116 results match your criteria selective non-response

The list experiment: An approach to measuring stigmatized behaviours related to sex-selective abortion.

Popul Stud (Camb) 2021 Apr 1:1-18. Epub 2021 Apr 1.

University of California, San Francisco.

Vietnam reports one of the highest levels of abortion globally and an increasingly skewed sex ratio at birth. Abortion and related stigmatized behaviours are notoriously difficult to measure, yet understanding women's ability and willingness to engage in sex selection is of interest to demographers and policymakers alike. We piloted the list experiment, an indirect questioning method, to estimate the prevalence of prenatal sex determination and sex-selective abortion. Read More

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Measurement of population mental health: evidence from a mobile phone survey in India.

Health Policy Plan 2021 Mar 9. Epub 2021 Mar 9.

r.i.c.e., a research institute for compassionate economics, Delhi, India.

In high-income countries, population health surveys often measure mental health. This is less common in low- and middle-income countries (LMICs), including in India, where mental health is under-researched relative to its disease burden. The objective of this study is to assess the performance of two questionnaires for measuring population mental health in a mobile phone survey. Read More

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Heroin use cannot be measured adequately with a general population survey.

Addiction 2021 Mar 2. Epub 2021 Mar 2.

University of Maryland, Department of Criminology and Criminal Justice, College Park, MD, USA.

Background: Globally, heroin and other opioids account for more than half of deaths and years-of-life-lost due to drug use and comprise one of the four major markets for illegal drugs. Having sound estimates of the number of problematic heroin users is fundamental to formulating sound health and criminal justice policies. Researchers and policymakers rely heavily upon general population surveys (GPS), such as the US National Survey on Drug Use and Health (NSDUH), to estimate heroin use, without confronting their limitations. Read More

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Melancholic features in major depression - a European multicenter study.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Feb 18;110:110285. Epub 2021 Feb 18.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria; Center for Brain Research, Medical University of Vienna, Vienna, Austria. Electronic address:

There is still a debate, if melancholic symptoms can be seen rather as a more severe subtype of major depressive disorder (MDD) or as a separate diagnostic entity. The present European multicenter study comprising altogether 1410 MDD in- and outpatients sought to investigate the influence of the presence of melancholic features in MDD patients. Analyses of covariance, chi-squared tests, and binary logistic regression analyses were accomplished to determine differences in socio-demographic and clinical variables between MDD patients with and without melancholia. Read More

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February 2021

A framework for exploring non-response patterns over time in health surveys.

BMC Med Res Methodol 2021 Feb 18;21(1):37. Epub 2021 Feb 18.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Most health surveys have experienced a decline in response rates. A structured approach to evaluate whether a decreasing - and potentially more selective - response over time biased estimated trends in health behaviours is lacking. We developed a framework to explore the role of differential non-response over time. Read More

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February 2021

Self-Stigma and Treatment Effectiveness in Patients with SSRI Non-Responsive Obsessive-Compulsive Disorder.

Psychol Res Behav Manag 2021 5;14:85-97. Epub 2021 Feb 5.

Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University in Olomouc, University Hospital in Olomouc, Olomouc, The Czech Republic.

Purpose: Obsessive compulsive disorder (OCD) is a debilitating mental disorder that often takes a chronic course. One of the factors influencing the treatment effectiveness in anxiety and depressive disorders is the self-stigma. This study focused on the relationship between the self-stigma, symptomatology, and therapeutic outcomes in patients with OCD. Read More

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February 2021

Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders.

Eur J Nucl Med Mol Imaging 2021 Jan 8. Epub 2021 Jan 8.

Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.

Background: Cardiac resynchronization therapy (CRT) is effective in selective heart failure (HF) patients, but non-response rate remains high. Positron emission tomography (PET) may provide a better insight into the pathophysiology of left ventricular (LV) remodeling; however, its role for evaluating and selecting patients for CRT remains uncertain.

Purpose: We investigated if regional LV glucose metabolism in combination with myocardial scar could predict response to CRT. Read More

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January 2021

Feasibility and success rates of response enhancing strategies in a stepwise prevention program for cardiometabolic diseases in primary care.

BMC Fam Pract 2020 11 6;21(1):228. Epub 2020 Nov 6.

Netherlands Institute for Health Services Research (NIVEL), P.O. Box 1568, 3500, BN, Utrecht, the Netherlands.

