90 results match your criteria sdb depression


A preliminary study on the relationship between sleep, depression and cardiovascular dysfunction in a 4 sample population.

Int J Cardiol Heart Vasc 2021 Aug 25;35:100814. Epub 2021 Jun 25.

Department of Psychology, University of Michigan, Ann Arbor, MI, USA.

Background: Major Depressive Disorder (MDD) has been linked in the literature to poorer prognosis in patients with cardiovascular dysfunction, although the mechanisms of this relationship remain unclear. Underlying Sleep Disordered Breathing (SDB) serves as a potential candidate to explain this effect due to its downstream effects on inflammatory activation and decreased nitric oxide (NO) bioavailability, both of which have been shown to contribute to the pathophysiology of both MDD and cardiovascular disease (CVD).

Methods: This study utilizes overnight polysomnography and an inflammation panel to examine the links between cardiovascular dysfunction and sleep difficulties in control participants and patients diagnosed with SDB only, MDD only, and both SDB and MDD. Read More

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Sleep Disordered Breathing Measures in Early Pregnancy Are Associated with Depressive Symptoms in Late Pregnancy.

Diagnostics (Basel) 2021 May 11;11(5). Epub 2021 May 11.

Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Sleep disordered breathing (SDB) and depression are both common complications of pregnancy and increase risk for adverse maternal and neonatal outcomes. SDB precedes onset of depression in non-pregnant adults; however, the longitudinal relationship has not been studied in pregnancy. The present research examined temporal associations between SDB and depressive symptoms in 175 pregnant women at risk for SDB (based on frequent snoring and obesity), but without an apnea hypopnea index of ≥5 events per hour at enrollment. Read More

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Frequent nightmares and its associations with psychological and sleep disturbances in hospitalized patients with cardiovascular diseases.

Eur J Cardiovasc Nurs 2021 Jun;20(5):421-427

Division of Cardiology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Aims: Frequent nightmares can pose a serious clinical problem, especially in association with sleep and psychological disturbances, in the general population. However, this association has not been investigated in inpatients with cardiovascular (CV) diseases. Furthermore, whether CV medications could induce iatrogenic nightmares remains unknown. Read More

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Psychological disturbances and their association with sleep disturbances in patients admitted for cardiovascular diseases.

PLoS One 2021 4;16(1):e0244484. Epub 2021 Jan 4.

Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: Depression and anxiety are common mental health problems that are strongly associated with sleep disturbances, according to community-based researches. However, this association has not been investigated among patients admitted for cardiovascular diseases (CVDs). We examined the prevalence of depression and anxiety in inpatients with various CVDs and their association with sleep disturbances. Read More

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Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults.

J Gerontol A Biol Sci Med Sci 2021 02;76(3):528-533

Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago Medicine, Illinois.

Background: Sleep-disordered breathing (SDB) is a common, underdiagnosed condition in older adults with major health consequences, including disrupted central nervous system functioning. Whether SDB may affect sensory function is unclear. We sought to address this question by comparing 2 forms of olfactory testing which measure peripheral and central olfactory processing. Read More

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February 2021

Cardiovascular and somatic comorbidities and sleep measures using three hypopnea criteria in mild obstructive sleep-disordered breathing: sex, age and body mass index differences in a retrospective sleep clinic cohort.

J Clin Sleep Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School -Baystate, Springfield, Massachusetts.

Study Objectives: To describe sex, age and body mass index (BMI) differences in comorbidities and polysomnography (PSG) measures, categorized using three different apnea-hypopnea index (AHI) criterion, in sleep clinic patients with mild obstructive sleep-disordered breathing (SDB).

Methods: A retrospective cohort of 305 (64% female) adult sleep clinic patients who underwent full night in-laboratory polysomnography diagnosed with mild SDB and prescribed positive airway pressure (PAP). Effects of sex, age and BMI on comorbidities and PSG measures including rates of AHI defined by ≥3% desaturations (AHI), with arousals (AHI), by ≥4% desaturations (AHI) and by respiratory disturbance index (RDI) were evaluated. Read More

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Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives.

Nat Sci Sleep 2019 9;11:97-111. Epub 2019 Aug 9.

Department of Neurology, University Hospital Muenster, Muenster, Germany.

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading to generalized muscle weakness and premature death. Sleep disturbances are extremely common in patients with ALS and substantially add to the burden of disease for both patients and caregivers. Disruption of sleep can be caused by physical symptoms, such as muscle cramps, pain, reduced mobility, spasticity, mucus retention, and restless legs syndrome. Read More

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The Epidemiology of Patient-Reported Hypersomnia in Persons With Advanced Age.

