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THE ROLE OF CHEST CT IN DECIPHERING INTERSTITIAL LUNG INVOLVEMENT: SYSTEMIC SCLEROSIS VERSUS COVID-19.

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Department of Experimental and Clinical Medicine, University of Florence, and Infectious and TropicalDiseases Unit, AOUC, Florence, Italy.

Objective: To identify the main computed tomography (CT) features that may help distinguishing a progression of interstitial lung disease (ILD) secondary to Systemic sclerosis (SSc) from COVID-19 pneumonia.

Methods: This multicentric study included 22 international readers divided in the radiologist group (RAD) and non-radiologist group (nRAD). A total of 99 patients, 52 with COVID-19 and 47 with SSc-ILD, were included in the study. Read More

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Pain location is associated with fracture type in acute osteoporotic thoracolumbar vertebral fracture: a prospective observation study.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Spine Surgery, Honghui Hospital of Xi'an Jiaotong University Health Science Center.

Objective: This study investigated the relationship between pain location and fracture type in the patients with acute osteoporotic vertebral fracture (OVF).

Design: A prospective observation study.

Subject: A total of 306 patients with acute OVF were included. Read More

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How do clinical and socioeconomic factors impact on work disability in early axial spondyloarthritis? Five-year data from the DESIR cohort.

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden, Netherlands.

Objectives: To investigate the impact of clinical and socioeconomic factors on work disability (WD) in early axial spondyloarthritis (axSpA).

Methods: Patients from the DESIR cohort with a clinical diagnosis of axSpA were studied over 5 years. Time to WD and potential baseline and time-varying predictors were explored, with a focus on socioeconomic (including ethnicity, education, job-type, marital/parental status) and clinical (including disease activity, function, mobility) factors. Read More

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Prevalence of aortic coarctation in Bogotá-Colombia from 2001 to 2018. The diagnostic needs to improve.

Arch Cardiol Mex 2021 Jul 28. Epub 2021 Jul 28.

Human Genetic Institute, Pontificia Universidad Javeriana-Hospital Universitario San Ignacio. Bogotá, Colombia.

Objectives: Aortic coarctation is the most frequent structural anomaly out of congenital heart diseases. This congenital defect is an important cause of death worldwide. We sought to determine the prevalence of aortic coarctation in Colombia and whether new policies have had an impact on its diagnosis. Read More

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Morphometric Analysis of the Mental Foramen Variation in an Iraqi Population by Using Cone-Beam Computed Tomography.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Chairman of Iraqi Scientific Council of Maxillofacial Surgery, Iraqi Board for Medical Specializations, Baghdad University Department of Oral and Maxillofacial Surgery, Dental Teaching Hospital, Al-Mustansyria University Department of Oral Diagnosis, Dental Teaching Hospital, College of Dentistry, Baghdad University, Baghdad, Iraq.

Abstract: The effects of gender, side, and ridge condition on the position of the mental foramen (MF) were investigated in this research. A total of 122 cone-beam computed tomography scans were chosen from healthy patients with age ranging from 18 to 72 years. The following parameters were used to evaluate images: MS-MF (horizontal distance to the mandibular symphysis from the anterior MF limit) and MB-MF (vertical measurement of distance from the inferior boundary of the mandible to the lower border of the MF). Read More

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Renal Outcomes of Dialysis-Dependent Acute Kidney Injury in Noncritically Ill Patients: A Retrospective Study.

Blood Purif 2021 Jul 28:1-7. Epub 2021 Jul 28.

Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Introduction: Acute kidney injury (AKI) is a common complication among hospitalized patients, potentially affecting short- and long-term clinical outcomes. In this retrospective study, we evaluated renal outcomes in noncritically ill patients who required acute hemodialysis (HD) because of an AKI episode occurring during hospitalization.

Methods: Sixty-three hemodynamically stable patients with AKI undergoing acute intermittent HD were included. Read More

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Validation of Neurologic Impairment Diagnosis Codes as Signifying Documented Functional Impairment in Hospitalized Children.

Acad Pediatr 2021 Jul 25. Epub 2021 Jul 25.

Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado and Children's Hospital Colorado, 13199 East Montview Boulevard, Suite 300, Aurora, Colorado 80045, USA. Electronic address:

Objective: To assess the performance of previously published high-intensity neurologic impairment (NI) diagnosis codes in identification of hospitalized children with clinical NI.

Methods: Retrospective study of 500 randomly selected discharges in 2019 from a freestanding children's hospital. All charts were reviewed for 1) NI discharge diagnosis codes and 2) documentation of clinical NI (a neurologic diagnosis and indication of functional impairment like medical technology). Read More

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A Rare Collecting Duct Carcinoma With Widespread Metastasis Visualized by 18F-FDG PET/CT.

