9,807 results match your criteria sebaceous gland


[Malassezia spp.: interactions with topically applied lipids-a review : Malassezia and topically applied lipids].

Hautarzt 2021 Jul 24. Epub 2021 Jul 24.

Symrise AG, Muehlenfeldstr. 1, 37603, Holzminden, Deutschland.

Lipophilic Malassezia yeasts are an important part of the human resident skin flora, especially in seborrheic areas. Besides mutualistic interactions with the host they are also linked to diseases although the specific causes are not yet comprehensively understood. The amount of available lipids on the skin correlates with the Malassezia density and also with the occurrence of certain diseases like tinea versicolor. Read More

View Article and Full-Text PDF

Trop2 Expression in Extramammary Paget's Disease and Normal Skin.

Int J Mol Sci 2021 Jul 19;22(14). Epub 2021 Jul 19.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the apocrine gland-rich areas. Most EMPD tumors are dormant, but metastatic lesions are associated with poor outcomes owing to the lack of effective systemic therapies. Trophoblast cell surface antigen 2 (Trop2), a surface glycoprotein, has drawn attention as a potential therapeutic target for solid tumors. Read More

View Article and Full-Text PDF

Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 Tenerife, Spain.

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e. Read More

View Article and Full-Text PDF

Non-thymoma-associated exfoliative dermatitis in a European shorthair cat: A case report.

Vet Med Sci 2021 Jul 22. Epub 2021 Jul 22.

Department of Biopharmacy, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland.

The current case report presents a case of non-thymoma-associated exfoliative dermatitis in an 8-year-old European Shorthair female cat. The animal displayed extensive alopecia and excessive peeling of the epidermis. There were no other apparent disorders, except for the skin lesions. Read More

View Article and Full-Text PDF

GLUT1 Expression in Cutaneous Sebaceous Lesions Determined by Immunohistochemical Staining Patterns.

Dermatopathology (Basel) 2021 Jul 5;8(3):258-264. Epub 2021 Jul 5.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased GLUT1 expression in various tumor types and a role in cancer prognosis. The aim of this study was to determine whether cutaneous sebaceous lesions have a differential expression of GLUT1 by immunohistochemistry (IHC). Read More

View Article and Full-Text PDF

Peripunctal Mass Lesions: Clinicopathological Analysis and Surgical Outcomes-A Multicentric Series.

Ophthalmic Plast Reconstr Surg 2021 Jul 19. Epub 2021 Jul 19.

Ophthalmic Plastic Surgery and Ocular Oncology Services, Advanced Eye Hospital & Institute, A Unit of Dr. Agarwal's Eye Hospital, Navi Mumbai, India Ophthalmic Plastic Surgery and Ocular Oncology Services, Aditya Jyot Eye Hospital, Mumbai, India Ophthalmic Plastic Surgery and Ocular Oncology Services, Aayush Eye Clinic, A Unit of Dr. Agarwal's Eye Hospital, Mumbai, India Department of Ophthalmology, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, India Department of Orbit, Oculoplasty, Reconstructive & Aesthetic Services, Sankara Nethralaya, Chennai, India EyeHUB Vision Care, Faridabad, India Ophthalmic Plastic Surgery and Ocular Oncology Services, L J Eye Institute, Ambala, India Ophthalmic Plastic Surgery & Facial Aesthetics, L V Prasad Eye Institute, Hyderabad, India Department of Orbit, Oculoplasty, Reconstructive & Aesthetic Services, Aditya Birla Sankara Nethralaya, Kolkata, India Clinico-Path Laboratory, Chembur, Mumbai, India.

Purpose: To report the epidemiology, histopathological spectrum, and surgical outcomes of peripunctal mass lesions.

Methods: Multicentric retrospective case series involving 6 centers in India. All cases of peripunctal masses with histopathological diagnoses and minimum follow up of 3 months were included. Read More

View Article and Full-Text PDF

A Novel Surgical Approach for Rhinophyma: Experience From a Cohort of Thirty Patients.

J Craniofac Surg 2021 Jul 15. Epub 2021 Jul 15.

Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai, China.

Background: Rhinophyma is the severe rosacea whit hypertrophy of sebaceous glands in nasal tissue, which severely influences the patient's appearance. Surgical therapy is the best method for treating moderate-to-severe rhinophyma. In this study, we used a new ameliorated scarification for 30 patients with moderate-to-severe rhinophyma. Read More

View Article and Full-Text PDF

Rare upper lip pleomorphic adenoma presents as cutaneous skin lesion: Case report.

Int J Surg Case Rep 2021 Aug 29;85:106142. Epub 2021 Jun 29.

Department of Surgery, King Khalid University Hospital, King Saud University, Saudi Arabia.