Background: Prevention programs for cardiometabolic diseases (CMD), including cardiovascular disease, diabetes mellitus and chronic kidney disease are feasible, but evidence for the cost-effectiveness of selective CMD prevention programs is lacking. Response rates have an important role in effectiveness, but methods to increase response rates have received insufficient attention. The aim of the current study is to determine the feasibility and the success rate of a variety of response enhancing strategies to increase the participation in a selective prevention program for CMD. Read More

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November 2020

Long term absence of invasive breast cancer diagnosis in 2,402,672 pre and postmenopausal women: A systematic review and meta-analysis.

PLoS One 2020 10;15(9):e0237925. Epub 2020 Sep 10.

Department of Mathematics and Computer Science, Ursinus College, Collegeville, Pennsylvania, United States of America.

Background: Invasive Breast Cancer (IBC) risk estimates continue to be based on data collated from cancer registries, i.e., retrospective research that excludes disease-free women. Read More

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October 2020

Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma.

Hepatol Res 2020 Nov 31;50(11):1275-1283. Epub 2020 Aug 31.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Suita, Japan.

Aim: Repeated transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) eventually leads to either deteriorated hepatic reserve or TACE refractoriness. Switching to molecular targeted agents after TACE requires preservation of hepatic reserve. This study aimed to investigate the predictive factors associated with early deterioration of hepatic reserve by repeated TACE prior to refractoriness. Read More

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November 2020

Management of synchronous lateral pelvic nodal metastasis in rectal cancer in the era of neoadjuvant chemoradiation: A systemic review.

World J Gastrointest Surg 2020 May;12(5):247-258

Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.

Background: Lateral pelvic lymph node (LLN) metastasis (LLNM) occur in up to 28% of patients with low rectal tumours. While prophylactic lateral pelvic lymph node dissection (LLND) has been abandoned by most western institutions in the era of neoadjuvant chemoradiation therapy (CRT), the role of selective LLND in patients with enlarged LLN on pre-CRT imaging remains unclear. Some studies have shown improved survival and recurrence outcomes when LLNs show "response" to CRT. Read More

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Paroxetine binding and activation of phosphofructokinase implicates energy metabolism in antidepressant mode of action.

J Psychiatr Res 2020 10 6;129:8-14. Epub 2020 Jun 6.

Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, 80804, Munich, Germany.

Selective serotonin reuptake inhibitors (SSRIs) are the predominant drugs prescribed for Major Depressive Disorder. The immediate pharmacological target of SSRIs is the serotonin transporter. However, the delayed therapeutic effect and high rate of patient non-response make it highly likely that SSRIs also have other molecular targets that are yet to be identified. Read More

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October 2020

Mapping non-response in a prevention program for cardiometabolic diseases in primary care: How to improve participation?

Prev Med Rep 2020 Sep 8;19:101092. Epub 2020 Apr 8.

Netherlands Institute for Health Services Research (NIVEL), The Netherlands.

Non-response in prevention programs for cardiometabolic diseases (CMD) in primary care is often overlooked. The aim for this study was to define factors that influence the primary response to a selective CMD prevention program and to determine response-enhancing strategies that influence the willingness to participate. We conducted a non-response analysis within a randomized controlled trial evaluating a selective CMD prevention program, the study was conducted from 2013 to 2018 in Netherlands. Read More

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September 2020

Real-world Effectiveness of Tofacitinib for Moderate to Severe Ulcerative Colitis: A Multicentre UK Experience.

J Crohns Colitis 2020 Oct;14(10):1385-1393

Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.

Background: Tofacitinib is a partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis [UC]. We sought to define the effectiveness and adverse effects of tofacitinib in a real-world cohort.

Methods: We conducted a retrospective observational cohort study of 134 patients with UC [64% male; median age 37 years [range 16-81]; 83% of patients had previously received at least one biologic] treated with tofacitinib from October 2018 to October 2019 in four UK centres. Read More

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October 2020

Adjunctive vortioxetine for SSRI-resistant major depressive disorder: a "real-world" chart review study.

Braz J Psychiatry 2020 9;42(3):317-321. Epub 2020 Mar 9.

Department of Neurosciences and Imaging, University "G. D'Annunzio" Chieti, Italy.

Objective: Selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of treatment of major depressive disorder (MDD). However, non-response is common, often necessitating combination strategies. The present study assessed the efficacy of vortioxetine as an add-on therapy in patients with SSRI-resistant MDD. Read More

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Correcting for selective participation in cohort studies using auxiliary register data without identification of non-participants.

Scand J Public Health 2019 Dec 11:1403494819890784. Epub 2019 Dec 11.

School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Sweden.

