37,654 results match your criteria selection marker

Mapping of a major QTL controlling plant height using a high-density genetic map and QTL-seq methods based on whole-genome resequencing in Brassica napus.

G3 (Bethesda) 2021 Apr 9. Epub 2021 Apr 9.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences/The Key Laboratory of Biology and Genetic Improvement of Oil Crops, The Ministry of Agriculture and Rural Affairs, Wuhan 430062, P. R. China.

Plant height is a crucial element related to plant architecture that influences the seed yield of oilseed rape (Brassica napus L.). In this study, we isolated a natural B. Read More

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Tackling Diversity in Prostate Cancer Clinical Trials: A Report From the Diversity Working Group of the IRONMAN Registry.

JCO Glob Oncol 2021 Apr;7:495-505

Moffitt Cancer Center, Tampa, FL.

Prostate cancer disproportionately affects racial and ethnic minority populations. Reasons for disparate outcomes among minority patients are multifaceted and complex, involving factors at the patient, provider, and system levels. Although advancements in our understanding of disease biology have led to novel therapeutics for men with advanced prostate cancer, including the introduction of biomarker-driven therapeutics, pivotal translational studies and clinical trials are underrepresented by minority populations. Read More

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Development of Neuroimaging-Based Biomarkers in Major Depression.

Adv Exp Med Biol 2021 ;1305:85-99

Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Ansan, Republic of Korea.

A leading goal in the field of biological psychiatry for depression is to find a promising diagnostic biomarker and selection of specific psychiatric treatment mode that is most likely to benefit patients with depression. Recent neuroimaging studies have characterized the pathophysiology of major depressive disorder (MDD) with functional and structural alterations in the neural circuitry involved in emotion or reward processing. Particularly, structural and functional magnetic resonance imaging (MRI) studies have reported that the brain structures deeply involved in emotion regulation or reward processing including the amygdala, prefrontal cortex (PFC), anterior cingulate cortex (ACC), ventral striatum, and hippocampus are key regions that provide useful information about diagnosis and treatment outcome prediction in MDD. Read More

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January 2021

DisBalance: a platform to automatically build balance-based disease prediction models and discover microbial biomarkers from microbiome data.

Brief Bioinform 2021 Apr 8. Epub 2021 Apr 8.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China.

How best to utilize the microbial taxonomic abundances in regard to the prediction and explanation of human diseases remains appealing and challenging, and the relative nature of microbiome data necessitates a proper feature selection method to resolve the compositional problem. In this study, we developed an all-in-one platform to address a series of issues in microbiome-based human disease prediction and taxonomic biomarkers discovery. We prioritize the interpretation, runtime and classification accuracy of the distal discriminative balances analysis (DBA-distal) method in selecting a set of distal discriminative balances, and develop DisBalance, a comprehensive platform, to integrate and streamline the workflows of disease model building, disease risk prediction and disease-related biomarker discovery for microbiome-based binary classifications. Read More

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LSD1 as a Biomarker and the Outcome of Its Inhibitors in the Clinical Trial: The Therapy Opportunity in Tumor.

J Oncol 2021 25;2021:5512524. Epub 2021 Mar 25.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Tumors are the foremost cause of death worldwide. As a result of that, there has been a significant enhancement in the investigation, treatment methods, and good maintenance practices on cancer. However, the sensitivity and specificity of a lot of tumor biomarkers are not adequate. Read More

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Improving selection of patients with metastatic colorectal cancer to benefit from cetuximab based on KIR genotypes.

J Immunother Cancer 2021 Apr;9(4)

Medical Oncology, Reina Sofia University Hospital, Cordoba, Andalucía, Spain.

Aim: Cetuximab is a standard-of-care treatment for wild-type metastatic colorectal cancer (mCRC), but it may also be effective in a subgroup of mutant patients by its immunomodulatory activity. Here, we explore if KIR (killer cell immunoglobulin-like receptor) genotyping can provide a significant added value in the clinical outcome of patients with mutant mCRC based on cetuximab treatment.

Methods: We included 69 patients with histologically confirmed mCRC and mutation, positive EGFR expression, and Eastern Cooperative Oncology Group performance status ≤2. Read More

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Predictive and prognostic biomarkers with therapeutic targets in colorectal cancer: A 2021 update on current development, evidence, and recommendation.

