541,807 results match your criteria selective


Accelerating drug access from advanced to early breast cancer: the special case of oral selective estrogen receptor degraders.

Curr Opin Oncol 2021 Sep 22. Epub 2021 Sep 22.

Division of Medical Oncology & Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada University of New South Wales, Kensington, New South Wales, Australia.

Purpose Of Review: For hormone receptor positive breast cancer, the development of endocrine resistance commonly occurs, presenting as either disease progression in the metastatic setting or recurrence during or following adjuvant endocrine therapy. Various mechanisms of resistance have been described. In order to reduce or overcome endocrine resistance, there has been substantial interest in developing potent and orally bioavailable selective estrogen receptor degraders (SERDs) for metastatic disease and select patients with early-stage estrogen receptor positive breast cancer. Read More

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September 2021

Placental Abruption after Fetoscopic Laser Surgery in Twin-Twin Transfusion Syndrome: The Role of the Solomon Technique.

Fetal Diagn Ther 2021 Sep 23:1-7. Epub 2021 Sep 23.

Division of Fetal Medicine, Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Twin-twin transfusion syndrome (TTTS) is a complication in monochorionic twin pregnancies which is preferably treated with fetoscopic laser surgery. A few small studies suggested a possible association between the Solomon laser technique and placental abruption.

Methods: The objective of this study is to compare the rate of and to explore potential risk factors for placental abruption in TTTS treated with fetoscopic laser surgery according to the Selective and Solomon laser technique. Read More

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September 2021

Nonlinear, neuronal adaptation in insect vision models improves target discrimination within repetitively moving backgrounds.

Bioinspir Biomim 2021 Sep 23. Epub 2021 Sep 23.

School of Medicine, The University of Adelaide, North Terrace, Adelaide, South Australia, 5005, AUSTRALIA.

Neurons which respond selectively to small moving targets, even against a cluttered background, have been identified in several insect species. To investigate what underlies these robust and highly selective responses, researchers have probed the neuronal circuitry in target-detecting, visual pathways. Observations in flies reveal nonlinear adaptation over time, composed of a fast onset and gradual decay. Read More

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September 2021

Intermediate accumulation and toxicity reduction during the selective photoelectrochemical process of atrazine in complex water bodies.

Water Res 2021 Sep 15;205:117663. Epub 2021 Sep 15.

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092, China. Electronic address:

Selective removal of atrazine (ATZ) in wastewater and clarification of the degradation intermediate-toxicity correlation are of great importance. A newly molecularly imprinted, {001} facets-exposed TiO (MI-TiO) photoanode with strong catalytic and selective ability was designed. ATZ was selectively removed from pesticide wastewater, reaching 1. Read More

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September 2021

Structure of the K87 capsular polysaccharide and KL87 gene cluster of Acinetobacter baumannii LUH5547 reveals a heptasaccharide repeating unit.

Carbohydr Res 2021 Sep 7;509:108439. Epub 2021 Sep 7.

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.

K87 capsular polysaccharide (CPS) was isolated from Acinetobacter baumannii isolate LUH5547 that carries the KL87 capsule biosynthesis gene cluster at the chromosomal K locus. Studies by sugar analysis, selective chemical cleavages, and 1D and 2D H and C NMR spectroscopy showed that the CPS has a branched heptasaccharide repeat (K unit) containing one residue each of d-glucose (d-Glсp), d-glucuronic acid (d-GlсpA), N-acetyl-d-glucosamine (d-GlсpNAc), 6-deoxy-l-talose (l-6dTalp), and three residues of l-rhamnose (l-Rhap). The following structure of the CPS was established: →3)-α-L-Rhap-(1→2)-α-L-Rhap-(1→3)-α-L-6dTalp-(1→3)-β-D-GlcpNAc-(1→2↑1β-D-GlcpA-(4←1)-α-D-Glcp(2←1)-α-L-Rhap The position of a minor O-acetyl group present in the CPS was not determined. Read More

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September 2021

A bio-inspired plasmonic nanosensor for angiotensin-converting enzyme through peptide-mediated assembly of gold nanoparticles.

