438,081 results match your criteria secondary neoplasms

Implication of the New AJCC pT Classification of SCC of the Lip Comparing With Other Oral Subsites.

Laryngoscope 2021 May 5. Epub 2021 May 5.

Head and Neck Surgery Department, University of São Paulo Medical School, São Paulo, Brazil.

Objective: To determine the implication of the new AJCC staging system for pT classification in a cohort of patients with SCC of the lip mucosa and compare it to other oral cavity sites.

Methods: Retrospective cohort of 744 patients treated between 2002 and 2017, by the Head and Neck Surgery Department of the University of Sao Paulo.

Results: Of 95 lip patients, 42 had pT upstage (58. Read More

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Pathological axis fracture secondary to a solitary bone plasmacytoma: Two cases and a literature review.

Surg Neurol Int 2021 14;12:165. Epub 2021 Apr 14.

Spine unit, Department of Orthopedic and Traumatology, Clínica Alemana, Santiago, Chile.

Background: Solitay bone plasmocytoma (SBP) account for just 5-10% of all plasma cell neoplasms. They are infrequent in the cervical spine, especially involving the C0-C2 segment. In this article we conducted a literature review and present the diagnosis, management and long term course of two patients with SBP of C2 causing cervical instability. Read More

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Cardiovascular Toxicities Secondary to Biotherapy and Molecular Targeted Therapies in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.

Cancers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

1st Department of Propaedeutic Internal Medicine, Endocrine Unit, National and Kapodistrian, University of Athens, 11527 Athens, Greece.

A broad spectrum of novel targeted therapies with prime antitumor activity and/or ample control of hormonal symptoms together with an overall acceptable safety profile have emerged for patients with metastatic neuroendocrine neoplasms (NENs). In this systematic review and quantitative meta-analysis, the PubMed, EMBASE, Cochrane Central Register of Controlled Trials and clinicaltrials.gov databases were searched to assess and compare the safety profile of NEN treatments with special focus on the cardiovascular adverse effects of biotherapy and molecular targeted therapies (MTTs). Read More

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Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.

J Endocrinol Invest 2021 May 3. Epub 2021 May 3.

Neuromed Institute, IRCCS, Pozzilli, IS, Italy.

Purpose: Salivary gland (SG) tissue and derived neoplasms may occur in the sellar region. As the current literature is mostly limited to case reports, the puzzling case of an inflammatory SG removed by transsphenoidal surgery (TS) and mimicking a prolactinoma prompted us to perform the first systematic review of these unusual conditions.

Methods: A systematic literature search was conducted according to the PRISMA guidelines. Read More

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Evaluating Knowledge Regarding Cervical Cancer and Its Screening among Woman in Rural India.

Divya Khanna

South Asian J Cancer 2020 Jul 19;9(3):141-146. Epub 2021 Mar 19.

Department of Preventive Oncology, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India.

 Cervical cancer is the most common cancer among rural women of India. However, awareness of cancer of the uterine cervix and its screening coverage among the general population of India remains insufficient.  The study aims to assess awareness of cervical cancer and its screening among women attending a rural health care center in northern India and determine factors associated with satisfactory knowledge. Read More

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Solitary pancreatic metastasis of occult pulmonary small cell carcinoma diagnosed by EUS-FNA cytology: a case report.

Int J Clin Exp Pathol 2021 15;14(4):514-518. Epub 2021 Apr 15.

Department of Gastroenterology and Hepatology, Shiga General Hospital Japan.

A 74-year-old man presented with symptoms suggestive of acute pancreatitis, and a mass lesion measuring 25 mm was detected in the pancreatic head. Cytological and histopathological examinations of EUS-FNA specimens taken from the lesion demonstrated small cell (neuroendocrine) carcinoma. Tumor cells were immunoreactive for cytokeratin, synaptophysin, chromogranin A, CD56, and TTF-1, and PET-CT of the chest revealed a small tumor in the upper lobe of the left lung. Read More

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Chronic lymphoid leukemia metastasis to the gallbladder as a focal mass: A case report.

Radiol Case Rep 2021 Jun 15;16(6):1477-1484. Epub 2021 Apr 15.

Department of Radiology, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA.

Chronic lymphocytic leukemia (CLL) is the second most common hematologic malignancy, and it is characterized by lymphocytic leukocytosis and secondary hematologic deficiencies. While it most commonly presents as a systemic disease, extramedullary involvement may rarely occur. The literature surrounding CLL metastatic disease to the gallbladder is particularly sparse. Read More

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The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.

