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Paclitaxel-Coated Balloons for the Treatment of Symptomatic Central Venous Stenosis in Vascular Access: Results From a European, Multicenter, Single-Arm Retrospective Analysis.

J Endovasc Ther 2021 Apr 9:15266028211007471. Epub 2021 Apr 9.

Interventional Radiology, Patras University Hospital, Patras, Greece.

Introduction: This was a European, multicenter, investigator-initiated and run, single-arm retrospective analysis to assess the safety and the clinical benefit of the use of paclitaxel-coated balloon (PCB) for the treatment of symptomatic central venous stenosis (CVS).

Materials And Methods: Eleven centers from 7 countries across Europe, submitted 86 cases performed during the period between October 2015 and June 2018. Minimum follow-up was 6 months. Read More

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as a Model System to Assess the Effect of Epstein-Barr Virus DNA on Inflammatory Gut Diseases.

Front Immunol 2021 22;12:586930. Epub 2021 Mar 22.

Department of Experimental Pathology and Immunology, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.

The Epstein-Barr virus (EBV) commonly infects humans and is highly associated with different types of cancers and autoimmune diseases. EBV has also been detected in inflamed gastrointestinal mucosa of patients suffering from prolonged inflammation of the digestive tract such as inflammatory bowel disease (IBD) with no clear role identified yet for EBV in the pathology of such diseases. Since we have previously reported immune-stimulating capabilities of EBV DNA in various models, in this study we investigated whether EBV DNA may play a role in exacerbating intestinal inflammation through innate immune and regeneration responses using the model. Read More

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Danish teleophthalmology platform reduces optometry referrals into the national eye care system.

BMJ Open Ophthalmol 2021 18;6(1):e000671. Epub 2021 Mar 18.

Moorfields Eye Hospital City Road Campus, London, London, UK.

Objective: The purpose of this study was to evaluate the stratification of follow-up and referral pathways after implementation of a systematic cloud-based electronic-referral teleophthalmological service for optometry-initiated ocular posterior segment disease referrals to the Danish national eye care system.

Methods And Analysis: A retrospective cohort study was conducted in the period from 1 August 2018 to 31 July 2019. Patients with suspected ocular posterior segment disease reviewed by the telemedical ophthalmology service were included. Read More

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Focal ST-segment elevation without coronary occlusion: myocardial infarction with no obstructive coronary atherosclerosis associated with COVID-19-a case report.

Eur Heart J Case Rep 2021 Feb 12;5(2):ytaa532. Epub 2021 Jan 12.

Department of Cardiology, Abington Hospital, Jefferson Health Abington, 1200 Old York Road, PA, 19118, USA.

Background: While it is understood that coronavirus disease 2019 (COVID-19) is primarily complicated by respiratory failure, more data are emerging on the cardiovascular complications of this disease. A subset of COVID-19 patients present with ST-elevations on electrocardiogram (ECG) yet normal coronary angiography, a presentation that can fit criteria for myocardial infarction with no obstructive coronary atherosclerosis (MINOCA). There is little known about non-coronary myocardial injury observed in patients with COVID-19, and we present a case that should encourage further conversation and study of this clinical challenge. Read More

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February 2021

A 66-Year-Old Woman with Intermittent Chest Pain and Dyspnea Who Underwent Continued ST-Segment Monitoring to Identify Occult ST-Segment Elevation that Expedited Coronary Angiography and Revascularization.

Am J Case Rep 2021 Mar 20;22:e929736. Epub 2021 Mar 20.

Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark.

BACKGROUND In patients admitted to the hospital owing to suspected acute coronary syndrome and where the first electrocardiogram (ECG) is non-diagnostic of ST-elevated myocardial infarction (STEMI), international guidelines recommend that sequential ECGs are performed to identify new or intermittent ST-deviations. Continued monitoring for ST-segment alterations is rarely performed, in contrast to the continued monitoring for arrhythmias. Continued monitoring for ST-segment alteration may detect intermittent ST-segment elevations not captured by routine 12-lead ECGs. Read More

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Effective chemotherapy and targeted therapy supplemented with stereotactic radiotherapy of a patient with metastatic colon cancer following renal transplantation: a case report.

