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Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

Personality in Children With Vocal Fold Nodules: A Multitrait Analysis.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

Pediatric Otolaryngology Clinic, Primary Children's Medical Center, Salt Lake City, UT.

Purpose Vocal fold nodules (VNs) are bilateral, symmetrical, callous-like lesions secondary to phonotrauma and possibly related to specific personality traits. This case-control study examined the relation between personality and VNs in children within the context of the Trait Theory of VNs. Method Parents of children with VNs ( = 39, = 7. Read More

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September 2021

Application of the Challenge Point Framework During Treatment of Speech Sound Disorders.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

School of Communication Sciences and Disorders, McGill University, Montréal, Québec, Canada.

Purpose The purpose of this article is to provide trial-by-trial practice performance data in relation to learning (outcome probe data) as collected from 18 treatment sessions provided to children with severe speech sound disorders. The data illustrate the practice-learning paradox: Specific, perfect practice performance is not required for speech production learning. Method We detailed how nine student speech-language pathologists (SSLPs) implemented and modified the motor learning practice conditions to reach a proposed challenge point during speech practice. Read More

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September 2021

Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?

Horm Mol Biol Clin Investig 2021 Sep 16. Epub 2021 Sep 16.

Department of Biochemisty, All India Institute of Medical Sciences, Nagpur, India.

Objectives: The incidence of metabolic syndrome is increasing even at younger ages. Metabolic syndrome constitutes a group of cardiovascular risk factors that include high cholesterol, triacylglycerol, hyperglycemia, central obesity, etc., which increases the risk of cardiovascular disease, diabetes mellitus, may be even cancer. Read More

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September 2021

Elastography is unable to exclude cirrhosis after sustained virological response in HCV-infected patients with advanced chronic liver disease.

Liver Int 2021 Sep 15. Epub 2021 Sep 15.

Liver Section, Gastroenterology Department, Hospital del Mar, Barcelona, Spain.

Background: Liver fibrosis and transient elastography (TE) correlation in hepatitis C virus (HCV)-infected patients with compensated advanced chronic liver disease (cACLD) after sustained virological response (SVR) is unknown.

Aims: To evaluate TE accuracy at identifying cirrhosis 3 years after HCV-eradication.

Methods: Prospective, multi-centric study including HCV-cACLD patients before direct-acting antivirals (DAA). Read More

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September 2021

The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomized clinical trial.

Int J Clin Pract 2021 Sep 15:e14872. Epub 2021 Sep 15.

University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, The Department of Anesthesiology and Reanimation, Istanbul, Turkey.

Aims: In this study, we aimed to investigate the anti-inflammatory and antioxidant effects of intravenous ibuprofen by using the C-reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker.

Materials And Methods: This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either preemptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). Read More

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September 2021

The Reliability and Validity of the Turkish Version of the Post-Dialysis Fatigue Scale.

Int J Clin Pract 2021 Sep 15:e14871. Epub 2021 Sep 15.

Acibadem Mehmet Ali Aydınlar University, School of Nursing, Istanbul, Turkey.

Aim: Hemodiallysis (HD) commonly leads to post-dialysis fatigue (PDF), and thus worsens the quality of life and the clinical outcomes. The aim of this study was to translate, linguistically validate, and determine the psychometric properties of the "Post-Dialysis Fatigue" Scale for Turkish HD patients.

Study Design: A methodological study. Read More

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September 2021

Using the Physical Activity Rating questionnaire improved the diagnostic accuracy of the Asthma Control Test.

Acta Paediatr 2021 Sep 15. Epub 2021 Sep 15.

Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy.

Waiting lists can make it difficult to follow up children with persistent asthma in a timely way. One remote management solution could be structured questionnaires like the popular Asthma Control Test (ACT). ACT scores indicate uncontrolled (5-19), partially controlled (20-24) and well controlled asthma (25). Read More

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September 2021

Intestinal Ultrasound to Evaluate Treatment Response During Pregnancy in Patients With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2021 Sep 15. Epub 2021 Sep 15.

Amsterdam University Medical Center, Department of Gastroenterology and Hepatology, University of Amsterdam, Amsterdam, the Netherlands.

Introduction: Active disease in inflammatory bowel disease patients during pregnancy is associated with poor maternal and fetal outcomes. Objective evaluation of disease activity is a core strategy in IBD, and during pregnancy noninvasive modalities are preferred. We aimed to evaluate feasibility and accuracy of intestinal ultrasound (IUS) to objectify disease activity throughout pregnancy. Read More

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September 2021

Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly.

PLoS One 2021 15;16(9):e0256444. Epub 2021 Sep 15.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.

