17,948 results match your criteria segregated phellinus

Large-scale network topology reveals brain functional abnormality in Chinese dyslexic children.

Neuropsychologia 2021 May 7:107886. Epub 2021 May 7.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, PR China. Electronic address:

It has been revealed that dyslexic children learning alphabetic languages are characterized by aberrant topological organization of brain networks. However, little is known about the functional organization and the reconfiguration pattern of brain networks in Chinese dyslexic children. Using graph theoretical analysis and functional magnetic resonance images (fMRI), we examined this issue specifically from the perspective of functional integration and segregation. Read More

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Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of COPD.

Am J Respir Crit Care Med 2021 May 10. Epub 2021 May 10.

Johns Hopkins University, Medicine, Baltimore, Maryland, United States;

Rationale: Racial residential segregation has been associated with worse health outcomes, but the link with COPD morbidity has not been established.

Objectives: To investigate whether racial residential segregation is associated with COPD morbidity among urban Black adults with or at risk of COPD.

Methods: Racial residential segregation was assessed using isolation index, based on 2010 decennial census and baseline address, for Black former and current smokers in the multi-center SPIROMICS study of adults with or at risk for COPD. Read More

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Fine mapping of hybrid necrosis gene Ne1 in common wheat (Triticum aestivum L.).

Theor Appl Genet 2021 May 10. Epub 2021 May 10.

The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, the Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China.

Key Message: Hybrid necrosis gene Ne1 was delimited into an approximate 4.06 Mb region on chromosome arm 5BL and an InDel marker that co-segregated with Ne1 alleles was developed. Hybrid necrosis in wheat, characterized by progressive chlorosis and necrosis of plant leaves, tillers or whole plants in certain hybrids, is caused by complementary genes Ne1 and Ne2 located on chromosome arms 5BL and 2BS, respectively. Read More

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Molecular Epidemiology of Salmonellosis in Florida, USA, 2017-2018.

Front Med (Lausanne) 2021 22;8:656827. Epub 2021 Apr 22.

Animal Sciences Department, Emerging Pathogens Institute, Food Systems Institute, University of Florida, Gainesville, FL, United States.

The state of Florida reports a high burden of non-typhoidal with approximately two times higher than the national incidence. We retrospectively analyzed the population structure and molecular epidemiology of 1,709 clinical isolates from 2017 and 2018. We found 115 different serotypes. Read More

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Genetic Defects in Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice.

Front Cell Dev Biol 2021 23;9:662903. Epub 2021 Apr 23.

Department of Cellular and Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT, United States.

Asthenozoospermia accounts for over 80% of primary male infertility cases. Reduced sperm motility in asthenozoospermic patients are often accompanied by teratozoospermia, or defective sperm morphology, with varying severity. Multiple morphological abnormalities of the flagella (MMAF) is one of the most severe forms of asthenoteratozoospermia, characterized by heterogeneous flagellar abnormalities. Read More

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Meiosis Progression and Recombination in Holocentric Plants: What Is Known?

Front Plant Sci 2021 22;12:658296. Epub 2021 Apr 22.

Department of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.

Differently from the common monocentric organization of eukaryotic chromosomes, the so-called holocentric chromosomes present many centromeric regions along their length. This chromosomal organization can be found in animal and plant lineages, whose distribution suggests that it has evolved independently several times. Holocentric chromosomes present an advantage: even broken chromosome parts can be correctly segregated upon cell division. Read More

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Analysis of productivity in raceway photobioreactor using computational fluid dynamics particle tracking coupled to a dynamic photosynthesis model.

Bioresour Technol 2021 Apr 30;334:125226. Epub 2021 Apr 30.

Department of Chemical Engineering, Universidad de Almería, Spain. Electronic address:

Raceway photobioreactors (RWPs) are the most common and affordable device for the mass culture of microalgae but due to geometry and the requirement of low input power, its photosynthetic performance is low. The fluid dynamics of RWPs have been studied for information such as energy dissipation and shear rate, CFD has never been used to analyze photosynthesis efficiency by coupling dynamic photosynthesis models with microalgae trajectories. In this work, we investigate by CFD simulation the effect of circulation velocities between 0. Read More

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Spinocerebellar ataxia type 2 from an evolutionary perspective: Systematic review and meta-analysis.

Clin Genet 2021 May 7. Epub 2021 May 7.

Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Dominant diseases due to expanded CAG repeat tracts, such as spinocerebellar ataxia type 2 (SCA2), are prone to anticipation and worsening of clinical picture in subsequent generations. There is insufficient data about selective forces acting on the maintenance of these diseases in populations. We made a systematic review and meta-analysis on the effect of the CAG length over age at onset, instability of transmissions, anticipation, de novo or sporadic cases, fitness, segregation of alleles, and ancestral haplotypes. Read More

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Two cortical representations of voice control are differentially involved in speech fluency.

Brain Commun 2021 5;3(2):fcaa232. Epub 2021 Jan 5.

Department of Clinical Neurophysiology, Georg August University, Göttingen, Göttingen 37075, Germany.

Recent studies have identified two distinct cortical representations of voice control in humans, the ventral and the dorsal laryngeal motor cortex. Strikingly, while persistent developmental stuttering has been linked to a white-matter deficit in the ventral laryngeal motor cortex, intensive fluency-shaping intervention modulated the functional connectivity of the dorsal laryngeal motor cortical network. Currently, it is unknown whether the underlying structural network organization of these two laryngeal representations is distinct or differently shaped by stuttering intervention. Read More

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January 2021

A Novel Homozygous Splice-Site Mutation Causing the Skipping of Exon 38 in a Chinese Family With Cohen Syndrome.

Front Pediatr 2021 20;9:651621. Epub 2021 Apr 20.

Medical Genetic Department, The Affiliated Hospital of Qingdao University, Qingdao, China.

Cohen syndrome (CS) is a clinically heterogeneous disorder characterized by extensive phenotypic variation with autosomal recessive inheritance. was identified to be the disease-causing gene for CS. The objectives of the present study were to screen likely pathogenic mutations of the patient with developmental delay and mental retardation, and to determinate the effect of this splice-site mutation by reverse transcription analysis. Read More

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Knowledge of prostate cancer presentation, etiology, and screening practices among women: a mixed-methods systematic review.

Syst Rev 2021 May 6;10(1):138. Epub 2021 May 6.

University of KwaZulu-Natal, Durban, South Africa.

Background: With the burden of prostate cancer, it has become imperative to exploit cost-effective ways to tackle this menace. Women have demonstrated their ability to recognize early cancer signs, and it is, therefore, relevant to include women in strategies to improve the early detection of prostate cancer. This systematic review seeks to gather evidence from studies that investigated women's knowledge about (1) the signs and symptoms, (2) causes and risk factors, and (3) the screening modalities of prostate cancer. Read More

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Single-Domain Antibodies for the Detection of SARS-CoV-2 Nucleocapsid Protein.

Anal Chem 2021 May 6. Epub 2021 May 6.

Center for Biomolecular Science and Engineering, US Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, District of Columbia 20375, United States.

The goal of this work was to develop recombinantly expressed variable domains derived from camelid heavy-chain antibodies known as single-domain antibodies (sdAbs) directed against the SARS-CoV-2 nucleocapsid protein for incorporation into detection assays. To achieve this, a llama was immunized using a recombinant SARS-CoV-2 nucleocapsid protein and an immune phage-display library of variable domains was developed. The sdAbs selected from this library segregated into five distinct sequence families. Read More

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Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass.

Pediatr Nephrol 2021 May 5. Epub 2021 May 5.

Department of Anesthesiology, University of Colorado, Aurora, CO, USA.

Background: We sought to determine differences in the circulating metabolic profile of infants with or without acute kidney injury (AKI) following cardiothoracic surgery with cardiopulmonary bypass (CPB).

Methods: We performed a secondary analysis of preoperative and 24-h postoperative serum samples from infants ≤ 120 days old undergoing CPB. Metabolic profiling of the serum samples was performed by targeted analysis of 165 serum metabolites via tandem mass spectrometry. Read More

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Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype.

Can J Gastroenterol Hepatol 2021 12;2021:6610434. Epub 2021 Apr 12.

Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China.

A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer. Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disease caused by mutations in the adenomatous polyposis coli (APC) gene. Read More

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Segregated oceanic crust trapped at the bottom mantle transition zone revealed from ambient noise interferometry.

Nat Commun 2021 May 5;12(1):2531. Epub 2021 May 5.

Laboratory of Seismology and Physics of Earth's Interior, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, China.

