5,827 results match your criteria selected excision

Is local excision sufficient in selected grade 1 or 2 type III gastric neuroendocrine neoplasms?

Endocrine 2021 Jun 12. Epub 2021 Jun 12.

Neuroendocrine Tumour Unit, Centre for Gastroenterology, ENETS Centre of Excellence, Royal Free Hospital, London, UK.

Purpose: Type III gastric neuroendocrine neoplasms (g-NENs) have historically been regarded as aggressive tumours, hence current guidelines advocate radical surgery with lymph node dissection. Data on the roles of endoscopic or less extensive surgical resections are more limited. The aim of our study is to evaluate the clinicopathological features and long-term outcomes of patients undergoing endoscopic or limited surgical resection for localised grade 1 or 2 type III g-NENs when compared to radical surgery. Read More

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Clinical and oncological outcomes of surgery in Anorectal melanoma in Asian population: A 15 year analysis at a tertiary cancer institute.

Cancer Treat Res Commun 2021 Jun 10;28:100415. Epub 2021 Jun 10.

Department of Surgical Oncology, The Gujarat Cancer and Research Institute, Civil Hospital Campus, Medicity, Asarwa, Ahmedabad, Gujarat, India.

Introduction: Anorectal malignant melanoma (ARMM) is an aggressive malignancy with dismal prognosis and a 5-year survival rate less than 20% in most of the previous studies. The ideal surgical treatment has still remained controversial. This retrospective study aims at analysing the outcome in patients with ARMM treated with curative surgical resection. Read More

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Use of flaps in inguinal lymphadenectomy in metastatic penile cancer.

Int Braz J Urol 2021 Jun 10;47. Epub 2021 Jun 10.

Unidade de Pesquisa Urogenital, Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, RJ, Brasil.

Purpose: Reviewing surgical procedures using fasciocutaneous and myocutaneous flaps for inguinal reconstruction after lymphadenectomy in metastatic penile cancer.

Material And Methods: We reviewed the current literature of the Pubmed database according to PRISMA guidelines. The search terms used were "advanced penile cancer", "groin reconstruction", and "inguinal reconstruction", both alone and in combination. Read More

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An Optimal Surgical Plane for Laparoscopic Functional Total Mesorectal Excision in Rectal Cancer.

J Gastrointest Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.

Background: Intraoperative damage of pelvic autonomic nerves is the primary reason for postoperative sexual and urinary dysfunction after rectal cancer surgery,1,2 especially in patients with low rectal cancer. In the present study, we developed the nerve plane as a novel concept in rectal cancer surgery, which served as a landmark for better preservation of pelvic autonomic nerves in standardized total mesorectal excision (TME) surgery. The nerves never exist alone, and are always surrounded by tiny capillaries and adipose tissue, which are covered by a thin layer of membranous tissue, leading to a continuous plane, which we defined as the nerve plane. Read More

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Doppler-guided hemorrhoidal artery ligation with suture mucopexy compared with LigaSure™-assisted pile excision for the treatment of grade III hemorrhoids: a prospective randomized controlled trial.

Minerva Surg 2021 Jun;76(3):264-270

Emergency Department, Puzi Hospital, Taiwan, China.

Background: Doppler-guided hemorrhoid artery ligation and stapled hemorrhoidopexy have been used in surgical practices to avoid post-hemorrhoidectomy pain. Our study compared Doppler-guided hemorrhoid artery ligation with suture mucopexy (DGHAL-SM) and ligature-assisted pile excision (LAP) for greater than three grades of internal hemorrhoids.

Methods: Eighty patients with greater than 3 grades of internal hemorrhoids were selected (age range: 20-28 years; average age: 23 years) between January and June 2015. Read More

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Botulinum Neurotoxin Type A as an Adjuvant to Reduce Scarring After Dermatological Surgery.