Objective: To describe the neurological and neurodevelopmental outcomes of children with Congenital Zika Syndrome (CZS) associated microcephaly beyond 2 years of age.

Method: We followed children with CZS-associated microcephaly in an outpatient clinic in Salvador, Brazil. Neurological and neurodevelopmental assessments were performed using the Hammersmith Infant Neurological Examination (HINE) and Bayley Scales of Infant and Toddler Neurodevelopment (Bayley-III) respectively. Read More

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September 2021

Association of Sleep and Circadian Patterns and Genetic Risk with Incident Type 2 Diabetes: A Large Prospective Population-Based Cohort Study.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

C Mao, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.

Objective To examine the association of incident type 2 diabetes (T2D) risk with sleep factors, genetic risk, and their combination effects. Design Large prospective population-based cohort study. Methods This population-based prospective cohort study included 360 403 (mean [SD] age: 56. Read More

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September 2021

sp. nov., subsp. subsp. nov. and subsp. subsp. nov. isolated from entomopathogenic nematodes.

Int J Syst Evol Microbiol 2021 Sep;71(9)

Division of Nematology, Indian Council of Agricultural Research, Indian Agricultural Research Institute (ICAR-IARI), New Delhi, India.

Two Gram-negative, rod-shaped bacteria, H1 and H3, isolated from the digestive tract of entomopathogenic nematodes were biochemically and molecularly characterized to determine their taxonomic positions. The 16S rRNA gene sequences of these strains indicate that they belong to the Gammaproteobacteria, to the family , and to the genus. Deeper analyses using whole genome-based phylogenetic reconstructions show that strains H1 and H3 are closely related to DSM 15138, to DSM 22397, and to PB45. Read More

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September 2021

The paradox of wellbeing: what happens among women with fibromyalgia? The effect of cognitive fusion.

Aging Ment Health 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Basic and Clinical Psychology and Psychobiology, Jaume I University, Castellón, Spain.

Objetive: Our study examined the 'paradox of wellbeing' among women with fibromyalgia and the role of cognitive fusion on wellbeing in relation to age.

Methods: A total of 228 women diagnosed with fibromyalgia according to the American College of Rheumatology criteria were included. In order to explore the conditional effects of age in the moderation analyzes, as recommended in the PROCESS Macro, the 16th, 50th, and 84th percentiles were calculated. Read More

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September 2021

Developing a Psychological Intervention for Decreasing Bedtime Procrastination: The BED-PRO Study.

Behav Sleep Med 2021 Sep 15:1-15. Epub 2021 Sep 15.

Department of Psychology, Sungshin University, Seoul, Republic of Korea.

Introduction: Bedtime Procrastination (BP) is defined as the behavior of going to bed later than intended, without having external reasons for doing so. Previous studies have shown that BP has a negative effect on sleep and health, emphasizing the need to develop interventions to decrease BP. This intervention development study is a proof-of-concept study for a psychological intervention designed for decreasing bedtime procrastination, namely BED-PRO. Read More

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September 2021

Occupational Competence and Activities of Daily Living Performance in Bronchial Asthma : Compétence professionnelle et activités de la vie quotidienne Performance dans l'asthme bronchique.

Can J Occup Ther 2021 Sep 15:84174211022883. Epub 2021 Sep 15.

Activity restriction is one of the most common symptoms reported by people living with bronchial asthma. The study aimed to determine occupational competence and values in people living with bronchial asthma and compare with the occupational competence and activities of daily living (ADL) of healthy controls. Twenty individuals with asthma and 20 healthy controls were enrolled. Read More

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September 2021

Utilizing High-Throughput Screening Data, Integrative Toxicological Prioritization Index Score, and Exposure-Activity Ratios for Chemical Prioritization: A Case Study of Endocrine-Active Pesticides in Food Crops.

J Agric Food Chem 2021 Sep 15. Epub 2021 Sep 15.

Institute of Food Safety and Health, College of Public Health, National Taiwan University, 17 Xuzhou Road, Zhongzheng District, Taipei 100, Taiwan.

Endocrine-active chemicals can directly act on nuclear receptors and trigger the disturbances of metabolism and a homeostatic system, which are important risk factors for complicating chronic diseases in humans. The endocrine-active potentials of pesticides acting on estrogen, androgen, and thyroid hormone receptors have been extensively evaluated for pesticides; however, the effects on other receptors are less understood. This study aims to comprehensively characterize and prioritize the endocrine-active pesticides using an exposure-activity ratio (EAR) method and toxicological prioritization index (ToxPi). Read More

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September 2021

Prediction accuracy of commonly used pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia - a retrospective study.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, Alice Springs Hospital, Central Australian Health Service, Alice Springs, Northern Territory,, Australia.

