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Neutrophil extracellular traps induced by pro-inflammatory cytokines enhance procoagulant activity in NASH patients.

Clin Res Hepatol Gastroenterol 2021 Apr 10:101697. Epub 2021 Apr 10.

Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin Heilongjiang, China; Department of Research, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1400 VFW Parkway, West Roxbury, Boston, MA 02132, USA. Electronic address:

Background: Nonalcoholic steatohepatitis (NASH) patients are at a high risk of developing venous thromboembolism, with a high rate of morbidity and mortality. The role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) in patients with NASH remains unclear. Our study aimed to investigate the formation of NETs in NASH patients stimulated by specific pro-inflammatory factors. Read More

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The risks of recurrent small for gestational age infants at term is dependent on the number of previous affected births.

Am J Obstet Gynecol 2021 Apr 10. Epub 2021 Apr 10.

Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Faculty of Medicine, The University of Queensland, Australia,. Electronic address:

Background: Small-for-gestational age (SGA) infants are at significantly increased risk of perinatal complications, but the risk of recurrent SGA is not well known, particularly as there are many demographic and obstetric factors that interact and modify this risk. We investigated the relationship between previous SGA births and the risk of recurrence at term in a large Australian cohort.

Objective(s): We aimed to identify key demographic and obstetric variables that influence the risk of recurrence of an SGA infant at term. Read More

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The position of the choroid plexus of the fourth ventricle in the first- and second-trimester fetuses: an early different approach to diagnostic imaging of cystic posterior fossa anomalies.

Ultrasound Obstet Gynecol 2021 Apr 13. Epub 2021 Apr 13.

Department of Clinical Science and Community Health, University of Milan, Italy.

Objective: The aim of this study was to describe the sonographic appearance and position of the choroid plexus of the fourth ventricle (4thVCP) between 12 and 21 weeks' gestation in normal fetuses and in fetuses with posterior fossa anomalies.

Methods: Two-dimensional ultrasound (US) images of the midsagittal and coronal views of the brain through the posterior fontanelle and three-dimensional volumes datasets were obtained between 12 and 21 weeks prospectively from 90 normal singletons and retrospectively from 41 fetuses identified as having an abnormal posterior brain on first-trimester ultrasound examination. In all cases the diagnosis was confirmed at MRI, prenatally and/or postnatally, and/or at postmortem examination. Read More

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Role of dietary selenium in alleviating bisphenol A toxicity of liver albino rats: Histological, ultrastructural, and biomarker assessments.

J Food Biochem 2021 Apr 13:e13725. Epub 2021 Apr 13.

Pathology Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Bisphenol A (BPA) is used as a plasticizer in polycarbonate plastics. It has been used in consumer products and epoxy resins for decades as protective coatings and linings for food and beverage bottles. This can trigger human reactions to BPA which interferes with estrogen receptors. Read More

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Candidate symptomatic markers for predicting violence in schizophrenia: A cross-sectional study of 7711 patients in a Chinese population.

Asian J Psychiatr 2021 Apr 5;59:102645. Epub 2021 Apr 5.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Centre, Shanghai Jiao Tong University, Shanghai, 200030, China. Electronic address:

Objective: Violent behaviour is an alarming problem among schizophrenia patients. The effects of historical, clinical, and pathological risk factors for violence have been investigated by multiple studies, but consensus has not been achieved. As psychotic symptoms are more direct and intuitive indicators for violence, identifying robustly associated symptoms is a crucial part of the future prediction and precise management of violent patients in clinics. Read More

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Prevention of deep venous thrombosis in stroke: a best practice implementation project.

JBI Evid Implement 2021 Apr 9. Epub 2021 Apr 9.

Neurology Department, Nanfang Hospital, Southern Medical University The Nanfang Nursing Centre for Evidence-based Practice: A JBI Centre of Excellence Nursing Department, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.

Objectives: The current evidence implementation project aims to promote evidence-based practice in the care of patients with stroke, specifically around the prevention of deep venous thrombosis (DVT), in the neurology department of a tertiary hospital in Guangzhou, China.

Introduction: The prevalence of DVT within 14 days after stroke is 10-75%. Approximately 20% of patients with DVT develop pulmonary embolism, the third most common cause of death in patients with stroke and the most common cause of autopsy-verified death between the second and fourth week after stroke. Read More

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Autonomic Nervous System Maturation and Emotional Coordination in Interactions of Preterm and Full-Term Infants With Their Parents: Protocol for a Multimethod Study.

JMIR Res Protoc 2021 Apr 12;10(4):e28089. Epub 2021 Apr 12.

Department of Neonatology, Neonatal Intensive Care Unit, School of Medicine, University of Crete, Heraklion, Greece.