J Am Geriatr Soc 2019 12 7;67(12):2545-2552. Epub 2019 Aug 7.

Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

Objective: To examine the epidemiology and key demographic and clinical correlates of patient-reported hypersomnia in persons with advanced age.

Design: Cross-sectional design.

Setting: Community. Read More

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December 2019

Sleep-Disordered Breathing in Hospitalized Geriatric Patients with Mild Dementia and Its Association with Cognition, Emotion and Mobility.

Int J Environ Res Public Health 2019 03 9;16(5). Epub 2019 Mar 9.

Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.

Sleep-disordered breathing (SDB) is an emerging dementia risk factor. Data on the prevalence of SDB in dementia patients and its association with cognitive impairment is so far only based on patients with severe dementia. In 101 geriatric patients mostly with mild dementia recruited on German geriatric wards, SDB was assessed during overnight polygraphy in the patient room with a portable sleep apnea examination device and associations of SDB severity with severity of impairment in cognitive and emotional function as well as mobility were investigated. Read More

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Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing.

Sleep Med 2018 11 26;51:29-36. Epub 2018 Jun 26.

Center for Investigation and Research in Sleep (CIRS), Lausanne, Switzerland.

Objective: Sleep-disordered breathing (SDB) is currently considered as a unique condition, but it has been suggested that the prevalence, clinical presentation, and associated conditions may differ by sex or by menopausal status in women. We aimed to assess the prevalence of SDB and associated comorbidities in pre- and postmenopausal women compared with men.

Methods: Participants of the population-based HypnoLaus Sleep Cohort study underwent polysomnography in their home environment and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression. Read More

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November 2018

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort.

Eur Respir J 2018 08 16;52(2). Epub 2018 Aug 16.

Center for Investigation and Research in Sleep (CIRS), University Hospital of Lausanne, Lausanne, Switzerland.

This study determined the prevalence of rapid eye movement (REM) related sleep-disordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. Read More

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Excessive Daytime Sleepiness Is Associated With Depression Scores, But Not With Sleep-Disordered Breathing in Patients With Cardiovascular Diseases.

Circ J 2018 07 13;82(8):2175-2183. Epub 2018 Jun 13.

Division of Cardiology, Department of Medicine, Keio University School of Medicine.

Background: Excessive daytime sleepiness (EDS) is a significant public health concern, with sleep-disordered breathing (SDB) being a common cause. However, their precise relationship in patients with cardiovascular disease (CVD) is unclear. Furthermore, whether comorbid psychological disorders could contribute to EDS remains unknown. Read More

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Insomnia in Community-Living Persons with Advanced Age.

J Am Geriatr Soc 2018 08 21;66(8):1592-1597. Epub 2018 May 21.

Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut.

Objective: To evaluate the epidemiology of insomnia, including demographic and clinical correlates, in older adults.

Design: Cross-sectional.

Setting: Community. Read More

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Opioids, respiratory depression, and sleep-disordered breathing.

Best Pract Res Clin Anaesthesiol 2017 Dec 22;31(4):469-485. Epub 2017 May 22.

Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

The increasing use of opioids in the perioperative period has increased opioid-associated morbidity and mortality. There is a well-established connection between opioids, sleep-disordered breathing (SDB), and respiratory depression. The treatment of postoperative pain with opioids in patients with SDB may result in respiratory depression. Read More

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December 2017

Wake-up stroke is not associated with sleep-disordered breathing in women.

Neurol Clin Pract 2018 Feb;8(1):8-14

Stroke Program (DLB, CL, EC, NMG, LDL) and Sleep Disorders Center and Department of Neurology (RDC), University of Michigan Medical School; Department of Epidemiology (CL, EC, NMG, LDL), University of Michigan School of Public Health, Ann Arbor; and Corpus Christi physician (SDT), TX.

Background: We sought to investigate the frequency of wake-up stroke (WUS) and its association with sleep-disordered breathing (SDB) in women.

Methods: Within a population-based study, women with acute ischemic stroke were asked about their stroke symptom onset time. SDB screening was performed with the well-validated ApneaLink Plus device; SDB was defined by a respiratory event index ≥10. Read More

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February 2018

Behavioral consequences of children with sleep-disordered breathing after adenotonsillectomy.

World J Pediatr 2018 02 20;14(1):57-65. Epub 2018 Feb 20.

Otorhinolaryngology Department, CHA University, Seongnam, Korea.

Background: Adenotonsillectomy (AT) has been an effective treatment for sleep-disordered breathing (SDB) in children, and several studies described the risk of postoperative weight gain and obesity in children treated with AT. The present study aimed to evaluate behavioral improvements in children with SDB one year after adenotonsillectomy and to investigate an influence of postoperative weight gain on behaviors.