Selective participation may hamper the validity of population-based cohort studies. The resulting bias can be alleviated by linking auxiliary register data to both the participants and the non-participants of the study, estimating propensity scores for participation and correcting for participation based on these. However, registry holders may not be allowed to disclose sensitive data on (invited) non-participants. Read More

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December 2019

Early child stimulation and attention-related executive functions at 11 years: 2004 Pelotas birth cohort study.

Eur Child Adolesc Psychiatry 2020 Sep 20;29(9):1265-1276. Epub 2019 Nov 20.

Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

The study aimed to explore associations between socioeconomic position (SEP) indicators, early child stimulation (ECS) and attention-related executive functions (EF) at age 11. Children born in Pelotas, Brazil, in 2004, were recruited to a birth cohort (n = 4231, non-response rate at recruitment < 1%) and followed from birth to age 11. SEP variables were family income and maternal schooling. Read More

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September 2020

Preventing bias from selective non-response in population-based survey studies: findings from a Monte Carlo simulation study.

BMC Med Res Methodol 2019 06 13;19(1):120. Epub 2019 Jun 13.

Department of Child Development, Norwegian Institute of Public Health, Oslo, Norway.

Background: Health researchers often use survey studies to examine associations between risk factors at one time point and health outcomes later in life. Previous studies have shown that missing not at random (MNAR) may produce biased estimates in such studies. Medical researchers typically do not employ statistical methods for treating MNAR. Read More

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Antifungal prophylaxis in lung transplant: A survey of United States' transplant centers.

Clin Transplant 2019 07 23;33(7):e13630. Epub 2019 Jun 23.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Background: Antifungal prophylaxis strategies for lung transplant recipients vary without consensus or standard of care. Our current study aims to identify antifungal prophylaxis practices in the United States.

Methods: From November 29, 2018, to February 15, 2019, we emailed surveys to medical directors of adult lung transplant centers. Read More

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[Efficacy and safety of recombinant human thrombopoietin in adult patients with primary immune thrombocytopenia during the perioperative period].

Zhonghua Xue Ye Xue Za Zhi 2019 Mar;40(3):191-194

Department of Hematology, Institute of Hematology, Shanghai Jiao Tong University School of Medicine, Shanghai Rui Jin Hospital, Shanghai 200025, China.

To evaluate the efficacy and safety of recombinant human thrombopoietin (rhTPO) treatment for primary immune thrombocytopenia (ITP) patients during the perioperative period. Adult ITP patients who were refractory to first-line glucocorticoid therapy and underwent selective surgery were enrolled to be treated with rhTPO at the dosage of 1.5×10(4)U/d subcutaneously during the perioperative period. Read More

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Are estimates of intergenerational mobility biased by non-response? Evidence from the Netherlands.

Soc Choice Welfare 2019 18;52(1):29-63. Epub 2018 Jun 18.

Department of Economics, Maastricht University, P.O. Box 616, 6200MD Maastricht, The Netherlands.

Intergenerational mobility is often studied using survey data. In such settings, selective unit or item non-response may bias estimates. Linking Dutch survey data to administrative income data allows us to examine whether selective responses bias the estimated relationship between parental income and children's mathematics and language test scores in grades 6 and 9. Read More

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Sociodemographic Factors Influenced Response to the 2015 National Nutrition Survey on Preschool Children: Results From Linkage With the Comprehensive Survey of Living Conditions.

J Epidemiol 2020 Feb 2;30(2):74-83. Epub 2019 Mar 2.

Department of Health Promotion, National Institute of Public Health.

Background: The National Nutrition Survey on Preschool Children, Japan (NNSPC) provides fundamental information for policy making for child nutrition. However, the response rate and background characteristics of subjects are unclear. Here, we examined response rate and sociodemographic factors related with response to the survey and evaluated the magnitude of bias due to selective response in the survey estimates of the NNSPC. Read More

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February 2020

Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder.

Br J Psychiatry 2019 08 30;215(2):494-501. Epub 2019 Jan 30.

Professor,Psychosis Research Unit,Aarhus University Hospital - Psychiatry;Department of Clinical Medicine,Aarhus University;and iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research,Denmark.

Background: For patients with major depressive disorder (MDD) experiencing side-effects or non-response to their first antidepressant, little is known regarding the effect of switching between a tricyclic antidepressant (TCA) and a selective serotonin reuptake inhibitor (SSRI).AimsTo compare the switch between the TCA nortriptyline and the SSRI escitalopram.

Method: Among 811 adults with MDD treated with nortriptyline or escitalopram for up to 12 weeks, 108 individuals switched from nortriptyline to escitalopram or vice versa because of side-effects or non-response (trial registration: EudraCT No. Read More

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Recommendations for design and analysis of health examination surveys under selective non-participation.

