25,641 results match your criteria secondary metabolites


Saccharopolyspora karakumensis sp. nov., Saccharopolyspora elongata sp. nov., Saccharopolyspora aridisoli sp. nov., Saccharopolyspora terrae sp. nov. and their biotechnological potential revealed by genome analysis.

Syst Appl Microbiol 2021 Oct 4;44(6):126270. Epub 2021 Oct 4.

Department of Molecular Biology and Genetics, Faculty of Sciences and Arts, Ondokuz Mayis University, 55139 Samsun, Turkey. Electronic address:

Exploration of unexplored habitats for novel actinobacteria with high bioactivity potential holds great promise in the search for novel entities. During the course of isolation of actinobacteria from desert soils, four actinobacteria, designated as 5K548, 7K502, 16K309 and 16K404, were isolated from the Karakum Desert and their bioactivity potential as well as taxonomic provenances were revealed by comprehensive genome analyses. Pairwise sequence analyses of the 16S rRNA genes indicated that the four strains are representatives of putatively novel taxa within the prolific actinobacterial genus Saccharopolyspora. Read More

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October 2021

Comparative Analyses of Phyllosphere Bacterial Communities and Metabolomes in Newly Developed Needles of (Lamb.) Hook. at Four Stages of Stand Growth.

Front Plant Sci 2021 28;12:717643. Epub 2021 Sep 28.

Department of Plant Sciences, School of Life Sciences, Jilin Normal University, Siping, China.

Host-plant-associated bacteria affect the growth, vigor, and nutrient availability of the host plant. However, phyllosphere bacteria have received less research attention and their functions remain elusive, especially in forest ecosystems. In this study, we collected newly developed needles from sapling (age 5 years), juvenile (15 years), mature (25 years), and overmature (35 years) stands of Chinese fir [ (Lamb. Read More

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September 2021

Complete Genome Sequence of LM1 and Comparative Genomic Analysis.

Front Microbiol 2021 28;12:749218. Epub 2021 Sep 28.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

The genus is attracting an increasing amount of attention because of its multiple functions and probiotic potential. In particular, the species is known to have great potential in industrial applications and exhibits numerous biological functions. However, the knowledge on this bacterium in insects is not investigated. Read More

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September 2021

Natural-derived glycosides with potential activity against Staphylococcus aureus.

Authors:
Yulin Zou Wei Fang

Curr Top Med Chem 2021 Oct 14. Epub 2021 Oct 14.

Department of Emergency, Zhuji People's Hospital of Zhejiang Province, Zhuji, Shaoxing, 311800. China.

Staphylococcus aureus (S. aureus) is one of the most common pathogens and implicated in a wide range of infections. It is responsible for a high rate of morbidity and mortality and has already posed a great burden on the healthcare system. Read More

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October 2021

Potential of Producing Flavonoids Using Cyanobacteria As a Sustainable Chassis.

J Agric Food Chem 2021 Oct 14. Epub 2021 Oct 14.

College of Forestry, Beijing Forestry University, Beijing 100083, P.R. China.

Numerous plant secondary metabolites have remarkable impacts on both food supplements and pharmaceuticals for human health improvement. However, higher plants can only generate small amounts of these chemicals with specific temporal and spatial arrangements, which are unable to satisfy the expanding market demands. Cyanobacteria can directly utilize CO, light energy, and inorganic nutrients to synthesize versatile plant-specific photosynthetic intermediates and organic compounds in large-scale photobioreactors with outstanding economic merit. Read More

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October 2021

Sex and self defense.

Authors:
Milton T Drott

Elife 2021 10 14;10. Epub 2021 Oct 14.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Wisconsin-Madison, United States.

The fungus produces secondary metabolites during sexual development to protect itself from predators. Read More

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October 2021

Cytochalasans and azaphilones: suitable chemotaxonomic markers for the Chaetomium species.

Appl Microbiol Biotechnol 2021 Oct 14. Epub 2021 Oct 14.

College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding, 071002, People's Republic of China.

The accurate taxonomic concept of the fungal Chaetomium species has been a hard work due to morphological similarity. Chemotaxonomy based on secondary metabolites is a powerful tool for taxonomical purposes, which could be used as an auxiliary reference to solve the problems encountered in the classification of Chaetomium. Among secondary metabolites produced by Chaetomium, cytochalasans and azaphilones exhibited a pattern of distribution and frequency of occurrence that establish them as chemotaxonomic markers for the Chaetomium species. Read More

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October 2021

The isolation of water-soluble natural products - challenges, strategies and perspectives.