Aims: Assess the prediction accuracy of pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia (SCAP) and identify risk factors for poor prognosis.

Methods: Retrospective cohort study examining Aboriginal patients admitted to intensive care unit (ICU) with confirmed SCAP between January 2011 and December 2014. Severity scores were calculated for SMARTCOP, SMARTACOP, CURB65, PSI, IDSA/ATS SCAP (IASCAP) and APACHE II/III scores using medical records. Read More

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September 2021

Compensatory bladder behaviors ("coping") in women with overactive bladder.

Neurourol Urodyn 2021 Sep 15. Epub 2021 Sep 15.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Aims: There is little information on how often or within what contexts individuals with OAB use compensatory behaviors ("coping") to manage symptoms. We sought to examine how frequently women with OAB report using coping behaviors and whether these are associated with psychosocial factors.

Methods: One hundred twenty adult women with OAB completed the OAB questionnaire (OAB-q), ICIQ-FLUTS questionnaire, PROMIS Anxiety and Depression, Perceived Stress Scale, patient perception of bladder condition, and demographic and clinical data. Read More

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September 2021

Bone health in Duchenne muscular dystrophy: clinical and biochemical correlates.

J Endocrinol Invest 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical and Experimental Medicine, A.O.U. Policlinico "G. Martino", University of Messina, Via C. Valeria, 98125, Messina, Italy.

Purpose: An increased fracture risk is commonly reported in Duchenne muscular dystrophy (DMD). Our aim was to investigate bone mineral density (BMD) and bone turnover, including sclerostin, and their association with markers of cardiac and respiratory performance in a cohort of DMD subjects.

Methods: In this single center, cross sectional observational study, lumbar spine (LS) BMD Z-scores, C-terminal telopeptide of procollagen type I (CTX) and osteocalcin (BGP), as bone resorption and formation markers, respectively, and sclerostin were assessed. Read More

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September 2021

The Assessment of Functional Movement in Children and Adolescents: A Systematic Review and Meta-Analysis.

Sports Med 2021 Sep 15. Epub 2021 Sep 15.

School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Background: The Functional Movement Screen™ (FMS™) is an assessment of human movement that may signal potential deficits that could predispose an otherwise healthy person to injury risk. FMS™ scores are well reported in both athletic and adult samples. However, to date, there has been no comprehensive systematic review and meta-analysis of FMS™ data among school-aged children and adolescents. Read More

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September 2021

The estimated prevalence of no reported dementia-related diagnosis in older Americans living with possible dementia by healthcare utilization.

Aging Clin Exp Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, NDSU Dept 2620, PO Box 6050, Fargo, ND, 58108, USA.

Background: Screening for dementia in relevant healthcare settings may help in identifying low cognitive functioning for comprehensive cognitive assessments and subsequent dementia treatment after diagnosis.

Aims: This study sought to estimate the prevalence of no reported dementia-related diagnosis in a nationally-representative sample of older Americans with a cognitive impairment consistent with dementia (CICD) by healthcare utilization.

Methods: The unweighted analytical sample included 1514 Americans aged ≥ 65 years that were identified as having a CICD without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010-2016 waves of the Health and Retirement Study. Read More

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September 2021

Patient and Caregiver Health State Utilities in Tuberous Sclerosis Complex.

Pharmacoecon Open 2021 Sep 15. Epub 2021 Sep 15.

Acaster Lloyd Consulting Ltd, 16 Upper Woburn Place, Bloomsbury, London, WC1H 0BS, UK.

Background: Tuberous sclerosis complex (TSC) is a rare multisystem disorder often associated with treatment-resistant epilepsy. Cost-effectiveness analysis for new antiseizure medications typically requires health state utilities (HSUs) that reflect the burden of a given condition.

Objective: This study aimed to estimate HSUs, with a focus on valuing the impact of seizure type and seizure frequency on health-related quality of life (HRQL) for patients with TSC and their caregivers. Read More

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September 2021

Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected.

J Neurovirol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We investigated the association of metabolic syndrome (MetS) and its components [abdominal obesity, elevated triglycerides (TG), low HDL cholesterol, elevated blood pressure (BP), and impaired fasting glycemia (IFG)] with neurocognitive impairment in youth with perinatally acquired HIV (YPHIV) or who are perinatally HIV-exposed uninfected (YPHEU). This was an observational study with a comparison group of 350 YPHIV and 68 YPHEU ages 10-19 years. Youth with MetS components measured between 1 year before and 3 months after a baseline neurocognitive assessment (Wechsler Intelligence Scale) were selected from the Pediatric HIV/AIDS Cohort Study (PHACS). Read More

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September 2021

Impact of the menstrual cycle on commercial prognostic gene signatures in oestrogen receptor-positive primary breast cancer.