Introduction: Pleomorphic adenoma of the minor salivary gland is not uncommon. Although malignant lesion is the most common in the minor salivary glands, benign lesion has been also reported. Many ectopic sites for minor salivary gland including the lip have been reported mainly intra-orally. Read More

View Article and Full-Text PDF

Corona virus disease 2019-associated Stevens-Johnson syndrome: a case report.

BMC Ophthalmol 2021 Jul 12;21(1):274. Epub 2021 Jul 12.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: To report Stevens-Johnson syndrome (SJS) in a patient with acute pneumonia secondary to SARS-CoV-2 infection.

Case Presentation: A 45-years-old woman with a diagnosis of acute pneumonia secondary to SARS-CoV-2 infection who had received azithromycin and naproxen. Three days after starting the medication, she appeared ill and developed ocular discomfort, photophobia, dysuria, and macular rashes on the trunk and the extremities. Read More

View Article and Full-Text PDF

Shifts in the Skin Bacterial and Fungal Communities of Healthy Children Transitioning through Puberty.

J Invest Dermatol 2021 Jul 10. Epub 2021 Jul 10.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Previous cross-sectional studies have shown that skin microbiomes in adults are distinct from those in children. However, the human skin microbiome in individuals as they sexually mature has not been studied as extensively. We performed a prospective, longitudinal study to investigate the puberty-associated shifts in skin microbiota. Read More

View Article and Full-Text PDF

Can a radiofrequency device reduce the pore size?

Lasers Med Sci 2021 Jul 12. Epub 2021 Jul 12.

Department of Dermatology, Korea University Ansan Hospital, Korea University, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.

A facial pore is an empty funnel-shaped structure filled with cornified cylindrical plugs that can be cosmetically bothersome to some patients. In the previous report, the new unipolar radiofrequency (RF) device with a vacuum showed excellent skin tightening and patient satisfaction with improved pores. This study aims to confirm the treatment's efficacy with the new unipolar RF device on facial dilated pores by measuring quantitative sebum production differences and doing a histologic examination of pore size. Read More

View Article and Full-Text PDF

[Vulva anatomopathological peculiarities].

Ann Pathol 2021 Jul 6. Epub 2021 Jul 6.

Cabinet de dermatopathologie Mathurin Moreau, Paris 19(ième) ; service de pathologie, hôpital Cochin, Paris 14(e), France. Electronic address:

The vulva is the transition zone between the skin and the lower genital tract. As such, it presents histological specificities, comprises physiological modifications which are specific to it and is characterized by particular artifacts. Knowledge of them prevents many questions or even diagnostic errors. Read More

View Article and Full-Text PDF

Serum resistin levels and resistin gene polymorphism in patients with acne vulgaris: does it correlate with disease severity?

Int J Dermatol 2021 Jul 7. Epub 2021 Jul 7.

Medical Biochemistry and Molecular Biology Department, Menoufia University, Shebin EL-Kom, Egypt.

Background: Acne vulgaris is a disease that inflames the sebaceous gland with multiple etiologies. Many proinflammatory adipokines contribute to this pathogenesis. Resistin is a proinflammatory mediator that activates kappa B, a nuclear factor, and c-Jun N-terminal kinases pathways inducing toll-like receptor-2, interleukin-1, 6, and tumor necrosis factor alpha. Read More

View Article and Full-Text PDF

Pleomorphic Adenoma of the Submandibular Gland in a 10-Year-Old Child: A Case Report.

Ear Nose Throat J 2021 Jul 8:1455613211022113. Epub 2021 Jul 8.

ENT Department, Fattouma Bourguiba Hospital of Monastir, Monastir, Tunisia.

We report the case of a 10-year-old girl with a painless slowly growing mass that had developed over the course of 2 years in the left submandibular area. Physical examination revealed a firm painless submandibular mass with no other associated signs. Ultrasound graphics were in favor of a sebaceous cyst. Read More

View Article and Full-Text PDF

Dermoid Cyst with Intracranial Extension Presenting With Headache.

Mymensingh Med J 2021 Jul;30(3):860-862

Dr Shameem Ahmed, Chief Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati, India.

Dermoid cysts (DC) are benign cutaneous developmental anomalies comprising of hair follicles, sweat glands and sebaceous glands, and lined by stratified squamous epithelium. They are most commonly found on the face, lower back, and ovaries. We present a case of DC with intracranial extension in a 9 year old boy who presented with headache and a fluctuant scalp swelling. Read More

View Article and Full-Text PDF

The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature.

Reprod Toxicol 2021 09 2;104:85-95. Epub 2021 Jul 2.

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany.

