7,358 results match your criteria sebaceous glands

[Malassezia spp.: interactions with topically applied lipids-a review : Malassezia and topically applied lipids].

Hautarzt 2021 Jul 24. Epub 2021 Jul 24.

Symrise AG, Muehlenfeldstr. 1, 37603, Holzminden, Deutschland.

Lipophilic Malassezia yeasts are an important part of the human resident skin flora, especially in seborrheic areas. Besides mutualistic interactions with the host they are also linked to diseases although the specific causes are not yet comprehensively understood. The amount of available lipids on the skin correlates with the Malassezia density and also with the occurrence of certain diseases like tinea versicolor. Read More

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Trop2 Expression in Extramammary Paget's Disease and Normal Skin.

Int J Mol Sci 2021 Jul 19;22(14). Epub 2021 Jul 19.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Read More

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Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 Tenerife, Spain.

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e. Read More

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Non-thymoma-associated exfoliative dermatitis in a European shorthair cat: A case report.

Vet Med Sci 2021 Jul 22. Epub 2021 Jul 22.

Department of Biopharmacy, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland.

The current case report presents a case of non-thymoma-associated exfoliative dermatitis in an 8-year-old European Shorthair female cat. The animal displayed extensive alopecia and excessive peeling of the epidermis. There were no other apparent disorders, except for the skin lesions. Read More

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A Novel Surgical Approach for Rhinophyma: Experience From a Cohort of Thirty Patients.

J Craniofac Surg 2021 Jul 15. Epub 2021 Jul 15.

Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai, China.

Background: Rhinophyma is the severe rosacea whit hypertrophy of sebaceous glands in nasal tissue, which severely influences the patient's appearance. Surgical therapy is the best method for treating moderate-to-severe rhinophyma. In this study, we used a new ameliorated scarification for 30 patients with moderate-to-severe rhinophyma. Read More

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Rare upper lip pleomorphic adenoma presents as cutaneous skin lesion: Case report.

Int J Surg Case Rep 2021 Jun 29;85:106142. Epub 2021 Jun 29.

Department of Surgery, King Khalid University Hospital, King Saud University, Saudi Arabia.

Introduction: Pleomorphic adenoma of the minor salivary gland is not uncommon. Although malignant lesion is the most common in the minor salivary glands, benign lesion has been also reported. Many ectopic sites for minor salivary gland including the lip have been reported mainly intra-orally. Read More

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Corona virus disease 2019-associated Stevens-Johnson syndrome: a case report.

BMC Ophthalmol 2021 Jul 12;21(1):274. Epub 2021 Jul 12.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: To report Stevens-Johnson syndrome (SJS) in a patient with acute pneumonia secondary to SARS-CoV-2 infection.

Case Presentation: A 45-years-old woman with a diagnosis of acute pneumonia secondary to SARS-CoV-2 infection who had received azithromycin and naproxen. Three days after starting the medication, she appeared ill and developed ocular discomfort, photophobia, dysuria, and macular rashes on the trunk and the extremities. Read More

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[Vulva anatomopathological peculiarities].

Ann Pathol 2021 Jul 6. Epub 2021 Jul 6.

Cabinet de dermatopathologie Mathurin Moreau, Paris 19(ième) ; service de pathologie, hôpital Cochin, Paris 14(e), France. Electronic address:

The vulva is the transition zone between the skin and the lower genital tract. As such, it presents histological specificities, comprises physiological modifications which are specific to it and is characterized by particular artifacts. Knowledge of them prevents many questions or even diagnostic errors. Read More

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Dermoid Cyst with Intracranial Extension Presenting With Headache.

Mymensingh Med J 2021 Jul;30(3):860-862

Dr Shameem Ahmed, Chief Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati, India.

Dermoid cysts (DC) are benign cutaneous developmental anomalies comprising of hair follicles, sweat glands and sebaceous glands, and lined by stratified squamous epithelium. They are most commonly found on the face, lower back, and ovaries. We present a case of DC with intracranial extension in a 9 year old boy who presented with headache and a fluctuant scalp swelling. Read More

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The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature.

