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A comprehensive model based on temporal dynamics of peripheral T cell repertoire for predicting post-treatment distant metastasis of nasopharyngeal carcinoma.

Cancer Immunol Immunother 2021 Aug 3. Epub 2021 Aug 3.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China.

Many nasopharyngeal carcinoma (NPC) patients develop distant metastases after treatment, leading to poor outcomes. To date, there are no peripheral biomarkers suitable for all NPC patients to predict distant metastasis. Hence, we purposed to develop a noninvasive comprehensive model for predicting post-treatment distant metastasis of all NPC. Read More

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Exploring the effectiveness of in ovo feeding of vitamin C based on the embryonic vitamin C synthesis and absorption in broiler chickens.

J Anim Sci Biotechnol 2021 Aug 3;12(1):86. Epub 2021 Aug 3.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.

Background: Many researches about in ovo feeding (IOF) of vitamin C (VC) are gradually carried out to explore physiological development in chicken, but little studies focus on VC synthesis capacity of the embryo itself, the selection of injection site and the effectiveness of IOF of VC. This study aims to explore the above problems.

Results: Kidney and yolk sac were the main organs for VC synthesis and L-gulonolactone oxidase (GLO) expression was lower during pre-hatch development than that during post-hatch development. Read More

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Short- and long-term mortality prediction after an acute ST-elevation myocardial infarction (STEMI) in Asians: A machine learning approach.

PLoS One 2021 2;16(8):e0254894. Epub 2021 Aug 2.

Cardiology Department, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia.

Background: Conventional risk score for predicting short and long-term mortality following an ST-segment elevation myocardial infarction (STEMI) is often not population specific.

Objective: Apply machine learning for the prediction and identification of factors associated with short and long-term mortality in Asian STEMI patients and compare with a conventional risk score.

Methods: The National Cardiovascular Disease Database for Malaysia registry, of a multi-ethnic, heterogeneous Asian population was used for in-hospital (6299 patients), 30-days (3130 patients), and 1-year (2939 patients) model development. Read More

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Effectiveness of experimental and commercial pertussis vaccines in the elimination of Bordetella pertussis isolates with different genetic profiles in murine model.

Med Microbiol Immunol 2021 Aug 2. Epub 2021 Aug 2.

Department of Vaccines and Sera Evaluation, National Institute of Public Health, National Institute of Hygiene, Warsaw, Poland.

The aim of this study was to compare the elimination of Bordetella pertussis clinical isolates, representing different genotypes in relation to alleles encoding virulence factors (MLST-multi-locus antigen sequence typing), MLVA type (multi-locus variable-number tandem repeat analysis) and PFGE group (pulsed-field gel electrophoresis) from the lungs of naive mice or mice were immunised with the commercial whole-cell pertussis vaccine, the acellular pertussis vaccine and the experimental whole-cell pertussis vaccine. Molecular data indicate that the resurgence of pertussis in populations with high vaccine coverage is associated with genomic adaptation of B. pertussis, to vaccine selection pressure. Read More

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Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 Aug 2;4(8):e2118895. Epub 2021 Aug 2.

Department of Otolaryngology - Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Importance: Platinum-induced ototoxic effects are a significant issue because platinum-based chemotherapy is one of the most commonly used therapeutic medications. Sodium thiosulfate (STS) is considered a potential otoprotectant for the prevention of platinum-induced ototoxic effects that functions by binding the platinum-based agent, but its administration raises concerns regarding the substantial attenuation of the antineoplastic outcome associated with platinum.

Objective: To evaluate the association between concurrent STS and reduced risk of ototoxic effects among patients undergoing platinum-based chemotherapy and to evaluate outcomes, including event-free survival, overall survival, and adverse outcomes. Read More

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Effects of different sources of dietary protein on markers of kidney function in individuals with diabetes: a systematic review and meta-analysis of randomized controlled trials.

Nutr Rev 2021 Aug 2. Epub 2021 Aug 2.

I. Eckert is with the Undergraduate Nutrition Program, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rio Grande do Sul, Brazil. I.C. Koehler is with the Undergraduate Medical Program, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rio Grande do Sul, Brazil. J. Bauer is with the Postgraduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rio Grande do Sul, Brazil. F.M. Busnello and F.M. Silva are with the Department of Nutrition and Postgraduate Program in Nutrition Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Rio Grande do Sul, Brazil.

Context: The type of dietary protein may modulate markers of diabetic kidney disease; however, no attempt to summarize the evidence from randomized controlled trials (RCTs) has been performed to date.

Objective: To assess the effects of different types of dietary protein on urinary albumin excretion and glomerular filtration rate in individuals with diabetes.

Data Sources: MEDLINE, EMBASE, and Scopus were searched for all published RCTs, with no language restriction, up to July 2020. Read More

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A systematic review and meta-analysis of the effectiveness of individual-level interventions to reduce occupational stress perceptions among teachers.