Clin Nucl Med 2021 Jul 23. Epub 2021 Jul 23.

From the Departments of Pulmonary and Critical Care Medicine Nuclear Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Abstract: Collecting duct carcinoma is a rare and highly aggressive renal tumor with a poor prognosis. The presence of metastasis is common at collecting duct carcinoma diagnosis, but widespread metastases involving multiple soft tissues are extremely unusual. Here, we describe a 65-year-old man presenting with fever and lower leg pain as the first and main manifestations. Read More

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Use of Recombinant Factor VIIa for Bleeding Control in Treatment of Acute Extremity Compartment Syndrome Secondary to Primary Myelofibrosis: A Case Report.

JBJS Case Connect 2021 Jul 28;11(3). Epub 2021 Jul 28.

Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Case: A 40-year-old man was admitted to our emergency department with a painful and swollen calf. There was no history of significant trauma, and the physical examination revealed a pulseless, swollen left lower leg. Clinical history revealed a diagnosis of primary myelofibrosis, and magnetic resonance imaging showed a rupture of the gastrocnemius medial head. Read More

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Epigenetic modifications underlie the differential adipogenic potential of preadipocytes derived from human subcutaneous fat tissue.

Am J Physiol Cell Physiol 2021 Jul 28. Epub 2021 Jul 28.

Department of Plastic Surgery, grid.136304.3Chiba University, Chiba-city, Chiba, Japan.

Aim: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) can be harvested from human subcutaneous fat tissue using the specific gravity method. Both cell types possess a similar spindle shape without lipid droplets. We previously reported that ccdPAs have a higher adipogenic potential than ASCs, even after a 7-week culture. Read More

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A comparison among gamma distribution, intravoxel incoherent motion, and mono-exponential models with turbo spin-echo diffusion-weighted MR imaging in the differential diagnosis of orofacial lesions.

Dentomaxillofac Radiol 2021 Jul 28:20200609. Epub 2021 Jul 28.

Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Objectives: To compare the gamma distribution (GD), intravoxel incoherent motion (IVIM), and monoexponential (ME) models in terms of their goodness-of-fit, correlations among the parameters, and the effectiveness in the differential diagnosis of various orofacial lesions.

Methods: A total of 85 patients underwent turbo spin-echo diffusion-weighted imaging with six b-values. The goodness-of-fit of three models was assessed using Akaike Information Criterion. Read More

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Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.

Cell Oncol (Dordr) 2021 Jul 28. Epub 2021 Jul 28.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 11031, Taipei, Taiwan.

Purpose: Metastasis of lung adenocarcinoma (LADC) is a crucial factor determining patient survival. Repurposing of the antipsychotic agent penfluridol has been found to be effective in the inhibition of growth of various cancers. As yet, however, the anti-metastatic effect of penfluridol on LADC has rarely been investigated. Read More

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Crop rotation reduces the frequency of anaerobic soil bacteria in Red Latosol of Brazil.

Braz J Microbiol 2021 Jul 28. Epub 2021 Jul 28.

ABC Foundation, Rod. PR 151 km 288, Caixa-postal: 1003, Castro, PR, CEP 84165-700, Brazil.

Crop diversity affects the processes of soil physical structuring and most likely provokes changes in the frequencies of soil microbial communities. The study was conducted for soil prokaryotic diversity sequencing 16S rDNA genes from a 25-year no-tillage experiment comprised of two crop systems: crop succession (Triticum aestivum-Glycine max) and rotation (Vicia sativa-Zea mays-Avena sativa-Glycine max-Triticum aestivum-Glycine max). The hypothesis was that a crop system with higher crop diversification (rotation) would affect the frequencies of prokaryotic taxa against a less diverse crop system (succession) altering the major soil functions guided by bacterial diversity. Read More

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Clinical Value of Circulating ZFAS1 and miR-590-3p in the Diagnosis and Prognosis of Chronic Heart Failure.

Cardiovasc Toxicol 2021 Jul 28. Epub 2021 Jul 28.

Department of Science and Education, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China.

Long non-coding RNAs (lncRNAs) have been reported to be involved in the development of various cardiovascular diseases, including chronic heart failure (CHF). In this study, we aimed to investigate the role of ZFAS1/miR-590-3p axis in the diagnosis and prognosis of CHF. The expression of ZFAS1 and miR-590-3p in the serum samples of CHF was measured using quantitative real-time polymerase chain reaction. Read More

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Pediatric interfacility transport effects on mortality and length of stay.

World J Pediatr 2021 Jul 28. Epub 2021 Jul 28.

University of California, Irvine, Irvine, CA, USA.