Biosens Bioelectron 2021 Sep 12;195:113621. Epub 2021 Sep 12.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310058, Zhejiang, China; Ningbo Research Institute, Zhejiang University, Ningbo, 315100, Zhejiang, China. Electronic address:

Angiotensin-converting enzyme (ACE) can indicate blood pressure that relates to human health such as the cardiovascular disease. However, current methods are not competent to detect the ACE activity in a rapid and straightforward way. Plasmonic biosensors built on the modulation of metallic nanomaterials have emerged as novel tools for the detection of biomarkers. Read More

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September 2021

Combination therapy of vanillic acid and oxaliplatin co-loaded in polysaccharide based functionalized polymeric micelles could offer effective treatment for colon cancer: A hypothesis.

Med Hypotheses 2021 Sep 14;156:110679. Epub 2021 Sep 14.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India. Electronic address:

Colon cancer is characterised by the persistent change in bowel habits due to the formation of polyps (cancerous) in the inner lining of the colon. Clinically, there are several anticancer drugs available to treat colon cancer. Oxaliplatin (third generation platinum drug) is widely prescribed anticancer drug due to its broad range anticancer properties and low toxicities over cisplatin and carboplatin. Read More

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September 2021

Evidence for two distinct thalamocortical circuits in retrosplenial cortex.

Neurobiol Learn Mem 2021 Sep 20:107525. Epub 2021 Sep 20.

Institute of Behavioural Neuroscience, Division of Psychology and Language Sciences, University College London, London WC1E 6BT, UK.

Retrosplenial cortex (RSC) lies at the interface between sensory and cognitive networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present study investigated how these subregions differ with respect to their electrophysiology and thalamic connectivity, as a step towards understanding their functions. Read More

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September 2021

Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: synthesis, biological activity and in silico study.

Bioorg Med Chem Lett 2021 Sep 20:128374. Epub 2021 Sep 20.

ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. Electronic address:

Alzheimeŕs disease (AD) is the most common neurodegenerative disorder, characterized by neuronal loss and cognitive impairment. Currently, very few drugs are available for AD treatment, and a search for new therapeutics is urgently needed. Thus, in the current study, twenty-eight new derivatives of montanine-type Amaryllidaceae alkaloids were synthesized and evaluated for their ability to inhibit human recombinant acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE). Read More

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September 2021

Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly.

Virus Res 2021 Sep 20:198565. Epub 2021 Sep 20.

Institute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.

Hepatitis B virus (HBV) is the causative agent of chronic liver disease and is correlated with the development of subsequent hepatic cirrhosis and hepatocellular carcinoma. Current antiviral therapy using nucleos(t)ide analogs is effective in suppressing viral replication and interrupting disease progression, but HBV is rarely cured completely. Thus, there remains an unmet need for the development of novel anti-HBV drugs. Read More

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September 2021

Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin.

Biochim Biophys Acta Biomembr 2021 Sep 20:183782. Epub 2021 Sep 20.

Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Transient receptor potential vanilloid 1 (TRPV1) is a voltage-dependent non-selective cation channel activated by capsaicin, the main pungent ingredient of chili peppers, and noxious heat. Although TRPV1 channels produce outwardly rectifying currents even in the absence of capsaicin, little is known about the regulation mechanism of the TRPV1 currents. In the present study, we found that intracellular ATP regulates the basal activities of TRPV1 channels in a concentration-dependent manner. Read More

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September 2021

Recent advances in the highly sensitive determination of zearalenone residues in water and environmental resources with electrochemical biosensors.