Arch Environ Occup Health 2021 Aug 2:1-15. Epub 2021 Aug 2.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Teachers are largely affected by OS, during their most productive years, leading to catastrophic physical, psychological, and economic burden on themselves, families and society by large. Teachers are responsible for producing the workforce of any nation, and thus have a major impact indirectly on the economy and health of a nation. There are several individual-level interventions conducted to reduce occupational stress (OS) among teachers. Read More

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Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.

Eur Urol Open Sci 2021 Jul 25;29:19-29. Epub 2021 May 25.

CRUK Beatson Institute, Glasgow, UK.

Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively.

Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis.

Design Setting And Participants: We applied multiplex immunofluorescence and targeted transcriptomic analysis on 94 radical prostatectomy specimens in patients with (LN+) or without (LN-) pelvic nodal metastases. Read More

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Percutaneous Coronary Sinus-Based Mitral Valve Repair Differentially Modulates Coronary Sinus to Mitral Valve Annulus Geometry and Topography.

Front Cardiovasc Med 2021 15;8:678812. Epub 2021 Jul 15.

Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.

Coronary sinus (CS) based mitral annuloplasty using the Carillon device is a therapeutic option for the treatment of functional mitral valve regurgitation (FMR). Little is known about the change of CS and mitral valve annulus (MVA) planes following Carillon implantation and how they are modulated by the tension applied on the device. In a retrospective single-center analysis, 10 patients underwent Carillon device implantation and received CT-angiography (CTA) prior and post CS based percutaneous mitral valve repair. Read More

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Identification of Disease-Related 2-Oxoglutarate/Fe (II)-Dependent Oxygenase Based on Reduced Amino Acid Cluster Strategy.

Front Cell Dev Biol 2021 16;9:707938. Epub 2021 Jul 16.

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China.

The 2-oxoglutarate/Fe (II)-dependent (2OG) oxygenase superfamily is mainly responsible for protein modification, nucleic acid repair and/or modification, and fatty acid metabolism and plays important roles in cancer, cardiovascular disease, and other diseases. They are likely to become new targets for the treatment of cancer and other diseases, so the accurate identification of 2OG oxygenases is of great significance. Many computational methods have been proposed to predict functional proteins to compensate for the time-consuming and expensive experimental identification. Read More

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Quality assurance data for regional drip-and-ship strategies- gearing up the transfer process.

Neurol Res Pract 2021 Aug 2;3(1):38. Epub 2021 Aug 2.

Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany.

Background: Stroke patients with large vessel occlusion (LVO) require endovascular therapy (EVT) provided by comprehensive stroke centers (CSC). One strategy to achieve fast stroke symptom 'onset to treatment' times (OTT) is the preclinical selection of patients with severe stroke for direct transport to CSC. Another is the optimization of interhospital transfer workflow. Read More

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Risk-adjusted analysis of long-term outcomes after on- versus off-pump coronary artery bypass grafting.

Interact Cardiovasc Thorac Surg 2021 Aug 1. Epub 2021 Aug 1.

Department of Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.

Objectives: Recent data suggested that off-pump coronary artery bypass (OPCAB) may carry a higher risk for mortality in the long term when compared to on-pump coronary artery bypass (ONCAB). We, therefore, compared long-term survival and morbidity in patients undergoing ONCAB versus OPCAB in a large single-centre cohort.

Methods: A total of 8981 patients undergoing isolated elective/urgent coronary artery bypass grafting between January 2009 and December 2019 were analysed. Read More

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Medication selection, health services outcomes, and cost trajectories for Medicaid beneficiaries with infantile spasms.

Epilepsy Res 2021 Jul 24;176:106733. Epub 2021 Jul 24.

Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA; Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Objective: There are three recommended first-line treatments for infantile spasms, adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin, though non-standard treatments such as topiramate are sometimes selected. Is it uncertain how treatment selection influences health services outcomes.

Methods: We conducted a retrospective cohort study of Medicaid beneficiaries newly diagnosed with infantile spasms from 2009-2010. Read More

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Health insurance enrollment and vision health in rural China: an epidemiological survey.

BMC Health Serv Res 2021 Jul 31;21(1):761. Epub 2021 Jul 31.

Department of Ophthalmology, Tianjin Medical University General Hospital, 300052, Tianjin, China.

Background: Vision health is an important aspect of health worldwide. Visual impairment (VI) is associated with poor quality of life and is usually more prevalent in rural areas. To help rural populations obtain vision care, health insurance policies have emerged throughout the world. Read More

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Population structure and the influence of microenvironment and genetic similarity on individual growth at Alaskan white spruce treelines.

Sci Total Environ 2021 Jul 26;798:149267. Epub 2021 Jul 26.

