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Metabolic syndrome and coronary artery disease in adults with congenital heart disease.

Authors:
Koichiro Niwa

Cardiovasc Diagn Ther 2021 Apr;11(2):563-576

Department of Cardiology, Cardiovascular Center, St Luke's International Hospital, Tokyo 104-8560, Japan.

In adults with congenital heart disease (ACHD), conditions acquired with aging, such as metabolic syndrome, hypertension, diabetes mellitus, and obesity, can negatively influence the original cardiovascular disease. Metabolic syndrome has a higher prevalence in ACHD than in the general population. In contrast, coronary artery disease shows a similar prevalence in adults with acyanotic CHD and the general population, while adults with cyanotic CHD, even after repair, have an even lower incidence of coronary artery disease than the general population/adults with acyanotic CHD. Read More

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Socioeconomic disparities in the management of coronary heart disease in 438 general practices in Australia.

Eur J Prev Cardiol 2021 May;28(4):400-407

The George Institute for Global Health, University of New South Wales, Australia.

Background: This population-based cross-stional and panel study investigated disparities in the management of coronary heart disease (CHD) by level of socioeconomic status.

Methods: CHD patients (aged ≥18 years), treated in 438 general practices in Australia, with ≥3 recent encounters with their general practitioners, with last encounter being during 2016-2018, were included. Secondary prevention prescriptions and number of treatment targets achieved were each modelled using a Poisson regression adjusting for demographics, socioeconomic indicators, remoteness of patient's residence, comorbidities, lifetime follow-up, number of patient-general practitioner encounters and cluster effect within the general practices. Read More

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Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.

BMC Cardiovasc Disord 2021 May 8;21(1):233. Epub 2021 May 8.

School of Forensic Medicine, Guizhou Medical University, 4 Beijing Road, Guiyang, 550001, Guizhou, China.

Background: The Cathepsins family, including cathepsin B and cathepsin D, potentially affects the entire processes involved in atherosclerosis. Although coronary heart disease (CHD) has been widely studied as the basis of Sudden Cardiac Death (SCD), the relationship between CHD and CTSB/D remains unclear.

Methods: We screened for differentially expressed proteins (DEPs) associated with autophagy by limma package in R. Read More

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Traditional Chinese medicine injection for promoting blood circulation and removing blood stasis in treating angina pectoris of coronary heart disease: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25608

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, PR China.

Background: As a common cardiovascular disease, the morbidity and mortality of coronary heart disease (CHD) are increasing year by year. In recent years, many RCTs have proved that compared with conventional therapy, the combination of TCMIs for promoting blood circulation and removing blood stasis can improve clinical efficacy. However, there is still a lack of direct comparative study between different kinds of TCMIs. Read More

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Pulse oximetry screening to detect critical congenital heart diseases in asymptomatic neonates.

Med J Armed Forces India 2021 Apr 2;77(2):214-219. Epub 2020 Dec 2.

Professor (Pediatrics), MM Institute of Medical Sciences & Research, Ambala, India.

Background: Critical congenital heart diseases (CCHDs), 10% to 25% of all CHD, are duct-dependent defects that are life threatening without intervention in the neonatal period or infancy. One third of neonates with CCHDs are discharged home undetected and have a poorer outcome. Pulse oximetry screening before discharge is increasingly being used to diagnose CCHDs in developed countries. Read More

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Mechanism of Baihe Decoction in the treatment of coronary heart disease based on network pharmacology and molecular docking.

Ann Palliat Med 2021 Mar;10(3):3205-3218

Henan University of Chinese Medicine, Zhengzhou, China.

Background: Network pharmacology is widely used in mechanistic studies of traditional Chinese medicines (TCMs). The present study aimed to predict the target and signaling pathway of Baihe Decoction in the intervention of coronary heart disease (CHD) based on a network pharmacology approach and molecular docking.

Methods: The active ingredients of Baihe Decoction were screened by the Traditional Chinese Medicine Systems Pharmacology (TCMSP), and their potential target genes and proteins in CHD were predicted. Read More

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Risk factors of in-stent restenosis in patients with diabetes mellitus after percutaneous coronary intervention: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25484

Department of Hematology, Zhuzhou Central Hospital, Zhuzhou 412000, Hunan Province, China.

Background: Percutaneous coronary intervention (PCI) has become one of the effective methods for the treatment of coronary heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects the therapeutic effects. The incidence of ISR in diabetes mellitus (DM) patients increased by 2 to 4 times. Read More

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Risk Factors for Failure in First-Time Hearing Screening Tests among High-Risk Neonates in Neonatal Intensive Care Unit.

Audiol Neurootol 2021 Apr 8:1-8. Epub 2021 Apr 8.