J Med Case Rep 2021 Mar 20;15(1):125. Epub 2021 Mar 20.

Department of Oncotherapy, Clinical Center, University of Pécs, Édesanyák Street 10, 7624, Pécs, Hungary.

Background: Previous studies have shown that patients who underwent renal transplantation were at a greater risk of developing malignancies. Due to advances in effective surgical techniques and immunosuppressive therapies, organ recipients live longer. Yet, there is insufficient information about the recommended type of therapy for colorectal cancer patients following transplantation. Read More

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Early surgery with antibiotic medication was effective and efficient in treating pyogenic spondylodiscitis.

BMC Musculoskelet Disord 2021 Mar 18;22(1):288. Epub 2021 Mar 18.

Department of Orthopedic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Pyogenic spondylodiscitis (PSD) is challenging to the orthopedist with regards to diagnosis and treatment. The present study was designed to assess and suggest the most indicative diagnostic method and evaluate the effect of surgery comprising of debridement, instrumentation and fusion in treating PSD.

Methods: Seventy-six patients with PSD who underwent surgical intervention were retrospectively enrolled. Read More

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Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal N-R Correlation Matrices.

J Am Chem Soc 2021 Mar 18;143(12):4668-4679. Epub 2021 Mar 18.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton ON L8S4M1, Canada.

Soluble oligomers formed by amyloidogenic intrinsically disordered proteins are some of the most cytotoxic species linked to neurodegeneration. Due to the transient and heterogeneous nature of such oligomeric intermediates, the underlying self-association events often remain elusive. NMR relaxation measurements sensitive to zero-frequency spectral densities (J(0)), such as the N - R rates, are ideally suited to map sites of self-association at atomic resolution without the need of exogenous labels. Read More

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Biodegradable- Versus Durable-Polymer Drug-Eluting Stents for STEMI: Final 2-Year Outcomes of the BIOSTEMI Trial.

JACC Cardiovasc Interv 2021 Mar;14(6):639-648

Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland. Electronic address:

Objectives: The aim of this study was to investigate the safety and efficacy of biodegradable-polymer sirolimus-eluting stents (BP-SES) compared with durable-polymer everolimus-eluting stents (DP-EES) in patients with ST-segment elevation myocardial infarction (STEMI).

Background: Primary percutaneous coronary intervention (PCI) is an effective treatment for patients with STEMI, and long-term outcomes are determined by the safety and efficacy profile of the newest generation drug-eluting stents.

Methods: BIOSTEMI (A Comparison of an Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent With a Durable Polymer Everolimus-Eluting Stent for Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention) was an investigator-initiated, multicenter, assessor-blind, randomized superiority trial using Bayesian methods. Read More

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Pembrolizumab-induced myocarditis in a patient with malignant mesothelioma: plasma exchange as a successful emerging therapy-case report.

Transl Lung Cancer Res 2021 Feb;10(2):1039-1046

Intensive Care Unit, Medical Clinic I, Ludwig Maximilian University Munich, Munich, Germany.

Malignant mesothelioma is an aggressive cancer associated with prior exposure to asbestos and dismal prognosis. Immune checkpoint inhibitor therapy is currently approved by the Food and Drug Administration for pre-treated malignant pleural mesothelioma. We describe a 75-year-old patient with disseminated, progressive malignant mesothelioma receiving 2 cycles of pembrolizumab who presented with generalized muscle weakness, shortness of breath, double vision and ptosis. Read More

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February 2021

Genetic assessment of captive red pandas (Ailurus fulgens) in American zoos to address management separation by putative subspecies.

Lucy A Dueck

Zoo Biol 2021 Mar 10. Epub 2021 Mar 10.

Savannah River Ecology Laboratory, Aiken, South Carolina, USA.