Eur J Public Health 2019 02;29(1):8-12

Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.

Background: The decreasing participation rates and selective non-participation peril the representativeness of health examination surveys (HESs).

Methods: Finnish HESs conducted in 1972-2012 are used to demonstrate that survey participation rates can be enhanced with well-planned recruitment procedures and auxiliary information about survey non-participants can be used to reduce selection bias.

Results: Experiments incorporated to pilot surveys and experience from previously conducted surveys lead to practical improvements. Read More

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February 2019

ESCAlate - Adaptive treatment approach for adolescents and adults with ADHD: study protocol for a randomized controlled trial.

Trials 2018 May 18;19(1):280. Epub 2018 May 18.

Institute for Forensic Psychology and Psychiatry, Saarland University, Kirrberger Straße, 66421, Homburg, Saarland, Germany.

Background: Over the last decade, a wide range of attention-deficit/hyperactivity disorder (ADHD) treatment approaches for adults, including both pharmacological interventions and psychosocial treatments, have been proposed and observed to be efficient. In practice, individual treatment concepts are based on results of clinical studies as well as international guidelines (NICE Guidelines) that recommend a step-by-step treatment approach. Since the evidence supporting this approach is limited, the aim of the present study is to determine an optimal intervention regarding severity levels of ADHD symptomatology conducting a randomized controlled trial. Read More

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Predictive factor for volume reduction of uterine fibroids after short-term use of ulipristal acetate.

Eur J Obstet Gynecol Reprod Biol 2018 May 17;224:133-136. Epub 2018 Mar 17.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea. Electronic address:

Objectives: Ulipristal acetate (UPA) is a selective progesterone receptor modulator, which has been used to treat uterine fibroids. Many published reports about the outcomes indicate effective control of bleeding and reduction in the fibroid volume following both short- and long-term therapy. However, the reported volume reduction varies across different reports. Read More

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Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells.

BMC Cancer 2018 02 6;18(1):149. Epub 2018 Feb 6.

Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.

Background: Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all therapies is induction of tumor apoptosis. The highly resistance nature of PDACs to all therapies suggests that the intrinsic tumor cell factors, likely the deregulated apoptosis pathway, are key mechanisms underlying PDAC non-response to these therapies, rather than the therapeutic agents themselves. Read More

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February 2018

Adjunctive Trazodone and Depression Outcome in Adolescents Treated with Serotonin Re-uptake Inhibitors.

J Can Acad Child Adolesc Psychiatry 2017 1;26(3):233-240. Epub 2017 Oct 1.

Formerly a Subspecialty Fellow, Child and Adolescent Psychiatry Program, Department of Psychiatry, University of Ottawa, Ottawa, Ontario.

Objectives: Recent published evidence suggests that adjunctive trazodone treatment may limit serotonin reuptake inhibitor (SRI) response in depressed adolescents in the context of a controlled trial. This study examined the effects of adjunctive trazodone on depression outcome in adolescents in a naturalistic treatment environment.

Methods: We conducted a cohort study through chart review of a clinical sample. Read More

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October 2017

EEG-arousal regulation as predictor of treatment response in patients suffering from obsessive compulsive disorder.

Clin Neurophysiol 2017 10 31;128(10):1906-1914. Epub 2017 Jul 31.

Department for Psychiatry PUK, University Zurich, Switzerland.

Objectives: Aim of this study was to analyze whether electroencephalogram (EEG)-based CNS-arousal markers differ for patients suffering from obsessive compulsive disorder (OCD) that either respond or do not respond to cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs) or their combination. Further the study aimed to identify specific response-predictors for the different therapy approaches.

Methods: CNS-arousal from 51 unmedicated patients during fifteen-minute resting state was assessed using VIGALL (Vigilance Algorithm Leipzig). Read More

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October 2017

The safety and efficacy of the 5-HT 1F receptor agonist lasmiditan in the acute treatment of migraine.

Expert Opin Pharmacother 2017 Sep 10;18(13):1409-1415. Epub 2017 Aug 10.

a Department of Neurology , Charité Universitätsmedizin Berlin , Berlin , Germany.

Introduction: Migraine is among the most disabling disorders worldwide, with a significant therapeutic need. Triptans are drugs of choice in the acute attack treatment, but they are contraindicated in patients with vascular conditions due to their potential vasoconstrictive properties. Further limitations include side effects, inconsistency in therapeutic action and possible non-response. Read More

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September 2017