526,133 results match your criteria scores


Examining concurrent validity between COMLEX-USA Level 2-Cognitive Evaluation and COMLEX-USA Level 2-Performance Evaluation.

J Osteopath Med 2021 May 13. Epub 2021 May 13.

Midwestern University, Glendale, AZ, USA.

Context: The Comprehensive Osteopathic Medical Licensing Examination of the United States of America (COMLEX-USA) is a three level examination used as a pathway to licensure for students in osteopathic medical education programs. COMLEX-USA Level 2 includes a written assessment of Fundamental Clinical Sciences for Osteopathic Medical Practice (Level 2-Cognitive Evaluation [L2-CE]) delivered in a computer based format and separate performance evaluation (Level 2-Performance Evaluation [L2-PE]) administered through live encounters with standardized patients. L2-PE was designed to augment L2-CE. Read More

View Article and Full-Text PDF

Reliability of the Patient and Observer Scar Assessment Scale in Evaluating Linear Scars after Thyroidectomy.

Adv Skin Wound Care 2021 Jun;34(6):1-6

In the Department of Plastic and Reconstructive Surgery, Korea University Hospital, Seoul, Republic of Korea, Jae-Ho Chung, MD, PhD, is Clinical Assistant Professor; Sang-Ho Kwon, MD, is a resident; Ki-Jae Kim, MD, MS, is a resident; Jae-Min Lee, MD, MS, is a resident; Jeong-Min Yoon, MD, MS, is Public Health Physician; Jeong-Hyun Cheon, MD, MS, is Clinical Instructor; Eul-Sik Yoon, MD, PhD, is Professor; Seung-Ha Park, MD, PhD, MBA, is Professor. The authors have disclosed no financial relationships related to this article. Submitted October 19, 2020; accepted in revised form December 4, 2020.

Objective: To compare the reliability of the Patient and Observer Scar Assessment Scale (POSAS) with the Vancouver Scar Scale (VSS) in evaluating thyroidectomy scars.

Methods: At 6 months after the operation, 112 patients who underwent thyroid surgery via collar neck incision were evaluated by two blinded plastic surgeons and two senior residents using the VSS and the observer component of the POSAS. In addition, the observer-reported VAS score and patient-reported Likert score were evaluated. Read More

View Article and Full-Text PDF

A Qualitative Analysis of Ostomy-Related Patient Education Videos on YouTube.

Adv Skin Wound Care 2021 Jun;34(6):314-320

At Medipol University in Istanbul, Turkey, Pelin Basim, MD, is Faculty, Department of General Surgery; and Derya Argun, MD, is Faculty, Department of Internal Medicine. The authors have disclosed no financial relationships related to this article. Submitted October 9, 2020; accepted in revised form December 7, 2020.

Objective: To analyze the content, reliability, and quality of the most viewed YouTube videos targeting patients with ostomies intending to learn about ostomy care (OC).

Methods: Using the keywords "stoma care," "colostomy care," and "ileostomy care," researchers assessed the publicly visible English-language ostomy patient education videos available on YouTube. A total of 84 videos were independently analyzed by two physicians experienced in OC. Read More

View Article and Full-Text PDF

Usability of a Novel Instrument to Measure Damaged Peristomal Skin in Patients with an Ostomy.

Adv Skin Wound Care 2021 Jun;34(6):309-312

At the Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Hui Yang, MM, RN, WT, is Head Nurse, Lecturer, and Wound Therapist, Gastrointestinal Surgery Center; Xinyue Zhao, RN, WOCN, is Wound Ostomy and Continence Nurse, Gastrointestinal Surgery Center; Qing Yang, PhD, is Deputy Director, Nursing Department; and Qinghua Jiang, RN, is Director, Nursing Department. Acknowledgments: This research was supported by Sichuan Province Science and Technology Support Program (no. 2019YFS0387) and Health and Family Planning Commission of Sichuan Province (no. 19PJ141). The authors have disclosed no other financial relationships related to this article. Submitted July 8, 2020; accepted in revised form October 22, 2020.

Objective: To evaluate the usability of a novel instrument (stoma ruler) to measure damaged peristomal skin in patients with an ostomy.