Red pandas (Ailurus fulgens) are small charismatic mammals native across montane southern Asia, now endangered by human impacts. They are considered "living fossils" as the sole member of a distinct family, warranting higher conservation priority. Therefore, ex situ breeding programs were initiated to prevent extinction and act as genetic reservoirs for reintroduction, although complicated by apparent taxonomic subdivision. Read More

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Controversy of indomethacin eye drops in the treatment of rheumatoid arthritis-induced corneal ulceration: a case report.

J Med Case Rep 2021 Mar 4;15(1):116. Epub 2021 Mar 4.

Department of Ophthalmology, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, 400012, Cluj-Napoca, Romania.

Background: Perforation of the cornea is a rare finding in patients with rheumatoid arthritis (RA). Addressing a perforated cornea associated with RA is challenging, since its pathogenesis is not fully elucidated. Topical nonsteroidal anti-inflammatory drugs (NSAIDs) were developed to prevent cystoid macular edema following cataract surgery in patients at risk. Read More

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Pneumorrhachis and pneumothorax after epidural analgesia: A case report and review.

Qatar Med J 2021 18;2021(1):01. Epub 2021 Feb 18.

Department of Obstetrics and Gynecology, Al Wakra Hospital, Hamad Medical Corporation, Al Wakra, Qatar.

Epidural analgesia or anesthesia is a common procedure for pain relief, especially in obstetrics. Pneumorrhachis and pneumothorax are rare complications of epidural analgesia. They are considered asymptomatic entities but have recently caused increased morbidity and mortality. Read More

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February 2021

Rationale and design of the OPTIMAL-REPERFUSION trial: A prospective randomized multi-center clinical trial comparing different fibrinolysis-transfer percutaneous coronary intervention strategies in acute ST-segment elevation myocardial infarction.

Clin Cardiol 2021 Apr 25;44(4):455-462. Epub 2021 Feb 25.

Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.

Primary percutaneous coronary intervention (PPCI), the preferred reperfusion strategy for all acute ST-segment elevation myocardial infarction (STEMI) patients, is not universally available in clinical practice. Pharmacoinvasive strategy has been proposed as a therapeutic option in patients with STEMI when timely PPCI is not feasible. However, pharmacoinvasive strategy has potential delay between clinical patency and complete myocardial perfusion. Read More

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Be aware of misdiagnosis tied to COVID-19 focusing: a case report of abciximab-induced alveolar haemorrhage thought to be SARS-CoV-2 in a patient with ST-segment elevation myocardial infarction.

Eur Heart J Case Rep 2020 Dec 12;4(6):1-6. Epub 2020 Dec 12.

Department of Cardiology, University of Health Sciences Trabzon Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Vatan St., Ortahisar/Trabzon 61000, Turkey.

Background: Early diagnosis of diffuse alveolar haemorrhage (DAH) can be extremely difficult, as the common clinical picture is often attributed to more common clinical conditions. High degree of suspicion is key to diagnosis which can be much more difficult during the coronavirus disease 2019 (COVID-19) pandemic.

Case Summary: A 61-year-old man with inferolateral ST-segment elevation myocardial infarction treated by a stent to the left circumflex artery and intravenous abciximab treatment was started for the high thrombus burden. Read More

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December 2020

Intravital microscopy of tumor vessel morphology and function using a standard fluorescence microscope.

Eur J Nucl Med Mol Imaging 2021 Feb 19. Epub 2021 Feb 19.

Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Box 4953 Nydalen, 0424, Oslo, Norway.

Purpose: The purpose of the study was to demonstrate the performance and possible applications of an intravital microscopy assay using a standard fluorescence microscope.

Methods: Melanoma and pancreatic ductal adenocarcinoma xenografts were initiated in dorsal window chambers and subjected to repeated intravital microscopy. The entire tumor vasculature as well as the normal tissue surrounding the tumor was imaged simultaneously with high spatial and temporal resolution. Read More

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February 2021

A case report of isolated rheumatic tricuspid regurgitation and pericarditis.

Osama Alhadramy

J Taibah Univ Med Sci 2021 Feb 17;16(1):121-126. Epub 2020 Dec 17.

Department of Internal Medicine, College of Medicine, Taibah University, Almadinah Almunawwarah, KSA.

