1,732 results match your criteria scz

Genetic and functional analysis reveals contributes to schizophrenia.

iScience 2021 Sep 30;24(9):103063. Epub 2021 Aug 30.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030, PR China.

, encoding a member of the teneurin protein family, is a risk gene shared by many types of mental diseases and is implicated in neuronal plasticity and signaling. However, the role and the mechanisms of in schizophrenia (SCZ) remain unclear. We identified possible pathogenic mutations in the gene through target sequencing of in 68 SCZ families. Read More

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September 2021

mRNA Expression of the CUB and Sushi Multiple Domains 1 () and Its Serum Protein Level as Predictors for Psychosis in the Familial High-Risk Children and Young Adults.

ACS Omega 2021 Sep 4;6(37):24128-24138. Epub 2021 Sep 4.

Department of Medical Biochemistry and Molecular Biology, Menoufia University, Shebin El-Kom 13829, Egypt.

: Schizophrenia (SCZ) is still a challenging, refractory, and severe disorder. It is not a fully understood disease with genetic and epigenetic susceptibility and about 80% substantial heritability. The CUB and Sushi multiple domains 1 () gene is implicated in neurogenesis, memory, immunity, neuropsychology, and monoamine metabolism. Read More

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September 2021

Behavioural equivalents of schizophrenia in people with intellectual disability and autism spectrum disorder. A selective review.

Int J Dev Disabil 2021 18;67(5):310-317. Epub 2021 Sep 18.

National Advisory on Mental Health in Intellectual Disability, Oslo University, Oslo, Norway.

Assessment of schizophrenia (SCZ) in people with autism spectrum disorder (ASD) is complicated due to confounding symptoms between ASD and SCZ. These confounding factors are aggravated when the patient has sparse verbal skills. A selective review was conducted to identify behavioural equivalents when assessing SCZ in individuals with ASD with sparse verbal skills, from 16 years of age. Read More

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September 2021

Comparative study of emotion recognition and theory of mind between major depressive disorder and schizophrenia.

J Affect Disord 2021 Sep 17. Epub 2021 Sep 17.

Research Division, Institute of Mental Health, 10 Buangkok View, 539747, Singapore; Department of Psychosis, Institute of Mental Health, Singapore; Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:

Background: Social cognition as a transdiagnostic construct between major depressive disorder (MDD) and schizophrenia (SCZ) is not well understood. This may be attributed to the variability of social cognitive measures indexing the same construct. This study aims to compare emotion recognition and theory of mind domains, known to be impaired in SCZ, between MDD and SCZ. Read More

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September 2021

Association of acute psychosocial stress with oxidative stress: Evidence from serum analysis.

Redox Biol 2021 Sep 16;47:102138. Epub 2021 Sep 16.

Institute for Bioscience & Biotechnology Research, University of Maryland, College Park, MD, 20742, USA; Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD, 20742, USA. Electronic address:

Growing evidence implicates an association between psychosocial stress and oxidative stress (OxSt) although there are not yet reliable biomarkers to study this association. We used a Trier Social Stress Test (TSST) and compared the response of a healthy control group (HC; N=10) against the response of a schizophrenia group (SCZ; N=10) that is expected to have higher levels of OxSt. Because our previous study showed inconsistent changes in conventional molecular markers for stress responses in the neuroendocrine and immune systems, we analyzed the same serum samples using a separate reducing capacity assay that provides a more global measurement of OxSt. Read More

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September 2021

Unstable Belief Formation and Slowed Decision-making: Evidence That the Jumping-to-Conclusions Bias in Schizophrenia Is Not Linked to Impulsive Decision-making.

Schizophr Bull 2021 Sep 23. Epub 2021 Sep 23.

Department of Psychiatry, Psychotherapy and Psychosomatics of the University Augsburg, Medical Faculty, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany.

Background: Jumping-to-conclusions (JTC) is a prominent reasoning bias in schizophrenia (SCZ). While it has been linked to not only psychopathological abnormalities (delusions and impulsive decision-making) but also unstable belief formation, its origin remains unclear. We here directly test to which extend JTC is associated with delusional ideation, impulsive decision-making, and unstable belief formation. Read More

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September 2021

Antioxidant enzymes and weight gain in drug-naive first episode schizophrenia patients treated with risperidone for 12 weeks: a prospective longitudinal study.