Dinesh Maini

J Drugs Dermatol 2021 Jun;20(6):677-680

Botulinum neurotoxin type A (BoNTA) is thought to have biological effects beyond muscle paralysis, including direct effects on wound healing. This provides a potential rationale for adjuvant intradermal BoNTA injection in selected patients undergoing minor dermatological surgeries, such as sebaceous cyst or intradermal naevus excision, which often lead to problematic scarring. Case studies are presented showing that BoNTA treatment may be associated with more rapid post-procedural healing and less visible scarring. Read More

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Recurrence in Oral Premalignancy: Clinicopathologic and Immunohistochemical Analysis.

Diagnostics (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Oral leukoplakia (OL) has a propensity for recurrence and malignant transformation (MT). Herein, we evaluate sociodemographic, clinical, microscopic and immunohistochemical parameters as predictive factors for OL recurrence, also comparing primary lesions (PLs) with recurrences. Thirty-three patients with OL, completely removed either by excisional biopsy or by laser ablation following incisional biopsy, were studied. Read More

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Rectourethral Fistula Repair Using Robotic Transanal Minimally Invasive Surgery (TAMIS) Approach.

Urology 2021 May 29. Epub 2021 May 29.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Small non-irradiated rectourethral fistula (RUF) without tissue necrosis or peri-fistula abscess are often treated via a trans-sphincteric or transperineal approach. Attempts at transanal rectal advancement flap to reduce associated morbidity have been widely abandoned due to poor visualization, inability to close the urethral defect in a watertight fashion, and compromise of rectal flap vascularity. Robotic transanal minimally invasive surgery (R-TAMIS) has emerged as a useful tool to address distal rectal lesions as it provides enhanced visualization and surgical dexterity. Read More

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What management for patients with R1 resection after total mesorectal excision for rectal cancer? A review of the literature.

J Visc Surg 2021 May 25. Epub 2021 May 25.

Department of Digestive Surgery, CHU de Nimes, University Montpellier, Nimes, France.

Aim Of The Study: Treatment for rectal cancer is very standardized. However, for total mesorectal excision (TME) with positive margins at microscopic pathological examination (classified R1 ), there is no consensus regarding management. The objective of this update was, through a review of the literature, to identify the most suitable management to improve overall survival and/or recurrence-free survival after R1 TME for rectal cancer. Read More

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Non-conventional applications for Transanal endoscopic microsurgery. A single centre experience and a systematic review of literature.

Minerva Surg 2021 May 28. Epub 2021 May 28.

General Surgery Department, Careggi Hospital, University of Florence, Florence, Italy.

Background: Transanal endoscopic microsurgery (TEM) and Transanal endoscopic operation (TEO) have been initially described for local excision of rectal adenomas and selected cases of rectal carcinomas. In the past decade, however, several new indications raised, and others could raise in the future. The aim of this review was to evaluate, both in the literature and in our personal experience, the use of TEM and TEO for nonconventional applications, different from rectal tumors. Read More

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Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids.

BMC Surg 2021 May 22;21(1):256. Epub 2021 May 22.

Department of Plastic Surgery, The First Hospital of China Medical University, 155 Nanjing North Road, Heping District, Shenyang, 110001, China.

Background: Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy and triamcinolone acetonide injection is considered to be the proper choice for comprehensive treatment of auricular keloids. This study aimed at evaluating the therapeutic effect of individualized surgery combined with radiotherapy for the treatment of auricular keloids. Read More

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Systematic review of transanal total mesorectal excision literature according to the ideal framework: The evolution never ends.

Surgery 2021 May 18. Epub 2021 May 18.

General Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. Electronic address: https://twitter.com/AlbertoBiondi78.

Background: Designing studies to assess critically novel procedures can be challenging; thus, the process to achieve robust evidence is frequently problematic. The aim of this systematic review was to evaluate if literature on transanal total mesorectal excision is evolving according to the Idea, Development, Exploration, Assessment, and Long-term results framework.