Reprod Toxicol 2021 Jul 2;104:85-95. Epub 2021 Jul 2.

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

Isotretinoin (13-cis-retinoic acid), a derivative of vitamin A, is used in the treatment of severe acne resulting in sebum suppression induced by sebocyte apoptosis. Isotretinoin treatment is associated with several adverse effects including teratogenicity, hepatotoxicity, and dyslipidemia. Isotretinoin's effects on endocrine systems and its potential role as an endocrine disruptor are not yet adequately investigated. Read More

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Vulvar Fordyce adenitis: A cohort of 45 women.

Ann Dermatol Venereol 2021 Jun 30. Epub 2021 Jun 30.

Study group for anogenital diseases, French Society of Dermatology, Maison de la Dermatologie, 10, cité Malesherbes, 75009 Paris, France; Private Vulvar Clinic, 4, rue Léon-Delhomme, 75015 Paris, France.

Background: Recurrent episodes of painful papules and nodules, mostly located on the labia minora, have been reported under the denominations of vulvar sebaceous adenitis (14 published cases) and vulvar acne (16 published cases).

Objectives: The primary aim of this study was to delve further into the clinical and pathological features of this condition. The secondary aim was to collect therapeutic data. Read More

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Sex Hormones Related Ocular Dryness in Breast Cancer Women.

J Clin Med 2021 Jun 14;10(12). Epub 2021 Jun 14.

Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.

Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Read More

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Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment.

Medicina (Kaunas) 2021 Jun 14;57(6). Epub 2021 Jun 14.

Clinic of Ophthalmology, Geneva University Hospitals & Faculty of Medicine, University of Geneva, CH-1205 Geneva, Switzerland.

Evaporative dry eye disease is frequently associated with meibomian gland dysfunction. Patients are often unhappy because of daily drops, care burden, and suboptimal conventional treatments. In this study, we assessed the efficacy of a novel device, the Eye-light, a combination of intense pulsed light therapy and low-level light therapy, as a novel treatment for meibomian gland dysfunction and dry eye disease. Read More

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Molecular pathology of skin adnexal tumors.

Histopathology 2021 Jul 1. Epub 2021 Jul 1.

Department of Pathology, University of Michigan, Ann Arbor, 48109, MI, USA.

Aims: Tumors of the cutaneous adnexa arise from, or differentiate toward, structures in normal skin such as hair follicles, sweat ducts/glands, sebaceous glands, or a combination of these elements. This class of neoplasms includes benign tumors and highly aggressive carcinomas. Adnexal tumors often present as solitary sporadic lesions, but can herald the presence of an inherited tumor syndrome such as Muir-Torre Syndrome, Cowden Syndrome, or CYLD Cutaneous Syndrome. Read More

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Antibacterial Susceptibility Testing of in Acne Vulgaris Patients.

Clin Cosmet Investig Dermatol 2021 18;14:671-677. Epub 2021 Jun 18.

Riga Stradiņš University, Faculty of Medicine, Riga, LV-1007, Latvia.

Introduction: Combination therapy is widely used for the treatment of acne vulgaris (AV), including local anti-inflammatory drugs containing antimicrobials, such as clindamycin or erythromycin, to inhibit () growth and at the same time reduce the production of inflammatory mediators. The aim of the study is to compare the antibacterial susceptibility of to clindamycin and erythromycin in AV patients compared with healthy patients in the control group (CG).

Methods: The prospective study included 56 patients with clinically diagnosed AV symptoms and 12 patients were included in the CG who did not have AV. Read More

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Clinicopathologic features of nasopalatine duct cysts: A retrospective study in two Brazilian oral and maxillofacial pathology referral centers.

Med Oral Patol Oral Cir Bucal 2021 Jun 24. Epub 2021 Jun 24.

Oral Pathology Section, Dep. of Oral Diagnosis University of Fortaleza (UNIFOR) Av. Washington Soares, 1321 - Edson Queiroz Fortaleza - CE, 60811-905

Background: Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. Read More

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In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.