Isotretinoin (13-cis-retinoic acid), a derivative of vitamin A, is used in the treatment of severe acne resulting in sebum suppression induced by sebocyte apoptosis. Isotretinoin treatment is associated with several adverse effects including teratogenicity, hepatotoxicity, and dyslipidemia. Isotretinoin's effects on endocrine systems and its potential role as an endocrine disruptor are not yet adequately investigated. Read More

View Article and Full-Text PDF
September 2021

Vulvar Fordyce adenitis: A cohort of 45 women.

Ann Dermatol Venereol 2021 Jun 30. Epub 2021 Jun 30.

Study group for anogenital diseases, French Society of Dermatology, Maison de la Dermatologie, 10, cité Malesherbes, 75009 Paris, France; Private Vulvar Clinic, 4, rue Léon-Delhomme, 75015 Paris, France.

Background: Recurrent episodes of painful papules and nodules, mostly located on the labia minora, have been reported under the denominations of vulvar sebaceous adenitis (14 published cases) and vulvar acne (16 published cases).

Objectives: The primary aim of this study was to delve further into the clinical and pathological features of this condition. The secondary aim was to collect therapeutic data. Read More

View Article and Full-Text PDF

Sex Hormones Related Ocular Dryness in Breast Cancer Women.

J Clin Med 2021 Jun 14;10(12). Epub 2021 Jun 14.

Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.

Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Read More

View Article and Full-Text PDF

Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment.

Medicina (Kaunas) 2021 Jun 14;57(6). Epub 2021 Jun 14.

Clinic of Ophthalmology, Geneva University Hospitals & Faculty of Medicine, University of Geneva, CH-1205 Geneva, Switzerland.

Evaporative dry eye disease is frequently associated with meibomian gland dysfunction. Patients are often unhappy because of daily drops, care burden, and suboptimal conventional treatments. In this study, we assessed the efficacy of a novel device, the Eye-light, a combination of intense pulsed light therapy and low-level light therapy, as a novel treatment for meibomian gland dysfunction and dry eye disease. Read More

View Article and Full-Text PDF

Molecular pathology of skin adnexal tumors.

Histopathology 2021 Jul 1. Epub 2021 Jul 1.

Department of Pathology, University of Michigan, Ann Arbor, 48109, MI, USA.

Aims: Tumors of the cutaneous adnexa arise from, or differentiate toward, structures in normal skin such as hair follicles, sweat ducts/glands, sebaceous glands, or a combination of these elements. This class of neoplasms includes benign tumors and highly aggressive carcinomas. Adnexal tumors often present as solitary sporadic lesions, but can herald the presence of an inherited tumor syndrome such as Muir-Torre Syndrome, Cowden Syndrome, or CYLD Cutaneous Syndrome. Read More

View Article and Full-Text PDF

Homogeneous blue lumps of the nipple-areola complex in pubertal girls.

Pediatr Dermatol 2021 Jul 28;38(4):887-891. Epub 2021 Jun 28.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), IRCCS University Hospital of Bologna S Orsola-Malpighi Polyclinic Dermatology Division, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Retroareolar cysts are benign breast lesions caused by the obstruction and consequent dilatation of Montgomery tubercles. Herein, we report two cases of premenarchal girls who developed retroareolar cysts. Their course and differential diagnosis are discussed. Read More

View Article and Full-Text PDF

[Combined Intense Pulsed Light and low-level light therapy in the treatment of Meibomian gland dysfunction].

J Fr Ophtalmol 2021 Sep 23;44(7):1021-1028. Epub 2021 Jun 23.

Service d'ophtalmologie, hôpital Charles-Nicolle, CHU Rouen, 76000 Rouen, France. Electronic address:

Introduction: Meibomian gland dysfunction (MGD) is the most common cause of dry eye syndrome. The goal of this study was to evaluate the efficacy of combined intense pulsed light (IPL) and low-level light therapy (LLLT) in symptomatic MGD.

Materials And Methods: This retrospective study analyzed data from 30 patients with MGD causing dry eye symptoms not relieved by medical therapy and managed with combined IPL and LLLT. Read More

View Article and Full-Text PDF
September 2021

Antibacterial Susceptibility Testing of in Acne Vulgaris Patients.

Clin Cosmet Investig Dermatol 2021 18;14:671-677. Epub 2021 Jun 18.

Riga Stradiņš University, Faculty of Medicine, Riga, LV-1007, Latvia.

Introduction: Combination therapy is widely used for the treatment of acne vulgaris (AV), including local anti-inflammatory drugs containing antimicrobials, such as clindamycin or erythromycin, to inhibit () growth and at the same time reduce the production of inflammatory mediators. The aim of the study is to compare the antibacterial susceptibility of to clindamycin and erythromycin in AV patients compared with healthy patients in the control group (CG).

