endopeptidase that promotes angiogenesis, tumor growth, metastasis and cell invasion through the degradation of extracellular matrix. This work reports a magnetic microbeads (MBs)-based sandwich immunoassay for the amperometric determination of MMP-9 at screen-printed carbon electrodes (SPCEs). The suitable capture antibody (cAb) is immobilized onto carboxylic MBs to selectively capture the antigen which is sandwiched with a biotinylated detector antibody (biotin-dAb) further conjugated with a commercial streptavidin-horseradish peroxidase (Strep-HRP) polymer. Read More

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7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.

Biochem Pharmacol 2021 Apr 8;186:114460. Epub 2021 Feb 8.

Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Electronic address:

N-methyl-D-aspartaterecepro receptor (NMDARs) are a subclass of glutamate receptors, which play an essential role in excitatory neurotransmission, but their excessive overactivation by glutamate leads to excitotoxicity. NMDARs are hence a valid pharmacological target for the treatment of neurodegenerative disorders; however, novel drugs targeting NMDARs are often associated with specific psychotic side effects and abuse potential. Motivated by currently available treatment against neurodegenerative diseases involving the inhibitors of acetylcholinesterase (AChE) and NMDARs, administered also in combination, we developed a dually-acting compound 7-phenoxytacrine (7-PhO-THA) and evaluated its neuropsychopharmacological and drug-like properties for potential therapeutic use. Read More

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A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting.

Cell Stem Cell 2021 Feb 2. Epub 2021 Feb 2.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

The use of the dual recombinase-mediated intersectional genetic approach involving Cre-loxP and Dre-rox has significantly enhanced the precision of in vivo lineage tracing, as well as gene manipulation. However, this approach is limited by the small number of Dre recombinase driver constructs available. Here, we developed more than 70 new intersectional drivers to better target diverse cell lineages. Read More

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February 2021

The influence of training procedure and stimulus valence on the long-term maintenance of equivalence relations.

Behav Processes 2021 Apr 4;185:104343. Epub 2021 Feb 4.

Universidade Federal de São Carlos - Departamento de Psicologia, UFSCar-DPsi, Campus São Carlos, Brazil.

In the current research, we aimed at extending Silveira et al. (2016) results by verifying whether the long-term maintenance of the equivalence classes is influenced by stimulus valence and MTS training procedures. The delayed and simultaneous MTS were used to train two groups of participants in series of conditional relation trials involving pictures of humans' faces expressing familiar emotions (A) and abstract forms (B, C, and D). Read More

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Rational nanocarrier design towards the clinical translation of cancer nanotherapy.

Biomed Mater 2021 Feb 4. Epub 2021 Feb 4.

SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York, 13210-2306, UNITED STATES.

The past decades have witnessed an exponential growth in research of cancer nanomedicine, which has evolved into an interdisciplinary field involving chemistry, physics, biology, and pharmacology, pathophysiology, immunology and clinical science in cancer research and treatment. The application of nanoparticles in drug delivery increases the solubility and decreases the toxicity of free drug molecules. The unique feature of cancer pathophysiology, e. Read More

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February 2021

Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models.

Invest New Drugs 2021 Feb 3. Epub 2021 Feb 3.

Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Liuying west road, 666, Jingyue Economic & Technological Development Zone, Changchun, Jilin, 130122, People's Republic of China.

As a potential cancer therapy, we developed a recombinant adenovirus named Ad-VT, which was designed to express the apoptosis-inducing gene (apoptin) and selectively replicate in cancer cells via E1a manipulation. However, how it performs in bladder cancer remains unclear. We examined the antitumor efficacy of Ad-VT in bladder cancers using CCK-8 assays and xenograft models. Read More

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February 2021

Motor Planning Modulates Neural Activity Patterns in Early Human Auditory Cortex.

Cereb Cortex 2021 Jan 29. Epub 2021 Jan 29.

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada.

It is well established that movement planning recruits motor-related cortical brain areas in preparation for the forthcoming action. Given that an integral component to the control of action is the processing of sensory information throughout movement, we predicted that movement planning might also modulate early sensory cortical areas, readying them for sensory processing during the unfolding action. To test this hypothesis, we performed 2 human functional magnetic resonance imaging studies involving separate delayed movement tasks and focused on premovement neural activity in early auditory cortex, given the area's direct connections to the motor system and evidence that it is modulated by motor cortex during movement in rodents. Read More

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January 2021

Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions.