Institute of Botany und Landscape Ecology, University of Greifswald, Soldmannstr. 15, 17487 Greifswald, Germany. Electronic address:

Knowledge on the adaptation of trees to rapid environmental changes is essential to preserve forests and their ecosystem services under climate change. Treeline populations are particularly suitable for studying adaptation processes in trees, as environmental stress together with reduced gene flow can enhance local adaptation. We investigated white spruce (Picea glauca) populations in Alaska on one moisture-limited and two cold-limited treeline sites with a paired plot design of one forest and one treeline population each, resulting in six plots. Read More

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Treatment strategies and outcomes for elderly patients with locally advanced squamous cell carcinoma of the esophagus.

Surg Today 2021 Jul 30. Epub 2021 Jul 30.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Purpose: A multidisciplinary treatment strategy for locally advanced esophageal squamous cell carcinoma (ESCC) is required to achieve prolonged survival. We aimed to clarify the differences in treatment strategies for locally advanced ESCC and the outcomes of elderly (aged ≥ 75 years) vs. younger patients (aged < 75 years). Read More

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Volunteering as an Equalizer: A Quasi-Experimental Study Using Propensity Score Analysis.

Am J Prev Med 2021 Jul 26. Epub 2021 Jul 26.

School of Social Work, Boston College, Boston, Massachusetts.

Introduction: Formal volunteering in later life is beneficial for both physical and psychological well-being. However, research points to potential selection bias because older adults with key advantages, such as wealth, are more likely to volunteer and reap its benefits. Accordingly, this study addresses this selection bias by considering the characteristics of volunteers and nonvolunteers using the inverse probability of treatment weighting. Read More

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Selection strategy for sedation depth in critically ill patients on mechanical ventilation.

BMC Med Inform Decis Mak 2021 Jul 30;21(Suppl 2):79. Epub 2021 Jul 30.

Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Background: Analgesia and sedation therapy are commonly used for critically ill patients, especially mechanically ventilated patients. From the initial nonsedation programs to deep sedation and then to on-demand sedation, the understanding of sedation therapy continues to deepen. However, according to different patient's condition, understanding the individual patient's depth of sedation needs remains unclear. Read More

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Co-AMPpred for in silico-aided predictions of antimicrobial peptides by integrating composition-based features.

BMC Bioinformatics 2021 Jul 30;22(1):389. Epub 2021 Jul 30.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Xing Street, Taipei, 11031, Taiwan.

Background: Antimicrobial peptides (AMPs) are oligopeptides that act as crucial components of innate immunity, naturally occur in all multicellular organisms, and are involved in the first line of defense function. Recent studies showed that AMPs perpetuate great potential that is not limited to antimicrobial activity. They are also crucial regulators of host immune responses that can modulate a wide range of activities, such as immune regulation, wound healing, and apoptosis. Read More

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From late fatherhood to prenatal screening of monogenic disorders: evidence and ethical concerns.

Hum Reprod Update 2021 Jul 30. Epub 2021 Jul 30.

Competence Centre on Health Technologies, Tartu, Estonia.

Background: With the help of ART, an advanced parental age is not considered to be a serious obstacle for reproduction anymore. However, significant health risks for future offspring hide behind the success of reproductive medicine for the treatment of reduced fertility associated with late parenthood. Although an advanced maternal age is a well-known risk factor for poor reproductive outcomes, understanding the impact of an advanced paternal age on offspring is yet to be elucidated. Read More

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Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.

PLoS One 2021 30;16(7):e0253945. Epub 2021 Jul 30.

Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep quality, physical activity, affective state, pain catastrophizing and psychophysical pain sensitivity have all been suggested to be involved. This study aimed to investigate whether factors at baseline could predict musculoskeletal pain intensity to an experimental delayed onset of muscle soreness (DOMS) pain model. Read More

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Multiparametric Quantitative US Examination of Liver Fibrosis: A Feature-engineering and Machine-learning Based Analysis.

IEEE J Biomed Health Inform 2021 Jul 30;PP. Epub 2021 Jul 30.

Quantitative ultrasound (QUS), which is commonly used to extract quantitative features from the ultrasound radiofrequency (RF) data or the RF envelope signals for tissue characterization, is becoming a promising technique for noninvasive assessments of liver fibrosis. However, the number of feature variables examined and finally used in the existing QUS methods is typically small, to some extent limiting the diagnostic performance. Therefore, this paper devises a new multiparametric QUS (MP-QUS) method which enables the extraction of a large number of feature variables from US RF signals and allows for the use of feature-engineering and machinelearning based algorithms for liver fibrosis assessment. Read More

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Staphyloxanthin inhibitory potential of thymol impairs antioxidant fitness, enhances neutrophil mediated killing and alters membrane fluidity of methicillin resistant Staphylococcus aureus.