Environ Res 2021 Sep 20:112082. Epub 2021 Sep 20.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037, China. Electronic address:

Zearalenone (ZEN), a significant class of mycotoxin which is considered as a xenoestrogen, permits, similar to natural estrogens, it's binding to the receptors of estrogen resulting in various reproductive diseases especially, hormonal misbalance. ZEN has toxic effects on human and animal health as a result of its teratogenicity, carcinogenicity, mutagenicity, nephrotoxicity, genotoxicity, and immunotoxicity. To ensure water and environmental resources safety, precise, rapid, sensitive, and reliable analytical and conventional methods can be progressed for the determination of toxins such as ZEN. Read More

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September 2021

Unexpected bite-force conservatism as a stable performance foundation across mesoeucrocodylian historical diversity.

Anat Rec (Hoboken) 2021 Sep 23. Epub 2021 Sep 23.

Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA.

Effective interpretation of historical selective regimes requires comprehensive in vivo performance evaluations and well-constrained ecomorphological proxies. The feeding apparatus is a frequent target of such evolutionary studies due to a direct relationship between feeding and survivorship, and the durability of craniodental elements in the fossil record. Among vertebrates, behaviors such as bite force have been central to evaluation of clade dynamics; yet, in the absence of detailed performance studies, such evaluations can misidentify potential selective factors and their roles. Read More

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September 2021

Estimating evolutionary changes between highly passaged and original parental lumpy skin disease virus strains.

Transbound Emerg Dis 2021 Sep 23. Epub 2021 Sep 23.

Federal Center for Animal Health, Vladimir, 600901, Russia.

Research into the phylogenetic relationships of lumpy skin disease virus (LSDV) strains was long overlooked, partially due to its original restricted distribution to sub-Saharan Africa. However, recent incursions into northern latitudes, and a rapid spread causing major economic losses worldwide, have intensified additional research on the disease and the causative virus. This study delineates the phylogeny of LSDV in the context of full genome sequences of strains recovered in the field, as well as strains highly passaged in cell culture. Read More

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September 2021

Rotation in an Enantiospecific Self-Assembled Array of Molecular Raffle Wheels.

Angew Chem Int Ed Engl 2021 Sep 23. Epub 2021 Sep 23.

Technical University Munich, Physics Department E20, James-Franck Strasse 1, D-85748, Garching, GERMANY.

Tailored nano-spaces can control enantioselective adsorption and molecular motion. We report on the spontaneous assembly of a dynamic one-component system - a rigid kagome network with each pore occupied by a guest molecule - employing solely 2,6-bis(1H-pyrazol-1-yl)pyridine-4-carboxylic acid on Ag(111). The network cavity snugly hosts the guest, bestows enantiomorphic adsorption and allows selective rotational motions. Read More

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September 2021

Absence of prostacyclin greatly relieves cyclophosphamide-induced cystitis and bladder pain in mice.

FASEB J 2021 Oct;35(10):e21952

Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan.

Cyclophosphamide (CP) has been widely used in the treatment of various malignancies and autoimmune diseases, but acrolein, a byproduct of CP, causes severe hemorrhagic cystitis as the major side effect of CP. On the other hand, a large amount of prostacyclin (PGI ) is produced in bladder tissues, and PGI has been shown to play a critical role in bladder homeostasis. PGI is biosynthesized from prostaglandin (PG) H , the common precursor of PGs, by PGI synthase (PTGIS) and is known to also be involved in inflammatory responses. Read More

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October 2021

Iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with secondary allylic alcohols.

Chem Commun (Camb) 2021 Sep 23;57(76):9684-9687. Epub 2021 Sep 23.

Department of Chemistry and Biological Science, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.

The development of efficient synthetic methods of 7-azaindoles has been desired due to the useful biological activities and physical properties. We report the first example of the iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with racemic secondary allylic alcohols to give only branched allylation products in good to high yields with high enantioselectivity (up to >99.5% ee). Read More

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September 2021

Sustainable Passerini-tetrazole three component reaction (PT-3CR): selective synthesis of oxaborol-tetrazoles.

Chem Commun (Camb) 2021 Sep 23;57(76):9708-9711. Epub 2021 Sep 23.

Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow-226031, India.