Department of Otolaryngology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Objective: The aim of the study was to investigate into the risk factors for failure in the first-time screening test among high-risk neonates in neonatal intensive care unit (NICU) in order to further clarify the etiology of neonatal hearing impairment, thus providing insights into early prevention and intervention.

Methods: We performed automated auditory brainstem response (AABR), distortion product otoacoustic emission (DPOAE), and acoustic immittance (AI) on 2,194 high-risk neonates admitted into the NICU of Shanghai Children's Medical Center from January 2015 to December 2019, and the risk factors, including premature birth, hyperbilirubinemia, and infant respiratory distress syndrome, were analyzed retrospectively by the univariate χ2 test and multivariate stepwise logistic regression analysis.

Results: The pass rates of AABR, DPOAE, and AI were 70. Read More

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Pulmonary infection after cardiopulmonary bypass surgery in children: a risk estimation model in China.

J Cardiothorac Surg 2021 Apr 7;16(1):71. Epub 2021 Apr 7.

Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University, No.136, Zhongshan 2nd Road, Yuzhong Dis, Chongqing, 400014, P.R. China.

Objectives: The occurrence of pulmonary infection after congenital heart disease (CHD) surgery can lead to significant increases in intensive care in cardiac intensive care unit (CICU) retention time, medical expenses, and risk of death risk. We hypothesized that patients with a high risk of pulmonary infection could be screened out as early after surgery. Hence, we developed and validated the first risk prediction model to verify our hypothesis. Read More

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Carcinoid Heart Disease: a Review.

Curr Oncol Rep 2021 Mar 16;23(4):48. Epub 2021 Mar 16.

Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, London, UK.

Purpose Of Review: The development of carcinoid heart disease (CHD) is a fibrotic complication of neuroendocrine neoplasms (NEN) which is associated with a poor prognosis. This review aims to summarise the clinical features, investigations and management of this condition.

Recent Findings: CHD can affect up to 50% of NET patients with carcinoid syndrome. Read More

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A gain-of-function mutation in CITED2 is associated with congenital heart disease.

Mutat Res 2021 Mar 1;822:111741. Epub 2021 Mar 1.

Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Electronic address:

CITED2 is a transcription co-activator that interacts with TFAP2 and CBP/ P300 transcription factors to regulate the proliferation and differentiation of the cardiac progenitor cells. It acts upstream to NODAL-PITX2 pathways and regulates the left-right asymmetry. Both human genetic and model organism studies have shown that altered expression of CITED2 causes various forms of congenital heart disease. Read More

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Interventions that improve adherence to antihypertensive medications in coronary heart disease patients: a systematic review.

Postgrad Med J 2021 Feb 15. Epub 2021 Feb 15.

Family Medicine and Primary Care, University of Hong Kong, Hong Kong, Hong Kong.

A systematic review is conducted to identify effective interventions that improved adherence to antihypertensive drugs among patients with coronary heart diseases (CHDs). Primary studies designed to measure interventions to improve adherence on antihypertensive drugs in patients with CHD were included. Three online databases, COCHRANE, EMBASE and MEDLINE, were searched for primary studies published in English from 2005 to 2019. Read More

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February 2021

SNP Array as a Tool for Prenatal Diagnosis of Congenital Heart Disease Screened by Echocardiography: Implications for Precision Assessment of Fetal Prognosis.

Risk Manag Healthc Policy 2021 27;14:345-355. Epub 2021 Jan 27.

Center for Prenatal Diagnosis, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, People's Republic of China.

Objective: This study aimed to examine the effectiveness of the SNP array for the prenatal diagnosis of congenital heart disease (CHD) screened by echocardiography.

Patients And Methods: A total of 356 pregnant women with fetal congenital heart malformations revealed by echocardiography at the Center for Prenatal Diagnosis of Fujian Maternal and Children Hospital during the period from November 2016 through July 2019 were recruited. The fetuses were assigned into three cohorts, including 142 with a single cardiac malformation, 106 with multiple cardiac malformations and 108 with cardiac and extracardiac malformations. Read More

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January 2021

Eligibility for subcutaneous implantable cardioverter-defibrillator in adults with congenital heart disease.

ESC Heart Fail 2021 Apr 3;8(2):1502-1508. Epub 2021 Feb 3.

Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, D-30625, Germany.

Aims: Patients with adult congenital heart disease (ACHD) carry an increased risk for sudden cardiac death. Implantable cardioverter-defibrillator (ICD) therapy may be challenging in these patients due to anatomical barriers, repeated cardiac surgery, or complicated transvenous access. Thus, the subcutaneous ICD (S-ICD) can be a promising alternative in this patient population. Read More

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A Novel Hybrid Approach for Risk Evaluation of Vehicle Failure Modes.

Sensors (Basel) 2021 Jan 19;21(2). Epub 2021 Jan 19.

Engineering Technology and Industrial Department, Texas A&M University, College Station, TX 77840, USA.