Rheumatic fever (RF) is a complex syndrome in which the human body develops antibodies against β-haemolytic streptococcus, and triggers inflammation in various organs. RF valvulitis mostly affects the mitral valve (MV) and, to a lesser extent, the aortic valve (AV). Isolated rheumatic tricuspid valve (TV) disease and pericarditis is extremely rare and is not well described in the RF guidelines. Read More

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February 2021

Purulent pericarditis-induced intracardiac perforation and infective endocarditis due to : a case report.

Eur Heart J Case Rep 2021 Feb 29;5(2):ytaa528. Epub 2020 Dec 29.

Department of Cardiology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Background: Purulent pericarditis, a rare disease with a high associated mortality rate in patients without adequate treatment, can cause serious complications, such as perforation of the surrounding tissue and organs. is a very rare cause of purulent pericarditis.

Case Summary: A 70-year-old male patient presented to our emergency room with chest pain of 10 days' duration. Read More

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February 2021

Optical coherence tomography analyses based segmentation and relative intensity evaluation of outer retinal layers in patients affected with X-linked juvenile retinoschisis.

Eur J Ophthalmol 2021 Feb 17:1120672121995110. Epub 2021 Feb 17.

Ophthalmology Clinic, General Hospital of Patras, Patras, Greece.

Purpose: We aim to provide a description of the optical coherence tomography findings in the outer macula hyperreflective bands of our patients with X-linked juvenile retinoschisis. Also to categorize these changes and to quantitatively and qualitatively correlate their reflectivity levels with visual function.

Methods: We manually segmented the borders, and depicted relative intensity of the inner segment ellipsoid band, and quantified the volume of edema. Read More

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February 2021

Combined venous and arterial thrombosis revealing underlying myeloproliferative disorder in a young patient: a case report.

J Med Case Rep 2021 Feb 16;15(1):76. Epub 2021 Feb 16.

Cardiology department, Hospital University Center Ibn Rochd, Casablanca, Morocco.

Background: Myeloproliferative neoplasms (MPNs) such as polycythemia Vera (PV) and Essential Thrombocythemia (ET) can be associated with a high risk of both venous and arterial thrombosis. However, the co-existence between these two complications is very rare and has never been described before, especially in young adults with no known history of MPNs.

Case Presentation: We report the case of a 39 year-old Caucasian Moroccan male patient without cardiovascular risk factors (CVRF), who presented with acute chest pain. Read More

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February 2021

A 75-Year-Old Woman with COVID-19 Pneumonia and Wellens Syndrome Diagnosed by Electrocardiography.

Am J Case Rep 2021 Feb 3;22:e930125. Epub 2021 Feb 3.

Department of Advanced Heart Failure, Prisma Health, Columbia, SC, USA.

BACKGROUND There are increasing reports of cardiovascular complications associated with coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2. Wellens syndrome, or left anterior descending T-wave syndrome, is diagnosed by a pattern of electrocardiographic (ECG) changes that include inverted or biphasic T waves in leads V2-V3. CASE REPORT A 75-year-old woman presented to the emergency department with a 1-week history of fatigue and progressive shortness of breath who acutely decompensated, necessitating mechanical ventilator support. Read More

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February 2021

Takotsubo syndrome triggered by change in position in a patient with thoracic vertebral fracture: A case report.

Medicine (Baltimore) 2021 Jan;100(2):e24088

Department of Anesthesiology.

Rationale: Takotsubo syndrome (TTS) is characterized by recovery of wall motion abnormalities and acute left ventricular dysfunction, which are often caused by acute physical or emotional stressors. It is rarely reported that TTS can be precipitated by change in position in the patient in the operating room. We report a case of a patient with a thoracic vertebral fracture who presented with TTS precipitated by changing from a supine to a prone position before percutaneous kyphoplasty (PKP) under local anesthesia. Read More

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January 2021

Pheochromocytoma crisis with cyclic fluctuation in blood pressure mimics acute coronary syndrome.