Nat Prod Rep 2021 Oct 14. Epub 2021 Oct 14.

Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.

Covering period: up to 2019Water-soluble natural products constitute a relevant group of secondary metabolites notably known for presenting potent biological activities. Examples are aminoglycosides, β-lactam antibiotics, saponins of both terrestrial and marine origin, and marine toxins. Although extensively investigated in the past, particularly during the golden age of antibiotics, hydrophilic fractions have been less scrutinized during the last few decades. Read More

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October 2021

Comparative metabolomics reveals differences in primary and secondary metabolites between "Shixia" and "Chuliang" longan ( Lour.) pulp.

Food Sci Nutr 2021 Oct 28;9(10):5785-5799. Epub 2021 Aug 28.

College of Horticulture South China Agricultural University/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center of Southern Horticultural Products Preservation Ministry of Education Guangzhou China.

Longan was a characteristic fruit for both medicine and food in China, which was rich in primary and secondary metabolites. Comprehensive high-throughput identification and comparison of metabolites in longan pulp among different varieties were still lacked. "Shixia" (SX) and "Chuliang" (CL) were the biggest major cultivars of longan in China. Read More

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October 2021

Responses of Root Endophytes to Phosphorus Availability in Peach Rootstocks With Contrasting Phosphorus-Use Efficiencies.

Front Plant Sci 2021 27;12:719436. Epub 2021 Sep 27.

Beijing Academy of Forestry and Pomology Sciences, Beijing, China.

Phosphorus (P) is an important macronutrient for all lives, but it is also a finite resource. Therefore, it is important to understand how to increase the P availability and plant uptake. The endophytes can help host plants to improve P uptake and will be apparently affected by plant genotypes. Read More

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September 2021

New Tetramic Acid Derivatives From the Deep-Sea-Derived Fungus sp. SCSIO06868 With SARS-CoV-2 M Inhibitory Activity Evaluation.

Front Microbiol 2021 27;12:730807. Epub 2021 Sep 27.

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.

Three new tetramic acid derivatives (-) and a new polyketide () along with eight known compounds (-) were isolated from cultures of the deep-sea-derived fungus sp. SCSIO06868. Four new structures were elucidated by analysis of one-dimensional/two-dimensional nuclear magnetic resonance (NMR) data and high-resolution electrospray ionization mass spectrometry. Read More

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September 2021

Changes in "natural antibiotic" metabolite composition during tetraploid wheat domestication.

Sci Rep 2021 Oct 13;11(1):20340. Epub 2021 Oct 13.

WDS Inc., Contractor to Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30033, USA.

Gramineous plants protect their seeds from a variety of biotic stresses by producing toxic and deterrent secondary metabolites such as benzoxazinoids. It is unclear how the composition and abundance of these natural toxins has changed over the course of crop-plant domestication. To address this uncertainty, we characterized differences in metabolic levels of benzoxazinoids and their derivatives, between four lines of tetraploid wheat: wild emmer wheat (WEW), the direct progenitor of modern wheat; non-fragile domesticated emmer wheat (DEW), which was first domesticated about 11,000 years ago; the subsequently developed non-fragile and free-threshing durum landraces (LD); and modern durum (MD) varieties. Read More

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October 2021

CRISPR/Cas 9-Based Editing in the Production of Bioactive Molecules.

Mol Biotechnol 2021 Oct 13. Epub 2021 Oct 13.

Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India.

Plants, fungi, and bacteria synthesize a wide range of secondary metabolites that exhibit diverse biological activities. These bioactives, due to their potential benefits in research and therapeutics, have gained immense industrial importance. There is a need to synthesize these bioactives at significantly higher concentrations using cost-effective measures to be economically viable. Read More

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October 2021

Roseitranquillus sediminis gen. nov., sp. nov. a novel genus and species of the family Rhodobacteraceae, isolated from sediment of an Arctic fjord.

Antonie Van Leeuwenhoek 2021 Oct 13. Epub 2021 Oct 13.

National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala, 682 016, India.

A Gram-negative, aerobic, non-motile, oxidase-positive, catalase-positive, rod-shaped bacterium, designated strain MCCB 386 was isolated from sediment samples collected from Kongsfjorden, an Arctic fjord. The strain MCCB 386 showed growth at 4-37 °C (optimum 27°C) in the presence of 1-8% NaCl (w/v, optimum 3.5%) and at pH 6. Read More

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October 2021

Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis.

Acta Derm Venereol 2021 Oct 13. Epub 2021 Oct 13.