Clement Chung

J Oncol Pharm Pract 2021 Apr 9:10781552211005525. Epub 2021 Apr 9.

23530Houston Methodist West Hospital, Houston, TX, USA.

Although therapeutically actionable molecular alterations are widely distributed across many cancer types, only a handful of them show evidence of clinical utility and are recommended for routine clinical practice in the management of cancers of colon and rectum (CRC). This 2021 update aims to provide a succinct summary on the use of prognostic and/or predictive biomarkers (expanded , , microsatellite-high [MSI-H] or deficient mismatch repair [dMMR], neurotrophic tyrosine receptor kinase [] fusion genes, and human epidermal growth factor receptor type II [] gene amplification) associated with CRC. Therapeutic implications of each relevant predictive or prognostic biomarker for patients with CRC are described, along with discussion on new developments on (1) biomarker-driven therapies such as testing of , promoter methylation and germline genes in differentiating sporadic CRC or hereditary conditions such as Lynch syndrome; (2) first-line use of immune checkpoint inhibitors in metastatic CRC; (3) risk stratification and therapy selection based on primary tumor location (left-sided vs. Read More

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GC-MS-based metabolomics reveals new biomarkers to assist the differentiation of prostate cancer and benign prostatic hyperplasia.

Clin Chim Acta 2021 Apr 5. Epub 2021 Apr 5.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China. Electronic address:

Lack of efficient noninvasive biomarkers for differentiating prostate cancer (PCa) and benign prostate hyperplasia (BPH) is a serious concern for men's health worldwide. In this study, we aimed to improve the diagnostic capability of the existing noninvasive biomarkers for PCa. GC-MS-based untargeted metabolomics was employed to analyze plasma samples for 41 PCa patients and 38 BPH controls. Read More

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Multi-omics reveals novel prognostic implication of SRC protein expression in bladder cancer and its correlation with immunotherapy response.

Ann Med 2021 Dec;53(1):596-610

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, PR China.

Purpose: This study aims to identify potential prognostic biomarkers of bladder cancer (BCa) based on large-scale multi-omics data and investigate the role of SRC in improving predictive outcomes for BCa patients and those receiving immune checkpoint therapies (ICTs).

Methods: Large-scale multi-comic data were enrolled from the Cancer Proteome Atlas, the Cancer Genome Atlas and gene expression omnibus based on machining-learning methods. Immune infiltration, survival and other statistical analyses were implemented using R software in cancers ( = 12,452). Read More

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December 2021

Measuring Sensitivity, Specificity and Accuracy of HRCT of Chest and Comparison with Biomarkers in COVID-19 Suspected Patients: A Cross Sectional Study.

Mymensingh Med J 2021 Apr;30(2):503-508

Dr Farhana Selina, Associate Professor, Department of Anesthesiology, Sylhet Women's Medical College (SWMC), Sylhet, Bangladesh; E-mail:

COVID-19 is a declared pandemic by World Health Organization. The diagnostic tests are not of high specificity and sensitivity, so far. Pro-inflammatory biomarkers and High Resolution Computed Tomography (HRCT) of chest are the common investigations performed to evaluate the diagnosis and prognosis of COVID-19. Read More

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Usefulness of the Biomarker TIMP-2•IGFBP7 for Acute Kidney Injury Assessment in Critically Ill Patients: A Narrative Review.

Brian L Erstad

Ann Pharmacother 2021 Apr 8:10600280211005425. Epub 2021 Apr 8.

University of Arizona College of Pharmacy, Tucson, AZ, USA.

Objectives: To review the clinical usefulness of the biomarker TIMP-2•IGFBP7 in adult, general medical-surgical intensive care unit (ICU) settings.

Data Sources: PubMed (1946 to mid-February 2021) and EMBASE (1947 to mid-February 2021) with bibliographies of retrieved articles reviewed for additional articles.

Study Selection And Data Extraction: Studies evaluating use of the urinary TIMP-2•IGFBP7 assay in adult patients in ICU settings. Read More

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Genetic Association of Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo.

