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Treatment components in behavioral versus nondirective telephone-assisted self-help interventions for parents of children with externalizing behavior problems.

J Clin Psychol 2021 Sep 24. Epub 2021 Sep 24.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: The aim of this study was to analyze treatment differentiation in a behavioral and a nondirective telephone-assisted self-help intervention for parents of children with externalizing behavior problems, including the development and evaluation of a rating scale.

Methods: In a randomized controlled trial, 149 parents of children aged 4-11 years with externalizing behavior problems were allocated to a behavioral or a nondirective guided self-help intervention. Parents in both conditions received eight self-help booklets and ten telephone consultations. Read More

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September 2021

Primary Septic Arthritis in Children Demonstrates Presumed and Confirmed Varieties Which Require Age-specific Evaluation and Treatment Strategies.

J Pediatr Orthop 2021 Sep 27. Epub 2021 Sep 27.

Children's Health System of Texas Department of Orthopedics, Texas Scottish Rite Hospital for Children Department of Orthopedics and Pediatrics, University of Texas Southwestern, Dallas, TX.

Background: There is uncertainty involved in the evaluation and treatment of children suspected to have septic arthritis particularly when no causative pathogen is confirmed. This study evaluates children with primary septic arthritis to refine the processes of evaluation and treatment and improve the rate of pathogen confirmation.

Methods: Children suspected to have septic arthritis from 2009 to 2019 were retrospectively studied. Read More

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September 2021

Radiomic modeling to predict risk of vertebral compression fracture after stereotactic body radiation therapy for spinal metastases.

J Neurosurg Spine 2021 Sep 24:1-9. Epub 2021 Sep 24.

1Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore.

Objective: In the treatment of spinal metastases with stereotactic body radiation therapy (SBRT), vertebral compression fracture (VCF) is a common and potentially morbid complication. Better methods to identify patients at high risk of radiation-induced VCF are needed to evaluate prophylactic measures. Radiomic features from pretreatment imaging may be employed to more accurately predict VCF. Read More

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September 2021

Machine learning-based biomarkers identification from toxicogenomics - Bridging to regulatory relevant phenotypic endpoints.

J Hazard Mater 2021 Sep 11;423(Pt B):127141. Epub 2021 Sep 11.

Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA; School of Civil and Environmental Engineering, Cornell University, 263 Hollister Hall, Ithaca, NY 14853, USA. Electronic address:

One of the major challenges in realization and implementations of the Tox21 vision is the urgent need to establish quantitative link between in-vitro assay molecular endpoint and in-vivo regulatory-relevant phenotypic toxicity endpoint. Current toxicomics approach still mostly rely on large number of redundant markers without pre-selection or ranking, therefore, selection of relevant biomarkers with minimal redundancy would reduce the number of markers to be monitored and reduce the cost, time, and complexity of the toxicity screening and risk monitoring. Here, we demonstrated that, using time series toxicomics in-vitro assay along with machine learning-based feature selection (maximum relevance and minimum redundancy (MRMR)) and classification method (support vector machine (SVM)), an "optimal" number of biomarkers with minimum redundancy can be identified for prediction of phenotypic toxicity endpoints with good accuracy. Read More

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September 2021

Disease type detection in lung and colon cancer images using the complement approach of inefficient sets.

Authors:
Mesut Toğaçar

Comput Biol Med 2021 Sep 2;137:104827. Epub 2021 Sep 2.

Department of Computer Technology, Technical Sciences Vocational School, Fırat UniversityElazig, Turkey. Electronic address:

Lung and colon cancers are deadly diseases that can develop simultaneously in organs and adversely affect human life in some special cases. Although the frequency of simultaneous occurrence of these two types of cancer is unlikely, there is a high probability of metastasis between the two organs if not diagnosed early. Traditionally, specialists have to go through a lengthy and complicated process to examine histopathological images and diagnose cancer cases; yet, it is now possible to achieve this process faster with the available technological possibilities. Read More

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September 2021

Efficacy of hydrophilic resin-based sealant: A systematic review and meta-analysis.

J Dent 2021 Sep 21:103816. Epub 2021 Sep 21.

Restorative Dentistry, Department of Oral Rehabilitation, The Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Avenue, Charleston, SC, 29425, USA. Electronic address:

Objectives: This meta-analysis review aims to answer two questions: 1) What is the effectiveness of hydrophilic resin-based sealant (RBS) in preventing/arresting pits and fissures caries in permanent teeth, and 2) What is the retention rate of a hydrophilic RBS as compared to alternative treatments.

Data: Randomized control trials investigating the efficacy of hydrophilic RBS compared to any other (placebo) treatment for permanent teeth. Outcomes were retention rate and caries prevention/arresting. Read More

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September 2021

Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review.