Curr Neuropharmacol 2021 Sep 19. Epub 2021 Sep 19.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing. China.

Oxidative stress plays an important role in weight gain induced by antipsychotics in schizophrenia (SCZ). However, little is known about how antioxidant enzymes are involved in weight gain caused by risperidone monotherapy in antipsychotics-naïve first-episode (ANFE) patients with SCZ. Therefore, the main purpose of this study was to investigate the effects of risperidone on several antioxidant enzymes in patients with ANFE SCZ and the relationship between weight gain and changes in antioxidant enzyme activities. Read More

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September 2021

Molecular signatures from multi-omics of autism spectrum disorders and schizophrenia.

J Neurochem 2021 Sep 19. Epub 2021 Sep 19.

Department of Physiology and Cell Biology, Kobe University School of Medicine, Chuo, Kobe, 650-0017, Japan.

The genetic and phenotypic heterogeneity of autism spectrum disorder (ASD) impedes the unification of multiple biological hypotheses in an attempt to explain the complex features of ASD, such as impaired social communication, social interaction deficits, and restricted and repetitive patterns of behavior. However, recent psychiatric genetic studies have identified numerous risk genes and chromosome loci (copy number variation: CNV) which enable us to analyze at the single gene level and utilize system-level approaches. In this review, we focus on ASD as a major neurodevelopmental disorder and review recent findings mainly from the bioinformatics of omics studies. Read More

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September 2021

Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Sep 15:110440. Epub 2021 Sep 15.

Biomedical Research Networking Centre in Mental Health (CIBERSAM), Spain; Department of Psychiatry, Hospital Clínico Universitario de Valencia, INCLIVA, School of Medicine, Universidad de Valencia, Valencia, Spain.

Background: Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ).

Methods: The sample comprised 2039 individuals with schizophrenia, 2141 siblings, and 2049 healthy controls (HC). Read More

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September 2021

Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice.

Neurosci Lett 2021 Sep 15;765:136249. Epub 2021 Sep 15.

Faculty of Herbs, Amol University of Special Modern Technologies, Amol, Iran.

Curcumin as an antioxidant natural herb has shown numerous pharmacological effects. However, the poor bioavailability of curcumin is a significant pharmacological barrier for its antioxidant activities. The present study was conducted to develop curcumin-loaded nanophytosome (CNP) and explore their therapeutic potential in a ketamine (KET)-induced schizophrenia (SCZ) model. Read More

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September 2021

Effect of dimethyl fumarate on the changes in the medial prefrontal cortex structure and behavior in the poly(I:C)-induced maternal immune activation model of schizophrenia in the male mice.

Behav Brain Res 2021 Sep 14;417:113581. Epub 2021 Sep 14.

Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry & Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Background: The link between maternal immune activation (MIA) and the risk of developing schizophrenia (SCZ) later in life has been of major focus in recent years. This link could be bridged by activated inflammatory pathways and excessive cytokine release resulting in adverse effects on behavior, histology, and cytoarchitecture. The down-regulatory effects of immunomodulatory agents on the activated glial cells and their therapeutic effects on schizophrenic patients are consistent with this hypothesis. Read More

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September 2021

Functional Variants of miR-143 Are Associated with Schizophrenia Susceptibility: A Preliminary Population-Based Study and Bioinformatics Analysis.

Biochem Genet 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran.

Single nucleotide polymorphisms within genes encoding microRNAs may alter the expression of microRNAs and their target genes, contributing to the etiology of psychiatric disorders. We aimed to investigate the link between rs4705342T/C and rs4705343T/C polymorphisms in the promoter region of miR-143 and the risk of schizophrenia (SCZ) in a sample of an Iranian population. In this experimental study, a total of 398 subjects were recruited. Read More

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September 2021

Influence of E/I balance and pruning in peri-personal space differences in schizophrenia: A computational approach.

Schizophr Res 2021 Sep 8. Epub 2021 Sep 8.

The University of Edinburgh, School of Informatics, 10 Crichton Street, Edinburgh, United Kingdom. Electronic address:

The encoding of the space close to the body, named peri-personal space (PPS), is thought to play a crucial role in the unusual experiences of the self observed in schizophrenia (SCZ). However, it is unclear why SCZ patients and high schizotypal (H-SPQ) individuals present a narrower PPS and why the boundaries of the PPS are more sharply defined in patients. We hypothesise that the unusual PPS representation observed in SCZ is caused by an imbalance of excitation and inhibition (E/I) in recurrent synapses of unisensory neurons or an impairment of bottom-up and top-down connectivity between unisensory and multisensory neurons. Read More

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September 2021

Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.