Methods: Literature on transanal total mesorectal excision was searched according to the preferred reporting items for systematic reviews and meta-analyses statement, and these variables were recorded: bibliometric data, design, corresponding author's nationality, number of patients enrolled, and Idea, Development, Exploration, Assessment, and Long-term results stages (stage 0, stage 1, stage 2, stage 3, and stage 4). Read More

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Management of high-grade squamous intraepithelial lesion patients with positive margin after LEEP conization: A retrospective study.

Medicine (Baltimore) 2021 May;100(20):e26030

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.

Abstract: To explore the optimal way to manage patients with high-grade squamous intraepithelial lesion (HSIL) and positive margin by identifying the risk factors for its recurrence and residue.A retrospective study was conducted on 267 cases of a pathologically confirmed HSIL with positive margin following conization by loop electrosurgical excisional procedure (LEEP) between January 2010 and December 2015. One hundred two cases were selected for regular follow-up every 6 months, and 165 cases were selected for a second surgery (repeat cervical conization or hysterectomy) within 3 months of initial LEEP. Read More

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Clinical Relevance of Tubular Breast Carcinoma: Large Retrospective Study and Meta-Analysis.

Front Oncol 2021 29;11:653388. Epub 2021 Apr 29.

Pathology Unit, Department of Medical Sciences, University of Turin, Turin, Italy.

Tubular carcinoma (TC) is a low proliferative grade 1 (G1) breast cancer (BC). Despite its favorable outcome and allegedly lower aggressiveness, patients are treated like other luminal G1 BC, with radiotherapy (RT) and hormonal therapy (HT). We performed: (1) a retrospective study comparing a TC cohort and a control series of luminal G1 BC and (2) a systematic review and meta-analysis focused on TC outcome. Read More

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Application of OSNA Nomogram in Patients With Macrometastatic Sentinel Lymph Node: A Retrospective Assessment of Accuracy.

Breast Cancer (Auckl) 2021 10;15:11782234211014796. Epub 2021 May 10.

Division of Breast Surgical Oncology, Department of Medical and Surgical Maternal-Infantile and Adult Sciences, University Hospital of Modena, Modena, Italy.

Introduction: Almost 50% to 70% of patients who undergo axillary lymph node dissection (ALND) because of a single metastatic sentinel lymph node (SLN) have no further metastatic nodes at the axillary histology. On these grounds, the one-step nucleic acid amplification (OSNA) nomogram was designed and validated. As a mathematical model, calculated through tumor size (expressed in millimeters) and CK19 mRNA copy number, it is thought to predict nonsentinel lymph node (NSLN) status. Read More

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Influence of Minimally Invasive Resection Technique on Sphincter Preservation and Short-term Outcome in Low Rectal Cancer in the Netherlands.

Dis Colon Rectum 2021 May 13. Epub 2021 May 13.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, Netherlands Department of Surgery, Amphia, Breda, Netherlands Department of Surgery, Reinier de Graaf Hospital, Delft, the Netherlands. Department of Surgery, Amsterdam University Medical Centers, Free University Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands Department of Surgery, Gelderse Vallei Hospital, Ede, the Netherlands.

Background: Transanal and robotic-assisted total mesorectal excision are techniques that can potentially overcome challenges encountered with a pure laparoscopic approach in patients with rectal cancer.

Objective: The aim of this study was to evaluate the proportion and predictive factors of restorative procedures and subsequent short-term outcomes of three minimally invasive techniques to treat low rectal cancer.

Design: This is a nationwide observational comparative registry study. Read More

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Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study.

J Surg Oncol 2021 May 14. Epub 2021 May 14.

Department of Surgery, Isala Hospital Zwolle, Zwolle, the Netherlands.

Background: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT).

Methods: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I-III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Read More

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Outcomes and complications following minimally invasive excision of synovial cysts of the lumbar spine: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 Jul 4;206:106667. Epub 2021 May 4.

