27 results match your criteria sdg alkaline

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Effect of different structural flaxseed lignans on the stability of flaxseed oil-in-water emulsion: An interfacial perspective.

Food Chem 2021 Apr 8;357:129522. Epub 2021 Apr 8.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, and Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Wuhan 430062, China. Electronic address:

The influences of the different structural flaxseed lignans on flaxseed oil (FO) emulsions during storage and digestion were investigated, focusing on their interfacial behavior. From perspective of interface, more than 60% of secoisolariciresinol (SECO) and the acidic hydrolysates of flaxseed lignan macromolecule (FLEH) were located on the interface of FO emulsions. It improved the stability of FO emulsions both during storage and digestion by inhibiting of free radical penetration and improving their targeted antioxidative activity. Read More

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Experimental cirrhosis: liver morphology and function.

Wiad Lek 2020 ;73(5):947-952

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Objective: The aim was to establish the morphofunctional changes of liver in the experimental cirrhosis.

Patients And Methods: Materials and methods: The research was conducted on 24 white male Wistar rats. Experimental cirrhosis of the liver was simulated by oral administration of CCl4 2 g/kg 2 times weekly for three months. Read More

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Development and validation of an ultra-high performance liquid chromatography-high resolution mass spectrometry method for simultaneous quantification of cyanogenic glycosides and secoisolariciresinol diglucoside in flaxseed (Linum usitatissimum L.).

J Chromatogr A 2019 Sep 29;1601:214-223. Epub 2019 Apr 29.

Chimie Analytique des Molécules Bioactives et Pharmacognosie, Institut Pluridisciplinaire Hubert Curien (UMR 7178 CNRS/UDS), 74 route du Rhin, 67400, Illkirch, France. Electronic address:

An ultra performance liquid chromatography electrospray ionization high-resolution mass spectrometry (UPLC/ESI-HRMS) method was developed and validated for simultaneous quantification of cyanogenic glycosides (CGs), [linustatin (LIS) and neolinustatin (NLIS)], and the main lignan, secoisolariciresinol diglucoside (SDG) in Linoforce® (LF) [flaxseed (Linum usitatissimum L.) coated with two herbal extracts (Senna alexandrina mill and Frangula alnus)]. CGs and SDG were extracted from defatted ground LF by a new procedure consisting of an aqueous methanol ultrasound-assisted extraction followed by an aqueous alkaline ultrasound-assisted extraction of the residue. Read More

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September 2019

Laser Microdissection and Spatiotemporal Pinoresinol-Lariciresinol Reductase Gene Expression Assign the Cell Layer-Specific Accumulation of Secoisolariciresinol Diglucoside in Flaxseed Coats.

Front Plant Sci 2016 21;7:1743. Epub 2016 Nov 21.

Max Planck Institute for Chemical Ecology Jena, Germany.

The concentration of secoisolariciresinol diglucoside (SDG) found in flaxseed ( L.) is higher than that found in any other plant. It exists in flaxseed coats as an SDG-3-hydroxy-3-methylglutaric acid oligomer complex. Read More

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November 2016

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage.

Int J Mol Sci 2015 Dec 22;17(1). Epub 2015 Dec 22.

Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building, Suite 1016C, Philadelphia, PA 19104, USA.

Plant phenolic compounds are common dietary antioxidants that possess antioxidant and anti-inflammatory properties. Flaxseed (FS) has been reported to be radioprotective in murine models of oxidative lung damage. Flaxseed's protective properties are attributed to its main biphenolic lignan, secoisolariciresinol diglucoside (SDG). Read More

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December 2015

Antioxidant Activity of Flaxseed Extracts in Lipid Systems.

Molecules 2015 Dec 23;21(1):E17. Epub 2015 Dec 23.

Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, 10-748 Olsztyn, Tuwima 10, Poland.

The aim of this work was to compare the antioxidant activity of the extract of flaxseed and its alkaline hydrolysate in two model systems: lipid autoxidation of triacylglycerols of sunflower oil (TGSO)-in a homogeneous lipid media and during β-carotene-linoleate emulsion system. In addition, pure lignans were tested. The material was defatted with hexane and then phenolic compounds were extracted using dioxane-ethanol (50:50, v/v) mixture. Read More

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December 2015

Development and validation of an efficient ultrasound assisted extraction of phenolic compounds from flax (Linum usitatissimum L.) seeds.

Ultrason Sonochem 2015 Sep 28;26:176-185. Epub 2015 Feb 28.

Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), UPRES EA 1207, Université d'Orléans, Chartres, France. Electronic address:

Flaxseed accumulates in its seedcoat a macromolecular complex composed of lignan (secoisolariciresinol diglucoside, SDG), flavonol (herbacetin diglucoside, HDG) and hydroxycinnamic acids (p-couramic, caffeic and ferulic acid glucosides). Their antioxidant and/or cancer chemopreventive properties support their interest in human health and therefore, the demand for their extraction. In the present study, ultrasound-assisted extraction (UAE) of flaxseed phenolic compounds was investigated. Read More

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September 2015

[Metabolic adaptation resources of organism to studying at medical university students in European North].

Vestn Ross Akad Med Nauk 2014 (11-12):84-8

Background: A student studying is accompanied with psychoemotional stress that requires functional changes in metabolic systems. A blood leucocytes enzyme activity indexes that provides an adaptation are the indicators of energy metabolism.

Objective: The aim of investigation is to determine the features and role of metabolic adaptive changes in the white blood cells of the students in European North during educational process. Read More

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Concentration kinetics of secoisolariciresinol diglucoside and its biosynthetic precursor coniferin in developing flaxseed.

Phytochem Anal 2013 Jan-Feb;24(1):41-6. Epub 2012 Jun 12.

Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, Beutenberg Campus, 07745 Jena, Germany.

Introduction: In the plant kingdom, flaxseed (Linum usitatissimum L.) is the richest source of secoisolariciresinol diglucoside (SDG), which is of great interest because of its potential health benefits for human beings. The information about the kinetics of SDG formation during flaxseed development is rare and incomplete. Read More

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Patented techniques for the extraction and isolation of secoisolari-ciresinol diglucoside from flaxseed.

Recent Pat Food Nutr Agric 2009 Jan;1(1):25-31

University of Manitoba, Department of Food Science, Winnipeg, Manitoba, R3T 2N2 Canada.

Plant lignans are phenolic compounds generally containing a dibenzylbutane skeleton. Secoisolariciresinol diglucoside (SDG) is the major lignan found in flaxseed. SDG is known to have antioxidant and anticancer properties. Read More

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January 2009

Hydrolysis kinetics of secoisolariciresinol diglucoside oligomers from flaxseed.

J Agric Food Chem 2008 Nov 17;56(21):10041-7. Epub 2008 Oct 17.

State Key Laboratory of Biocontrol/Food Engineering Research Center of State Education Ministry, College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China.

Flaxseed is the richest dietary source of the lignan secoisolariciresinol diglucoside (SDG) and contains the largest amount of SDG oligomers, which are often hydrolyzed to break the ester linkages for the release of SDG and the glycosidic bonds for the release of secoisolariciresinol (SECO). The alkaline hydrolysis reaction kinetics of SDG oligomers from flaxseed and the acid hydrolysis process of SDG and other glucosides were investigated. For the kinetic modeling, a pseudo-first-order reaction was assumed. Read More

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November 2008

Validation of a reversed phase high performance thin layer chromatographic-densitometric method for secoisolariciresinol diglucoside determination in flaxseed.

J Chromatogr A 2008 Oct 27;1207(1-2):155-9. Epub 2008 Aug 27.

Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy.

The validation of a HPTLC-densitometric method for the determination of secoisolariciresinol diglucoside (SDG) in flaxseed was performed improving the reproducibility of a previously reported HPTLC densitometric procedure by the use of fully wettable reversed phase plates (silica gel 60 RP18W F(254S), 10cmx10cm) with MeOH:HCOOH 0.1% (40:60, v/v) mobile phase. The analysis required only the alkaline hydrolysis in aqueous medium of undefatted samples and densitometry at 282nm of HPTLC runs. Read More

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October 2008

Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography.

J Chromatogr A 2008 Mar 31;1185(2):223-32. Epub 2008 Jan 31.

State Key Laboratory of Biocontrol/Food Engineering Research Center of State Education Ministry, College of Life Sciences, Sun Yat-Sen University, 135 Xingang Xi Road, Guangzhou, China.

Flaxseed contains the largest amount of lignan secoisolariciresinol diglucoside (SDG) oligomers and is the richest dietary source of SDG. SDG oligomers in the flaxseed extract are often hydrolyzed to break the ester linkages for the release of SDG and the glycosidic bonds for the release of secoisolariciresinol (SECO). The hydrolysates of SDG oligomers are complicated because of the production of esters in an alcohol-containing medium. Read More

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Microwave-assisted extraction of the main phenolic compounds in flaxseed.

Phytochem Anal 2007 Jul-Aug;18(4):275-82

Laboratoire de Phytotechnologie EA 3900, Faculté de Pharmacie, Université de Picardie Jules Verne, 1 rue des Louvels, 80037 Amiens, France.