Background: There is limited knowledge on the physiological and behavioral pathways that may affect the developmental outcomes of preterm infants and particularly on the link between autonomic nervous system maturation and early social human behavior. Thus, this study attempts to investigate the way heart rate variability (HRV) parameters are related to emotional coordination in interactions of preterm and full-term infants with their parents in the first year of life and the possible correlation with the developmental outcomes of infants at 18 months.

Objective: The first objective is to investigate the relationship between emotional coordination and HRV in dyadic full-term infant-parent (group 1) and preterm infant-parent (group 2) interactions during the first postpartum year. Read More

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Costs and health resource use in patients with X-linked myotubular myopathy: insights from U.S. commercial claims.

J Manag Care Spec Pharm 2021 Apr 12:1-8. Epub 2021 Apr 12.

Harvard Medical School and Boston Children's Hospital, Boston, MA.

In X-linked myotubular myopathy (XLMTM), mutations in the gene result in absence or dysfunction of myotubularin, a protein required for normal development, maintenance, and function of skeletal muscle. Extreme muscle weakness results in severe respiratory failure that is fatal for approximately half of XLMTM-affected children by age 18 months. Most surviving patients require invasive mechanical ventilation, feeding tubes, and wheelchairs for mobility, due to profoundly impaired motor function. Read More

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Association Between Parenting and School Refusal Among Elementary School Children in Japan: Results From A-CHILD Longitudinal Study.

Front Pediatr 2021 26;9:640780. Epub 2021 Mar 26.

Department of Health and Welfare Services, National Institute of Public Health, Saitama, Japan.

The aim of this study was to examine the association between parenting, including the parent-child interaction and child maltreatment in the first grade (6-7 years old), and school refusal in the second (7-8 years old) and fourth (9-10 years old) grades among elementary school children in Japan. Data were from the Adachi Child Health Impact of Living Difficulty (A-CHILD) longitudinal study conducted in 2015, 2016, and 2018 in Adachi City, Tokyo, Japan. A questionnaire was distributed to all the first-grade school children ( = 5,355) in 2015. Read More

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Validation of the Patient Neurotoxicity Questionnaire for Patients Suffering From Chemotherapy-Induced Peripheral Neuropathy in Greek.

Cureus 2021 Apr 6;13(4):e14324. Epub 2021 Apr 6.

Department of Anesthesiology, Democritus University of Thrace, Alexandroupolis, GRC.

Purpose: The Patient Neurotoxicity Questionnaire (PNQ) represents a diagnostic tool concerning patients with chemotherapy-induced peripheral neuropathy (CIPN). The application of such a tool in the Greek clinical praxis requires validation.

Methods: Validation consists of three stages - translation, reverse translation, and patient application. Read More

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Corticosteroid Therapy in Optic Neuropathy Secondary to Nasopharyngeal Carcinoma.

Cureus 2021 Mar 6;13(3):e13735. Epub 2021 Mar 6.

Department of Ophthalmology and Visual Sciences, School of Medicine Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, MYS.

Introduction: Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells of the nasopharynx. NPC can spread and invade the base of skull, nasal cavity, paranasal sinuses, pterygopalatine fossa, and apex of the orbit. However, the involvement of the optic nerve in NPC is rare. Read More

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Association between the platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and axillary lymph node metastasis in cT1N0 breast cancer patients.

Am J Transl Res 2021 15;13(3):1854-1861. Epub 2021 Mar 15.

Department of General Surgery, The Second Medical Center of PLA General Hospital Beijing, China.

Objective: To investigate the relationship between platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and axillary lymph node metastasis in cT1N0 breast cancer patients.

Methods: The clinicopathological data of 154 patients with cT1N0 breast cancer from January 2015 to June 2020 were retrospectively analyzed. All patients underwent sentinel lymph node (SLN) biopsy. Read More

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Subjective Family Socioeconomic Status and Peer Relationships: Mediating Roles of Self-Esteem and Perceived Stress.

Front Psychiatry 2021 24;12:634976. Epub 2021 Mar 24.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

This study explored the relationships between subjective family socioeconomic status (FSES), self-esteem, perceived stress, and perceived peer relationships among Chinese adolescents. A total of 1,353 adolescents (age range: 15-19 years) were asked to complete a questionnaire. Mediation analysis revealed that subjective FSES influenced perceived peer relationships in three ways: first, through the mediating effect of perceived stress; second, through the mediating effect of self-esteem; and third, through the serial mediating effects of perceived stress and self-esteem. Read More

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Improving Ki67 Assessment Concordance with AI-Empowered Microscope: A Multi-institutional Ring Study.

Histopathology 2021 Apr 11. Epub 2021 Apr 11.

Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Purpose: The nuclear proliferation biomarker Ki67 plays potential prognostic and predictive roles in breast cancer treatment. However, lack of inter-pathologist consistency in Ki67 assessment limits the clinical use of Ki67. This paper reports a solution utilizing an artificial intelligence (AI)-empowered microscope to improve Ki67 scoring concordance. Read More

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Analysis of Risk Factors for Thromboembolic Events in 88 Patients with COVID-19 Pneumonia in Wuhan, China: A Retrospective Descriptive Report.

Med Sci Monit 2021 Apr 11;27:e929708. Epub 2021 Apr 11.

Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland).

BACKGROUND Since the outbreak of COVID-19 in December 2019, there have been 96 623 laboratory-confirmed cases and 4784 deaths by December 29 in China. We aimed to analyze the risk factors and the incidence of thrombosis from patients with confirmed COVID-19 pneumonia. MATERIAL AND METHODS Eighty-eight inpatients with confirmed COVID-19 pneumonia were reported (31 critical cases, 33 severe cases, and 24 common cases). Read More

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Protocol Use in Surgical Intensive Care Units.

J Surg Res 2021 Apr 8;264:242-248. Epub 2021 Apr 8.

Inova Fairfax Hospital, Falls Church, Virginia.

Background: Protocols are common in intensive care, however the association between protocol prevalence and outcomes in surgical ICU patients is unclear. We hypothesized that ICUs in a multicenter database using more protocols had better outcomes.

Material And Methods: This is a retrospective analysis of prospectively collected data from a 2-d prevalence study with 30-d follow up, on surgical and trauma patients in ICUs at 42 trauma centers. Read More

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New Developments in Fetal and Neonatal Alloimmune Thrombocytopenia.

Am J Obstet Gynecol 2021 Apr 8. Epub 2021 Apr 8.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology; Columbia Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Fetal and Neonatal AlloImmune Thrombocytopenia (FNAIT), the platelet equivalent of Hemolytic Disease of the Fetus and Newborn (HDFN), can have devastating effects on both the fetus and neonate. Current management of FNAIT in a subsequent affected pregnancy involves antenatal administration of IVIG and prednisone to the pregnant woman in order to prevent the development of severe fetal thrombocytopenia and secondary intracranial hemorrhage (ICH) in utero. That therapy has proven to be highly effective, but is associated with maternal side effects and is expensive. Read More

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Tofacitinib in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in China: A Cost-Effectiveness Analysis Based on a Mapping Algorithm Derived from a Chinese Population.

Adv Ther 2021 Apr 10. Epub 2021 Apr 10.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, 139 Renmin Rd., Changsha, 410011, Hunan, China.

Introduction: To estimate the cost-effectiveness of tofacitinib for patients with moderate-to-severe rheumatoid arthritis (RA) who failed conventional synthetic disease-modifying antirheumatic drugs from the Chinese healthcare system perspective.

Methods: An individual patient simulation model was used to estimate the lifetime cost and effectiveness. The comparator sequence commenced with etanercept, followed by rituximab-tocilizumab- non-biologic therapy. Read More

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Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: a systematic review and meta-analysis.

Eur J Neurol 2021 Apr 9. Epub 2021 Apr 9.

Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Mounting evidence supports an association between Guillain-Barré syndrome spectrum (GBSs) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, GBSs in the setting of coronavirus disease-2019 (COVID-19) remains poorly characterized, while GBSs prevalence among COVID-19 patients has not been previously systematically evaluated using a meta-analytical approach.

Methods: We performed a systematic review and meta-analysis of observational cohort and case-series studies reporting on the occurrence, clinical characteristics and outcomes of patients with COVID-19-associated GBSs. Read More

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Hammersmith Infant Neurological Examination and long-term cognitive outcome in children born very preterm.

Dev Med Child Neurol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatric Neurology, University of Turku, Turku, Finland.

Aim: To study the association between the Hammersmith Infant Neurological Examination (HINE) at age 2 years and neurocognition at age 11 years in children born very preterm. We hypothesized that the HINE at 2 years would be associated with neurocognition, that is, neurological, motor, and cognitive outcomes at 11 years.

Method: A total of 174 children (mean gestational age 29. Read More

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Relative Age Effect in 14- to 18-Year-Old Athletes and Their Initial Approach to This Effect-Has Anything Changed Over the Past 10 Years?

Front Sports Act Living 2021 23;3:622120. Epub 2021 Mar 23.

The Academic College at Wingate, Wingate Institute, Netanya, Israel.

One of the environmental variables associated with early talent development and the achievement of a high level of proficiency in sport is the relative age effect (RAE). The purpose of our study was threefold: (a) to calculate the RAE in young Israeli athletes (ages 14-18 years); (b) to examine how the athletes perceived this effect, if the effect indeed exists; and (c) to compare the RAE findings of this study with those of two previous studies on elite male (Lidor et al., 2010) and female (Lidor et al. Read More

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Standardized salvage completion pancreatectomy for grade C postoperative pancreatic fistula after pancreatoduodenectomy (with video).

