86 results match your criteria second-third levels

Evaluation of adherence to levothyroxine and out-of-range thyroid-stimulating hormone levels in pregnant women with primary hypothyroidism.

Int J Clin Pract 2021 May 17:e14312. Epub 2021 May 17.

Internal Medicine Clinics, Kocaeli Derince Training and Research Hospital, University of Health Sciences, Kocaeli, Turkey.

Purpose: Adherence to levothyroxine (LT4) and attaining thyroid-stimulating hormone (TSH) goal in pregnancy has not been well-defined yet. We aimed to investigate adherence to LT4, success to reach TSH goal, and association between them in pregnant women with primary hypothyroidism.

Materials And Methods: Eight-item Morisky Medication Adherence Scale (MMAS-8) was applied in third trimester in pregnant women with primary hypothyroidism (Hashimoto's thyroiditis, surgical hypothyroidism or iodine deficiency) whom LT4 was given for at least 3 months. Read More

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Helminthiasis, iron intake, and hemoglobin levels in pregnant women.

Enferm Clin 2021 04;31 Suppl 2:S252-S256

Department of Nutrition Science, Faculty of Health Sciences, Universitas Muhammadiyah Surakarta, Surakarta, Central of Java, Indonesia.

The study aims to analyze the correlation of helminthiasis, iron intake, and hemoglobin levels in pregnant women in the Public Health Center of Kemusu 2 Boyolali, Central Java, Indonesia. A cross-sectional research design was applied to 164 pregnant women who are in the second-third trimester and selected using simple random sampling. The Cyanmethemoglobin tool was utilized to measure the respondents' hemoglobin levels. Read More

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Wiad Lek 2021 ;74(3 cz 2):761-766


Objective: The aim: To realize analysis and assessment of completeness and efficacy in the field of perinatal aid regionalization in Ukraine.

Patients And Methods: Materials and methods: A retrospective analysis has been carried out as well as assessment of inculcation steps concerning regionalization of perinatal health care in Ukraine according to the data of state and branch statistics and monitoring (in 2013-2017). The methods used here are systemic approach, bibliography method, and statistical data evaluation. Read More

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Association between routine biomarkers and atrial fibrillation in patients undergoing implantation of a dual-chamber pacemaker.

J Arrhythm 2021 Feb 17;37(1):219-225. Epub 2020 Dec 17.

First Department of Cardiology University of Ioannina Medical School Ioannina Greece.

Background: Elderly patients having a permanent pacemaker frequently have atrial remodeling. We examined the association between routine biomarkers and atrial fibrillation (AF) in patients receiving a dual-chamber pacemaker for sinus node disease (SND) or second-/third-degree atrioventricular block.

Methods: We recorded clinical, laboratory, and electrocardiographic parameters as well as pacemaker lead parameters at implantation. Read More

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February 2021

Intrahepatic cholestasis of pregnancy: machine-learning algorithm to predict elevated bile acid based on clinical and laboratory data.

Arch Gynecol Obstet 2021 Feb 19. Epub 2021 Feb 19.

Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, Israel.

Purpose: Applying machine-learning models to clinical and laboratory features of women with intrahepatic cholestasis of pregnancy (ICP) and creating algorithm to identify these patients without bile acid measurements.

Methods: This retrospective study included 336 pregnant women with a chief complaint of pruritis without rash during the second/third trimesters. Data extracted included: demographics, obstetric, clinical and laboratory features. Read More

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February 2021

Episodes of strain experienced in the operating room: impact of the type of surgery, the profession and the phase of the operation.

BMC Surg 2020 Dec 7;20(1):318. Epub 2020 Dec 7.

Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.

Background: Strain episodes, defined as phases of higher workload, stress or negative emotions, occur everyday in the operating room (OR). Accurate knowledge of when strain is most intense for the different OR team members is imperative for developing appropriate interventions. The primary goal of the study was to investigate temporal patterns of strain across surgical phases for different professionals working in the OR, for different types of operations. Read More

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December 2020

Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia: The Angiogenic-Placental Syndrome.

Hypertension 2020 04 17;75(4):918-926. Epub 2020 Feb 17.

From the Department of Obstetrics, Leipzig University, Leipzig, Germany (H.S., T.A.).

Placental dysfunction underlies a spectrum of perinatal pathologies, including preeclampsia and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like tyrosine kinase 1) and PlGF (placental growth factor), play an important role in placental dysfunction; altered levels are detectable several weeks before onset of pregnancy complications. In vitro diagnostic tests for these biomarkers can improve early diagnosis and facilitate prediction of maternal and fetal outcomes. Read More

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Effects of progesterone variation on IVF Progesterone variation during controlled ovarian stimulation: effects on in vitro results.