Biomed Res Int 2021 18;2021:3653157. Epub 2021 Mar 18.

Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

gene plays an important role in the activation of various important hormone receptors and transcriptional factors involved in the regulation of adaptive thermogenesis, gluconeogenesis, fiber-type switching in skeletal muscle, mitochondrial biogenesis, and adipogenesis, regulating the reproduction and proposed as a candidate gene for milk-related traits in cattle. This study identified polymorphisms in the gene in Italian Mediterranean buffaloes and their associations to milk production and quality traits (lactation length, peak milk yield, fat and protein yield, and percentage). As a result, a total of seven SNPs (g. Read More

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Population structure and genome-wide association studies in bread wheat for phosphorus efficiency traits using 35 K Wheat Breeder's Affymetrix array.

Sci Rep 2021 Apr 7;11(1):7601. Epub 2021 Apr 7.

Life Sciences, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK.

Soil bioavailability of phosphorus (P) is a major concern for crop productivity worldwide. As phosphatic fertilizers are a non-renewable resource associated with economic and environmental issues so, the sustainable option is to develop P use efficient crop varieties. We phenotyped 82 diverse wheat (Triticum aestivum L. Read More

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Identification of a major-effect QTL associated with pre-harvest sprouting in cucumber (Cucumis sativus L.) using the QTL-seq method.

BMC Genomics 2021 Apr 7;22(1):249. Epub 2021 Apr 7.

Institute of Cucumber Research, Tianjin Academy of Agricultural Sciences, Tianjin, 300192, China.

Background: Cucumber (Cucumis sativus L.) is cultivated worldwide, and it is essential to produce enough high-quality seeds to meet demand. Pre-harvest sprouting (PHS) in cucumber is a critical problem and causes serious damage to seed production and quality. Read More

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The effect of CPT1B gene on lipid metabolism and its polymorphism analysis in Chinese Simmental cattle.

Anim Biotechnol 2021 Apr 7:1-13. Epub 2021 Apr 7.

College of Animal Sciences, Jilin University, Changchun, China.

Carnitine palmitoyltransferase 1B (CPT1B) is a candidate gene that regulates livestock animal lipid metabolism and encodes the rate-limiting enzyme in fatty acid β-oxidation. To explore the effect of this gene on lipid metabolism in cattle, this study examined CPT1B gene polymorphism in Chinese Simmental cattle and the effect of CPT1B on lipid metabolism. The results showed that the triglyceride content increased significantly with increasing CPT1B gene expression in bovine fetal fibroblasts (BFFs) ( < 0. Read More

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Spatial mapping of single cells in the embryo from transcriptomic data based on topological consistency.

F1000Res 2020 20;9:1014. Epub 2020 Aug 20.

Computer science, University of Texas at San Antonio, San Antonio, Texas, 78249, USA.

The advancement in single-cell RNA sequencing technologies allow us to obtain transcriptome at single cell resolution. However, the original spatial context of cells, a crucial knowledge for understanding cellular and tissue-level functions, is often lost during sequencing. To address this issue, the DREAM Single Cell Transcriptomics Challenge launched a community-wide effort to seek computational solutions for spatial mapping of single cells in tissues using single-cell RNAseq (scRNA-seq) data and a reference atlas obtained from in situ hybridization data. Read More

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How I treat primary ITP in adult patients who are unresponsive to or dependent on corticosteroid treatment.

Blood 2021 Apr 7. Epub 2021 Apr 7.

Massachusetts General Hospital, Boston, Mississippi, United States.

Approximately 80% of adult patients with immune thrombocytopenia (ITP) fail or become dependent on corticosteroids and require second-line therapy. Several new and effective therapies have been introduced during the last decade and our understanding of disease burden and its effect on quality of life has expanded. It is now recommended that splenectomy, the standard second-line therapy for decades, be delayed for at least 12-24 months allowing more patients to achieve remission on medical therapies before considering surgery. Read More

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High concordance of actionable genomic alterations identified between circulating tumor DNA-based and tissue-based next-generation sequencing testing in advanced non-small cell lung cancer: The Korean lung liquid versus invasive biopsy program.