Methods: A wound ostomy and continence nurse used both the stoma ruler and a linear ruler to assess DET (discoloration, erosion, tissue overgrowth) scores and the height of protrusion above the skin of 10 patients with ileostomies and took photographs. The photographs were presented to five ostomy care nurses for reliability testing. Read More

View Article and Full-Text PDF

The Quality of Life of Patients with Colorectal Cancer and a Stoma in China: A Quantitative Cross-sectional Study.

Adv Skin Wound Care 2021 Jun;34(6):302-307

In the Ostomy and Wound Care Clinic, Department of Nursing, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University, Changsha, Hunan, China, Huayun Liu, MD, and Xiaomei Zhu, MD, are Enterostomal Therapists. Juping Yu, PhD, is Research Fellow, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom. Pingping He, PhD, is Professor, School of Nursing, University of South China, Hengyang, Hunan. Also in the Department of Nursing, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University, Changsha, Boyong Shen, MD, is Manager, Surgical Ward; Xinhui Tang, BA, is Manager, Ostomy and Wound Care; Xianghua Xu, PhD, is Manager, Nursing Research; Di Wei, MD, is Enterostomal Therapist; Yongyi Chen, PhD, is Manager, Ostomy and Wound Care and Education; and Xuying Li, PhD, is Nurse Manager. Acknowledgments: The authors thank all of the patients who participated in this study and people who helped with data collection. This work was supported by Hunan Provincial Science and Technology Department in China (grant no. 2018SK7005) and Health and Family Planning Commission of Hunan Province in China (grant no. B2019080) and Natural Science of Hunan Provence (Grant No. 2020JJ8090). The authors have disclosed no other financial relationships related to this article. Submitted December 29, 2020; accepted in revised form March 15, 2021.

Objective: To explore quality of life (QOL) in patients with colorectal cancer and a stoma and factors associated with their QOL.

Methods: A quantitative cross-sectional study was carried out in the stoma and wound care clinic of a cancer hospital in China. Participants were recruited from clinic patients. Read More

View Article and Full-Text PDF

Varying Outcomes among Patients with Large Angiomyolipomas according to the Treatment Method.

Urol Int 2021 May 12:1-7. Epub 2021 May 12.

Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Purpose: This study aimed to evaluate the outcomes of large angiomyolipoma (AML) treatment by selective arterial embolization (SAE) versus nephron-sparing surgery (NSS) using a robotic surgical system.

Materials And Methods: Between January 2011 and June 2018, we retrospectively reviewed 25 patients who underwent robot-assisted partial nephrectomy (RAPN) or SAE for large AMLs. Ten patients underwent RAPN, and 15 underwent SAE. Read More

View Article and Full-Text PDF

Anti-CD20 antibody therapy and risk of infection in patients with demyelinating diseases.

Mult Scler Relat Disord 2021 May 1;52:102988. Epub 2021 May 1.

Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Anti-CD20 antibody therapy may be associated with an increased risk of infections. We therefore investigated risk factors for infection in patients with demyelinating diseases treated with anti-CD20 antibody therapy.

Methods: In this retrospective uncontrolled study, patients ever treated with anti-CD20 antibodies at an academic clinic were identified through the Danish Multiple Sclerosis Registry (DMSR). Read More

View Article and Full-Text PDF

Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unit.

Epilepsy Behav 2021 May 9;120:107987. Epub 2021 May 9.

Department of Medicine (RMH), The University of Melbourne, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Australia.

Objective: To compare the clinical, psychiatric, and cognitive characteristics of older with younger patients presenting to a video-EEG monitoring (VEM) unit.

Method: This was a retrospective case-control study involving patients admitted for VEM over a two-year period (from April 2018 to April 2020) at two comprehensive epilepsy units. Patients were categorized into an older (≥60 years) and a younger (<60 years) group. Read More

View Article and Full-Text PDF

Formal thought disorder in patients with first-episode schizophrenia: Results of a one-year follow-up study.

Psychiatry Res 2021 Apr 29;301:113972. Epub 2021 Apr 29.

Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Formal thought disorder (FTD) refers to abnormal speech patterns that can be characterized by deficiencies in thought organization and direction. The present study aimed to assess the factor structure of FTD and to examine its relationship with cognition and clinical features at first admission in patients with first-episode schizophrenia. We also examined the course of FTD during the twelve months after first admission. Read More

View Article and Full-Text PDF

High precision in microRNA prediction: A novel genome-wide approach with convolutional deep residual networks.