Radiother Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. Electronic address:

Patients with locally advanced cervical cancer (LACC) treated with chemoradiation often experience hematologic toxicity (HT), as chemoradiation can induce bone marrow (BM) suppression. Studies on the relationship between BM dosimetric parameters and clinically significant HT might provide relevant indices for developing BM-sparing (BMS) radiotherapy techniques. This systematic review studied the relationship between bone marrow dose and HT in LACC-patients treated with primary cisplatin-based chemoradiation. Read More

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September 2021

Pre-operative factors associated with anesthesia failure for patients undergoing non-surgical root canal therapy, a national dental practice-based research network study.

J Endod 2021 Sep 21. Epub 2021 Sep 21.

Division of TMD and Orofacial Pain, School of Dentistry, University of Minnesota, Minneapolis, Minnesota.

Introduction: The aim of this study was to identify preoperative factors associated with local anesthesia failure.

Methods: The National Dental Practice-Based Research Network (www.NationalDentalPBRN. Read More

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September 2021

Insights on microbial fuel cells for sustainable biological nitrogen removal from wastewater: A review.

Environ Res 2021 Sep 21:112095. Epub 2021 Sep 21.

School of Biochemical Engineering and Technology, Sirindhorn International Institute of Technology, Thammasat University, P.O. Box 22, Pathum Thani, 12121, Thailand. Electronic address:

Microbial fuel cells (MFCs) have emerged as a promising technology for energy-efficient wastewater treatment. The feasibility of integrating biological nitrogen removal into MFC systems has been reported. However, better pollutant removal efficiency and power production need to be achieved at a lower cost for a sustainable wastewater treatment system. Read More

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September 2021

Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study.

Lancet Psychiatry 2021 Sep 21. Epub 2021 Sep 21.

Mental Health Centre, West China Hospital, Sichuan University, Chengdu, China.

Background: In China, depressive disorders have been estimated to be the second leading cause of years lived with disability. However, nationally representative epidemiological data for depressive disorders, in particular use of mental health services by adults with these disorders, are unavailable in China. The present study, part of the China Mental Health Survey, 2012-15, aims to describe the socioeconomic characteristics and the use of mental health services in people with depressive disorders in China. Read More

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September 2021

Genome-wide identification of ZF-HD gene family in Triticum aestivum: Molecular evolution mechanism and function analysis.

PLoS One 2021 24;16(9):e0256579. Epub 2021 Sep 24.

Hubei Collaborative Innovation Center for Grain Industry/Engineering Research Center of Ecology and Agricultural Use of Wetland, Ministry of Education/College of Agriculture, Yangtze University, Jingzhou, China.

ZF-HD family genes play important roles in plant growth and development. Studies about the whole genome analysis of ZF-HD gene family have been reported in some plant species. In this study, the whole genome identification and expression profile of the ZF-HD gene family were analyzed for the first time in wheat. Read More

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September 2021

Noncontrast Cardiac Magnetic Resonance Imaging Predictors of Heart Failure Hospitalization in Heart Failure With Preserved Ejection Fraction.

J Magn Reson Imaging 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

Background: Heart failure patients with preserved ejection fraction (HFpEF) are at increased risk of future hospitalization. Contrast agents are often contra-indicated in HFpEF patients due to the high prevalence of concomitant kidney disease. Therefore, the prognostic value of a noncontrast cardiac magnetic resonance imaging (MRI) for HF-hospitalization is important. Read More

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September 2021

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis.

Cochrane Database Syst Rev 2021 May 4;5:CD013579. Epub 2021 May 4.

Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.

Background: Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably progresses or recurs after first line standard of care. There is no consensus regarding the best treatment/s to offer people upon disease progression or recurrence. For the purposes of this review, progression and recurrence are considered as one entity. Read More

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Pulmonary rehabilitation for interstitial lung disease.

Cochrane Database Syst Rev 2021 Feb 1;2:CD006322. Epub 2021 Feb 1.

Institute for Breathing and Sleep, Melbourne, Australia.

Background: Interstitial lung disease (ILD) is characterised by reduced functional capacity, dyspnoea and exercise-induced hypoxia. Pulmonary rehabilitation is often used to improve symptoms, health-related quality of life and functional status in other chronic lung conditions. There is accumulating evidence for comparable effects of pulmonary rehabilitation in people with ILD. Read More

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February 2021

Radiochemical Evidence for the Contribution of Chemotyped Siderophore Producing Bacteria Towards Plant Iron Nutrition.

Curr Microbiol 2021 Sep 24. Epub 2021 Sep 24.

Division of Microbiology, ICAR-Indian Agricultural Research Institute (IARI), New Delhi, 110012, India.