Background: We aimed to evaluate the effects of interfacility pediatric critical care transport response time, physician presence during transport, and mode of transport on mortality and length of stay (LOS) among pediatric patients. We hypothesized that a shorter response time and helicopter transports, but not physician presence, are associated with lower mortality and a shorter LOS.

Methods: Retrospective, single-center, cohort study of 841 patients (< 19 years) transported to a quaternary pediatric intensive care unit and cardiovascular intensive care unit between 2014 and 2018 utilizing patient charts and transport records. Read More

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Denosumab in chronic kidney disease: a narrative review of treatment efficacy and safety.

Arch Osteoporos 2021 Jul 28;16(1):116. Epub 2021 Jul 28.

Division of Endocrinology and Metabolism, Western University, London, ON, Canada.

People with chronic kidney disease (CKD) are at high risk of bone fractures. In this review, we summarize the complexity of fracture prevention in CKD, describe the usefulness of a medication called denosumab, and review its safety in this population. Our article will help doctors manage brittle bones in CKD and encourage researchers to conduct more studies to improve bone health in CKD. Read More

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Investigating diagnosis, treatment, and burden of disease in patients with ankylosing spondylitis in Central Eastern Europe and the United States: a real-world study.

Clin Rheumatol 2021 Jul 28. Epub 2021 Jul 28.

Oregon Health & Science University, Portland, OR, USA.

Introduction/objectives: Ankylosing spondylitis (AS) is a chronic inflammatory immune-mediated condition. We compared AS diagnosis, treatment, and burden in Central Eastern European countries (CEE), where this has been less researched, and the United States (US) from a real-world perspective.

Methods: Point-in-time survey of rheumatologists and their AS patients was conducted in the US (Apr-Oct 2018) and CEE (Aug-Nov 2019) via physician- and patient-completed record forms, including clinical and patient-reported outcomes. Read More

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Design and Performance Characterization of a Novel, Smartphone-Based, Portable Digital Slit Lamp for Anterior Segment Screening Using Telemedicine.

Transl Vis Sci Technol 2021 Jul;10(8):29

Research & Development, Remidio Innovative Solutions Pvt. Ltd., Bangalore, Karnataka, India.

Purpose: Telemedicine-enabled, portable digital slit lamps can help to decentralize screening to close-to-patient contexts. We report a novel design for a portable, digital slit lamp using a smartphone. It works on an advanced optical design and has the capability of instantaneous, objective photodocumentation to capture anterior segment images and is telemedicine-enabled. Read More

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Disparities in Anticoagulant Therapy Initiation for Incident Atrial Fibrillation by Race/Ethnicity Among Patients in the Veterans Health Administration System.

JAMA Netw Open 2021 Jul 1;4(7):e2114234. Epub 2021 Jul 1.

Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.

Importance: Atrial fibrillation is a common cardiac rhythm disturbance causing substantial morbidity and mortality that disproportionately affects racial/ethnic minority groups. Anticoagulation reduces stroke risk in atrial fibrillation, yet studies show it is underprescribed in racial/ethnic minority patients.

Objective: To compare initiation of anticoagulant therapy by race/ethnicity for patients in the Veterans Health Administration (VA) system with atrial fibrillation. Read More

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Acute neurologic decline in a patient with spinal stenosis: blame it on the epidural fat.

Br J Neurosurg 2021 Jul 28:1-6. Epub 2021 Jul 28.

Neurosurgery Unit San Carlo Borromeo Hospital, Milan, Italy.

Spinal epidural lipomatosis [SEL] is defined as an excessive accumulation of extradural normal adipose tissue. This condition may be idiopathic or acquired. Surgical decompression is considered the gold standard treatment in patients presenting with progressive neurologic deficit. Read More

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Challenges of Estimating Accurate Prevalence of Arm Weakness Early After Stroke.

Neurorehabil Neural Repair 2021 Jul 28:15459683211028240. Epub 2021 Jul 28.

Department of Physical Therapy, 574564University of British Columbia, Vancouver, BC, Canada.

. Recent studies have reported lower statistics of upper limb (UL) weakness (48-57%) compared to widely cited values collected over 2 decades ago (70-80%). . Read More

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Early Diagnosis of Oral Squamous Cell Carcinoma (OSCC) by miR-138 and miR-424-5p Expression as a Cancer Marker.

Asian Pac J Cancer Prev 2021 Jul 1;22(7):2185-2189. Epub 2021 Jul 1.

Craniomaxillofacial Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: MicroRNAs (miRs) are a group of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs. These molecules mediate the gene expression and are involved in regulating diverse cellular biological processes, i.e. Read More

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Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients.

J Leukoc Biol 2021 Aug;110(2):335-341

Department of Hematology, Zhongshan Hospital, Qingpu Branch, Fudan University, Shanghai, China.