Methods: The prospective study included 56 patients with clinically diagnosed AV symptoms and 12 patients were included in the CG who did not have AV. Read More

View Article and Full-Text PDF

Sebaceous carcinoma of the right palate: case report and literature review.

Gland Surg 2021 May;10(5):1819-1825

Department of stomatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.

Considering the low incidence rates of primary sebaceous carcinoma (SC) of extraorbital sites, let alone those occur in intraoral sites, clinicopathological characteristics and histogenesis are not fully understood. In the present case, a maxillary mass was presented and a low-grade malignant tumor was suspected according to the CT scans, preoperative FNA, and clinical conditions. Other carcinomas, including acinar cell carcinoma (ACC), basaloid cell carcinoma (BCC), SCC, mucoepidermoid carcinoma, and epithelial-myoepithelial carcinoma (EMC), were also considered before surgery. Read More

View Article and Full-Text PDF

Clinicopathologic features of nasopalatine duct cysts: A retrospective study in two Brazilian oral and maxillofacial pathology referral centers.

Med Oral Patol Oral Cir Bucal 2021 Sep 1;26(5):e676-e683. Epub 2021 Sep 1.

Oral Pathology Section, Dep. of Oral Diagnosis University of Fortaleza (UNIFOR) Av. Washington Soares, 1321 - Edson Queiroz Fortaleza - CE, 60811-905

Background: Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. Read More

View Article and Full-Text PDF
September 2021

Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications.

Int J Ophthalmol 2021 18;14(6):915-922. Epub 2021 Jun 18.

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation. The loss of normal functions of meibomian gland, known as meibomian gland dysfunction (MGD), is a chronic disease and is the leading cause of dry eye symptoms in the clinics. Studies have found sex hormones, especially androgen, play vital roles in the regulation of the functions of meibomian gland. Read More

View Article and Full-Text PDF

In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.

BMC Ophthalmol 2021 Jun 19;21(1):261. Epub 2021 Jun 19.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: To evaluate microstructural changes in the meibomian glands (MGs) in patients with active and inactive Graves' orbitopathy (GO), using in vivo confocal microscopy (IVCM), and to investigate the correlations between clinical and confocal findings.

Methods: Forty patients (80 eyes) with GO (34 eyes with active GO, 46 eyes with inactive GO), and 31 age- and sex-matched control participants (62 eyes) were enrolled consecutively. A researcher recorded the clinical activity score (CAS) for each patient. Read More

View Article and Full-Text PDF

[Management of malignant adnexal neoplasms of the skin].

Hautarzt 2021 Jul 17;72(7):619-632. Epub 2021 Jun 17.

Klinische Kooperationseinheit für Dermatoonkologie des Deutschen Krebsforschungszentrums (DKFZ) Heidelberg, Mannheim, Deutschland.

Malignant adnexal neoplasms of the skin are a heterogeneous group of rare malignancies with eccrine, apocrine, sebaceous and follicular differentiation. Essential clinical practice recommendations for the overall management of these cancers are presented. Moreover, specific evidence-based findings according to diagnosis, therapy and follow-up of porocarcinoma, sebaceous carcinoma and microcystic adnexcarcinoma will be explained. Read More

View Article and Full-Text PDF

Biochemical and morphological features of the uropygial gland of the Chilean Flamingo and their functional implications.

Zoology (Jena) 2021 08 23;147:125941. Epub 2021 May 23.

Sección Ornitología, Facultad de Ciencias Naturales y Museo, UNLP-CONICET, Paseo del Bosque s/n (1900), La Plata, Buenos Aires, Argentina.

Flamingos inhabit specialized habitats and breed in large colonies, building their nests on islands that limit the access of terrestrial predators. Many aspects of their uropygial gland are still unknown. The uropygial gland, a sebaceous organ exclusive to birds, shares some histological features among species such as the presence of a capsule, adenomers with stratified epithelium and secondary and primary chambers. Read More

View Article and Full-Text PDF

Studies on novel chitosan/alginate and chitosan/bentonite flexible films incorporated with ZnO nano particles for accelerating dermal burn healing: In vivo and in vitro evaluation.

Int J Biol Macromol 2021 Aug 11;184:235-249. Epub 2021 Jun 11.

Faculty of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.

This research work was performed to prepare chitosan-alginate-gelatin and chitosan-bentonite-gelatin films in different mass ratios incorporated with nano particles of Zinc Oxide, which were achieved through the method of green synthesis from Nettle leaf extract. The films were prepared and characterized based on their physicochemical properties, such as water absorption and porosity and surface morphology. Bentonite containing films illustrate more flexibility than alginate ones while the chitosan/bentonite composite films have a maximum water absorption capacity of about 170%. Read More

View Article and Full-Text PDF