This paper addresses the problem of evaluating vehicle failure modes efficiently during the driving process. Generally, the most critical factors for preventing risk in potential failure modes are identified by the experience of experts through the widely used failure mode and effect analysis (FMEA). However, it has previously been difficult to evaluate the vehicle failure mode with crisp values. Read More

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January 2021

Acquired Comorbidities in Adults with Congenital Heart Disease: An Analysis of the German National Register for Congenital Heart Defects.

J Clin Med 2021 Jan 16;10(2). Epub 2021 Jan 16.

Department of Congenital Heart Disease and Paediatric Cardiology, German Heart Centre Munich, TUM School of Medicine-Technical University of Munich, 80636 Munich, Germany.

Background: As adults with congenital heart disease (ACHD) are getting older, acquired comorbidities play an important role in morbidity and mortality. Data regarding their prevalence in ACHD that are representative on a population level are not available.

Methods: The German National Register for Congenital Heart Defects was screened for ACHD. Read More

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January 2021

Sami dietary habits and the risk of cardiometabolic disease: a systematic review.

Authors:
I K Dahl C Dalgård

Int J Circumpolar Health 2021 Dec;80(1):1873621

IST - Clinical Pharmacology, Pharmacy and Environmental Medicine and the Danish Twin Registry, University of Southern Denmark , Odense C, Denmark.

This systematic literary review investigates if an association between Sami dietary habits and cardiometabolic outcomes exists, and examines the dietary characteristics and cardiometabolic status of the Sami population. Included were all articles assessing Sami dietary habits and cardiometabolic disease or risk factors. Embase, Medline and SweMed were searched on 26 September 2019 and articles were screened for eligibility in October 2019. Read More

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December 2021

Pharmacological Network Reveals the Active Mechanism of Qi-Replenishing, Spleen-Strengthening, Phlegm-Dispelling, and Blood-Nourishing Fufang on Coronary Heart Disease.

Evid Based Complement Alternat Med 2020 29;2020:1062325. Epub 2020 Dec 29.

Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China.

This study aimed to investigate the potential targets and pathways of qi-replenishing, spleen-strengthening, phlegm-dispelling, and blood-nourishing Fufang in the treatment of coronary heart disease (CHD). The composition of Fufang was identified, followed by screening of the active components using ADME. The targets of active components were predicted and screened based on the TCMSP and BATMAN databases and were cross-validated using the CTD database and DisGeNET. Read More

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December 2020

Tele-Echocardiography for Congenital Heart Disease Screening in a Level II Neonatal Intensive Care Unit with Hybrid Telemedicine System.

Telemed J E Health 2021 Jan 15. Epub 2021 Jan 15.

Division of Cardiology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

The nationwide shortage of pediatric cardiologists in medically underserved areas poses a challenge to congenital heart disease (CHD) screening requiring echocardiography, resulting in transfer of neonates to regional Level III/IV Neonatal Intensive Care Units (NICUs). This study aimed to evaluate the accuracy, safety, and cost-effectiveness of tele-echocardiography for advanced CHD screening at a Level II NICU managed by a hybrid telemedicine system. Retrospective chart review of infants requiring tele-echocardiography at a Level II NICU. Read More

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January 2021

Association between congenital heart disease and gene polymorphisms: systematic review and meta-analysis.

Biomark Med 2020 12;14(18):1747-1757

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

To analyze the association of gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. Read More

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December 2020

Detection and treatment of mental disorders in patients with coronary heart disease (MenDis-CHD): A cross-sectional study.

PLoS One 2020 14;15(12):e0243800. Epub 2020 Dec 14.

Department of Psychosomatics and Psychotherapy, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, North Rhine-Westphalia, Germany.

Mental disorders (MD) are associated with an increased risk of developing coronary heart disease (CHD) and with higher CHD-related morbidity and mortality. There is a strong recommendation to routinely screen CHD patients for MDs, diagnosis, and treatment by recent guidelines. The current study aimed at mapping CHD patients' (1) state of diagnostics and, if necessary, treatment of MDs, (2) trajectories and detection rate in healthcare, and (3) the influence of MDs and its management on quality of life and patient satisfaction. Read More

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February 2021

Clinical score to detect congenital heart defects: Concept of second screening.

Ann Pediatr Cardiol 2020 Oct-Dec;13(4):281-288. Epub 2020 Sep 1.

Department of Pediatrics, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Introduction: Neonatal screening for congenital heart defects at birth can miss some heart defects, sometimes few critical ones, and the scenario is even worse in those neonates who had never undergone a neonatal checkup (home deliveries). Immunization clinic can serve as a unique opportunity as the second checkpoint for the screening of the children. A history- and examination-based test can serve as an effective tool to screen out children with heart defects. Read More

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September 2020

The screening of congenital heart disease by cardiac auscultation and 12-lead electrocardiogram among Indonesian elementary school students.