Breast Cancer Res Treat 2021 Sep 15. Epub 2021 Sep 15.

Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

Purpose: Changes occur in the expression of oestrogen-regulated and proliferation-associated genes in oestrogen receptor (ER)-positive breast tumours during the menstrual cycle. We investigated if Oncotype® DX recurrence score (RS), Prosigna® (ROR) and EndoPredict® (EP/EPclin) prognostic tests, which include some of these genes, vary according to the time in the menstrual cycle when they are measured.

Methods: Pairs of test scores were derived from 30 ER-positive/human epidermal growth factor receptor-2-negative tumours sampled at two different points of the menstrual cycle. Read More

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September 2021

Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice.

Neurol Sci 2021 Sep 15. Epub 2021 Sep 15.

Epilepsy Unit, Neurology Department, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.

Objectives: This study aims to evaluate the relationship between psychiatric comorbidity (anxiety and depression), somnolence, and quality of life, using validated scales in patients with epilepsy in real-life clinical practice and clinical and demographic variables.

Methods: A cross-sectional observational study was conducted. Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale (ESS)), and quality of life (QOLIE-31-P) in patients with epilepsy treated in the refractory epilepsy unit of a tertiary hospital were employed. Read More

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September 2021

Ultrasound-based evaluation revealed reliable postoperative knee stability after combined acute ACL and MCL injuries.

J Exp Orthop 2021 Sep 15;8(1):76. Epub 2021 Sep 15.

Department for Orthopedic Sports Medicine, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany.

Purpose: Anterior cruciate ligament (ACL) injuries are often combined with lesions of the medial collateral ligament (MCL). The aim of this study was to evaluate treatment outcome of combined acute ACL and MCL lesions using functional US and clinical examination.

Methods: Patients aged > 18 years undergoing primary ACL reconstruction with concomitant operative (group 1) or non-operative treatment of the MCL (group 2) between 2014 and 2019 were included after a minimum follow-up of 12 months. Read More

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September 2021

Three-dimensional high-definition exoscope (Kestrel View II) in anterior cervical discectomy and fusion: a valid alternative to operative microscope-assisted surgery.

Acta Neurochir (Wien) 2021 Sep 15. Epub 2021 Sep 15.

Orthopaedic Department, General Hospital of Central Theater Command of PLA, #627 Wuluo Road, Wuchang District, 43007, Wuhan, China.

Background: Operative microscope (OM) has greatly advanced modern spine surgery, but remains limited by several drawbacks. Therefore, a three-dimensional (3D) high-definition (HD) exoscope (EX) (Kestrel View II, Mataka Kohli, Japan) system has been developed and used as an alternative to the OM. The aim of this study was to assess and compare the perioperative data and clinical outcomes of anterior cervical discectomy and fusion (ACDF) procedure with either an EX or OM. Read More

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September 2021

Comparison of interventions and outcomes of enhanced recovery after surgery: a systematic review and meta-analysis of 2456 adolescent idiopathic scoliosis cases.

Eur Spine J 2021 Sep 15. Epub 2021 Sep 15.

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Purpose: The objective of this meta-analysis and systematic review is to compare the methodology and evaluate the efficacy of Enhanced recovery after Spine Surgery (ERAS) for adolescent idiopathic scoliosis (AIS) and to compare the outcomes with traditional discharge (TD) pathways.

Methods: Using major databases, a systematic search was performed. Studies comparing the implementation of ERAS or ERAS-like and TD pathways in patients with AIS were identified. Read More

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September 2021

Tendon transfer in foot drop: a systematic review.

Arch Orthop Trauma Surg 2021 Sep 15. Epub 2021 Sep 15.

Marienkrankenhaus Soest, Orthopedics and Trauma Surgery, Widumgasse 5, 59494, Soest, Germany.

Introduction: Foot drop is a disorder that impairs walking and leads to tripping and falling. Tendon transfer (e.g. Read More

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September 2021

Body mass index as a predictor of sonographic visualization of the pediatric appendix.

Pediatr Radiol 2021 Sep 15. Epub 2021 Sep 15.

Center for Pediatric Population Health, University of Texas Health Science Center at Houston and Children's Health System of Texas, Dallas, TX, USA.

Background: Appendicitis is a common condition that is often confirmed with imaging. Ultrasound (US) is recommended as the first radiologic test in the work-up of appendicitis in children. Increased body mass index (BMI) has been implicated as a limiting factor to the sensitivity of US. Read More

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September 2021