A microwave-assisted extraction (MAE) method has been applied for the first time to the extraction of the main lignan, secoisolariciresinol diglucoside (SDG), and the two most concentrated hydroxycinnamic acid glucosides in flaxseed. The effects of microwave power, extraction time and alkaline treatment were investigated. It was shown that a 3 min MAE resulted in an SDG content of 16. Read More

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September 2007

[Oxidative stress and oxygen status in ischemic stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2007 ;107(1):30-6

A dynamic assessment of oxygen status of the arterial blood, activity of antioxidant system enzymes (AOS), succinatedehydrogenase (SDG), mitochondrial alpha-glycero-phosphate-dehydrogenase (alpha-GPDH) and alkaline phosphatase (AP) as well as concentrations of reduced glutathione (GSH) and secondary products of lipid peroxidation reacting with thiobarbituric acid (PLPRTA) has been carried out in patients at the acute stage of ischemic stroke of hemispheric location. Relative hyperoxia as a result of the hyperventilation syndrome was mostly pronounced on day 1 and 3. At the same time, a reduced activity of AOS system and an increase of PLPRTA concentration have been observed from the 1st day after stroke. Read More

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High-performance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction.

J Chromatogr A 2003 Sep;1012(2):151-9

Department of Food Science, Swedish University of Agricultural Sciences (SLU), P.O. Box 7051, SE-750 07 Uppsala, Sweden.

A HPLC method was developed for the analysis of secoisolariciresinol diglucoside (SDG) and hydroxycinnamic acid glucosides in milled defatted flaxseed flour. Direct extraction by 1 M NaOH for 1 h at 20 degrees C resulted in a higher yield than that obtained by hydrolysis of alcoholic extracts. An internal standard, o-coumaric acid, was used and the method was found to be easy, fast, and with good repeatability. Read More

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September 2003

On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed.

J Chromatogr A 2002 Oct;972(2):195-203

Unilever Research & Development, Vlaardingen, The Netherlands.

Two secoisolariciresinol diglucoside (SDG) diastereomers were extracted from flaxseed and liberated through alkaline hydrolysis. Anion-exchange and reversed-phase chromatography were successfully employed to purify the hydrolyzed flaxseed extract. On-line LC-NMR-MS analyses revealed the structure of the isolated and purified SDG diastereomers, [2R,2'R]-2,3-bis[(4-hydroxy-3-methoxyphenyl)-methyl]-1,4-butanediyl-bis-beta-glucopyranoside the predominant flaxseed lignan and [2R,2'S]-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl-bis-beta-glucopyranoside, a previously incompletely characterized minor flaxseed lignan. Read More

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October 2002

[Drug-induced hepatitis].

T E Polunina

Ter Arkh 1999 ;71(12):46-9

Aim: To improve diagnosis and treatment of drug-induced hepatitis: to specify drugs with hepatotoxic effect, clinical variants of drug-induced hepatic diseases, management of drug-induced hepatitis (DIH).

Materials And Methods: Of 2300 examinees with hepatic lesions, 62 were diagnosed to have DIH. Measurements were made of serum levels of bilirubin and its fractions, total protein, some protein fractions, markers of hepatitis A, B, C, activity of aminotransferases (AlAT and AsAT), alkaline phosphatase (AP), glutamate dehydrogenase (GlDG), sorbitol dehydrogenase (SDG), gamma-glutamate transpeptidase (GGTP), choline esterase (CE). Read More

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February 2000

[The effect of exposure to 60Co accelerated electrons and gamma quanta on the activity of oxidative and hydrolytic enzymes in the rat brain].

Radiobiologiia 1992 Jan-Feb;32(1):56-9

In experiments with 112 male Wistar rats it was shown that accelerated electrons (85 Gy) caused a significant increase in activities of succinate dehydrogenase (SDG) by 15.8% and lactate dehydrogenase (LDG) by 17.0%, and a decrease in activities of alkaline phosphatase (AP) and monoamine oxidase (MAO) by 10. Read More

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Physicochemical characterization and solubilization of endothelin receptors.

Receptor 1991 ;1(4):229-42

Department of Biochemistry Boston University, School of Medicine, MA 02118.

[125I]Endothelin-1 (ET-1) bound to specific endothelin receptors (ET-R) with high affinity (Kd = 0.4-1 nM) and dissociated very slowly from ET-R at 37 degrees C (K-1 = 2.4 x 10(-3)/h). Read More

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February 1993

[A histochemical analysis of the enzymes of the enterocyte transport and bioenergetics in rat small intestine after vagotomy and dibunol administration].