Transl Oncol 2021 Apr 28;14(7):101106. Epub 2021 Apr 28.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Background: Recent studies have reported that diffuse large B-cell lymphoma (DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. However, the risk of secondary malignant neoplasms (SMNs) in DLBCL survivors with different primary extranodal sites are unknown.

Methods: A total of 40,714 patients diagnosed with stage I/II DLBCL were included from the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2015. Read More

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Safety and oncologic efficacy of percutaneous MRI-guided cryoablation of intraparenchymal renal cancers.

Diagn Interv Imaging 2021 Apr 27. Epub 2021 Apr 27.

Department of Interventional Radiology, University Hospital of Strasbourg, 67091 Strasbourg cedex, France; School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, WC2R 2LS London, United Kingdom.

Purpose: The purpose of this study was to evaluate the safety and oncologic efficacy of percutaneous magnetic resonance imaging (MRI)-guided cryoablation of intraparenchymal renal cancer.

Materials And Methods: Between February 2009 and August 2019, 31 consecutives patients with 31 entirely intraparenchymal biopsy-proven renal cancers were treated with cryoablation under MRI-guidance in our institution, and were retrospectively included. There were 20 men and 11 women with a mean age of 68. Read More

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Ocular Oncology-Primary and Metastatic Malignancies.

Med Clin North Am 2021 May 2;105(3):531-550. Epub 2021 Apr 2.

Medicine, 231 Albert Sabin Way, Suite 5412, Cincinnati, OH 45267-0567, USA. Electronic address: https://twitter.com/mauradinicola.

Several neoplastic processes can involve the eye, either primarily or secondary to a systemic malignancy. The most common primary tumors of the eye include conjunctival and uveal melanoma, retinoblastoma, conjunctival and intraocular lymphoma, and ocular surface squamous neoplasia. Metastatic spread from systemic malignancies, especially of the breast and lung, also can involve the eye. Read More

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Resistance to Immune Checkpoint Inhibitors Secondary to Myeloid-Derived Suppressor Cells: A New Therapeutic Targeting of Haematological Malignancies.

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

Department of Internal Medicine, University Hospital Rio Hortega, 47012 Valladolid, Spain.

Myeloid-derived suppressor cells (MDSCs) are a set of immature myeloid lineage cells that include macrophages, granulocytes, and dendritic cell precursors. This subpopulation has been described in relation to the tumour processes at different levels, including resistance to immunotherapy, such as immune checkpoint inhibitors (ICIs). Currently, multiple studies at the preclinical and clinical levels seek to use this cell population for the treatment of different haematological neoplasms, together with ICIs. Read More

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Radiological and Clinical Efficacy of Intra-Arterial Y-DOTATATE in Patients with Unresectable, Progressive, Liver Dominant Neuroendocrine Neoplasms.

J Clin Med 2021 Apr 20;10(8). Epub 2021 Apr 20.

Department of Cardiology and Internal Medicine, School of Medicine, University of Warmia and Mazury, Warszawska 30, 10-082 Olsztyn, Poland.

This study was performed to determine if intra-arterial (i.a.) administration of Y DOTATATE can provide an effective and safe alternative to the accepted standard for i. Read More

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Bilateral Nipple Enlargement as a Secondary Effect of Anabolic Drugs: A Histopathological Mimicker of Smooth Muscle Hamartoma.

Dermatopathology (Basel) 2021 Apr 15;8(2):103-106. Epub 2021 Apr 15.

Dermatopathologie Friedrichshafen, 88048 Friedrichshafen, Germany.

Smooth muscle hamartoma are usually solitary and congenital, may affect the genital area and nipples. Histopathologically, they are characterized by the presence of mature smooth muscle bundles. We present a 40 year-old male with bilateral nipple enlargement excised with clinical suspicion of bilateral leiomyoma. Read More

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[Detection of circulating tumor cells with chromosomes 7 and 8 polysomy in non-small cell lung cancer and its correlation with epidermal growth factor receptor mutations in cancer tissue].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):447-452

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To investigate the value of chromosomes 7 and 8 polysomy in circulating tumor cells (CTCs) for the diagnosis of non-small cell lung cancer, and the correlation of CTCs with clinical pathological characteristics and epidermal growth factor receptor (EGFR) mutations in cancer tissue. Fifty-seven patients with non-small cell lung cancer and 21 patients with benign lung diseases were enrolled at Beijing Chaoyang Hospital, Capital Medical University, Beijing, China from November 2017 to October 2020. Negative enrichment combined with immunofluorescence in situ hybridization (imFISH) was used to identify CTCs polysomy on chromosomes 7 and 8. Read More

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[Clinical and pathological analysis of ocular adnexal diffuse large B-cell lymphoma].