BMC Ophthalmol 2021 Jun 19;21(1):261. Epub 2021 Jun 19.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: To evaluate microstructural changes in the meibomian glands (MGs) in patients with active and inactive Graves' orbitopathy (GO), using in vivo confocal microscopy (IVCM), and to investigate the correlations between clinical and confocal findings.

Methods: Forty patients (80 eyes) with GO (34 eyes with active GO, 46 eyes with inactive GO), and 31 age- and sex-matched control participants (62 eyes) were enrolled consecutively. A researcher recorded the clinical activity score (CAS) for each patient. Read More

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Characterization of nucleic acids from extracellular vesicle-enriched human sweat.

BMC Genomics 2021 Jun 9;22(1):425. Epub 2021 Jun 9.

Faculty of Biochemistry and Molecular Medicine, Disease Networks Research Unit, Laboratory of Developmental Biology, Kvantum Institute, Infotech Oulu, University of Oulu, 90014 University of Oulu, Oulu, Finland.

Background: The human sweat is a mixture of secretions from three types of glands: eccrine, apocrine, and sebaceous. Eccrine glands open directly on the skin surface and produce high amounts of water-based fluid in response to heat, emotion, and physical activity, whereas the other glands produce oily fluids and waxy sebum. While most body fluids have been shown to contain nucleic acids, both as ribonucleoprotein complexes and associated with extracellular vesicles (EVs), these have not been investigated in sweat. Read More

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Effect of antioxidant treatment with n-acetylcysteine and swimming on lipid expression of sebaceous glands in diabetic mice.

Sci Rep 2021 Jun 7;11(1):11924. Epub 2021 Jun 7.

Morphology and Basic Pathology Department, Jundiaí Medical School (JMS) Jundiaí, Francisco Telles, 250 - Vila Arens II, 1109, Jundiaí, SP, 13202-550, Brazil.

The sebaceous gland (SG) is involved in different inflammatory, infectious and neoplastic processes of the skin and can be related to specific diseases, e.g., diabetes mellitus. Read More

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Sebaceous carcinoma of the chest wall: A case report.

Radiol Case Rep 2021 Jul 25;16(7):1870-1873. Epub 2021 May 25.

Consultant Breast Surgeon Cambridge University Hospital NHS Trust, Cambridge and Anglia Ruskin School of Medicine, Cambridge, UK.

Sebaceous carcinoma is a rare, malignant tumor of the sebaceous glands. This is a case report of a 75-year-old man who presented with a right lower axillary mass which initially was considered to be a benign sebaceous cyst from sonography. The lesion rapidly changed in clinical and sonographic appearances and on histology was a sebaceous carcinoma. Read More

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Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases.

Dis Markers 2021 21;2021:9990382. Epub 2021 May 21.

Department of Gynecology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Objective: To study the clinical characteristics and surgical outcomes of anti-NMDAR encephalitis and the immunopathology of associated teratomas.

Methods: Twenty-one patients were enrolled in this retrospective study, who were diagnosed with anti-NMDAR encephalitis with ovarian teratoma and admitted to two tertiary hospitals in South China from July 2014 to December 2019. The clinical data of patients were reviewed. Read More

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Applications of Gold and Silver Nanoparticles in the Treatment of Acne Vulgaris: A Systematic Review.

J Drugs Dermatol 2021 Jun;20(6):666-670

Background: Current treatments for acne are often accompanied by undesirable side effects and contribute to antibiotic resistance. Gold and silver nanoparticles are an emerging treatment method with potentially fewer adverse effects.

Objective: To evaluate current literature discussing the various uses of gold and silver nanoparticles in the potential treatment of acne vulgaris. Read More

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Comparative study of the external auditory canal in humans and large mammals.

Anat Rec (Hoboken) 2021 May 29. Epub 2021 May 29.

ENT Institute, Eye & ENT Hospital of Fudan University, Shanghai, China.

Given the limited source of human external auditory canal (EAC) skin, animal experiments remain an important approach for studying functional EAC reconstruction. However, differences between humans and animals in terms of the general EAC structure, histological characteristics of EAC skin, and cell markers of its specific glands in cartilaginous EAC skin remain unknown. We compared the characteristics of the EAC between humans and large animals, as a basis for appropriate animal model selection. Read More

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Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models.