University Hospitals Cleveland Medical Centre, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

Objective: Lumbar synovial cysts (LSC) are one of the manifestations of spinal degenerative cascade. Spinal stenosis or presence of instability in these patients can lead to various symptoms and surgery is indicated following failure of non-operative management for symptomatic synovial cysts. Surgery when performed consists of either decompression with resection of cyst with our without fusion. Read More

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Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects.

NPJ Breast Cancer 2021 May 12;7(1):52. Epub 2021 May 12.

School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.

Bi-allelic loss-of-function (LoF) variants in the base excision repair (BER) gene NTHL1 cause a high-risk hereditary multi-tumor syndrome that includes breast cancer, but the contribution of heterozygous variants to hereditary breast cancer is unknown. An analysis of 4985 women with breast cancer, enriched for familial features, and 4786 cancer-free women revealed significant enrichment for NTHL1 LoF variants. Immunohistochemistry confirmed reduced NTHL1 expression in tumors from heterozygous carriers but the NTHL1 bi-allelic loss characteristic mutational signature (SBS 30) was not present. Read More

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Genome-wide identification of 5-methylcytosine sites in bacterial genomes by high-throughput sequencing of MspJI restriction fragments.

PLoS One 2021 11;16(5):e0247541. Epub 2021 May 11.

Research Department, New England Biolabs, Ipswich, Massachusetts, United States of America.

Single-molecule Real-Time (SMRT) sequencing can easily identify sites of N6-methyladenine and N4-methylcytosine within DNA sequences, but similar identification of 5-methylcytosine sites is not as straightforward. In prokaryotic DNA, methylation typically occurs within specific sequence contexts, or motifs, that are a property of the methyltransferases that "write" these epigenetic marks. We present here a straightforward, cost-effective alternative to both SMRT and bisulfite sequencing for the determination of prokaryotic 5-methylcytosine methylation motifs. Read More

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Selective oestrogen receptor modulators (SERMs) for endometriosis.

Cochrane Database Syst Rev 2021 May 11;5:CD011169. Epub 2021 May 11.

Isala Hospitals Zwolle, Zwolle, Netherlands.

Background: Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. This chronic and recurring condition occurs in women of reproductive age. It is a common cause of pain or infertility and can cause non-specific symptoms such as lower back pain, dyspareunia (pain during or after intercourse), and dysmenorrhoea (menstrual pain). Read More

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Glenohumeral Arthrodesis Using Pelvic Reconstruction Plates: a Series of 15 Patients.

Ortop Traumatol Rehabil 2021 Apr;23(2):59-64

Artemis Hospital, Gurgaon, Haryana, India.

Background: Glenohumeral joint arthrodesis has become a rare entity due to the introduction of shoulder arthroplasty. It is an excellent salvage procedure for patients with severe shoulder dysfunction, with limited treatment options, indicated for brachial plexus injury, tumour resection, chronic infection, failed prosthetic arthroplasty, or pseudoparalysis of the shoulder due to combined rotator cuff and deltoid deficiency. Shoulder arthrodesis relieves the patient of pain and gives a decent amount of function. Read More

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Urachal Pathology: Review of Cases.

Urol Int 2021 May 6:1-4. Epub 2021 May 6.

Department of Urology, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Introduction: The urachus is an embryologic remnant which is formed from the obliteration of the allantois. Urachal abnormalities are caused when defective obliteration of the urachus happens. They are an infrequent condition. Read More

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Treatment strategies and predicting lymph node metastasis in elderly patients with papillary thyroid microcarcinoma.

Medicine (Baltimore) 2021 May;100(18):e25811

Department of Surgical Oncology, Shaanxi Provincial People's Hospital.