Zhonghua Yan Ke Za Zhi 2021 May;57(5):366-371

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin 300020, China.

To summarize the clinical and pathological characteristics of diffuse large B-cell lymphoma of ocular adnexal (OA-DLBCL). A retrospective case series study. Twenty-three cases of OA-DLBCL were collected in Tianjin Eye Hospital from January 2005 to December 2018. Read More

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Benign Metastasizing Leiomyoma in the Heart of a 45-Year-Old Woman.

Tex Heart Inst J 2021 Jan;48(1)

Harrington Heart & Vascular Institute, Cardiovascular Medicine Department, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

We report a rare case of benign metastasizing leiomyoma in the heart of a 45-year-old woman 2 years after a uterine leiomyoma had been discovered during hysterectomy. Computed tomograms at presentation showed a large mixed cystic mass in the pelvis and bilateral lung nodules suggestive of metastatic disease. A large cardiac mass, attached to the chordae of the tricuspid valve and later shown to be histopathologically consistent with uterine leiomyoma, was successfully resected through a right atriotomy. Read More

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January 2021

Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy.

Surg Oncol 2021 Apr 20;38:101572. Epub 2021 Apr 20.

Colorectal and Peritoneal Oncology Centre, The Christie Hospital, UK.

Introduction: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is offered in specialist centres as a treatment for peritoneal surface tumours. Despite its demonstrated efficacy, intra-abdominal recurrence occurs in 31-57% of patients. The aim of this study is to review the early and long-term outcomes in patients who undergo repeat CRS/HIPEC. Read More

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Histopathological evaluation of resected intraductal papillary mucinous neoplasmsreveals distinct patterns of invasion in associated carcinomas.

Hum Pathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

Invasive intraductal papillary mucinous neoplasms (inv-IPMNs) have a better prognosis than regular pancreatic ductal adenocarcinoma (PDAC) with similar stage, but no association with status of surgical margins and microscopic infiltration patterns has previously been described. The aim of this study is to review patterns of invasion and the predictive value of clinical guidelines in terms of rates of resection of high-grade dysplasia (HGD) and cancer among IPMNs. Consecutively resected IPMNs between 2011-2017 were analyzed. Read More

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[Therapeutic outcomes of nasopharyngeal carcinomas: a single-center study conducted at the Fattouma Bourguiba University Hospital in Monastir, Tunisia].

Pan Afr Med J 2021 9;38:143. Epub 2021 Feb 9.

Service d´Otorhinolaryngologie et de Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire Fattouma Bourguiba, Monastir, Tunisie.

Introduction: nasopharyngeal carcinomas (NPCs) are relatively common in the Mediterranean basin. Survival has been greatly improved by new radiation techniques and new molecular-targeted chemotherapy. The purpose of our study was to analyze the therapeutic outcomes and to describe the prognostic factors of NPCs. Read More

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Exploring factors associated with breast cancer screening among women aged 15-49 years in Lesotho.

Pan Afr Med J 2021 2;38:108. Epub 2021 Feb 2.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton ON, Canada.

Introduction: breast cancer is associated with serious morbidity, low quality of life and mortality. Prevention through early screening remains one of the most optimal strategies against breast cancer. The primary objective of this analysis was to determine the prevalence of breast cancer screening using the clinical breast examination (CBE) and breast self-examination (BSE) methods among women aged 15-49 years, and the secondary objective was to explore demographic and socio-economic factors associated with clinical breast examination (CBE) and breast self-examination (BSE) breast cancer screening methods. Read More

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Eccrine Poroma Arising within Nevus Sebaceous.

Ann Dermatol 2020 Dec 11;32(6):516-518. Epub 2020 Nov 11.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Secondary neoplasms in nevus sebaceous can develop during adolescence and adulthood. Trichoblastoma and syringocystadenoma papilliferum are the most common benign neoplasms, but poroma is rarely reported. A 28-year-old female presented with an asymptomatic mass on the scalp. Read More

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December 2020

Morbidity and mortality of parathyroid surgery - a retrospective analysis.

Rozhl Chir 2021 ;100(3):126-132

Introduction: The incidence of parathyroid - glandula parathyreoideae (PTG) diseases has been increasing worldwide. Unlike benign tumours, the incidence of malignant PTG tumours is rather a rare diagnosis. The morbidity of parathyroid surgery is associated with surgical removal of one or more pathologically altered parathyroid glands, particularly parathyroid adenoma associated with primary hyperparathyroidism (HPPT), but also hyperplasia associated with secondary or tertiary HPPT, and last but not least, HPPT due to parathyroid cancer. Read More

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The effect of melatonin on sleep quality and insomnia in patients with cancer: a systematic review study.