J Obstet Gynaecol 2020 Aug 26;40(6):825-829. Epub 2019 Nov 26.

Human Reproduction Service, Department of Obstetrics and Gynecology, La Paz University Hospital, Paseo de la Castellana 261, Madrid, Spain.

The objective of this study was to investigate the impact of the progesterone variation (PV) between early progesterone and preovulatory progesterone on pregnancy rate (PR), number of oocytes, and embryo quality. Three hundred and thirty-eight cycles of in vitro fertilisation were included and progesterone was measured on 5th day of stimulation GnRH as well as on the day of induction of ovulation. Fresh embryo transfer (ET) on the second-third day after follicular puncture was made in 152/338 cycles, with positive pregnancies in 61/152 (40%). Read More

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Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.

Mol Med 2019 11 14;25(1):48. Epub 2019 Nov 14.

Medical University Semey, Semey, Kazakhstan.

Background: To study the association of radiation risk in the 2nd -3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.

Methods: 5 polymorphic gene variants (rs1048943, rs4646421, rs2070676, rs3813867, rs1695) were studied in 399 people living in the East Kazakhstan region in this research. 248 people of the 2nd - 3rd generation lived in the territory with radiation exposure in Abai, Borodulikha areas, and 151 people the comparison group lived in Kurchum district without radiation exposure comparable in sex and age with control group. Read More

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November 2019

Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery.

Br J Anaesth 2019 12 14;123(6):839-852. Epub 2019 Oct 14.

Department of Pediatric Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA. Electronic address:

Background: Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for steady-state DEX plasma levels; and (iv) validate the PK model and dosing.

Methods: We included 122 neonates and infants (0-180 days) with D-transposition of the great arteries, ventricular septal defect, or tetralogy of Fallot. Read More

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December 2019

Sicca/Sjögren's syndrome triggered by PD-1/PD-L1 checkpoint inhibitors. Data from the International ImmunoCancer Registry (ICIR).

Clin Exp Rheumatol 2019 May-Jun;37 Suppl 118(3):114-122. Epub 2019 Aug 28.

Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France.

Objectives: To analyse the worldwide occurrence of sicca/Sjögren's (SS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer.

Methods: The ImmunoCancer International Registry (ICIR) is a Big Data-Sharing multidisciplinary network composed by 40 specialists in Rheumatology, Internal Medicine, Immunology and Oncology from 18 countries focused on the clinical and basic research of the immune-related adverse events (irAEs) related to cancer immunotherapies. For this study, patients who were investigated for a clinical suspicion of SS after being exposed to ICI were included. Read More

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October 2019

Presence of Precore (C)/C Promoter Mutants in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B (CHB) Carriers During Pregnancy Does Not Correlate with Increased Risk of Liver Disease in 4 Years of Follow-Up.

Dig Dis Sci 2020 01 2;65(1):204-214. Epub 2019 Aug 2.

Calgary Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, Cumming School of Medicine, University of Calgary, 6D21, Teaching, Research and Wellness Building, 3280 Hospital Drive N.W., Calgary, AB, T2N 4Z6, Canada.

Purpose: HBV precore (PC) and basal core promoter (BCP) mutants are associated with liver disease severity, yet have been suggested to protect against HBV vertical transmission. HBV within peripheral blood mononuclear cells (PBMC) has been reported in association with intrauterine HBV infection. We analyzed HBV replication status in PBMC and PC/BCP mutants in PBMC from pregnant chronic hepatitis B (CHB) patients. Read More

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January 2020

Thinking about what he thinks of what I think: Assessing higher theory of mind abilities in Indian bilingual children between 3.0 and 8.11 years of age.

Indian J Psychiatry 2019 Mar-Apr;61(2):167-176

Department of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Context: The competence in theory of mind (ToM) abilities occurs in parallel with the development of language. To gain a deeper discernment about its proficiency, tasks tapping on higher-order ToM abilities have been implemented.

Aims: This study aims to explore the development of higher-order ToM abilities in bilingual Indian children between 3. Read More

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Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study.

J Clin Med 2019 04 9;8(4). Epub 2019 Apr 9.

Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their pregnancy (Group C), 123 women with vaginal bleeding but without PA (Group D), and 46 healthy pregnant women who had undergone a control laboratory evaluation in the second/third trimester for history of previous cytomegalovirus (additional control group) were included. Hemoglobin, leukocytes, thrombocytes, C-reactive protein (CRP), and fibrinogen were obtained within 48 hours before C-section and/or at the time of bleeding onset. Read More

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Disease heterogeneity in IgG4-related hypophysitis: report of two histopathologically proven cases and review of the literature.