Schizophr Bull 2021 Sep 9. Epub 2021 Sep 9.

Norwegian Centre for Mental Disorders Research, NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Background: Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) belong to the tumor necrosis factor (TNF) super family and are essential in orchestrating immune responses. Abnormal levels of BAFF and APRIL have been found in autoimmune diseases with CNS affection. Read More

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September 2021

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking.

Transl Psychiatry 2021 Sep 8;11(1):466. Epub 2021 Sep 8.

NORMENT, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407, Oslo, Norway.

Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated with poor health outcomes. Positive genetic correlations are reported but an improved understanding of the shared genetic architecture between risk phenotypes and psychiatric disorders may provide insights into underlying neurobiological mechanisms. Read More

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September 2021

Prognostic value of polygenic risk scores for adults with psychosis.

Nat Med 2021 Sep 6;27(9):1576-1581. Epub 2021 Sep 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ PRS exceeds that of most other common diseases. Read More

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September 2021

Clustering of Multiple Psychiatric Disorders Using Functional Connectivity in the Data-Driven Brain Subnetwork.

Front Psychiatry 2021 18;12:683280. Epub 2021 Aug 18.

Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.

Recently, the dimensional approach has attracted much attention, bringing a paradigm shift to a continuum of understanding of different psychiatric disorders. In line with this new paradigm, we examined whether there was common functional connectivity related to various psychiatric disorders in an unsupervised manner without explicitly using diagnostic label information. To this end, we uniquely applied a newly developed network-based multiple clustering method to resting-state functional connectivity data, which allowed us to identify pairs of relevant brain subnetworks and subject cluster solutions accordingly. Read More

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MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population.

BMC Med Genomics 2021 09 4;14(1):218. Epub 2021 Sep 4.

Institute of Mental Health, Hainan Provincial Anning Hospital, No 10, Nanhai Avenue East, Haikou, 571100, Hainan, China.

Background: Schizophrenia (SCZ) is a severe mental illness with high heritability. This study aimed to explore the correlation between MAD1L1, TSNARE polymorphisms and SCZ susceptibility.

Methods: A total of 493 SCZ patients and 493 healthy controls were included. Read More

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September 2021

Genome-wide analysis reveals genetic overlap between alcohol use behaviors, schizophrenia and bipolar disorder and identifies novel shared risk loci.

Addiction 2021 Sep 2. Epub 2021 Sep 2.

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background And Aim: Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness severity. We aimed to identify genomic loci jointly associated with SCZ, BD, AUD, and AC to gain further insights into their shared genetic architecture.

Design: We analyzed summary data (p-values and z-scores) from genome-wide association studies (GWAS) using conjunctional false discovery rate (conjFDR) analysis, which increases power to discover shared genomic loci. Read More

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September 2021

The Relation between the Plasma Concentrations of Long-Acting Atypical Antipsychotics and Clinical Effectiveness in Patients Affected by Schizophrenia or Schizoaffective Disorder: A Comprehensive Overview.

Curr Pharm Des 2021 Aug 29. Epub 2021 Aug 29.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan. Italy.

Atypical antipsychotic depot medications are currently recommended for patients with schizophrenia (SCZ) to prevent relapse and ameliorate the long-term prognosis of these patients. This review critically summarizes the available data about the association between the plasma concentrations of long-acting SecondGeneration Antipsychotics (SGAs) and the clinical effectiveness of these compounds in patients affected by SCZ or schizoaffective disorder. Our question is if the measurement of these concentrations can be helpful for clinicians in predicting treatment response and clinical stabilization of patients. Read More

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Adiposity in schizophrenia: A systematic review and meta-analysis.

Acta Psychiatr Scand 2021 Aug 30. Epub 2021 Aug 30.

Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

Objective: Although a relationship between schizophrenia (SCZ), antipsychotic (AP) medication, and metabolic dysregulation is now well established, the effect of adiposity is less well understood. By synthesizing findings from imaging techniques that measure adiposity, our systematic review and meta-analysis (PROSPERO CRD42020192977) aims to determine the adiposity-related effects of illness and treatment in this patient population.