Cardiol Young 2021 Feb 14;31(2):264-273. Epub 2020 Dec 14.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Background: Screening for congenital heart disease (CHD) in school students is well-established in high-income countries; however, data from low-to-middle-income countries including Indonesia are limited.

Aim: This study aimed to evaluate CHD screening methods by cardiac auscultation and 12-lead electrocardiogram to obtain the prevalence of CHD, confirmed by transthoracic echocardiography, among Indonesian school students.

Methods: We conducted a screening programme in elementary school students in the Province of Special Region of Yogyakarta, Indonesia. Read More

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February 2021

Maternal folic acid supplementation mediates the associations between maternal socioeconomic status and congenital heart diseases in offspring.

Prev Med 2021 Feb 7;143:106319. Epub 2020 Nov 7.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Low maternal socioeconomic status (SES) is considered as a risk factor of congenital heart diseases (CHDs) in offspring. However, the pathways underpinning the SES-CHDs associations are unclear. We assessed if first trimester maternal folic acid supplementation (FAS) is a mediator of the SES-CHDs associations. Read More

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February 2021

Interactive effects of interferon-gamma functional single nucleotid polymorphism (+874 T/A) with cardiovascular risk factors in coronary heart disease and early myocardial infarction risk.

Mol Biol Rep 2020 Nov 26;47(11):8397-8405. Epub 2020 Oct 26.

Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Atherosclerosis is an inflammatory disease characterized by extensive lipid accumulation in the artery wall. Throughout the atherosclerotic process, interferon-gamma (IFN-γ), which is an important pro-inflammatory cytokine, plays a central role in atherosclerotic plaque instability and the occurrence of myocardial infarction (MI). In this study, we aimed to investigate the relationship between IFN-γ +874 T/A (rs2430561) polymorphism and coronary heart disease (CHD) as well as its effects on MI and CHD. Read More

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November 2020

Molecular sex identification of Malaysian White-Nest Swiftlet ( Thunberg, 1812).

Ecol Evol 2020 Oct 25;10(19):10440-10448. Epub 2020 Aug 25.

Department of Biology Faculty of Science Universiti Putra Malaysia Serdang Selangor Malaysia.

The difficulty in differentiating the sex of monomorphic bird species has made molecular sexing an important tool in addressing this problem. This method uses noninvasively collected materials such as feathers and may be advantageous for sexing endangered as well as commercialized bird species. In this study, seven primer sets for sexing birds were screened in using a total of 13 feather samples that were randomly selected from the state of Perak, Malaysia. Read More

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October 2020

Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus.

Risk Manag Healthc Policy 2020 21;13:1661-1675. Epub 2020 Sep 21.

School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Purpose: The study aimed to identify diseases that exhibit significant differences between hyperuricaemia (HUA) and non-hyperuricaemia (NHUA) groups and analyse the risk factors for HUA based on the related diseases in type 2 diabetes mellitus (T2DM).

Methods: A total of 3264 T2DM patients were investigated from 2013 to 2017 in the Jinyang and Sanlin communities by obtaining basic data from the electronic medical record system (EMRS). From September 2018 to July 2019, 3000 patients (264 patients were missing during follow-up) were investigated with questionnaires, physical examinations and biochemical index tests. Read More

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September 2020

Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia.

Animals (Basel) 2020 Sep 25;10(10). Epub 2020 Sep 25.

Department of Animal Science, Szent István University Kaposvár Campus, 40, Guba S. str., H-7400 Kaposvár, Hungary.

Pedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding-purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation method with GRain 2.2 software. Read More

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September 2020

Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients: A Retrospective Study of 855 Cases.

Chin J Integr Med 2020 Sep 2. Epub 2020 Sep 2.

The Third Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Objective: To investigate the effects of multidisciplinary and comprehensive Chinese medicine (CM) treatments on progression-free survival (PFS) and median survival time (MST) in patients with advanced non-small cell lung cancer (NSCLC) and identify factors that influence progression and prognosis.

Methods: Clinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively analyzed. Univariate analysis was performed by the Kaplan-Meier method and log-rank sequential inspection. Read More

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September 2020

Egg consumption and cardiovascular risk: a dose-response meta-analysis of prospective cohort studies.

Eur J Nutr 2020 Aug 31. Epub 2020 Aug 31.

Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 97, 95123, Catania, Italy.

Purpose: Cardiovascular disease (CVD) is a leading cause of mortality globally and is strongly influenced by dietary risk factors. The aim was to assess the association between egg consumption and risk of CVD risk/mortality, including coronary heart disease (CHD), stroke, and heart failure.

Methods: MEDLINE, Embase, and Web of Science databases were searched through April 2020 for prospective studies. Read More

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