Biull Eksp Biol Med 1990 Nov;110(11):543-5

It was shown that the vagotomy leads to the elevation of the activity of alkaline phosphatase (AP) 7 days after the operation and to the decrease of its activity 30 days after the operation, and to the decrease of the activity of succinic dehydrogenase (SDG) 7 and 30 days after the operation. Introduction of dibunol leads to normalization of these disturbances of the activity of AP and SDG induced by vagotomy. Read More

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November 1990

The response of the pulmonary surfactant-associated alkaline phosphatase following acute cadmium chloride inhalation.

Am Ind Hyg Assoc J 1989 Jul;50(7):331-5

Départment des sciences biologiques, Université du Québec à Montréal, Canada.

In order to identify sensitive and specific biochemical indicators of pulmonary damages caused by industrial contaminants, male Long-Evans rats were exposed to a cadmium chloride (CdCl2) aerosol (5 mg Cd/m3; MMAD = 1.4 microns; SDg = 1.8) for 1 hr. Read More

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[Changes in the activity of the oxidative and hydrolytic enzymes of the animal cerebral cortex in the early periods after gamma irradiation and the use of meksamine and the synthetic analog of prostaglandin F2 alpha-estrofan].

Radiobiologiia 1988 Jul-Aug;28(4):539-42

In experiments with (CBA x C57B1/6)F1 mice it was shown that LDH activity moderately increased 5 min after exposure of the head to 200 Gy gamma radiation. After 60 min, there was a 24.4 per cent decrease in alkaline phosphatase activity and a 24. Read More

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October 1988

Toxicity of inhaled cadmium chloride: early responses of the antioxidant and surfactant systems in rat lungs.

J Toxicol Environ Health 1988 ;23(2):241-56

Département des Sciences Biologiques, Université du Québec à Montréal, Canada.

In order to establish an animal model for assessing early and sensitive biochemical indicators of pulmonary damage, we studied the effects of inhaled CdCl2 (5 mg/m3.h; mass median aerodynamic diameter (MMAD) = 1.4 microns; SDg = 1. Read More

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[Characteristics of the development of the small intestine mucosa in man and rat].

Arkh Anat Gistol Embriol 1983 Oct;85(10):75-9

The process of the small intestine tunica mucosa embryonal development has been studied in 75 rat embryos from 10 to 21 days of development and in 82 human embryos at equivalent stages of development (from 28 days up to 13 weeks). The changes observed in the tunica mucosa structure and indices of the cellular activity [mitotic index, nuclear volumes, RNA content, alkaline phosphatase (APh), acid phosphatase (AcPh), succinic dehydrogenase (SDG), lactate dehydrogenase (LDG) activity] make it possible to distinguish 3 periods in the process of the small intestine tunica mucosa embryonal development: 1 - period of the germinal differentiation, 2 - prespecific and 3 - specific differentiation period, the latter is characterized by common signs for the man and the rat. Together with some retardation in the rat organogenesis (postnatal formation of criptae) its tunica mucosa is characterized by a higher, than in the man, activity of all the enzymes studied; AcPh and LDG activities are the most intensive, that is connected with low content of glycogen. Read More

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October 1983

[Morphohistochemical characteristics of the myons of the masseter muscle of the mammals and man].

V A Solov'ev

Arkh Anat Gistol Embriol 1982 Oct;83(10):65-71

In the musculus masseter of the man, dog, rabbit and rat (5 specimens for each) optic density of diformasan deposition [after succinatedehydrogenase (SDG) activity has been revealed], transversal section areas of myons, number of capillaries around them and thickness of the Z-line have been studied. In each muscle subjected to the investigation parameters for 150 myons randomly chosen have been defined. According to SDG activity, muscle fibres of three types have been visibly selected: red, white and intermediate. Read More

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October 1982

[Morphofunctional features of 10-12-day-old rabbit lymphoid tissue].

V A Chetvertnykh

Arkh Anat Gistol Embriol 1981 Jan;80(1):64-9

Histological, cytological, enzymatic (acid and alkaline phosphatase, SDG and alpha-GPhDG), immunomorphological (RNA, DNA, amount of T- and B-lymphocytes) peculiarities in structure of the lymphatic system organs have been studied in 10-12-day-old rabbits. It has been stated that T-lymphocytes predominant (in total amount) among the lymphoid cells in the organs; there is an essential amount of inactive cells. Besides, the activity of the hydrolytic enzymes is greater than that of the mitochondrial ones. Read More

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January 1981
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