Endocrinol Diabetes Metab Case Rep 2020 Sep 23;2020. Epub 2020 Sep 23.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Summary: Pheochromocytoma crisis results from the sudden release of large quantities of catecholamines and leads to progressive multiple organ dysfunction. Here we report a case of pheochromocytoma crisis with symptoms associated with acute coronary syndrome (ACS) and severe fluctuations in blood pressure (BP). A 43-year-old Japanese man with hypertension (240/120 mmHg) visited a general hospital for chest pain. Read More

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September 2020

Case report of non-ST-segment elevation myocardial infarction diagnosed in spectral detector-based computed tomography performed for the diagnosis of acute pulmonary embolism.

Eur Heart J Case Rep 2020 Oct 9;4(5):1-7. Epub 2020 Sep 9.

Department of Cardiology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaechou, Itabashi-ku, Tokyo 173-0015, Japan.

Background: Contrast-enhanced spectral detector-based computed tomography (SDCT) allows for the comprehensive and retrospective analysis. We report a case of pulmonary thromboembolism (PE) accompanied by non-ST-segment elevation myocardial infarction (NSTEMI) diagnosed by SDCT.

Case Summary: A 72-year-old man with diabetes mellitus, hypertension, and prostate cancer suddenly developed chest and back pain and had difficulty in breathing at rest. Read More

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October 2020

Biodegradable PLA/PBSA Multinanolayer Nanocomposites: Effect of Nanoclays Incorporation in Multinanolayered Structure on Mechanical and Water Barrier Properties.

Nanomaterials (Basel) 2020 Dec 20;10(12). Epub 2020 Dec 20.

Normandie Univ, UNIROUEN, INSA Rouen, CNRS, PBS, 76000 Rouen, France.

Biodegradable PLA/PBSA multinanolayer nanocomposites were obtained from semi-crystalline poly(butylene succinate--butylene adipate) (PBSA) nanolayers filled with nanoclays and confined against amorphous poly(lactic acid) (PLA) nanolayers in a continuous manner by applying an innovative coextrusion technology. The cloisite 30B (C30B) filler incorporation in nanolayers was considered to be an improvement of barrier properties of the multilayer films additional to the confinement effect resulting to forced assembly during the multilayer coextrusion process. 2049-layer films of ~300 µm thick were processed containing loaded PBSA nanolayers of ~200 nm, which presented certain homogeneity and were mostly continuous for the 80/20 wt% PLA/PBSA composition. Read More

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December 2020

Acute macular neuroretinopathy in a patient with acute myeloid leukemia and deceased by COVID-19: a case report.

J Ophthalmic Inflamm Infect 2021 Jan 8;10(1):39. Epub 2021 Jan 8.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Acute macular neuroretinopathy (AMN) is a visual-deteriorating rare clinical entity with an uncertain etiology. We aimed to report a case of AMN and underlying disease of acute myeloid leukemia (AML).

Case Presentation: A thirty-five-year-old female patient with bone marrow biopsy confirmed AML, and bicytopenia, under chemotherapy, complained of sudden paracentral visual field defect in her right eye was referred. Read More

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January 2021

Multiple ocular manifestations in a case of cat scratch disease without systemic signs.

GMS Ophthalmol Cases 2020 15;10:Doc45. Epub 2020 Dec 15.

Department of Ophthalmology, Jichi Medical University, Shimotsuke-shi, Japan.

A 43-year-old woman presented with impaired vision and redness in her left eye of 2 weeks duration. She had a pet cat that scratched her forehead 3 weeks before she presented to us. She had no systemic signs such as lymphadenopathy, fever, or fatigue. Read More

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December 2020

Visual Cues Promote Head First Strategies During Walking Turns in Individuals With Parkinson's Disease.

Front Sports Act Living 2020 11;2:22. Epub 2020 Mar 11.

Department of Applied Human Sciences, Faculty of Science, University of Prince Edward Island, Charlottetown, PE, Canada.

Anticipatory eye movement promotes cranio-caudal sequencing during walking turns. Clinical groups, such as Parkinson's disease (PD), do not produce anticipatory eye movements, leading to increased risk of falls. Visual cues may promote anticipatory eye movement by guiding the eyes into the turn. Read More

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