A sustainable catalyst- and solvent-free Passerini-tetrazole three component reaction (PT-3CR) has been developed for the selective synthesis of benzoxaborol-tetrazoles for the first time. The synthetic potential of oxaboroles was demonstrated towards various functionalized tetrazoles, which are otherwise difficult to achieve through conventional PT-3CR from aromatic aldehydes/ketones. The reaction features high practicality, broad substrate scope and excellent yields (80-98%). Read More

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September 2021

The NICU flora: An effective technique to sample surfaces.

PLoS One 2021 23;16(9):e0257821. Epub 2021 Sep 23.

Faculty of Medicine, The Hebrew University, Jerusalem, IL, United States of America.

Objective: Environmental surface sampling in healthcare settings is not routinely recommended. There are several methods for environmental surface sampling, however the yield of these methods is not well defined. The aim of the present study is to compare two methods of environmental surface sampling, to characterize the neonatal intensive care unit (NICU) flora, compare it with rates of infection and colonization and correlate it with the workload. Read More

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September 2021

Surface Zeta Potential of ALD-Grown Metal-Oxide Films.

Langmuir 2021 Sep 23. Epub 2021 Sep 23.

Chemical Sciences and Engineering Division and Center for Molecular Engineering, Argonne National Laboratory, Lemont, Illinois 60439, United States.

Membranes are among the most promising technologies for energy-efficient and highly selective separations, and the surface-charge property of membranes plays a critical role in their broad applications. Atomic layer deposition (ALD) can deposit materials uniformly and with high precision and controllability on arbitrarily complex and large substrates, which renders it a promising method to tune the electrostatics of water/solid interfaces. However, a systematic study of surface-charge properties of ALD-grown films in aqueous environments is still lacking. Read More

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September 2021

Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies.

ACS Synth Biol 2021 Sep 23. Epub 2021 Sep 23.

Department of Molecular Genetics, University of Groningen, Groningen 9747AG, The Netherlands.

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides characterized by the presence of lanthionine rings that provide stability and functionality. Genome mining techniques have shown their huge diversity and potential for the discovery of novel active molecules. However, in many cases, they are not easily produced under laboratory conditions. Read More

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September 2021

Chemical Modulation of DNA Replication along G-Quadruplex Based on Topology-Dependent Ligand Binding.

J Am Chem Soc 2021 Sep 23. Epub 2021 Sep 23.

FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.

Ligands that bind to and stabilize guanine-quadruplex (G4) structures to regulate DNA replication have therapeutic potential for cancer and neurodegenerative diseases. Because there are several G4 topologies, ligands that bind to their specific types may have the ability to preferentially regulate the replication of only certain genes. Here, we demonstrated that binding ligands stalled the replication of template DNA at G4, depending on different topologies. Read More

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September 2021

Stepwise Generation of Mono-, Di-, and Triply-Reduced Warped Nanographenes: Charge-Dependent Aromaticity, Surface Nonequivalence, Swing Distortion and Metal Binding Sites.

Angew Chem Int Ed Engl 2021 Sep 23. Epub 2021 Sep 23.

University of Albany, Department of Chemistry, State University of New York, 1400 Washington Avenue, 12222, Albany, UNITED STATES.

The stepwise chemical reduction of molecular warped nanographene (WNG) having a negatively curved π -surface and defined C 80 H 30 composition with Cs metal used as the reducing and complexing agent allowed the isolation of three different reduced states with one, two, and three electrons added to its π -conjugated system. This provided a unique series of contorted nanosized carbanions with increasing negative charge for in-depth structural analysis of consequences of controlled electron charging of non-planar nanographenes, using X-ray crystallographic and computational tools. The 3D molecular electrostatic potential (MEP) maps identified the negative charge localization at the central part of the WNG surface where selective coordination of Cs + ions has been confirmed crystallographically. Read More

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September 2021

Biosynthesis of phenylpyruvic acid from L-phenylalanine using chromosomally engineered Escherichia coli.

Biotechnol Appl Biochem 2021 Sep 23. Epub 2021 Sep 23.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China.