Immune thrombocytopenia (ITP) is an autoimmune-mediated disease characterized by decreased platelet counts. Cytokines play important roles in modulating the immune response and are involved in the pathogenesis of many autoimmune diseases. This study aimed at exploring the serum levels of a core set of cytokines that exert immune-regulatory functions in newly diagnosed ITP patients (both before and after treatment) and splenectomized ITP patients. Read More

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The reliability of low-dose chest CT for the initial imaging of COVID-19: comparison of structured findings, categorical diagnoses and dose levels.

Diagn Interv Radiol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, University of Health Sciences, Istanbul Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Purpose: The widespread use of computed tomography (CT) in COVID-19 may cause adverse biological effects. Many recommend to minimize radiation dose while maintaining diagnostic quality. This study was designed to evaluate the difference between findings of COVID-19 pneumonia on standard and low-dose protocols to provide data on the utility of the latter during initial imaging of COVID-19. Read More

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Linkage to HIV Medical Care and Social Determinants of Health Among Adults With Diagnosed HIV Infection in 41 States and the District of Columbia, 2017.

Public Health Rep 2021 Jul 28:333549211029971. Epub 2021 Jul 28.

1242 Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Objectives: To reduce the number of new HIV infections and improve HIV health care outcomes, the social conditions in which people live and work should be assessed. The objective of this study was to describe linkage to HIV medical care by selected demographic characteristics and social determinants of health (SDH) among US adults with HIV at the county level.

Methods: We used National HIV Surveillance System data from 42 US jurisdictions and data from the American Community Survey to describe differences in linkage to HIV medical care among adults aged ≥18 with HIV infection diagnosed in 2017. Read More

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Use of bivalirudin for anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO).

Perfusion 2021 Jul 28:2676591211034314. Epub 2021 Jul 28.

Congenital Heart Center, Shands Children's Hospital, University of Florida at Gainesville, Gainesville, FL, USA.

This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving bivalirudin were compared to patients receiving heparin as the anticoagulant on ECMO. Data was collected for children under 18 years of age supported by ECMO from January 2016 to December 2019. Read More

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Primary periocular squamous cell carcinoma in central Spain: Factors related to recurrence.

Eur J Ophthalmol 2021 Jul 28:11206721211035629. Epub 2021 Jul 28.

Department of Ophthalmology, Faculdade de Medicina de Botucatu - UNESP, Botucatu, São Paulo, Brazil.

Purpose: To describe the characteristics and recurrence rates of primary periocular squamous cell carcinoma (SCC) in Spain.

Methods: This retrospective study investigates the characteristics of primary periocular SCC at two tertiary centers in Spain from 2000 to 2020. Data were collected on demographics, skin phenotype, location, clinical and histological diagnosis, the commitment of surgical margins, recurrence, and risk factors. Read More

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Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of Coronary Artery Disease: A Cross-Sectional Study.

Angiology 2021 Jul 28:33197211028023. Epub 2021 Jul 28.

Department of Cardiology, Zhongshan People's Hospital, Zhongshan City, Guangdong, People's Republic of China.

Many studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2) is associated with metabolic disorders, which is a risk factor of arteriosclerosis. We assessed the level of LECT-2 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and included patients with non-CAD, patients with stable angina pectoris (SAP), patients with unstable angina (UA), patients with non-ST-segment elevation myocardial infarction (NSTEMI) and patients with ST-segment elevation myocardial infarction (STEMI). Read More

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[Impact of proximal femoral shape on leg length discrepancy after total hip arthroplasty].

Zhongguo Gu Shang 2021 Jul;34(7):641-5

Department of Orthopaedics, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui, China.

Objective: To investigate the effect of different proximal femoral shapes on leg length discrepancy(LLD) after total hip arthroplasty(THA).

Methods: Total 131 patients with osteoarthritis or osteonecrosis received unilateral biological total hip arthroplasty from June 2013 to June 2019. All patients' age, sex, side and pelvis anteroposterior digital radiography were retraspectively analyzed. Read More

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THE LATENT CLASS STRUCTURE OF SUBSTANCE USE IN U.S. ADULTS 50 YEARS AND OLDER.

Int J Geriatr Psychiatry 2021 Jul 27. Epub 2021 Jul 27.

Center for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing, University of Michigan, Ann Arbor, Michigan, USA.

Objective: Substance use rates have increased in adults 50 years and older, and substance use in this population is associated with significant consequences. Given that little is known about their underlying substance use patterns, the objective was to identify latent classes of adults 50 years and older by past-year substance use, past-month substance use, and past-year substance use disorder (SUD) diagnosis.

Methods: The National Survey on Drug Use and Health is an annual nationwide cross-sectional U. Read More

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