496,533 results match your criteria selected human

RIPK1 regulates cell function and death mediated by UVB radiation and TNF-α.

Mol Immunol 2021 May 5;135:304-311. Epub 2021 May 5.

College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. Electronic address:

The RIP family plays a key role in mediating cell inflammation, oxidative stress and death. Among them, RIPK1, as an important regulatory factor in the upstream of the NF-κB pathway, is involved in multiple pathways of cell inflammation and death. Epidermal cells constitute the outermost barrier of the human body. Read More

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Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain.

Eur J Pharmacol 2021 May 5:174152. Epub 2021 May 5.

State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; Shanghai Duomirui Biotechnology Co., Ltd., Shanghai, 201203, China. Electronic address:

Antigen-binding fragments (Fabs) are preferred alternatives to antibodies for medical application, whereas their short half-lives limit therapeutic effectiveness. Albumin binding domain (ABD) with high affinity for albumin possesses a great potential in enhancing in vivo performance of biotherapeutics. In this study, to mitigate the poor pharmacokinetics of adalimumab Fab targeting tumor necrosis factor-α (TNFα), an ABD fusion strategy was applied innovatively using GA3, ABD035, ABD094 and ABDCon with high affinities for albumin. Read More

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An intelligence design for detection and classification of COVID19 using fusion of classical and convolutional neural network and improved microscopic features selection approach.

Microsc Res Tech 2021 May 8. Epub 2021 May 8.

College of Computer Engineering and Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Coronavirus19 is caused due to infection in the respiratory system. It is the type of RNA virus that might infect animal and human species. In the severe stage, it causes pneumonia in human beings. Read More

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Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping.

Int Endod J 2021 May 8. Epub 2021 May 8.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Aim: To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis.

Methodology: The Gene Expression Omnibus (GEO) database, an international public repository of genomics datasets, was searched for human microarray datasets assessing pulpitis. An irreversible pulpitis gene expression signature was generated by differential expression analysis. Read More

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Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes.

Arch Pharm (Weinheim) 2021 May 8:e2100082. Epub 2021 May 8.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Small molecules have gained considerable interest in regenerative medicine, as they can effectively modulate cell fates in a spatiotemporal controllable fashion. A continuous challenge in the field represents genuine mimicry or activation of growth factor signaling with small molecules. Here, we selected and profiled three compounds for their capacity to directly or indirectly activate endogenous FGF-2, VEGF, or SHH signaling events in the context of skin regeneration. Read More

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An RNAi screening of clinically relevant transcription factors regulating human adipogenesis and adipocyte metabolism.

Endocrinology 2021 May 8. Epub 2021 May 8.

Lipid laboratory, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, SE-14186, Sweden.

Objective: Healthy hyperplasic (many but smaller fat cells) white adipose tissue (WAT) expansion is mediated by recruitment, proliferation and/or differentiation of new fat cells. This process (adipogenesis) is controlled by transcriptional programs mostly identified in rodents. A systemic investigation of adipogenic human transcription factors (TFs) that are relevant for metabolic conditions has not been revealed previously. Read More

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strains producing selected bacteriocins inhibit porcine enterotoxigenic (ETEC) both under and conditions.

Appl Environ Microbiol 2021 May 7. Epub 2021 May 7.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

Enterotoxigenic (ETEC) and Shiga toxin-producing (STEC) strains are the causative agents of severe foodborne diseases in both humans and animals. In this study, porcine pathogenic strains (n = 277) as well as porcine commensal strains (n = 188) were tested for their susceptibility to 34 bacteriocin monoproducers to identify the most suitable bacteriocin types inhibiting porcine pathogens. Under condition, the set of pathogenic was found to be significantly more susceptible to a majority of tested bacteriocins when compared to commensal Based on production of bacteriocins with specific activity against pathogen, three potentially probiotic commensal strains of human origin were selected. Read More

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Real-World Effectiveness of Mepolizumab in Severe Eosinophilic Asthma: A Systematic Review and Meta-analysis.

Clin Ther 2021 May 4. Epub 2021 May 4.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China. Electronic address:

Purpose: Mepolizumab is a human monoclonal antibody against interleukin 5 (IL-5) used to treat severe eosinophilic asthma. Several studies have evaluated the effectiveness of mepolizumab in the real world. We conducted a systematic review and meta-analysis in the context of heterogeneity among patients, clinicians, and treatment regimens to study the effectiveness of mepolizumab in the real world. Read More

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Association between socioeconomic status and prolonged television viewing time in a general Japanese population: NIPPON DATA2010.