Abstract: This study aims to explore the prognostic variables for elderly papillary thyroid microcarcinoma (PTMC) patients as well as create a nomogram that could predict the occurrence of cervical lymph node metastasis (CLNM) on the basis of a large population database with high quality.A total of 5165 PTMC patients from Surveillance, Epidemiology, and End Results database database were enrolled in the study. In the meantime, we retrospectively collected 205 PTMC patients who underwent thyroidectomy in our medical center as an external control to test the accuracy of the model. Read More

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Surgical Management of the Breast and Axilla after Neoadjuvant Therapy.

Dan Hershko

Chirurgia (Bucur) 2021 Mar-Apr;116(2):143-149

The indications for the use of neoadjuvant chemotherapy (NAC) for the management of breast cancer have broadened immensely in recent years. Initially intended mostly for inoperable breast cancers, this modality has then became the standard of care for locally advanced cancers. This treatment allowed safe surgical margin resection and in many patients with large tumors it allowed breast conserving surgery, avoiding the need for mastectomy. Read More

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Simultaneous or Staged Decompressions for Patients with Tandem Spinal Stenosis.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin, China.

Objective: To compare the clinical effects of cervical decompression first, lumbar decompression first, or simultaneous decompression of both lesions in the treatment of tandem spinal stenosis (TSS).

Methods: This is a retrospective analysis. From January 2013 to December 2018, 51 TSS patients underwent our surgery and postoperative investigation. Read More

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Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis.

Vaccines (Basel) 2021 Apr 21;9(5). Epub 2021 Apr 21.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, 20133 Milan, Italy.

Objective: The aim of this meta-analysis was to discuss evidence supporting the efficacy of adjuvant human papillomavirus (HPV) vaccination in reducing the risk of recurrent cervical intraepithelial neoplasia (CIN) 2 or greater after surgical treatment.

Methods: A systematic literature search was performed for studies reporting the impact of HPV vaccination on reducing the risk of recurrence of CIN 2+ after surgical excision. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Read More

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Risk of Breast Cancer in Selected Women with Atypical Ductal Hyperplasia Who do not Undergo Surgical Excision.

Ann Surg 2021 Mar 4. Epub 2021 Mar 4.

*Department of Clinical Cancer Prevention, University of Texas, MD Anderson Cancer Center, Houston, TX †Radiology, Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX ‡Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX.

Objective: To review breast cancer incidence in women with atypical ductal hyperplasia (ADH) diagnosed by core needle biopsy (CNB) and managed non-operatively.

Background: ADH found on CNB is associated with an upgrade to carcinoma in 10-50% of women, thus surgical excision remains the standard of care. Safety of non-operative management is unknown. Read More

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XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer.

Cancer Manag Res 2021 19;13:3417-3427. Epub 2021 Apr 19.

Department of Environmental and Occupational Health, School of Public Health, Hainan Medical University, Haikou, 571199, Hainan, People's Republic of China.

Objective: (Xeroderma pigmentosum group G, ), a single strand-specific DNA endonuclease in the nucleotide excision repair pathway, has been implicated in lung cancer. Potentially functional rs873601 in is consistently associated with gastrointestinal cancer, and miR-4715-3p, targeting 3UTR of , also influences the process of gastrointestinal carcinogenesis, however, the relationships between and miR-4715-3p and rs873601 in lung cancer have not been elucidated.

Methods: A case-control study included 264 lung cancer patients and 264 cancer-free healthy controls and was designed to determine the relationships between rs873601 and lung cancer and the effect of miR-4715-3p on expression in lung cancer. Read More

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[Correlation between the primary tumor size of endometrial carcinoma and lymph node metastasis and recurrence].

Zhonghua Fu Chan Ke Za Zhi 2021 Apr;56(4):264-270

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

To investigate the clinical significance of the primary tumor size in patients with endometrial carcinoma (EC). A total of 385 patients with EC admitted to Peking University People's Hospital from January 2006 to December 2016 with complete follow up data were selected, whose tumor size data before biopsy were retrospectively studied. (1) The mean diameter of the primary tumor was (3. Read More

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