Methods: We searched MEDLINE, EMBASE, PsychINFO and Scopus for all relevant case-control and prospective longitudinal studies from inception until February 2021. Read More

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Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents.

J Psychiatr Res 2021 Oct 6;142:384-388. Epub 2021 Aug 6.

Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil; Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil. Electronic address:

Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Read More

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October 2021

Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice.

Pharmacol Res 2021 Aug 24;173:105832. Epub 2021 Aug 24.

Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University, Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address:

Reelin, a large extracellular matrix protein, helps to regulate neuronal plasticity and cognitive function. Several studies have shown that Reelin dysfunction, resulting from factors such as mutations in gene RELN or low Reelin expression, is associated with schizophrenia (SCZ). We previously reported that microinjection of Reelin into cerebral ventricle prevents phencyclidine-induced cognitive and sensory-motor gating deficits. Read More

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Increasing sample diversity in psychiatric genetics - Introducing a new cohort of patients with schizophrenia and controls from Vietnam - Results from a pilot study.

World J Biol Psychiatry 2021 Aug 27:1-9. Epub 2021 Aug 27.

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany.

Objectives: Genome-Wide Association Studies (GWAS) of Schizophrenia (SCZ) have provided new biological insights; however, most cohorts are of European ancestry. As a result, derived polygenic risk scores (PRS) show decreased predictive power when applied to populations of different ancestries. We aimed to assess the feasibility of a large-scale data collection in Hanoi, Vietnam, contribute to international efforts to diversify ancestry in SCZ genetic research and examine the transferability of SCZ-PRS to individuals of Vietnamese Kinh ancestry. Read More

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Application of Artificial Intelligence in the MRI Classification Task of Human Brain Neurological and Psychiatric Diseases: A Scoping Review.

Diagnostics (Basel) 2021 Aug 3;11(8). Epub 2021 Aug 3.

715-3 Teaching Building No.5, Department of Biomedical Engineering, School of Life Sciences, Beijing Institute of Technology, 5 South Zhongguancun Road, Haidian District, Beijing 100081, China.

Artificial intelligence (AI) for medical imaging is a technology with great potential. An in-depth understanding of the principles and applications of magnetic resonance imaging (MRI), machine learning (ML), and deep learning (DL) is fundamental for developing AI-based algorithms that can meet the requirements of clinical diagnosis and have excellent quality and efficiency. Moreover, a more comprehensive understanding of applications and opportunities would help to implement AI-based methods in an ethical and sustainable manner. Read More

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Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics.

Biomedicines 2021 Jul 23;9(8). Epub 2021 Jul 23.

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, Italy.

The gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this work we characterized the composition of the gut microbiota in 38 patients with schizophrenia (SCZ) and 20 healthy controls (HC), and tested if SCZ patients with different response to antipsychotics (18 patients with treatment resistant schizophrenia (TRS), and 20 responders (R)) had specific patterns of gut microbiota composition associated with different response to antipsychotics. Read More

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Transcriptomic Data Analysis Reveals a Down-Expression of in Schizophrenia Hippocampus.

Brain Sci 2021 Jul 23;11(8). Epub 2021 Jul 23.

Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

Schizophrenia (SCZ) is a severe psychiatric disorder with several clinical manifestations that include cognitive dysfunction, decline in motivation, and psychosis. Current standards of care treatment with antipsychotic agents are often ineffective in controlling the disease, as only one-third of SCZ patients respond to medications. The mechanisms underlying the pathogenesis of SCZ remain elusive. Read More

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A protein-centric view of in vitro biological model systems for schizophrenia.

Stem Cells 2021 Aug 25. Epub 2021 Aug 25.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Read More

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The Cerebellar Dopaminergic System.

Front Syst Neurosci 2021 5;15:650614. Epub 2021 Aug 5.

Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.

In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive functions. Although the cerebellum is not been considered an elective dopaminergic region, studies attributed to it a critical role in dopamine deficit-related neurological and psychiatric disorders [e.g. Read More

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Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study.

Schizophr Bull 2021 Aug 22. Epub 2021 Aug 22.

Neuropsychology and Applied Cognitive Neuroscience Laboratory; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Amotivation is related to value representation. A comprehensive account of amotivation requires a mechanistic understanding of how the brain exploits external information to represent value. To achieve maximal value discriminability, brain valuation system will dynamically adapt its coding sensitivity to the range of values available in any given condition, so-called range adaptive coding. Read More

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