Virchows Arch 2019 Sep 25;475(3):373-381. Epub 2019 Mar 25.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

IgG4-related hypophysitis (IgG4-RH) is a rare disease, which can occur singularly or as manifestation of a systemic IgG4-related disease (IgG4-RD). Less than one hundred cases have been reported in the literature, very few of which were histopathologically documented. We analyzed the clinical, radiological, and histopathological features of two cases of IgG4-RH, the former observed in a 66-year-old man in the context of an IgG4-RD, and the latter affecting a 21-year-old woman, as an isolated lesion. Read More

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September 2019

Elevated levels of autoantibodies against EXD2 and PHAX in the sera of patients with chronic thromboembolic pulmonary hypertension.

PLoS One 2019 13;14(2):e0211377. Epub 2019 Feb 13.

Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.

While circulating autoantibodies have been detected in patients with several cardiovascular diseases, such studies have not been performed for chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Here we investigated the production of certain auto-antibodies in CTEPH patients. Initial screening was performed in 5 CTEPH patients and 5 healthy donors (HDs) using a ProtoArray Human Protein Microarray v5. Read More

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November 2019

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.

J Epidemiol 2019 Dec 12;29(12):478-486. Epub 2019 Jan 12.

Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health.

Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.

Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Read More

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December 2019

Glycated haemoglobin A1c as a predictor of preeclampsia in type 1 diabetic pregnant women: A systematic review and meta-analysis.

Pregnancy Hypertens 2018 Oct 7;14:49-54. Epub 2018 Apr 7.

Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.

Objective: To examine the relationship between the increase of glycated haemoglobin A1c (HbA1c) levels and the risk of preeclampsia in pregnant with type 1 diabetes mellitus; and to determine from which trimester the increase of HbA1c levels better predicts the risk of suffering preeclampsia in type 1 diabetic pregnant women.

Methods: We systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews and Web of Science databases, from inception to May 2017, for observational studies addressing the association of HbA1c levels with preeclampsia. Fixed effects models were used to compute pooled estimates of odds ratio (OR) and respective 95% confidence intervals (95% CI) for preeclampsia in type 1 diabetic pregnant women. Read More

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October 2018

Do the adiponectin and leptin levels in preterm and term breast milk samples relate to infants' short-term growth?

J Dev Orig Health Dis 2019 04 11;10(2):253-258. Epub 2018 Sep 11.

3Medical Faculty,Department of Pediatrics,Division of Neonatology,Gazi University,Beşevler,Ankara,Turkey.

Adiponectin and leptin are involved in appetite control and body weight regulation. We aimed to evaluate the relationship between breast milk adipokine levels and short-term growth of preterm and term infants. Thirty-one preterm (median=35. Read More

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Pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression during or following platinum-containing chemotherapy. A Cochrane Rapid Review.

Cochrane Database Syst Rev 2018 07 23;7:CD012838. Epub 2018 Jul 23.

Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA.

Background: The use of systemic immunotherapy targets is emerging as an important treatment option for metastatic urothelial carcinoma, particularly for patients who cannot tolerate or who fail cisplatin-based chemotherapy. One such target is the inhibition of the checkpoint protein programmed cell death-1 (PD-1) receptor and its ligand (PD-L1) by monoclonal antibodies.

Objectives: To assess the effects of pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression during or following platinum-containing chemotherapy. Read More

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Efficacy of laboratory tests and ultrasonography in the diagnosis of acute appendicitis in gravid patients according to the stages of pregnancy.

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):333-336

İnönü University, Institute of Liver Transplantation, Turgut Özal Medical Center, Malatya-Turkey.

Background: Normal physiologic changes during pregnancy result in similar laboratory and symptomatology changes as those during acute appendicitis (AA), making the diagnosis extremely difficult. The aim of the present study was to analyze the efficacy of conventional laboratory and radiologic tests in the diagnosis of AA according to different stages of pregnancy.

Methods: Twenty-five pregnant patients with pathologically confirmed AA operated at our department between 2012 and 2017 were retrospectively analyzed in terms of changes in conventional laboratory parameters as well as neutrophil-to lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios to aid the diagnosis of AA according to different stages of pregnancy. Read More

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The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS).

Environ Res 2018 10 28;166:562-569. Epub 2018 Jun 28.

Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. Electronic address:

Background: Heavy metals are widely distributed in the environment. Recent reports have demonstrated the risk of preterm birth following heavy metal exposure. Preterm births are classified as early and late, depending on the duration of pregnancy, and are associated with increased risk of congenital illnesses such as heart failure, asthma, etc. Read More

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October 2018

[Association between pregnancy-related anxiety of pregnant women and autism-like behavior in their offspring at 18 months of age].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Jun;39(6):826-829

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Heifei 230032, China.