Cancer 2021 Apr 7. Epub 2021 Apr 7.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Because of the growing number of actionable biomarkers in non-small cell lung cancer (NSCLC), sufficient tissue availability for testing is becoming a greater challenge. Liquid biopsy offers a potential solution by complementing standard tissue-based methods. In this study, the authors analyzed the concordance of actionable genomic alterations sequenced from circulating tumor DNA (ctDNA; Guardant360) and tissue (Oncomine Focus Assay). Read More

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Comparison of Conventional Gadoxetate Disodium-Enhanced MRI Features and Radiomics Signatures With Machine Learning for Diagnosing Microvascular Invasion.

AJR Am J Roentgenol 2021 Apr 7:1-11. Epub 2021 Apr 7.

Department of Radiology, Guangxi Medical University First Affiliated Hospital, No. 6 Shuangyong Rd, Nanning, Guangxi 530021, China.

This study aimed to determine the best model for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) using conventional gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadoxetate disodium)-enhanced MRI features and radiomics signatures with machine learning. This retrospective study included 269 patients with a postoperative pathologic diagnosis of HCC. Gadoxetate disodium-enhanced MRI features were assessed, including T1 relaxation time, tumor margin, tumor size, peritumoral enhancement, peritumoral hypointensity, and ADC. Read More

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Biomarkers of coagulation, endothelial function and fibrinolysis in critically-ill patients with COVID-19: A single-centre prospective longitudinal study.

J Thromb Haemost 2021 Apr 7. Epub 2021 Apr 7.

Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.

Background: Immunothrombosis and coagulopathy in the lung microvasculature may lead to lung injury and disease progression in COVID-19. We aim to identify biomarkers of coagulation, endothelial function, and fibrinolysis that are associated with disease severity and may have prognostic potential.

Methods: We performed a single-center prospective study of 14 adult COVID-19(+) ICU patients who were age and sex-matched to 14 COVID-19(-) ICU patients, and healthy controls. Read More

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Indel mutations of sheep gene and their associations with growth traits.

Anim Biotechnol 2021 Apr 7:1-7. Epub 2021 Apr 7.

Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.

is mainly expressed in embryonic development, and it is reported to take an effect on the growth performance of mice, cattle, pigs, and sheep. To explore how conservative the is in different sheep breeds, the effects of the two indel variants on the growth traits of the Chinese Luxi blackhead (LXBH) sheep were firstly detected. The P2-del 30 bp and P4-del 45 bp indel loci of the sheep gene were significantly related to 15 growth traits ( < 0. Read More

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Genome survey and high-resolution genetic map provide valuable genetic resources for Fenneropenaeus chinensis.

Sci Rep 2021 Apr 6;11(1):7533. Epub 2021 Apr 6.

Key Laboratory for Sustainable Utilization of Marine Fisheries Resources of Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, China.

Fenneropenaeus chinensis is one of the most important aquaculture species in China. Research on its genomic and genetic structure not only helps us comprehend the genetic basis of complex economic traits, but also offers theoretical guidance in selective breeding. In the present study, a genome survey sequencing was performed to generate a rough reference genome utilized for groping preliminary genome characteristics and facilitate linkage and quantitative trait locus (QTL) mapping. Read More

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Novel therapies emerging in oncology to target the TGF-β pathway.

J Hematol Oncol 2021 Apr 6;14(1):55. Epub 2021 Apr 6.

Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter or tumor suppressor. As a tumor promoter, the TGF-β pathway enhances cell proliferation, migratory invasion, metastatic spread within the tumor microenvironment and suppresses immunosurveillance. Read More

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Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term.

J Neuropathol Exp Neurol 2021 Apr 6. Epub 2021 Apr 6.

From the Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, Zagreb, Croatia (IK, MR, ŽK); Polyclinic "Neuron", Zagreb, Croatia (MR); Department of Health Psychology, University of Applied Health Sciences, Zagreb, Croatia (MK-S); and Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, School of Medicine, University of Zagreb, Zagreb, Croatia (MK-S).