Comput Biol Med 2021 May 5;134:104448. Epub 2021 May 5.

Research Institute for Signals, Systems and Computational Intelligence, sinc(i), FICH-UNL, CONICET, Ciudad Universitaria UNL, 3000, Santa Fe, Argentina. Electronic address:

MicroRNAs (miRNAs) are small non-coding RNAs that have a key role in the regulation of gene expression. The importance of miRNAs is widely acknowledged by the community nowadays and computational methods are needed for the precise prediction of novel candidates to miRNA. This task can be done by searching homologous with sequence alignment tools, but results are restricted to sequences that are very similar to the known miRNA precursors (pre-miRNAs). Read More

View Article and Full-Text PDF

Internet-based cognitive assessment tool: Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder.

J Affect Disord 2021 Apr 27;289:125-134. Epub 2021 Apr 27.

Digital Health Section, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Copenhagen Center for Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients' cognition at a much larger scale to a reduced cost. Read More

View Article and Full-Text PDF

Depressive and stress symptoms in insomnia patients predict group cognitive-behavioral therapy for insomnia long-term effectiveness: A data-driven analysis.

J Affect Disord 2021 Apr 24;289:117-124. Epub 2021 Apr 24.

Sleep Disorder Center, San Raffaele Hospital Milan, Italy.

Background: Insomnia Disorder is characterized by high degree of phenotypic heterogeneity, that might influence treatment response.

Methods: 123 of 294 insomnia patients initially recruited (66.7% females, age=40. Read More

View Article and Full-Text PDF

The empty nest, depressive symptoms and loneliness of older parents: Prospective findings from the German Ageing Survey.

Arch Gerontol Geriatr 2021 Apr 29;95:104425. Epub 2021 Apr 29.

Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: The aim of this study was to analyse the longitudinal association between the transition to an empty nest and depressive symptoms and loneliness, respectively.

Method: Longitudinal data was used from the German Ageing Survey, a representative sample of community-dwelling adults aged 40 and over. The indication of children living outside the respondent's household was defined as an empty nest. Read More

View Article and Full-Text PDF

The association between transthoracic echocardiogram parameters and white matter hyperintensities.

Clin Neurol Neurosurg 2021 May 4;206:106672. Epub 2021 May 4.

Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA. Electronic address:

Objective: Identify abnormal cardiac chamber size and hemodynamic parameters on transthoracic echocardiogram (TTE) as predictors of advancing cerebral small vessel disease (CSVD) on brain magnetic resonance imaging (MRI).

Materials And Methods: A retrospective chart review of adults with a brain MRI and a 2-dimensional TTE was performed. WMH measured by the Fazekas score served as the primary outcome. Read More

View Article and Full-Text PDF

Surveillance of Fontan associated liver disease in childhood and adolescence.

Semin Thorac Cardiovasc Surg 2021 May 9. Epub 2021 May 9.

University Hospital Schleswig-Holstein, Campus Kiel, Department of Congenital Heart Disease and Pediatric Cardiology; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany.

Fontan associated liver disease (FALD) has been recognized as a potentially serious sequela of the Fontan circulation. Prevalence of FALD among different age groups and risk factors for advanced changes were assessed. FALD screening included abdominal ultrasound and laboratory tests. Read More

View Article and Full-Text PDF

Exercise for Patients with Gastrointestinal Cancer Undergoing Chemotherapy and at High Risk for Depression: A Randomized Clinical Trial.

J Altern Complement Med 2021 May 12. Epub 2021 May 12.

Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

This study evaluated the effects of a Chinese traditional exercise-monkey frolic in Wuqinxi on depression and quality of life in patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression. In this prospective, randomized-controlled clinical trial, 80 patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression were randomized to an intervention group or a control group. Participants in the intervention group participated in exercise five sessions each week and also received conventional treatment for 4 weeks; whereas participants in the control group received conventional treatment only. Read More

View Article and Full-Text PDF

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.