To investigate the relationship of pregnancy-related anxiety of pregnant women in second/third trimesters and autism-like behaviors in their offspring at 18 months of age. Based on a prospective cohort study design, we evaluated the situation of pregnancy-related anxiety of women during second and third trimesters through a Pregnancy-Related Anxiety Questionnaire. Subjects under study were classified into three groups, 1) those with pregnancy- related anxiety during both trimesters, 2) those with pregnancy-related anxiety at one trimester and 3) those without pregnancy-related anxiety in either trimester. Read More

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Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Pregnancy Hypertens 2018 Oct 10;14:252-259. Epub 2018 Mar 10.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland, HiLIFE Unit, University of Helsinki, Helsinki, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

Objectives: To study first and second/third trimester levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF) and soluble endoglin (sEng) in FINNPEC case-control cohort. The participants were further divided into subgroups based on parity and onset of the disease. Recommended cut-off values in aid of pre-eclampsia (PE) prediction and diagnosis were also tested. Read More

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October 2018

Patterns and effects of GC3 heterogeneity and parsimony informative sites on the phylogenetic tree of genes.

Gene 2018 May 21;655:56-60. Epub 2018 Feb 21.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

The explosive growth in genomic data has provided novel insights into the conflicting signals hidden in phylogenetic trees. Although some studies have explored the effects of the GC content and parsimony informative sites (PIS) on the phylogenetic tree, the effect of the heterogeneity of the GC content at the first/second/third codon position on parsimony informative sites (GC1/2/3) among different species and the effect of PIS on phylogenetic tree construction remain largely unexplored. Here, we used two different mammal genomic datasets to explore the patterns of GC1/2/3 heterogeneity and the effect of PIS on the phylogenetic tree of genes: (i) all GC1/2/3 have obvious heterogeneity between different mammals, and the levels of heterogeneity are GC3 > GC2 > GC1; (ii) the number of PIS is positively correlated with the metrics of "good" gene tree topologies, and excluding the third codon position (C3) decreases the quality of gene trees by removing too many PIS. Read More

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Posaconazole oral dose and plasma levels in pediatric hematology-oncology patients.

Eur J Haematol 2018 Mar 10;100(3):315-322. Epub 2018 Jan 10.

Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Background: Posaconazole is a triazole with limited pharmacokinetic information in children. This study assessed the correlation between posaconazole oral solution daily dosage/kg/body weight and trough plasma level.

Methods: A total of 97 hematology-oncology pediatric patients with ≥1 posaconazole plasma concentration level (PPC) assessment in the first 6 weeks after the start of posaconazole treatment were included. Read More

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Coronary artery calcium quantification on first, second and third generation dual source CT: A comparison study.

J Cardiovasc Comput Tomogr 2017 Nov 8;11(6):444-448. Epub 2017 Sep 8.

University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands; University Medical Center Groningen, Dept. of Radiology, Groningen, The Netherlands. Electronic address:

Background: Differences in coronary artery calcium (CAC) quantification of successive CT systems of one vendor could impact results of CAC screening and progression studies. The purpose of this study is to compare CAC quantification between three generations of dual-source computed tomography (DSCT) systems.

Methods: Three DSCT generations were used to repeatedly scan an anthropomorphic chest phantom and three inserts. Read More

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November 2017

Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Ann Med 2017 11 9;49(7):593-602. Epub 2017 Jun 9.

a Medical and Clinical Genetics , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Objectives: The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke.

Subjects And Methods: First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE. Read More

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November 2017

The effect of health-promoting lifestyle education on the treatment of unexplained female infertility.

Eur J Obstet Gynecol Reprod Biol 2016 Dec 2;207:109-114. Epub 2016 Nov 2.

Eskişehir Osmangazi University, Faculty of Medicine, Department of Gynecology and Obstetrics, Reproductive Endocrinology and Infertility, Eskişehir, Turkey.

Objective: This study aimed to reveal the 1) awareness, 2) improvements of a health-promoting lifestyle on women with unexplained infertility having at least one of the risk factors that have been indicated to negatively affect fertility (smoking, body mass index lower than 18.5kg/m and more than 25kg/m, over-exercising or not exercising at all, alcohol consumption, caffeine consumption of more than 300mg/day, and high levels of stress) by means of health-promoting lifestyle education, 3) the effect of this improvement on the result of assisted-reproduction treatment in terms of clinical pregnancy.

Study Design: 64 women diagnosed with unexplained infertility were divided into a group receiving Health-Promoting Lifestyle (HPL) education and a control group. Read More

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December 2016