Methods: The study included 170 children aged 5-11 years who underwent adenotonsillectomy for SDB and 150 controls. Read More

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February 2018

Sleep disorder prevalence in at-risk adolescents and potential effects of nightmare triad syndrome.

Int J Adolesc Med Health 2018 Feb 17;32(1). Epub 2018 Feb 17.

Robert F. Kennedy Charter School, Albuquerque, NM 87121, USA.

Objective At-risk high school students, those considered to have a higher probability for academic failure or dropping out, were assessed for various sleep disorders. Effects were compared between students with and without the nightmare triad syndrome (NTS+), the sleep disorders' cluster of frequent nightmares, insomnia disorder and suspected sleep-disordered breathing (SDB). Methods Data were gathered at a charter school for at-risk youth using: computer based surveys, physical airway exams, and mental health interviews by school social worker. Read More

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February 2018

Depression score changes in response to sleep disordered breathing treatment with positive airway pressure in a large clinic-based cohort.

Sleep Breath 2018 03 29;22(1):195-203. Epub 2018 Jan 29.

Sleep Disorders Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Objective: The clinical-population impact of positive airway pressure (PAP) on depressive symptoms in sleep disordered breathing (SDB) awaits clear documentation. We hypothesized that depressive symptoms improve in response to PAP treatment in a large clinical setting, and that lower socio-economic status poses barriers to full therapeutic response.

Method: We performed a retrospective cohort study of SDB patients attending a tertiary ambulatory sleep center between January 1, 2010 and December 31, 2015. Read More

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Sleep-Disordered Breathing in People with Multiple Sclerosis: Prevalence, Pathophysiological Mechanisms, and Disease Consequences.

Front Neurol 2017 15;8:740. Epub 2018 Jan 15.

Neuroscience Research Australia (NeuRA), Sydney, NSW, Australia.

Sleep problems are common in people with multiple sclerosis (MS). Reported prevalence rates of sleep-disordered breathing (SDB) vary between 0 and 87%. Differences in recruitment procedures and study designs likely contribute to the wide variance in reported prevalence rates of SBD in MS. Read More

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January 2018

Fitness, Sleep-Disordered Breathing, Symptoms of Depression, and Cognition in Inactive Overweight Children: Mediation Models.

Public Health Rep 2017 Nov/Dec;132(2_suppl):65S-73S

5 Georgia Prevention Institute, Augusta University, Augusta, GA, USA.

Objectives: We used mediation models to examine the mechanisms underlying the relationships among physical fitness, sleep-disordered breathing (SDB), symptoms of depression, and cognitive functioning.

Methods: We conducted a cross-sectional secondary analysis of the cohorts involved in the 2003-2006 project PLAY (a trial of the effects of aerobic exercise on health and cognition) and the 2008-2011 SMART study (a trial of the effects of exercise on cognition). A total of 397 inactive overweight children aged 7-11 received a fitness test, standardized cognitive test (Cognitive Assessment System, yielding Planning, Attention, Simultaneous, Successive, and Full Scale scores), and depression questionnaire. Read More

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December 2017

Parent-Reported Symptoms of Sleep-Disordered Breathing Are Associated With Increased Behavioral Problems at 2 Years of Age: The Canadian Healthy Infant Longitudinal Development Birth Cohort Study.

Sleep 2018 01;41(1)

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Study Objectives: To examine the association between the age of onset and duration of parent-reported symptoms of sleep-disordered breathing (SDB) and behavioral problems at age 2.

Methods: Parent-reported SDB symptoms were assessed quarterly between 3 months and 2 years among 583 Canadian Healthy Infant Longitudinal Development Edmonton-site participants. Parent-reported SDB symptoms were clustered into phenotypes using group-based trajectory analysis based on age of onset and duration of symptoms. Read More

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January 2018

Association of sleep disordered breathing symptoms with early postoperative analgesic requirement in pediatric ambulatory surgical patients.

Int J Pediatr Otorhinolaryngol 2017 May 19;96:145-151. Epub 2017 Mar 19.

Department of Anesthesiology, Section of Pediatric Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Introduction: Sleep disordered breathing (SDB) symptoms are associated with increased rates of opioid-induced respiratory depression as well as enhanced nociception. Consequently, practitioners often withhold or administer lower intraoperative doses of opioids out of concern for postoperative respiratory depression. Therefore, SDB may be a critical determinant of analgesic requirement in the post-anesthesia care unit (PACU). Read More

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Associations of sedentary time and moderate-vigorous physical activity with sleep-disordered breathing and polysomnographic sleep in community-dwelling adults.