N Engl J Med 2021 May;384(19):1800-1809

From Royal Brompton Hospital, London (A.M.-G.), Leicester National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester (C.E.B.), and Late-stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge (S.P.) - all in the United Kingdom; the David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (J.C.), and Global Development, Amgen, Thousand Oaks (P.K.) - both in California; Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Centre National de la Recherche Scientifique, INSERM, Centre Hospitalier Universitaire de Montpellier, Montpellier, France (A.B.); the Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT (G. Chupp); the Division of Pulmonary and Critical Care Medicine and Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston (E.I.); National Jewish Health, Denver (M.E.W.); Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (J.M.G.), and Biometrics (K.B.), Late-stage Development, Respiratory and Immunology (G. Colice), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD; and Biometrics (Å.H.), Late-stage Development, Respiratory and Immunology (G.A.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Background: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma require further assessment.

Methods: We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled trial. Read More

View Article and Full-Text PDF

Using Multivariate Analyses To Explore Disease Progression of Finch Mycoplasmosis.

J Wildl Dis 2021 May 12. Epub 2021 May 12.

Department of Ecology, Evolution, and Organismal Biology, Iowa State University, 251 Bessey Hall, 2200 Osborne Drive, Ames, Iowa 50011, USA.

Lesion severity scales have been developed for a number of wildlife diseases causing external pathology. Perhaps the best known and most widely used scoring system has been developed for finch mycoplasmosis in which observers measure conjunctival pathology along a four-point scale of increasing severity. We developed novel techniques to characterize variation in host phenotype based on occupancy of multidimensional trait space (disease space). Read More

View Article and Full-Text PDF

Neoadjuvant radiotherapy for locoregional Siewert type II gastroesophageal junction adenocarcinoma: A propensity scores matching analysis.

PLoS One 2021 12;16(5):e0251555. Epub 2021 May 12.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.

Objective: To analyze the effect of neoadjuvant radiotherapy (nRT) on prognosis in patients with locoregional Siewert type II gastroesophageal junction adenocarcinoma (GEA).

Method: All patients pathologically diagnosed as Siewert type II GEA between 2004 and 2015 were retrieved from the Surveillance, Epidemiology and Final Results (SEER) database. We analyzed the impact of different treatment regimens on the prognosis in each stage. Read More

View Article and Full-Text PDF

Auditory evoked potentials: Differences by sex, race, and menstrual cycle and correlations with common psychoacoustical tasks.

PLoS One 2021 12;16(5):e0251363. Epub 2021 May 12.

Department of Speech, Language, and Hearing Sciences, University of Texas, Austin, Texas, United States of America.

Auditory brainstem responses (ABRs) and auditory middle-latency responses (AMLRs) to a click stimulus were measured in about 100 subjects. Of interest were the sex differences in those auditory evoked potentials (AEPs), the correlations between the various AEP measures, and the correlations between the AEP measures and measures of otoacoustic emissions (OAEs) and behavioral performance also measured on the same subjects. Also of interest was how the menstrual cycle affected the various AEP measures. Read More

View Article and Full-Text PDF

Factors determining cognitive, motor and language scores in low birth weight infants from North India.

PLoS One 2021 12;16(5):e0251387. Epub 2021 May 12.

Department of Research, Innlandet Hospital Trust, Lillehammer, Norway.

Background: Children born with low birth weight (LBW) tend to have lower neurodevelopmental scores compared to term normal birth weight children. It is important to determine factors that influence neurodevelopment in these low birth weight children especially in the first 2-3 years of life that represents a period of substantial brain development.

Methods: This secondary data analysis was conducted using data from LBW infants enrolled soon after birth in an individually randomized controlled trial (RCT) and followed up till end of 1st year. Read More

View Article and Full-Text PDF

OpTrust: An Effective Educational Bundle for Enhancing Faculty-resident Intraoperative Entrustment.

Ann Surg 2021 Jun;273(6):e255-e261

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Objective: The purpose of this study was to measure the efficacy of a novel faculty and resident educational bundle focused on development of faculty-resident behaviors and entrustment in the operating room.

Summary Background Data: As surgical training environments are orienting to entrustable professional activities (EPAs), successful transitions to this model will require significant faculty and resident development. Identifying an effective educational initiative which prepares faculty and residents for optimizing assessment, teaching, learning, and interacting in this model is critical. Read More

View Article and Full-Text PDF

Validity and reliability of the QLQ-MY20 module for assessing the health-related quality of life in Brazilians with multiple myeloma.

Curr Med Res Opin 2021 May 12. Epub 2021 May 12.

Department of Social Pharmacy - UFMG. Belo Horizonte, Minas Gerais, Brazil.