The recycling of oceanic crust, with distinct isotopic and chemical signature from the pyrolite mantle, plays a critical role in the chemical evolution of the Earth with insights into mantle circulation. However, the role of the mantle transition zone during this recycling remains ambiguous. We here combine the unique resolution reflected body waves (P410P and P660P) retrieved from ambient noise interferometry with mineral physics modeling, to shed new light on transition zone physics. Read More

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Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature.

Stem Cells Transl Med 2021 May 5. Epub 2021 May 5.

Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly understood. We characterized renal mesenchymal cell heterogeneity in young vs old animals and after ischemia-reperfusion-injury (IRI) using multiplex immunolabeling and single cell transcriptomics. Read More

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Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.

This study examined for the first time whether bee bread (BB, consisting of monofloral rape bee pollen) could alleviate lipid derangements and reduced bone quality in Zucker diabetic fatty (ZDF) rats, which are considered an appropriate animal model for type 2 diabetes mellitus (T2DM) investigation. Adult ZDF rats were segregated into four groups: lean non-diabetic rats (L group), obese diabetic rats untreated (C group), and those treated with the BB at two doses (500 and 700 mg/kg body weight, respectively, B1 and B2 groups) for 10 weeks. Significantly reduced levels of total cholesterol and triglyceride were recorded in the B2 group versus the C group. Read More

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Assessment of the Genetic Potential of the Peregrine Falcon () Population Used in the Reintroduction Program in Poland.

Genes (Basel) 2021 Apr 29;12(5). Epub 2021 Apr 29.

Department of Animal Genetics and Conservation, Warsaw University of Life Sciences, 02-787 Warszawa, Poland.

Microsatellite DNA analysis is a powerful tool for assessing population genetics. The main aim of this study was to assess the genetic potential of the peregrine falcon population covered by the restitution program. We characterized individuals from breeders that set their birds for release into the wild and birds that have been reintroduced in previous years. Read More

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Identification of a novel heterozygous mutation in the MITF gene in an Iranian family with Waardenburg syndrome type II using next-generation sequencing.

J Clin Lab Anal 2021 May 4:e23792. Epub 2021 May 4.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Waardenburg syndrome (WS) is a genetically heterogeneous syndrome with both autosomal recessive and dominant inheritance. WS causes skin and iris pigmentation accumulation and sensorineural hearing loss, in varying degrees. There are four WS types with different characteristics. Read More

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Type II/III cell composition and NCAM expression in taste buds.

Cell Tissue Res 2021 May 4. Epub 2021 May 4.

Oral Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima-shi, Kagoshima, 890-8544, Japan.

Taste buds are localized in fungiform (FF), foliate (FL), and circumvallate (CV) papillae on the tongue, and taste buds also occur on the soft palate (SP). Mature elongate cells within taste buds are constantly renewed from stem cells and classified into three cell types, Types I, II, and III. These cell types are generally assumed to reside in respective taste buds in a particular ratio corresponding to taste regions. Read More

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Process-oriented life cycle assessment modelling in EASETECH.

Waste Manag 2021 Apr 30;127:168-178. Epub 2021 Apr 30.

Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet, 115 2800 Kgs, Lyngby, Denmark.

Life cycle assessment (LCA) modelling of resource-related technologies can be challenging in the context of circular economy, bioeconomy, recycling and integrated waste management, where materials are recirculated within processes and undergo chemical-physical transformations. This implies redefinition of physical flows within the LCA model. Additionally, physical flows may have non-linear responses to changes in model parameters and background processes, involve activities such as extraction of materials and chemical substances, and directly affect emissions. Read More

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Increased Glucose Activity in Subgenual Anterior Cingulate and Hippocampus of High Performing Older Adults, Despite Amyloid Burden.

J Alzheimers Dis 2021 Apr 28. Epub 2021 Apr 28.

Brain Institute of Rio Grande do Sul (BraIns), PUCRS, Porto Alegre, Brazil.

Background: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition of successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations are yet to be uncovered. Read More

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Intracranial EEG evidence of functional specialization for taxonomic and thematic relations.

Cortex 2021 Apr 9;140:40-50. Epub 2021 Apr 9.

Department of Psychology, University of Edinburgh, Edinburgh, UK.