Sleep Med 2021 Apr 25;82:96-103. Epub 2021 Apr 25.

Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran; World Federation of Acupuncture-Moxibustion Societies (WFAS), Beijing, China. Electronic address:

Background: Considering the importance of sleep in the treatment success and quality of life in patients with cancer, it is necessary to seek effective solutions to improve their sleep quality. In this regard, a comprehensive review of the effect of melatonin on sleep can be very useful to provide an evidence-based clinical guide. Therefore, the aim of the present systematic review was to investigate effect of melatonin on sleep quality and insomnia in patients with cancer. Read More

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Arq Gastroenterol 2021 Jan-Mar;58(1):39-47

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Belo Horizonte, MG, Brasil.

Background: H. pylori chronic atrophic gastritis is a premalignant lesion, and its staging, according to OLGA and OLGIM systems aims to identify patients at increased risk of developing gastric cancer and optimize their follow-up. GastroPanel®, serum biomarkers panel including pepsinogen I (PGI), pepsinogen II (PGII), Gastrin 17 (G17) and anti- H. Read More

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[Professor 's experience in treatment of obese polycystic ovary syndrome based on spleen and kidney functions].

Zhongguo Zhen Jiu 2021 Apr;41(4):429-32

Yueyang Clinic Medical College, Shanghai University of TCM, Shanghai 201203, China.

Professor 's clinical experience in treatment of obese polycystic ovary syndrome (PCOS) accompained with infertility with acupuncture and moxibustion in view of spleen and kidney functions is summarized. Professor believes PCOS is commonly seen in obese women of childbearing age, accompained with infertility, with kidney and spleen involved in terms of the disorder location. In pathogenesis, spleen and kidney deficiency is the primary and obstruction of phlegm (damp) in collateral is the secondary. Read More

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Single early palliative care intervention added to usual oncology care for patients with advanced cancer: A randomized controlled trial (SENS Trial).

Palliat Med 2021 Apr 28:2692163211005340. Epub 2021 Apr 28.

CTU Bern, University of Bern, Bern, Switzerland.

Background: International oncology societies recommend early palliative care. Specific models to integrate early palliative care efficiently into clinical practice are debated. The authors designed a study to look at the quantitative and qualitative outcomes of an early palliative care intervention in oncological care to decrease stress and improve quality of life. Read More

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Serum Hypoxia Inducible Factor-2: A Candidate Prognostic Biomarker for Laryngeal Cancer.

Clin Otolaryngol 2021 Apr 28. Epub 2021 Apr 28.

Dokuz Eylül University, Institute of Oncology, Izmir, Turkey.

Objectives: To determine the serum hypoxia inducible factor-1, -2 and -3 (HIF-1, -2 and -3) levels in patients with laryngeal neoplasm, and to investigate their role in differential diagnosis, prediction of tumor characteristic and extension, and prognosis and survival.

Study Design: Prospective, cohort study at a tertiary referral center.

Settings: The study was conducted in a tertiary medical centre. Read More

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Evaluation of the efficiency of peptide receptor radionuclide therapy in patients with metastatic prostate carcinoma: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(17):e25612

Department of Nuclear Medicine.

Background: Metastatic prostate carcinoma has poor prognoses with a median survival period ranging from 2 to 5 years with existing therapeutic challenges. Currently, peptide receptor radionuclide therapy is permitted as a treatment method for metastatic prostate carcinoma patients. Therefore, it is crucial to comprehend the efficiency and safety of peptide receptor radionuclide therapy among this patient population. Read More

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A randomized phase II trial comparing capecitabine with oxaliplatin or docetaxel as first-line treatment in advanced gastric and gastroesophageal adenocarcinomas.

Medicine (Baltimore) 2021 Apr;100(17):e25493

Department of Abdominal Oncology.

Background: A combination of fluoropyrimidines and platinum is widely accepted as the standard first-line treatment for advanced gastric and gastroesophageal adenocarcinomas. However, the benefit compared with platinum-free chemotherapeutic regimens remains controversial. We compared the efficacy and safety of capecitabine with oxaliplatin or docetaxel, as first-line therapy in advanced gastric cancer. Read More

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Neuroblastoma metastasized to the mandible and the spinal extradural regions: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e24399

Cancer Center.

Abstract: Neuroblastoma (NB) metastasized into the mandible and spinal extradural region was rarely reported. We present a case with metastatic NB to the mandible and the spinal extradural regions. The patient received chemotherapy using NB 97 regimen and was tumor free after 8 months, but 9 months after the treatment, the patient presented with lower limb paralysis and persistent pain in maxillofacial region as well as swelling in the left mandibular area. Read More

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