Purpose: Multiple myeloma (MM) is a rare but treatable hematological cancer, which makes Health-Related Quality of Life (HRQoL) an important patient-report outcome measure in clinical studies. The Quality of Life Questionnaire Multiple Myeloma Module (QLQ-MY20) was developed by the European Organization for Research and Treatment of Cancer (EORTC) to measure HRQoL in people with MM. However, the Brazilian Portuguese version of QLQ-MY20 has not yet been validated for Brazil. Read More

View Article and Full-Text PDF

Intra-articular Injection of Bevacizumab Enhances Bone Marrow Stimulation-Mediated Cartilage Repair in a Rabbit Osteochondral Defect Model.

Am J Sports Med 2021 May 12:3635465211005102. Epub 2021 May 12.

Center for Regenerative Sports Medicine at the Steadman Philippon Research Institute, Vail, Colorado, USA; Department of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.

Background: Bone marrow stimulation (BMS) via microfracture historically has been a first-line treatment for articular cartilage lesions. However, BMS has become less favorable because of resulting fibrocartilage formation. Previous studies have shown that angiogenesis blockade promotes cartilage repair. Read More

View Article and Full-Text PDF

Discriminative Validity of Vestibular Ocular Motor Screening in Identifying Concussion Among Collegiate Athletes: A National Collegiate Athletic Association-Department of Defense Concussion Assessment, Research, and Education Consortium Study.

Am J Sports Med 2021 May 12:3635465211012359. Epub 2021 May 12.

Department of Orthopedic Surgery, UPMC Sports Medicine Concussion Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Vestibular and ocular motor screening tools, such as the Vestibular/Ocular Motor Screening (VOMS), are recognized as important components of a multifaceted evaluation of sport-related concussion. Previous research has supported the predictive utility of the VOMS in identifying concussion, but researchers have yet to examine the predictive utility of the VOMS among collegiate athletes in the first few days after injury.

Purpose: To determine the discriminative validity of individual VOMS item scores and an overall VOMS score for identifying collegiate athletes with an acute sport-related concussion (≤72 hours) from healthy controls matched by age, sex, and concussion history. Read More

View Article and Full-Text PDF

Are we ready to use activity scores for intestinal ultrasound in ulcerative colitis?

United European Gastroenterol J 2021 May 12. Epub 2021 May 12.

Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada.

View Article and Full-Text PDF

Measuring quality of hepatitis B care in a remote Australian Aboriginal community; opportunities for improvement.

Intern Med J 2021 May 12. Epub 2021 May 12.

Hepatology and Liver Transplantation Medicine Unit, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Background: Chronic hepatitis B (CHB) infection remains a significant public health issue for Indigenous Australians, in particular for remote communities.

Aim: This study aimed to evaluate the spectrum of hepatitis B virus (HBV) care provided to a remote Aboriginal community. Measures studied included screening, seroprevalence, vaccination rates and efficacy, and HCC risk and surveillance adherence. Read More

View Article and Full-Text PDF

Migraine prevalence in visual snow with prior illicit drug use (Hallucinogen Persisting Perception Disorder) versus without.

Eur J Neurol 2021 May 12. Epub 2021 May 12.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Background/objective: To investigate migraine prevalence in persons with Hallucinogen Persisting Perception Disorder (HPPD) presenting as visual snow syndrome (VSS).

Methods: Persons with visual snow as persisting symptom after illicit drug use (HPPD) were recruited via a Dutch consulting clinic for recreational drug use. A structured interview on (visual) perceptual symptomatology, details of drugs use, medical and headache history was taken. Read More

View Article and Full-Text PDF

Telephone veteran peer coaching for mental health treatment engagement among rural veterans: The importance of secondary outcomes and qualitative data in a randomized controlled trial.

J Rural Health 2021 May 12. Epub 2021 May 12.

Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana, USA.

Purpose: To determine the effectiveness of telephone motivational coaching delivered by veteran peers to improve mental health (MH) treatment engagement among veterans.

Methods: Veterans receiving primary care from primarily rural VA community-based outpatient clinics were enrolled. Veterans not engaged in MH treatment screening positive for ≥1 MH problem(s) were randomized to receive veteran peer-delivered feedback on MH screen results and referrals plus 4 sessions of telephone motivational coaching (intervention) versus veteran peer-delivered MH results and referrals without motivational coaching (control). Read More

View Article and Full-Text PDF