Cancers (Basel) 2021 Jan 25;13(3). Epub 2021 Jan 25.

Biomaterials, Biomechanics and Tissue Engineering Group, Department Materials Science and Engineering, Escola d'Enginyeria Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), 08930 Barcelona, Spain.

Plasma-conditioned liquids (PCL) are gaining increasing attention in the medical field, especially in oncology, and translation to the clinics is advancing on a good path. This emerging technology involving cold plasmas has great potential as a therapeutic approach in cancer diseases, as PCL have been shown to selectively kill cancer cells by triggering apoptotic mechanisms without damaging healthy cells. In this context, PCL can be injected near the tumor or intratumorally, thereby allowing the treatment of malignant tumors located in internal organs that are not accessible for direct cold atmospheric plasma (CAP) treatment. Read More

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January 2021

A naphthalimide-linked new pyridylazo phenol derivative for selective sensing of cyanide ions (CN) in sol-gel medium.

Anal Methods 2021 02 22;13(5):695-702. Epub 2021 Jan 22.

Department of Chemistry, University of Kalyani, Kalyani-741235, India.

Napthalimide-linked pyridylazo derivatives 1 and 2 have been designed and synthesized. Compound 1 acts as a gelator in DMF-HO (1 : 1, v/v). The brown gel is photostable and shows good viscoelastic properties. Read More

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February 2021

Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell lines.

Oncol Rep 2021 Mar 18;45(3):879-890. Epub 2021 Jan 18.

Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman 4184, UAE.

Waterpipe tobacco smoking (WPS) continues to spread globally and presents serious health hazards. The aim of the present study was to investigate the effects of treatment with WPS condensate (WPSC) on lung cell proliferation and plasticity as well as tumor cell recognition and killing by natural killer (NK) cells using cytotoxicity assays. The results indicated that exposure of normal and cancer lung cell lines to WPSC resulted in a decrease in their in vitro growth in a dose-dependent manner and it induced tumor senescence. Read More

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Pluronic F127-mediated control of insulin release rates from NPH microcrystals and blood glucose depression in STZ-induced diabetic rats.

Bioimpacts 2021 12;11(1):59-64. Epub 2020 Dec 12.

Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.

Neutral protamine Hagedorn (NPH) insulin is an intermediate-acting basal insulin with a long history of clinical use, consisting native human insulin. Its rather undesirable action profile, characterized by a peak release within a few hours, followed by insufficient insulin delivery upon a single subcutaneous (s.c. Read More

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December 2020

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.

J Neuroinflammation 2021 Jan 18;18(1):23. Epub 2021 Jan 18.

Department of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.

Background: Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson's disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely elusive. Targeting metabotropic glutamate receptor 5 (mGluR5) has been an attractive strategy to mediate microglia activation for neuroprotection, which might be an essential regulator to modulate α-syn-induced neuroinflammation for the treatment of PD. Read More

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January 2021

Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.

Sci Rep 2021 Jan 15;11(1):1492. Epub 2021 Jan 15.

Cell Regulation Laboratory, Bionics Program, Tokyo University of Technology Graduate School of Bionics, Computer and Media Science, Hachioji, Japan.

Cancer therapy is often hampered by the disease's development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is responsible for the cisplatin resistance of HeLa cisR cells and that it is likely responsible for the poor prognosis of cervical cancer patients treated with cisplatin. Here we show that cloperastine and two other histamine H1 receptor antagonists selectively kill HeLa cisR cells at concentrations that little affect parental HeLa S cells. Read More

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January 2021

Behavior of Hydroxyl Radicals on Water Ice at Low Temperatures.

Acc Chem Res 2021 Feb 14;54(3):471-480. Epub 2021 Jan 14.

Institute of Low Temperature Science, Hokkaido University, N19-W8, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

ConspectusBecause chemical reactions on/in cosmic ice dust grains covered by amorphous solid water (ASW) play important roles in generating a variety of molecules, many experimental and theoretical studies have focused on the chemical processes occurring on the ASW surface. In laboratory experiments, conventional spectroscopic and mass-spectrometric detection of stable products is generally employed to deduce reaction channels and mechanisms. However, despite their importance, the details of chemical reactions involving reactive species (i. Read More

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February 2021

Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease.

Stem Cell Res Ther 2021 Jan 13;12(1):59. Epub 2021 Jan 13.