Dermatology and Venereology Unit, Karolinska University Hospital, Solna, Eugeniavägen 3, A6:01, SE-171 76, Stockholm, Sweden.

High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. Read More

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October 2021

The Antimicrobial Activities of Silver Nanoparticles from Aqueous Extract of Grape Seeds against Pathogenic Bacteria and Fungi.

Molecules 2021 Oct 8;26(19). Epub 2021 Oct 8.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

Grape seed extract (GSE) is a natural source of polyphenolic compounds and secondary metabolites, which have been tested for their possible antimicrobial activities. In the current study, we tested the antibacterial and antifungal activities of aqueous GSE and the biosynthesized silver nanoparticles loaded with GSE (GSE-AgNPs) against different pathogens. The biosynthesized GSE-AgNPs were assessed by UV spectroscopy, dynamic light scattering (DLS), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and gas chromatography/mass spectrometry (GC/MS). Read More

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October 2021

The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective.

Molecules 2021 Oct 2;26(19). Epub 2021 Oct 2.

Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Neurodegenerative diseases (NDDs) are one of the leading causes of death and disability in humans. From a mechanistic perspective, the complexity of pathophysiological mechanisms contributes to NDDs. Therefore, there is an urgency to provide novel multi-target agents towards the simultaneous modulation of dysregulated pathways against NDDs. Read More

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October 2021

L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review.

Molecules 2021 Sep 26;26(19). Epub 2021 Sep 26.

Department of Biology, Faculty of Arts and Sciences, University of Balamand, P.O. Box 100, Tripoli 1300, Lebanon.

genus is a prominent staple crop globally. Long-term breeding and much hybridization engendered a myriad of species, each characterized by a specific metabolism generating different secondary metabolites. L. Read More

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September 2021

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review.

Molecules 2021 Sep 23;26(19). Epub 2021 Sep 23.

Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. Read More

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September 2021

Secondary Metabolites with Anti-Inflammatory Activities from One Actinobacteria .

Molecules 2021 Sep 23;26(19). Epub 2021 Sep 23.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan.

Phytochemical investigation and chromatographic separation of extracts from one new actinobacteria strain that was isolated from soil of Yilan township, in the north of Taiwan, led to the isolation of nine new compounds, amycolataiwanensins A-I (-, resp.), and one , namely amycolataiwanensin J (). The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. Read More

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September 2021

Chemical Evaluation, Antioxidant, Antiproliferative, Anti-Inflammatory and Antibacterial Activities of Organic Extract and Semi-Purified Fractions of the Adriatic Sea Fan, .

Molecules 2021 Sep 23;26(19). Epub 2021 Sep 23.

Faculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, 51000 Rijeka, Croatia.

Due to sedentary lifestyle and harsh environmental conditions, gorgonian coral extracts are recognized as a rich source of novel compounds with various biological activities, of interest to the pharmaceutical and cosmetic industries. The presented study aimed to perform chemical screening of organic extracts and semi-purified fractions obtained from the common Adriatic gorgonian, sea fan, (Koch, 1887) and explore its abilities to exert different biological effects in vitro. Qualitative chemical evaluation revealed the presence of several classes of secondary metabolites extended with mass spectrometry analysis and tentative dereplication by using Global Natural Product Social Molecular Networking online platform (GNPS). Read More

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September 2021

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine-A Review.

Int J Mol Sci 2021 Oct 4;22(19). Epub 2021 Oct 4.

Institute of Microbiology, Faculty of Medicine and the University Hospital in Bratislava, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.

Bacterial infections of skin and wounds may seriously decrease the quality of life and even cause death in some patients. One of the largest concerns in their treatment is the growing antimicrobial resistance of bacterial infectious agents and the spread of resistant strains not only in the hospitals but also in the community. This trend encourages researchers to seek for new effective and safe therapeutical agents. Read More

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October 2021

Isopimarane-type diterpenoids from the rhizomes of L. and their biological activities.

Nat Prod Res 2021 Oct 12:1-10. Epub 2021 Oct 12.

Faculty of Science, Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand.

Fourteen isopimarane diterpenoids (-) were isolated from the rhizomes of , including four new compounds (-). The isolated secondary metabolites were identified through analysis of spectroscopic (1 D and 2 D NMR) and mass spectrometric data, together with X-ray diffraction studies. Compounds -, -, and showed strong antimalarial activities, with IC values in the range of 1. Read More

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October 2021

Metagenomic Sequencing of Multiple Soil Horizons and Sites in Close Vicinity Revealed Novel Secondary Metabolite Diversity.

mSystems 2021 Oct 12:e0101821. Epub 2021 Oct 12.

Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingengrid.10392.39, Tübingen, Germany.

Discovery of novel antibiotics is crucial for combating rapidly spreading antimicrobial resistance and new infectious diseases. Most of the clinically used antibiotics are natural products-secondary metabolites produced by soil microbes that can be cultured in the lab. Rediscovery of these secondary metabolites during discovery expeditions costs both time and resources. Read More

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October 2021

A comparative study at bioprocess and metabolite levels of superhost strain Streptomyces coelicolor M1152 and its derivative M1581 heterologously expressing chloramphenicol biosynthetic gene cluster.

Biotechnol Bioeng 2021 Oct 12. Epub 2021 Oct 12.

Department of Biotechnology and Food Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.

Microbial superhost strains should provide an ideal platform for the efficient homologous or heterologous phenotypic expression of biosynthetic gene clusters (BGCs) of new and novel bioactive molecules. Our aim in the current study was to perform a comparative study at the bioprocess and metabolite levels of the previously designed superhost strain Streptomyces coelicolor M1152 and its derivative strain S. coelicolor M1581 heterologously expressing chloramphenicol BGC. Read More

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October 2021

Toward the Synthesis of a Heterocyclic Analogue of Natural Cyclooligopeptide with Improved Bio-Properties.

Curr Org Synth 2021 Oct 5. Epub 2021 Oct 5.

Department of Pharmaceutics, Nootan Pharmacy College, Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Mehsana, Gujarat. India.

Aims: The present investigation is targeted toward the synthesis of a novel analogue of a natural peptide of marine origin.

Background: Marine sponges are enriched with bioactive secondary metabolites especially circular peptides. Heterocycles are established organic compounds with potential biological value. Read More

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October 2021

Direct quantification of red wine phenolics using fluorescence spectroscopy with chemometrics.

Talanta 2022 Jan 8;236:122857. Epub 2021 Sep 8.

South African Grape and Wine Research Institute (SAGWRI), Department of Viticulture and Oenology, Stellenbosch University, South Africa.

Phenolic compounds are secondary metabolites known to play crucial roles in important chemical reactions impacting the mouthfeel, colour and ageing potential of red wine. Their complexity has resulted in a number of advanced analytical methods, which often prevent routine phenolic analysis in winemaking. Fluorescence spectroscopy could be an alternative to current spectrophotometric techniques and its combination with chemometrics was investigated for its suitability in directly quantifying phenolic content of unaltered red wine and fermenting samples. Read More

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January 2022

Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals.

Elife 2021 10 12;10. Epub 2021 Oct 12.

University of Göttingen, Molecular Microbiology and Genetics and Göttingen Center for Molecular Biosciences (GZMB), Göttingen, Germany.

Fungal Hülle cells with nuclear storage and developmental backup functions are reminiscent of multipotent stem cells. In the soil, Hülle cells nurse the overwintering fruiting bodies of . The genome of harbors genes for the biosynthesis of xanthones. Read More

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October 2021

Application of modified Michaelis - Menten equations for determination of enzyme inducing and inhibiting drugs.

BMC Pharmacol Toxicol 2021 Oct 11;22(1):57. Epub 2021 Oct 11.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, P.M.B.2373, Makurdi, Benue State, Nigeria.

Background: Pharmacokinetics (PK) is the process of absorption, distribution, metabolism and elimination (ADME) of drugs. Some drugs undergo zero-order kinetics (ethyl alcohol), first order kinetics (piroxicam) and mixed order kinetics (ascorbic acid). Drugs that undergo Michaelis-Menten metabolism are characterized by either increased or decreased metabolism constant (Km) and maximum velocity (Vmax) of enzyme reaction. Read More

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October 2021

Phylogeny of the family Cladoniaceae (Lecanoromycetes, Ascomycota) based on sequences of multiple loci.

Cladistics 2019 Aug 6;35(4):351-384. Epub 2018 Dec 6.

Finnish Museum of Natural History, Botany Unit, University of Helsinki, PO Box 47, FI-00014, Helsinki, Finland.

Cladoniaceae is a family of lichenized fungi that belongs to the Lecanorales, Ascomycota. The family is distributed widely, although several genera are restricted to the Southern Hemisphere. The circumscriptions of the genera and species in the family have traditionally been based on thallus morphology, the type of vegetative propagules and the secondary metabolites. Read More

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