Environ Health Prev Med 2021 May 7;26(1):57. Epub 2021 May 7.

Department of Public Health, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga, 520-2192, Japan.

Background: It has been pointed out that prolonged television (TV) viewing is one of the sedentary behaviors that is harmful to health; however, the association between socioeconomic status (SES) and prolonged TV viewing time has not been sufficiently investigated in Japan.

Methods: The study population are the participants of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey 2010 in Japan. They were residents in 300 randomly selected areas across Japan. Read More

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Ultra-low coverage whole genome sequencing of ccfDNA in multiple myeloma: A tool for laboratory routine?

Cancer Treat Res Commun 2021 Apr 25;28:100380. Epub 2021 Apr 25.

Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Multiple myeloma (MM), is a heterogeneous disease in which chromosomal abnormalities are important for prognostic risk stratification. Cytogenetic profiling with FISH on plasma cells from bone marrow samples (BM-PCs) is the current gold standard, but variable infiltration of plasma cells or failed aspiration can hamper this process. Ultra-low coverage sequencing (ULCS) of circulating cell-free DNA (ccfDNA) may offer a minimally invasive alternative for the work-up of these cases. Read More

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Effect of the replacement of tripodal 4N donors by two 2N chelators on the redox and cytotoxic activity of maltolato and deferipronato containing Co(III) complexes.

J Inorg Biochem 2021 Jan 28;220:111372. Epub 2021 Jan 28.

Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4032 Debrecen, Egyetem tér 1, Hungary. Electronic address:

Fourteen novel Co ternary complexes with the general formula [Co(4N)(2O)]X or [Co(2N)(2O)]X where 4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa); 2N = 1,10-phenantroline (phen), 2,2'-bipyridine (bipy), 1,2-diaminoethane (en) or 2-(aminomethyl)pyridine (ampy) and 2O = 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone (dhpH), 3-hydroxy-2-methyl-4-pyrone (maltH) or 2-ethyl-3-hydroxy-4H-pyran-4-one (etmaltH) were synthesized, characterized and their redox features explored. Molecular structure of some selected [Co(2N)(2O)](ClO) (2N = phen, bipy, en; 2O = dhp, malt) or [Co(4N)(2O)](ClO) (4N = tpa; 2O = etmalt) type complexes were assessed by X-ray diffraction and showed the expected octahedral geometry. Replacement of the 4N donor ligands by two 2N donor ligands resulted in the decrease of the cathodic peak potential of the complexes indicating easier reduction and allowing therefore the tailoring of the redox properties of the complexes. Read More

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January 2021

CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis.

Toxicol Lett 2021 May 4. Epub 2021 May 4.

School of Public Health, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China. Electronic address:

For smoking-induced pulmonary fibrosis (PF), a serious disease endangering human health, there is no effective clinical treatment. Aberrant epithelium-fibroblast cross-talk is involved in formation of the excessive extracellular matrix (ECM) that contributes to PF. Circular RNAs have been associated with various pulmonary diseases. Read More

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Speed-related but not detrended gait variability increases with more sensitive self-paced treadmill controllers at multiple slopes.

PLoS One 2021 7;16(5):e0251229. Epub 2021 May 7.

Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, United States of America.

Self-paced treadmills are being used more frequently to study humans walking with their self-selected gaits on a range of slopes. There are multiple options to purchase a treadmill with a built-in controller, or implement a custom written self-paced controller, which raises questions about how self-paced controller affect treadmill speed and gait biomechanics on multiple slopes. This study investigated how different self-paced treadmill controller sensitivities affected gait parameters and variability on decline, level, and incline slopes. Read More

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Commercially Available Apps to Support Healthy Family Meals: User Testing of App Utility, Acceptability, and Engagement.

JMIR Mhealth Uhealth 2021 May 7;9(5):e22990. Epub 2021 May 7.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Background: Parents juggling caregiving and paid employment encounter a range of barriers in providing healthy food to their families. Mobile apps have the potential to help parents in planning, purchasing, and preparing healthy family food. The utility and acceptability of apps for supporting parents are unknown. Read More

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Correlations between DW-MRI and F-FDG PET/CT parameters in head and neck squamous cell carcinoma following definitive chemo-radiotherapy.

Cancer Rep (Hoboken) 2021 May 7:e1360. Epub 2021 May 7.

School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital, King's College, London, UK.