Mol Vis 2021 13;27:323-353. Epub 2021 May 13.

Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, Inserm, UMRS1138, Team 17, Physiopathology of ocular diseases: therapeutic innovations, Paris, France.

Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Read More

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Epidermal Growth Factor Modulates Palmitic Acid-Induced Inflammatory and Lipid Signaling Pathways in SZ95 Sebocytes.

Front Immunol 2021 6;12:600017. Epub 2021 May 6.

Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Epidermal growth factor (EGF) acts as a paracrine and autocrine mediator of cell proliferation and differentiation in various types of epithelial cells, such as sebocytes, which produce the lipid-rich sebum to moisturize the skin. However, sebum lipids direct contact and by penetrating through the epidermis may have regulatory roles on epidermal and dermal cells as well. As EGF receptor (EGFR) is expressed throughout the proliferating and the lipid-producing layers of sebaceous glands (SGs) in healthy and acne-involved skin, we investigated the effect of EGF on SZ95 sebocytes and how it may alter the changes induced by palmitic acid (PA), a major sebum component with bioactive roles. Read More

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Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil.

Transl Vis Sci Technol 2021 04;10(4):21

Pharmaceutical Research Laboratories, Research and Development Headquarters, Lion Corporation, Kanagawa, Japan.

Purpose: Meibomian gland dysfunction (MGD) is a major cause of evaporative dry eye. The purpose of this study is to assess the efficacy of a mineral oil-containing ophthalmic solution (MO) in mitigating the evaporative dry eye phenotypes in a mouse model in which fatty acid elongase Elovl1 is disrupted.

Methods: Elovl1-deficient mice were assessed in terms of number of plugged meibomian gland orifices, tear film breakup time (BUT), corneal fluorescein staining (CFS) score, tear quantity, and histology. Read More

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Meibography Phenotyping and Classification From Unsupervised Discriminative Feature Learning.

Transl Vis Sci Technol 2021 02;10(2)

Clinical Research Center, School of Optometry, University of California, Berkeley, CA, USA.

Purpose: The purpose of this study was to develop an unsupervised feature learning approach that automatically measures Meibomian gland (MG) atrophy severity from meibography images and discovers subtle relationships between meibography images according to visual similarity.

Methods: One of the latest unsupervised learning approaches is to apply feature learning based on nonparametric instance discrimination (NPID), a convolutional neural network (CNN) backbone model trained to encode meibography images into 128-dimensional feature vectors. The network aims to learn a similarity metric across all instances (e. Read More

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February 2021

TGF-β loaded exosome enhances ischemic wound healing and .

Theranostics 2021 30;11(13):6616-6631. Epub 2021 Apr 30.

Division of Plastic Surgery, Mayo Clinic, Rochester, MN, USA.

With over seven million infections and $25 billion treatment cost, chronic ischemic wounds are one of the most serious complications in the United States. The controlled release of bioactive factor enriched exosome from finbrin gel was a promising strategy to promote wound healing. To address this unsolved problem, we developed clinical-grade platelets exosome product (PEP), which was incorporate with injectable surgical fibrin sealant (TISSEEL), to promote chronic wound healing and complete skin regeneration. Read More

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Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer.

BMC Cancer 2021 May 13;21(1):547. Epub 2021 May 13.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas Gral. José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Ciudad de Buenos Aires, Argentina.

Background: Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitro photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene.

Methods: The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. Read More

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Risk Factors Associated with Meibomian Gland Dysfunction: A Hospital Based Study.

Nepal J Ophthalmol 2021 Jan;13(25):59-64

R.M. Kedia Eye Hospital, Birgunj, Nepal.

Introduction: Meibomian Gland Dysfunction (MGD) is a chronic diffuse abnormality of the Meibomian glands often found as a result of precipitating factors like dyslipidemia, infections, hypertension, diabetes, etc. This study aims to find the prevalence of various risk factors of Meibomian Gland Dysfunction (MGD) which will ultimately help in managing the disease and explaining the prognosis.

Materials And Methods: A hospital based cross-sectional study. Read More

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January 2021