Biomed Pharmacother 2021 Jul 26;141:111933. Epub 2021 Jul 26.

Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630003, Tamil Nadu, India. Electronic address:

Staphylococcus aureus is a leading pathogen responsible for mild to severe invasive infections in humans. Especially, methicillin resistant Staphylococcus aureus (MRSA) is prevalent in hospital and community associated infections. Staphyloxanthin is a golden yellow color eponymous pigment produced by S. Read More

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Percutaneous transthoracic catheter drainage for lung abscess: a systematic review and meta-analysis.

Eur Radiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, 03080, Korea.

Objectives: To evaluate the outcomes of patients receiving image-guided percutaneous catheter drainage (PCD) for lung abscesses in terms of treatment success, major complications, and mortality as well as the predictors of those outcomes.

Methods: Embase and OVID-MEDLINE databases were searched to identify studies on lung abscesses treated with PCD that had extractable outcomes. The outcomes were pooled using a random-intercept logistic regression model. Read More

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The effects of genetic drift and genomic selection on differentiation and local adaptation of the introduced populations of in southern Russia.

PeerJ 2021 21;9:e11776. Epub 2021 Jul 21.

Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov University, Moscow, Russian Federation.

Background: Asian tiger mosquito is an arbovirus vector that has spread from its native habitation areal in Southeast Asia throughout North and South Americas, Europe, and Africa. was first detected in the Southern Federal District of the Russian Federation in the subtropical town of Sochi in 2011. In subsequent years, this species has been described in the continental areas with more severe climate and lower winter temperatures. Read More

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Genome-Wide Identification of the () Gene Family in Cotton and Silent GhELF4-1 and GhEFL3-6 Decreased Cotton Stress Resistance.

Front Genet 2021 6;12:686852. Epub 2021 Jul 6.

Engineering Research Centre of Cotton, Ministry of Education, College of Agriculture, Xinjiang Agricultural University, Ürümqi, China.

The early flowering 4 (ELF4) family members play multiple roles in the physiological development of plants. participated in the plant biological clock's regulation process, photoperiod, hypocotyl elongation, and flowering time. However, the function in the gene is barely known. Read More

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Risk assessment models for venous thromboembolism in hospitalised adult patients: a systematic review.

BMJ Open 2021 07 29;11(7):e045672. Epub 2021 Jul 29.

Emergency Department, Salford Royal NHS Foundation Trust, Salford, UK.

Introduction: Hospital-acquired thrombosis accounts for a large proportion of all venous thromboembolism (VTE), with significant morbidity and mortality. This subset of VTE can be reduced through accurate risk assessment and tailored pharmacological thromboprophylaxis. This systematic review aimed to determine the comparative accuracy of risk assessment models (RAMs) for predicting VTE in patients admitted to hospital. Read More

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Metabolic surgery may protect against admission for COVID-19 in persons with nonalcoholic fatty liver disease.

Surg Obes Relat Dis 2021 Jun 29. Epub 2021 Jun 29.

Department of Surgery, University of Minnesota, Division of Surgical Oncology, Minneapolis, Minnesota.

Background: SARS-CoV-2 (COVID-19) disease causes significant morbidity and mortality through increased inflammation and thrombosis. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are states of chronic inflammation and indicate advanced metabolic disease.

Objective: The purpose of this observational study was to characterize the risk of hospitalization for COVID-19 in patients with NAFLD/NASH and evaluate the mitigating effect of various metabolic treatments. Read More

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Response of essential oil hemp (Cannabis sativa L.) growth, biomass, and cannabinoid profiles to varying fertigation rates.

PLoS One 2021 29;16(7):e0252985. Epub 2021 Jul 29.

Department of Agronomy, Tropical Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Homestead, Florida, United States of America.

Five essential oil hemp (Cannabis sativa L.) cultivars (Cherry Blossom, Cherry Blossom (Tuan), Berry Blossom, Cherry Wine, and Cherry Blossom × Trump) were treated with six fertigation treatments to quantify the effects of synthetic fertilizer rates and irrigation electrical conductivity on plant growth, biomass accumulation, and cannabinoid profiles. Irrigation water was injected with a commercial 20-20-20 fertilizer at rates of 0, 50, 150, 300, 450, and 600 ppm nitrogen equating to 0. Read More

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The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection.

Development 2021 Aug 29;148(15). Epub 2021 Jul 29.

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

During positive selection at the transition from CD4+CD8+ double-positive (DP) to single-positive (SP) thymocyte, TCR signalling results in appropriate MHC restriction and signals for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection of mouse T cells and that Foxa1 and Foxa2 have overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced positive selection and development of CD4SP, CD8SP and peripheral naïve CD4+ T cells. Read More

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