The efficiency of whole-cell biotransformation is often affected by genetic instability of plasmid-based expression systems, which require selective pressure to maintain the stability of the plasmids. To circumvent this shortcoming, we constructed a chromosome engineering strain for synthesis of phenylpyruvic acid (PPA) from L-phenylalanine. Firstly, L-amino acid deaminase (pmLAAD) from Proteus myxofaciens was incorporated into E. Read More

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September 2021

Twelve new microsatellite loci of Eurasian perch Perca fluviatilis Linnaeus, 1758.

Biol Futur 2021 Sep 24;72(3):385-393. Epub 2021 May 24.

Department of Aquaculture, Institute for Conservation of Natural Resources, Faculty of Agricultural and Environmental Sciences, Szent István University, Páter K. Str. 1, 2100, Gödöllő, Hungary.

The Eurasian perch (Perca fluviatilis Linnaeus, 1758) is native to almost entire Eurasia. For over the last two decades, this species became an important candidate for intensive freshwater aquaculture due to its high consumer's acceptance and overall market value. Hence, the intensive production of Eurasian perch has increased considerably allowing effective domestication; there is still a need for the development of effective selective breeding programmes allowing its further expansion. Read More

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September 2021

Sertraline in combination with sorafenib: A promising pharmacotherapy to target both depressive disorders and hepatocellular cancer.

Biol Futur 2019 Dec 1;70(4):341-348. Epub 2019 Dec 1.

Cancer and Stem Cell Research Center (MUKKAM), Maltepe University, Istanbul, Turkey.

Introduction: Hepatocellular carcinoma (HCC) is found within the first five most common tumors worldwide. Sorafenib is an approved agent in HCC treatment. Sertraline is a selective serotonin reuptake inhibitor. Read More

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December 2019

Expression of cry1Aa gene in cabbage imparts resistance against diamondback moth (Plutella xylostella).

Biol Futur 2020 Jun 11;71(1-2):165-173. Epub 2020 Jun 11.

ICAR-Directorate of Rapeseed-Mustard Research, Bharatpur, Rajasthan, 321 303, India.

Brassica oleracea cv. Pride of India is one of the most promising vegetable cultivars commercially grown as cash crop in Himachal Pradesh, India. However, its overall production is severely hampered by diamondback moth (Plutella xylostella), a notorious pest. Read More

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The crosstalk between adenosine A2B receptor and insulin signalling in rat skeletal muscle cells.

Biol Futur 2020 Sep 28;71(3):283-288. Epub 2020 Jul 28.

Department of Pharmacology, School of Medicine, The University of Jordan, Amman, 11942, Jordan.

Diabetes mellitus (DM) is a group of metabolic diseases characterised by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Insulin therapy might be affected by specific metabolic enzymes and transporters. There are conflicting reports in the literature on the role of adenosine receptor A2B (AR2B) in skeletal and cardiac muscle glucose metabolism. Read More

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September 2020

The Kv1.3 K channel in the immune system and its "precision pharmacology" using peptide toxins.

Biol Futur 2021 Mar 6;72(1):75-83. Epub 2021 Feb 6.

Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 1 Egytem ter, Debrecen, 4032, Hungary.

Since the discovery of the Kv1.3 voltage-gated K channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune system. Our knowledge about Kv1. Read More

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Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis.

J Microbiol 2021 Oct 23;59(10):931-940. Epub 2021 Sep 23.

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.

C-Glycosides are an important type of natural product with significant bioactivities, and the C-glycosidic bonds of C-glycosides can be cleaved by several intestinal bacteria, as exemplified by the human faeces-derived puerarin-degrading bacterium Dorea strain PUE. However, glycoside hydrolases in these bacteria, which may be involved in the C-glycosidic bond cleavage of C-glycosides, remain largely unknown. In this study, the genomes of the closest phylogenetic neighbours of five puerarin-degrading intestinal bacteria (including Dorea strain PUE) were retrieved, and the protein-coding genes in the genomes were subjected to sequence similarity network (SSN) analysis. Read More

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October 2021