Fe deficiency is a major challenge that limits agricultural productivity and is a serious human health concern worldwide. Under iron-limiting conditions soil microorganisms produce siderophores, that chelates Fe (ferric) and make it available to the plants. Selection of efficient siderophore producing bacteria and establishing their role in enhancing iron uptake is a strategic approach for improving plant nutrition. Read More

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September 2021

Efficacy and safety of traditional Chinese medicine injections in the treatment of chronic obstructive pulmonary disease: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27324

Chongqing Three Gorges Medical College, Chongqing, China.

Background: Chronic obstructive pulmonary disease (COPD) is a widespread, heterogeneous disease characterized by chronic inflammation of the airway and the gradual blockage of air flow due to bronchial obstruction. At present, a large number of traditional Chinese medicine injections (TCMIs) has been applied in the clinical treatment of COPD. However, there is insufficient evidence of evidence-based medicine of the interaction between them. Read More

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September 2021

Best-fit probability distribution models for monthly rainfall of Northeastern Brazil.

Water Sci Technol 2021 Sep;84(6):1541-1556

Universidade Federal Rural de Pernambuco, Recife, Brasil; Universidade Federal Rural de Pernambuco, Rua Dom Manuel de Medeiros, s/n - Dois Irmãos, Recife, PE 52171-900, Brasil; Programa de Pós-graduação em Biometria e Estatística Aplicada, Recife, Brazil.

The analysis of precipitation data is extremely important for strategic planning and decision-making in various natural systems, as well as in planning and preparing for a drought period. The drought is responsible for several impacts on the economy of Northeast Brazil (NEB), mainly in the agricultural and livestock sectors. This study analyzed the fit of 2-parameter distributions gamma (GAM), log-normal (LNORM), Weibull (WEI), generalized Pareto (GP), Gumbel (GUM) and normal (NORM) to monthly precipitation data from 293 rainfall stations across NEB, in the period 1988-2017. Read More

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September 2021

Enhanced Storage of Anaerobic Bacteria through Polymeric Encapsulation.

ACS Appl Mater Interfaces 2021 Sep 24. Epub 2021 Sep 24.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Live microbes such as lactobacilli have long been used as probiotic supplements and, more recently, have been explored as live biotherapeutic products with the potential to treat a range of conditions. Among these microbes is a category of anaerobes that possess therapeutic potential while exhibiting unique oxygen sensitivity and thus requiring careful considerations in the formulation and storage processes. Existing microbial formulation development has focused on facultative anaerobes with natural oxygen tolerance; a few strategies have been reported for anaerobes with demonstrated oxygen intolerance, warranting novel approaches toward addressing the challenges for these oxygen-sensitive anaerobes. Read More

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September 2021

Resequencing of 301 ramie accessions identifies genetic loci and breeding selection for fiber yield traits.

Plant Biotechnol J 2021 Sep 24. Epub 2021 Sep 24.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, China.

Ramie is an important fiber-producing crop in China; however, the genetic basis of its agronomic traits remains poorly understood. We produced a comprehensive map of genomic variation in ramie based on resequencing of 301 landraces and cultivars. Genetic analysis produced 129 signals significantly associated with six fiber yield-related traits, and several genes were identified as candidate genes for respective traits. Read More

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September 2021

Purebred-crossbred genetic parameters for reproductive traits in swine.

J Anim Sci 2021 Sep 24. Epub 2021 Sep 24.

Department of Animal Science, Iowa State University, Ames IA, USA.

For swine breeding programs, testing and selection programs are usually within purebred (PB) populations located in nucleus units that are generally managed differently and tend to have a higher health level than the commercial herds in which the crossbred (CB) descendants of these nucleus animals are expected to perform. This approach assumes that PB animals selected in the nucleus herd will have CB progeny that have superior performance at the commercial level. There is clear evidence that this may not be the case for all traits of economic importance and, thus, including data collected at the commercial herd level may increase the accuracy of selection for commercial CB performance at the nucleus level. Read More

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September 2021

Factors Influencing the Selection of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Non-Valvular Atrial Fibrillation.

J Cardiovasc Pharmacol Ther 2021 Sep 24:10742484211049919. Epub 2021 Sep 24.

College of Pharmacy, Pusan National University, Busan, Republic of Korea.

Background: Major atrial fibrillation (AF) guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over warfarin, except in rare clinical circumstances based on 4 randomized controlled trials comparing each NOAC with warfarin. We aimed to investigate the current NOAC prescription behaviors in alignment with the recent clinical evidence available.

Method: We conducted a cross-sectional analysis of NOAC-using patients with non-valvular atrial fibrillation (NVAF) who were aged ≥65 years on the index date (July 1, 2018) based on nationwide claims data. Read More

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September 2021

Self-organised pattern formation increases local diversity in metacommunities.

Ecol Lett 2021 Sep 23. Epub 2021 Sep 23.

Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.