Background: Posttreatment diffusion-weighted magnetic resonance imaging (DW-MRI) and 18F-fluorodeoxygluocose ( F-FDG) positron emission tomography (PET) with computed tomography (PET/CT) have potential prognostic value following chemo-radiotherapy (CRT) for head and neck squamous cell carcinoma (HNSCC). Correlations between these PET/CT (standardized uptake value or SUV) and DW-MRI (apparent diffusion coefficient or ADC) parameters have only been previously explored in the pretreatment setting.

Aim: To evaluate stage III and IV HNSCC at 12-weeks post-CRT for the correlation between SUV and ADC values and their interval changes from pretreatment imaging. Read More

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Progression of behavioral deficits during periadolescent development differs in female and male DISC1 knockout rats.

Genes Brain Behav 2021 May 7:e12741. Epub 2021 May 7.

Department of Psychology, Colby College, Waterville, Maine, USA.

Mutations in the disrupted in schizophrenia-1 (DISC1) gene are associated with an increased risk of developing psychological disorders including schizophrenia, bipolar disorder, and depression. Assessing the impact of knocking out genes, like DISC1, in animal models provides valuable insights into the relationship between the gene and behavioral outcomes. Previous research has relied on mouse models to assess these impacts, however these may not yield as reliable or rich a behavioral analysis as can be obtained using rats. Read More

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Establishment of an Agrobacterium-mediated genetic transformation and CRISPR/Cas9-mediated targeted mutagenesis in Hemp (Cannabis Sativa L.).

Plant Biotechnol J 2021 May 7. Epub 2021 May 7.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, Hunan, China.

Hemp (Cannabis sativa L.) is an annual and typically dioecious crop. Due to the therapeutic potential for human diseases, phytocannabinoids as a medical therapy is getting more attention recently. Read More

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Validity of claims-based algorithms for selected cancers in Japan: Results from the VALIDATE-J study.

Pharmacoepidemiol Drug Saf 2021 May 7. Epub 2021 May 7.

Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA.

Purpose: Real-world data from large administrative claims databases in Japan have recently become available, but limited evidence exists to support their validity. VALIDATE-J validated claims-based algorithms for selected cancers in Japan.

Methods: VALIDATE-J was a multicenter, cross-sectional, retrospective study. Read More

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Computational study on subfamilies of piperidine derivatives: QSAR modelling, model external verification, the inter-subset similarity determination, and structure-based drug designing.

SAR QSAR Environ Res 2021 May 7:1-30. Epub 2021 May 7.

Chemometrics Laboratory, Chemistry Department, Faculty of Science, University of Kurdistan, Sanandaj, Iran.

A new subset of furan-pyrazole piperidine derivatives was used for QSAR model development. These compounds exhibit good Akt1 inhibitory activity; moreover, antiproliferative activities in vitro against OVCAR-8 (Human ovarian carcinoma cells) and HCT116 (human colon cancer cells), were confirmed for them. Based on the relevant three-dimensional (3D) and 2D autocorrelation descriptors, selected by genetic algorithm (GA), multiple linear regression (MLR) was established on half maximal-inhibitory concentration (IC), in Akt1 and cancer cell lines independently. Read More

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Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat-A systematic review and meta-analysis.

Obes Rev 2021 May 6:e13269. Epub 2021 May 6.

Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière hospital, Department of Nutrition, Institute of Cardiometabolism and Nutrition, Sorbonne University, Paris, France.

This systematic review examined the impact of exercise intervention programs on selected cardiometabolic health indicators in adults with overweight or obesity. Three electronic databases were explored for randomized controlled trials (RCTs) that included adults with overweight or obesity and provided exercise-training interventions. Effects on blood pressure, insulin resistance (homeostasis model of insulin resistance, HOMA-IR), and magnetic resonance measures of intrahepatic fat in exercise versus control groups were analyzed using random effects meta-analyses. Read More

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Occupational stressors in oncology nurses: A qualitative descriptive study.

J Clin Nurs 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Aim And Objectives: The present study aims at exploring oncology nurses' perceptions regarding work-related stressors.

Background: Oncology nurses work in an environment with a high degree of stress, which can negatively affect their health. There is limited research on work-related stressors from the oncology nurses' perspective. Read More

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Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.

Drug Saf 2021 May 6. Epub 2021 May 6.

Department of Dermatology, San Gallicano Dermatological Institute-IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy.

Three cyclin-dependent kinases 4/6, including palbociclib, ribociclib, and abemaciclib, have been approved for the treatment of patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. The objective of this study was to evaluate the occurrence and clinical spectrum of cutaneous adverse events in patients with breast cancer following therapy with cyclin-dependent kinase 4/6 inhibitors. A systematic literature search was performed in the PubMed, Cochrane, and EMBASE databases up to November 2020 to evaluate studies published from 2015 to 2020. Read More

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A comprehensive bibliometric overview: antibiotic resistance and Escherichia coli in natural water.