Sleep Breath 2017 May 11;21(2):427-434. Epub 2016 Nov 11.

Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.

Purpose: The purpose of this study was to evaluate the relationship between daytime activity (sedentary time, moderate- to vigorous-intensity physical activity [MVPA]) and indices of polysomnographically (PSG) assessed sleep, including sleep-disordered breathing (SDB).

Methods: One hundred and thirty-six adults (65% female, 59.8 ± 9. Read More

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Impact of Sleep-Disordered Breathing Treatment on Patient Reported Outcomes in a Clinic-Based Cohort of Hypertensive Patients.

J Clin Sleep Med 2016 10 15;12(10):1357-1364. Epub 2016 Oct 15.

Sleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH.

Study Objectives: We hypothesized that patient reported outcomes (PROs) improve with positive airway pressure (PAP) in patients with sleep-disordered breathing (SDB) and hypertension (HTN).

Methods: Questionnaire-based PROs (sleepiness [Epworth Sleepiness Scale, (ESS)], depression [Patient Health Questionnaire-9 (PHQ-9)], and fatigue [Fatigue Severity Scale (FSS)]) were retrospectively examined in patients with SDB and HTN at baseline and within a year following PAP initiation. PRO changes were estimated using multivariable linear mixed-effect models adjusted for baseline age, sex, race, body mass index, resistant hypertension (RHTN) status, cardiac and diabetes history, and correlation between repeated measurements. Read More

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October 2016

Sleep disordered breathing symptoms and daytime sleepiness are associated with emotional problems and poor school performance in children.

Psychiatry Res 2016 Aug 24;242:218-225. Epub 2016 May 24.

University of Pennsylvania, School of Education, Philadelphia, PA, USA.

This study examined the prevalence of sleep disordered breathing (SDB) symptoms and their associations with daytime sleepiness, emotional problems, and school performance in Chinese children. Participants included 3979 children (10.99±0. Read More

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Continuous Positive Airway Pressure Mitigates Opioid-induced Worsening of Sleep-disordered Breathing Early after Bariatric Surgery.

Anesthesiology 2016 Jul;125(1):92-104

From the Department of Anesthesia, Critical Care and Pain Medicine (S.Z., C.H.S., S.A.M., S.D.G., T.M., D.D-.G., M.E.), Department of Surgery (M.M.H.), and Respiratory Care, Department of Anesthesia, Critical Care and Pain Medicine (D.H.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Sleep Medicine, Department of Neurology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany (S.Z.); German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Bonn, Germany (S.Z.); Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan (S.K.R.); Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Diego, La Jolla, California (A.M.); and Department of Anesthesia and Critical Care, University Hospital Essen, Essen, Germany (M.E.).

Background: Bariatric surgery patients are vulnerable to sleep-disordered breathing (SDB) early after recovery from surgery and anesthesia. The authors hypothesized that continuous positive airway pressure (CPAP) improves postoperative oxygenation and SDB and mitigates opioid-induced respiratory depression.

Methods: In a randomized crossover trial, patients after bariatric surgery received 30% oxygen in the postanesthesia care unit (PACU) under two conditions: atmospheric pressure and CPAP (8 to 10 cm H2O). Read More

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Metabolomic Profiling of Post-Mortem Brain Reveals Changes in Amino Acid and Glucose Metabolism in Mental Illness Compared with Controls.

Comput Struct Biotechnol J 2016 26;14:106-16. Epub 2016 Feb 26.

Strathclyde Institute of Pharmacy and Biomedical Sciences, 161, Cathedral Street, Glasgow G4 0RE, Scotland, UK.

Metabolomic profiling was carried out on 53 post-mortem brain samples from subjects diagnosed with schizophrenia, depression, bipolar disorder (SDB), diabetes, and controls. Chromatography on a ZICpHILIC column was used with detection by Orbitrap mass spectrometry. Data extraction was carried out with m/z Mine 2. Read More

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Prevalence of potential nonallergic rhinitis at a community-based sleep medical center.

Sleep Breath 2016 Sep 18;20(3):987-93. Epub 2016 Mar 18.

Los Alamos Medical Center Sleep Laboratory, Los Alamos, NM, USA.

Purpose: Nonallergic rhinitis (NAR) is a common condition involving symptomatic nasal congestion, stuffiness, or rhinorrhea, which overlap with symptoms of allergic rhinitis. Scant research has examined NAR and sleep. The aim of this study was to assess the frequency of potential NAR symptoms in a large sample of sleep center patients. Read More

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September 2016