Neuronascent, Inc., 15601 Crabbs Branch Way, Rockville, MD, 20855, USA.

Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression which is exacerbated in chronic neurodegenerative disorders, e.g. Read More

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January 2021

Investigating the mechanism of action of aggregation-inducing antimicrobial Pept-ins.

Cell Chem Biol 2021 Apr 11;28(4):524-536.e4. Epub 2021 Jan 11.

Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Aggregation can be selectively induced by aggregation-prone regions (APRs) contained in the target proteins. Aggregation-inducing antimicrobial peptides (Pept-ins) contain sequences homologous to APRs of target proteins and exert their bactericidal effect by causing aggregation of a large number of proteins. To better understand the mechanism of action of Pept-ins and the resistance mechanisms, we analyzed the phenotypic, lipidomic, and transcriptomic as well as genotypic changes in laboratory-derived Pept-in-resistant E. Read More

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A Macromolecular Drug for Cancer Therapy via Extracellular Calcification.

Angew Chem Int Ed Engl 2021 03 17;60(12):6509-6517. Epub 2021 Feb 17.

Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Cancer chemotherapy typically relies on drug endocytosis and inhibits tumor cell proliferation via intracellular pathways; however, severe side effects may arise. In this study, we performed a first attempt to develop macromolecular-induced extracellular chemotherapy involving biomineralization by absorbing calcium from the blood through a new type of drug, polysialic acid conjugated with folate (folate-polySia), which selectively induces biogenic mineral formation on tumor cells and results in the pathological calcification of tumors. The macromolecule-initiated extracellular calcification causes cancer cell death mainly by intervening with the glycolysis process in cancer cells. Read More

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Machine-OlF-Action: A unified framework for developing and interpreting machine-learning models for chemosensory research.

Bioinformatics 2021 Jan 8. Epub 2021 Jan 8.

Department of Computational Biology, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi-110020, India.

: Machine Learning-based techniques are emerging as state-of-the-art methods in chemoinformatics to selectively, effectively, and speedily identify biologically-relevant molecules from large databases. So far, a multitude of such techniques have been proposed, but unfortunately due to their sparse availability, and the dependency on high-end computational literacy, their wider adaptation faces challenges, at least in the context of G-Protein Coupled Receptors (GPCRs)-associated chemosensory research. Here we report Machine-OlF-Action (MOA), a user-friendly, open-source computational framework, that utilizes user-supplied SMILES (simplified molecular-input line-entry system) of the chemicals, along with their activation status, to synthesize classification models. Read More

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January 2021

Unravelling the unsolved paradoxes of cytokine families in host resistance and susceptibility to infection.

Cytokine X 2020 Dec;2(4):100043

Division of Immunology, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), South African Medical Research Council (SAMRC) on Immunology of Infectious Diseases, University of Cape Town, Observatory 7925, Cape Town, South Africa.

Leishmaniasis is a neglected disease caused by protozoan parasites of the genus . Successful clearance of relies on a robust human immune response and various cytokines have been implicated in resistance and susceptibility to infection. Accordingly, various immunotherapeutic approaches involving cytokines and cytokine receptors are being considered as novel avenues of treatment given the limited efficacy of current anti-leishmanial drugs. Read More

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December 2020

Sensitive universal detection of blood parasites by selective pathogen-DNA enrichment and deep amplicon sequencing.

Microbiome 2021 01 2;9(1). Epub 2021 Jan 2.

Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Targeted amplicon deep sequencing (TADS) has enabled characterization of diverse bacterial communities, yet the application of TADS to communities of parasites has been relatively slow to advance. The greatest obstacle to this has been the genetic diversity of parasitic agents, which include helminths, protozoa, arthropods, and some acanthocephalans. Meanwhile, universal amplification of conserved loci from all parasites without amplifying host DNA has proven challenging. Read More

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January 2021

Is massive hemothorax still an absolute indication for operation in blunt trauma?

Injury 2021 Feb 24;52(2):225-230. Epub 2020 Dec 24.

Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, 5 Fu-Xing Street, Guishan District, Taoyuan City, Taiwan.

Background: Surgery is usually suggested to treat massive haemothorax (MHT). The MHT criteria are based on penetrating trauma observations in military scenarios; the need for surgery in blunt trauma patients remains questionable. This study aimed to determine the characteristics of blunt trauma patients with MHT who required surgery. Read More

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February 2021