Self-organised formation of spatial patterns is known from a variety of different ecosystems, yet little is known about how these patterns affect the diversity of communities. Here, we use a food chain model in which autotroph diversity is described by a continuous distribution of a trait that affects both growth and defence against heterotrophs. On isolated patches, diversity is always lost over time due to stabilising selection, and the local communities settle on one of two alternative stable community states that are characterised by a dominance of either defended or undefended species. Read More

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September 2021

Optimal tax selection under monopoly: emission tax vs carbon tax.

Environ Sci Pollut Res Int 2021 Sep 24. Epub 2021 Sep 24.

School of Economics, Institute of Guangdong High Quality Development, National Economics Research Center, Guangdong University of Finance & Economics (GDUFE), Guangzhou, 510320, People's Republic of China.

Both carbon and emission taxes popularly exist all over the world. Therefore, it is important to compare carbon with emission tax. Under monopolization, this article establishes game theory model to compare carbon with emission tax. Read More

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September 2021

Brief Report: Feasibility of the Probabilistic Reversal Learning Task as an Outcome Measure in an Intervention Trial for Individuals with Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 23. Epub 2021 Sep 23.

Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

Cognitive flexibility deficits are a hallmark feature of autism spectrum disorder (ASD), but few evidence-based behavioral interventions have successfully addressed this treatment target. Outcome measurement selection may help account for previous findings. The probabilistic reversal learning task (PRL) is a measure of cognitive flexibility previously validated for use in ASD, but its use as an outcome measure has not yet been assessed. Read More

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September 2021

Development and Validation of a Nomogram to Predict the 180-Day Readmission Risk for Chronic Heart Failure: A Multicenter Prospective Study.

Front Cardiovasc Med 2021 7;8:731730. Epub 2021 Sep 7.

Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), Cardiology, Shantou, China.

The existing prediction models lack the generalized applicability for chronic heart failure (CHF) readmission. We aimed to develop and validate a widely applicable nomogram for the prediction of 180-day readmission to the patients. We prospectively enrolled 2,980 consecutive patients with CHF from two hospitals. Read More

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September 2021

An Corrosion Model for Biomedical Applications for Coupling With Biocompatibility Tests for Estimation of Long-Term Effects.

Front Bioeng Biotechnol 2021 7;9:718026. Epub 2021 Sep 7.

SPARTHA Medical, Strasbourg, France.

The release of metal particles and ions due to wear and corrosion is one of the main underlying reasons for the long-term complications of implantable metallic implants. The rather short-term focus of the established biocompatibility tests cannot take into account such effects. Corrosion behavior of metallic implants mostly investigated in body-like environments for long time periods and their coupling with long-term experiments are not practical. Read More

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September 2021

Preoperative Prediction of Microvascular Invasion in Patients With Hepatocellular Carcinoma Based on Radiomics Nomogram Using Contrast-Enhanced Ultrasound.

Front Oncol 2021 7;11:709339. Epub 2021 Sep 7.

Department of Internal Medicine, Hirslanden Clinic, Bern, Switzerland.

Purpose: This study aimed to develop a radiomics nomogram based on contrast-enhanced ultrasound (CEUS) for preoperatively assessing microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.

Methods: A retrospective dataset of 313 HCC patients who underwent CEUS between September 20, 2016 and March 20, 2020 was enrolled in our study. The study population was randomly grouped as a primary dataset of 192 patients and a validation dataset of 121 patients. Read More

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September 2021

National Resident Matching Program Performance Among US MD and DO Seniors in the Early Single Accreditation Graduate Medical Education Era.

Cureus 2021 Aug 20;13(8):e17319. Epub 2021 Aug 20.

Pathology, Kansas City University College of Osteopathic Medicine, Kansas City, USA.

Introduction: As of the 2020 National Resident Matching Program (NRMP), nearly all applicants are evaluated together for graduate medical education (GME) candidacy. We set out to characterize US MD and DO Senior residency match performance in the single-accreditation GME era.

Methods: A retrospective study was conducted in 2021 utilizing data collected from the 2018 and 2020 NRMP Charting Outcomes in the Match publications aggregated and subdivided into three groups based on competitiveness: low (LC), moderate (MC), and high (HC). Read More

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Towards a pragmatic use of statistics in ecology.

PeerJ 2021 1;9:e12090. Epub 2021 Sep 1.

Departamento de Ecologia/Instituto de Biociências, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Although null hypothesis testing (NHT) is the primary method for analyzing data in many natural sciences, it has been increasingly criticized. Recently, approaches based on information theory (IT) have become popular and were held by many to be superior because it enables researchers to properly assess the strength of the evidence that data provide for competing hypotheses. Many studies have compared IT and NHT in the context of model selection and stepwise regression, but a systematic comparison of the most basic uses of statistics by ecologists is still lacking. Read More

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September 2021