During the second half of gestation, the human cerebrum undergoes pivotal histogenetic events that underlie functional connectivity. These include the growth, guidance, selection of axonal pathways, and their first engagement in neuronal networks. Here, we characterize the spatiotemporal patterns of cerebral connectivity in extremely preterm (EPT), very preterm (VPT), preterm and term babies, focusing on magnetic resonance imaging (MRI) and histological data. Read More

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A Model-Based Approach for Pulse Selection from Electrodermal Activity.

IEEE Trans Biomed Eng 2021 Apr 6;PP. Epub 2021 Apr 6.

Objective: We present a statistical model for extracting physiologic characteristics from electrodermal activity (EDA) data in observational settings.

Methods: We used insight about the integrate-and-fire physiology of sweat gland bursts, which predicts inverse Gaussian (IG) inter-pulse interval structure. At the core of our model-based paradigm is a subject-specific amplitude threshold selection process for EDA pulses based on the statistical properties of four right-skewed models including the IG. Read More

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Inferring latent heterogeneity using many feature variables supervised by survival outcome.

Stat Med 2021 Apr 5. Epub 2021 Apr 5.

Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

In cancer studies, it is important to understand disease heterogeneity among patients so that precision medicine can particularly target high-risk patients at the right time. Many feature variables such as demographic variables and biomarkers, combined with a patient's survival outcome, can be used to infer such latent heterogeneity. In this work, we propose a mixture model to model each patient's latent survival pattern, where the mixing probabilities for latent groups are modeled through a multinomial distribution. Read More

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Advances In The Comprehensive Management of Post-Operative Crohn's Disease.

Clin Gastroenterol Hepatol 2021 Apr 2. Epub 2021 Apr 2.

Division of Gastroenterology, University of California San Diego, La Jolla, California, USA.

Patients with post-operative Crohn's disease are difficult to manage due to their risk of experiencing a more severe course, multiple symptom confounders and poor sensitivity of symptomatic remission to rule out intestinal inflammation. In this group, data are lacking on biologic therapeutic efficacy and recommendations are lacking for those with multiple medication failures. Novel non-invasive testing can simultaneously exclude alternate causes of symptoms (serum C4, fecal fat, SIBO breath testing) and assess intestinal inflammation (fecal calprotectin, endoscopic healing index). Read More

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Identification of leaf rust resistance genes and in common wheat ( L. ssp. ) lines of different origin using multiplex PCR.

Open Life Sci 2021 20;16(1):172-183. Epub 2021 Feb 20.

Department of Genetics and Plant Breeding, Poznań University of Life Sciences, 11 Dojazd St., Poznań, Poland.

Leaf rust caused by the fungus f. sp. is one of the most dangerous diseases of common wheat. Read More

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February 2021

SSR Markers Suitable for Marker Assisted Selection in Sunflower for Downy Mildew Resistance.

Open Life Sci 2018 Jan 22;13:319-326. Epub 2018 Sep 22.

Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, 34722, Turkey.

The effectiveness of genes is known to be resistant to downy mildew (DM) disease affected by fungus in sunflower. In this study phenotypic analysis was performed using inoculation tests and genotypic analysis were carried out with three DM resistance genes and . A total of 69 simple sequence repeat markers and 241 F individuals derived from a cross of RHA-419 (R) x P6LC (S), RHA-419 (R) x CL (S), RHA-419 (R) x OL (S), RHA419 (R) x 9758R (S), HA-R5 (R) x P6LC (S) and HA89 (R) x P6LC (S) parental lines were used to identify resistant hybrids in sunflower. Read More

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January 2018

Genotyping by Sequencing-Based Discovery of SNP Markers and Construction of Linkage Map from F Population of Pepper with Contrasting Powdery Mildew Resistance Trait.

Biomed Res Int 2021 15;2021:6673010. Epub 2021 Mar 15.

Department of Vegetable Crops, Korea National College of Agriculture and Fisheries, Jeonju 54874, Republic of Korea.

Powdery mildew (PM) is a common fungal disease infecting pepper plants worldwide. Molecular breeding of pepper cultivars with powdery mildew resistance is desirable for the economic improvement of pepper cultivation. In the present study, 188 F population derived from AR1 (PM resistant) and TF68 (PM sensitive) parents were subjected to high-throughput genotyping by sequencing (GBS) for the identification of single nucleotide polymorphism (SNP) markers. Read More

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