Environ Sci Pollut Res Int 2021 May 6. Epub 2021 May 6.

Department of Environmental Engineering, Istanbul University-Cerrahpasa, 34320, Istanbul, Turkey.

The environment is the most important reservoir for both resistance mechanisms and gene transfer in biological science studies. This study gives a bibliometric overview of studies of "antibiotic resistance" and "Escherichia coli" in the field of "Agricultural and Biological Sciences" from 2015 to 2019 to assess both research trends and scholarly networks in diverse research disciplines. The two keywords of "antibiotic resistance" and "Escherichia coli" were selected to search in the Scopus database. Read More

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Updates to HCOP: the HGNC comparison of orthology predictions tool.

Brief Bioinform 2021 May 6. Epub 2021 May 6.

HUGO Gene Nomenclature Committee (HGNC), European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Multiple resources currently exist that predict orthologous relationships between genes. These resources differ both in the methodologies used and in the species they make predictions for. The HGNC Comparison of Orthology Predictions (HCOP) search tool integrates and displays data from multiple ortholog prediction resources for a specified human gene or set of genes. Read More

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Evaluating the Potential Benefit of a Combined Weight Loss Program in Dogs and Their Owners.

Front Vet Sci 2021 20;8:653920. Epub 2021 Apr 20.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

Little has been published on the psychological bond between the owner and the pet, and how this might influence shared habits that could lead to overweight and obesity. Another factor that could improve the effectiveness of a weight loss plan, is that the owner would see the dog as a weight loss partner and therefore this could increase the motivation to follow the assigned diet and exercise guidelines. The aim of this research was to evaluate the potential mutual effects of weight loss programs for both dogs and dog owners. Read More

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Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations.

World J Hepatol 2021 Apr;13(4):504-514

Viral Hepatitis Laboratory, FIOCRUZ, Rio de Janeiro 21040360, Brazil.

Background: To achieve the elimination of hepatitis B and C, there is an urgent need to develop alternative strategies to increase the access of diagnosis, particularly among key populations such as people living with human immunodeficiency virus (HIV), individuals with coagulopathies and chronic kidney disease (CKD) patients.

Aim: To evaluate the use of dried blood spot (DBS) in the detection of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers.

Methods: A total of 430 individuals comprised of people living with HIV, coagulopathies and CKD provided paired serum and DBS samples. Read More

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Efficiency of Nebulizing Furosemide in the Treatment of Chronic Pulmonary Obstructive Disease: A Systematic Review and Meta-Analysis of Clinical Trials.

Tanaffos 2020 Dec;19(4):340-349

Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.

Background: Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in humans. Among both oral and intravenous diuretics, nebulizing furosemide (Lasix) is the most commonly used agent. The purpose of this study was to ascertain the therapeutic effects of nebulizing furosemide compared with placebo in the treatment of COPD using a systematic review and meta-analysis of clinical trials. Read More

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December 2020

A Novel User Emotional Interaction Design Model Using Long and Short-Term Memory Networks and Deep Learning.

Front Psychol 2021 20;12:674853. Epub 2021 Apr 20.

School of Design, Jiangnan University, Wuxi, China.

Emotional design is an important development trend of interaction design. Emotional design in products plays a key role in enhancing user experience and inducing user emotional resonance. In recent years, based on the user's emotional experience, the design concept of strengthening product emotional design has become a new direction for most designers to improve their design thinking. Read More

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Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.

Sci Rep 2021 May 6;11(1):9733. Epub 2021 May 6.

Division of Nuclear Medicine and Molecular Imaging, Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.

Treatment of cancers in the lung remains a critical challenge in the clinic for which gene therapy could offer valuable options. We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under the control of the cancer-selective progression elevated gene 3 (PEG-3) promoter, to treat tumors in the lungs of diseased mice. A clinically tested, untargeted, polyethylenimine carrier was selected to aid rapid transition to clinical studies, and a CpG-free plasmid backbone and coding sequences were used to reduce inflammation. Read More

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Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis.

Sci Rep 2021 May 6;11(1):9693. Epub 2021 May 6.

Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265 Str., 30-663, Kraków, Poland.

Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA. Here, potential associations between osteogenesis-linked gene expression profile in particular monocyte subpopulations and clinical signs of SpA were investigated. Read More

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