HPB (Oxford) 2021 Feb 13. Epub 2021 Feb 13.

Department of Surgery, Aix-Marseille University, Institut Paoli-Calmettes, CRCM, Marseille, France.

Background: Emergency completion pancreatectomy (CP) after pancreatoduodenectomy (PD) is a technically demanding procedure. We report our experiences with a four-step standardized technique used at our center since 2012.

Methods: In the first step, the gastrojejunostomy is divided with a stapler to quickly access the pancreatic anastomosis and permit adequate exposure, especially in cases of active bleeding. Read More

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February 2021

Imaging features of myopericytoma arising from the parotid gland: Report of 2 cases and literature review.

Medicine (Baltimore) 2021 Apr;100(14):e25471

Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiefang Road 88#, Hangzhou 310009.

Rationale: Myopericytoma of the parotid gland is a rare condition of which preoperative definitive diagnosis is relatively challenging. The purpose of this case report is to highlight the radiologic features of myopericytoma of parotid gland.

Patient Concerns: A 62-year-old man presented with a history of a walnut-size mass in left parotid gland when yawned for half-month, and a 48-year-old woman complaint about a grape-size, painless mass behind the right ear for a month. Read More

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Ecology and larval population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil.

PLoS One 2021 8;16(4):e0246215. Epub 2021 Apr 8.

Departamento de Bioestatística, Biologia Vegetal, Parasitologia e Zoologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.

Vale do Rio Juruá in western Acre, Brazil, is a persistent malaria transmission hotspot partly due to fish farming development that was encouraged to improve local standards of living. Fish ponds can be productive breeding sites for Amazonian malaria vector species, including Nyssorhynchus darlingi, which, combined with high human density and mobility, add to the local malaria burden.This study reports entomological profile of immature and adult Ny. Read More

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Gender- and age-related differences in distinct phenotypes of hypertrophic cardiomyopathy-associated mutation MYBPC3-E334K.

Heart Vessels 2021 Apr 8. Epub 2021 Apr 8.

Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 127# Changle West Road, Xi'an, Shaanxi, China.

The mutation MYBPC3-E334K is a culprit mutation of hypertrophic cardiomyopathy (HCM). The pathogenicity of MYBPC3-E334K is conflicting in ClinVar because of the limited segregation data and the relatively high frequency in gnomAD (0.03% overall, with 0. Read More

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Trend of Carcinoma of the Stomach in Relation to Site, Age and Aetiology: Study of 112 Cases in a Tertiary Level Hospital.

Mymensingh Med J 2021 Apr;30(2):395-401

Dr Mukti Mahamud, Assistant Professor, Surgery, Sheikh Hasina Medical College, Jamalpur, Bangladesh E-mail:

Stomach cancer is the fourth most common cancer worldwide, but due to its poor prognosis, it is the second most common cause of cancer deaths worldwide. The incidence of carcinoma of gastric cardia is found to be increasing, while that of the antrum is seen to be decreasing. Data from Bangladesh is lacking on this aspect. Read More

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[Longitudinal Study of the Association Between Handgrip Strength and Chronic Disease Multimorbidity among Middle-aged and Older Adults].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):267-273

Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To investigate the potential association between multimorbidity and the handgrip strength of middle-aged and older adults.

Methods: The baseline (2011) and second-round follow-up (2015) data of China Health and Retirement Longitudinal Study (CHARLS) were used. Adults≥40 were selected as the subjects of the study. Read More

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Association between plasma free fatty acid levels and primary angle-closure glaucoma based on a mass spectrometry metabolomics analysis.

Acta Ophthalmol 2021 Apr 7. Epub 2021 Apr 7.

Department of Ophthalmology, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Purpose: To determine the association between plasma free fatty acid (FFA) levels and primary angle-closure glaucoma (PACG).

Methods: Free fatty acid (FFA) levels in patients with PACG (n = 181) and people without glaucoma (n = 340) were compared. Twenty-two FFAs and six lipid classes were measured using metabolomics analysis. Read More

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Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis.

World J Gastroenterol 2021 Mar;27(12):1194-1212

Akita Health Care Center, Akita Red Cross Hospital, Akita 010-0001, Japan.

Background: It is a crucial issue for patients with refractory ulcerative colitis (UC), including steroid-dependent and steroid-refractory patients, to achieve and maintain steroid-free remission. However, clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient. Cytapheresis (CAP) is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects. Read More

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Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs.

Mol Psychiatry 2021 Apr 8. Epub 2021 Apr 8.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.

Mood disorders (depression, bipolar disorders) are prevalent and disabling. They are also highly co-morbid with other psychiatric disorders. Currently there are no objective measures, such as blood tests, used in clinical practice, and available treatments do not work in everybody. Read More

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