The dual-hub account posits that the neural organization of semantic knowledge is segregated by the type of semantic relation with anterior temporal lobe (ATL) specializing for taxonomic relations and inferior parietal lobule (IPL) for thematic relations. This study critically examined this account by recording intracranial EEG from an array of depth electrodes within ATL, IPL, and two regions within the semantic control network, inferior frontal gyrus (IFG) and posterior middle temporal gyrus (pMTG), while 17 participants with refractory epilepsy completed a semantic relatedness judgment task. We observed a significant difference between relation types in ATL and IPL approximately 600-800 ms after trial presentation, and no significant differences in IFG or pMTG. Read More

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Messenger RNA biomarkers of Bovine Respiratory Syncytial Virus infection in the whole blood of dairy calves.

Sci Rep 2021 Apr 30;11(1):9392. Epub 2021 Apr 30.

Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Co., Meath, Ireland.

Bovine Respiratory Syncytial Virus (BRSV) is a primary viral cause of Bovine Respiratory Disease (BRD) in young calves, which is responsible for substantial morbidity and mortality. Infection with BRSV induces global gene expression changes in respiratory tissues. If these changes are observed in tissues which are more accessible in live animals, such as whole blood, they may be used as biomarkers for diagnosis of the disease. Read More

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An intronic variant in the CELF4 gene is associated with risk for colorectal cancer.

Cancer Epidemiol 2021 Apr 28;72:101941. Epub 2021 Apr 28.

Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA; Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. Electronic address:

Background: Germline predisposition variants associated with colorectal cancer (CRC) have been identified but all are not yet identified. We sought to identify the responsible predisposition germline variant in an extended high-risk CRC pedigree that exhibited evidence of linkage to the 18q12.2 region (TLOD = +2. Read More

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In Situ and Intraoperative Detection of the Ureter Injury Using a Highly Sensitive Piezoresistive Sensor with a Tunable Porous Structure.

ACS Appl Mater Interfaces 2021 Apr 30. Epub 2021 Apr 30.

Schlegel Research Institute for Aging, University of Waterloo, Waterloo N2L 3G1, Canada.

Iatrogenic ureteral injury, as a commonly encountered problem in gynecologic, colorectal, and pelvic surgeries, is known to be difficult to detect in situ and in real-time. Consequently, this injury may be left untreated, thereby leading to serious complications such as infections, renal failure, or even death. Here, high-performance tubular porous pressure sensors were proposed to identify the ureter in situ intraoperatively. Read More

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Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition.

Cells 2021 Apr 26;10(5). Epub 2021 Apr 26.

Department of Theory and Bio-Systems, Max Planck Institut of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.

T cells are sensitive to 1 to 10 foreign-peptide-MHC complexes among a vast majority of self-peptide-MHC complexes, and discriminate selectively between peptide-MHC complexes that differ not much in their binding affinity to T-cell receptors (TCRs). Quantitative models that aim to explain this sensitivity and selectivity largely focus on single TCR/peptide-MHC complexes, but T cell adhesion involves a multitude of different complexes. In this article, we demonstrate in a three-dimensional computational model of T-cell adhesion that the cooperative stabilization of close-contact zones is sensitive to one to three foreign-peptide-MHC complexes and occurs at a rather sharp threshold affinity of these complexes, which implies selectivity. Read More

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Blend Structure and n-Type Thermoelectric Performance of PA6/SAN and PA6/PMMA Blends Filled with Singlewalled Carbon Nanotubes.

Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Leibniz-Institut für Polymerforschung Dresden e.V. (IPF), Hohe Str. 6, 01069 Dresden, Germany.

The present study investigates how the formation of melt-mixed immiscible blends based on PA6/SAN and PA6/PMMA filled with single walled nanotubes (SWCNTs) affects the thermoelectric (TE) properties. In addition to the detailed investigation of the blend morphology with compositions between 100/0 wt.% and 50/50 wt. Read More

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Sorghum () Gene Links Lignin Biosynthesis to Folate Metabolism.

Genes (Basel) 2021 Apr 28;12(5). Epub 2021 Apr 28.

Department of Agronomy, Purdue University, 915 W. State St., West Lafayette, IN 47907-2054, USA.

Genetic analysis of brown midrib sorghum () mutant lines assembled in our program has previously shown that the mutations fall into four allelic groups, , , or . Causal genes for allelic groups , and , have since been identified. In this report, we provide evidence for the nature of the mutation. Read More

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Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Department of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, Korea.

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral-gut barrier. Read More

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