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Radiographers and COVID-19 pneumonia: Diagnostic performance using CO-RADS.

Radiography (Lond) 2021 Apr 30. Epub 2021 Apr 30.

Department of Radiological Sciences, Oncology and Pathology, "Sapienza" University of Rome, I.C.O.T. Hospital, Via Franco Faggiana, 1668, 04100, Latina, Italy.

Introduction: A more structured role of radiographers is advisable to speed up the management of patients with suspected COVID-19. The purpose of our study was to evaluate the diagnostic performance of radiographers in the detection of COVID-19 pneumonia on chest CT using CO-RADS descriptors.

Methods: CT images of patients who underwent RT-PCR and chest CT due to COVID-19 suspicion between March and July 2020 were analysed retrospectively. Read More

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Genetic and non-genetic factors associated with health and vitality traits in beef calves.

J Anim Sci 2021 May 11. Epub 2021 May 11.

Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland.

Awareness and interest in calf health and wellbeing is intensifying, prompting change in the management and breeding decisions of producers and associated policy-makers. The objectives of the present study were to 1) quantify the risk factors associated with subjectively-measured scores of vigour and birth size as well as diagnoses of scour and pneumonia in a large national dataset of beef calves, and 2) to estimate the contribution of genetic variance to such phenotypic measures. After edits, the data consisted of health and birth size data subjectively scored by producers on 88,207 calves born in 6,126 Irish beef herds. Read More

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Application of a radiation pneumonitis prediction model in patients with locally advanced lung squamous cell cancer.

Ann Palliat Med 2021 Apr;10(4):4409-4417

Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The aim of the present study was to establish a new prediction model for radiation pneumonitis (RP) in locally advanced non-small cell lung cancer (LA-NSCLC) patients before and after radiotherapy.

Methods: The study involved 153 patients. Age, arterial partial oxygen pressure (PO2), forced vital capacity, pulmonary emphysema (PE), subclinical interstitial lung disease (sILD), and dosimetric parameters, such as mean lung dose and percentage of lung volume, and a dose >5/20 Gy (V5/V20), were considered candidate RP predictors. Read More

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Female sweet-likers have enhanced cross-modal interoceptive abilities.

Appetite 2021 May 6:105290. Epub 2021 May 6.

School of Psychology, University of Sussex, UK. Electronic address:

There are well known phenotypic differences in sweet-liking across individuals, but it remains unknown whether these are related to broader underlying differences in interoceptive abilities (abilities to sense the internal state of the body). Here, healthy women (N = 64) classified as sweet likers (SLs) or sweet dislikers (SDs) completed a bimodal interoception protocol. A heartbeat tracking and a heartbeat discrimination task determined cardiac interoception; both were accompanied by confidence ratings. Read More

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The Venous Occlusion Image Score: A Novel Quantitative Scoring Instrument for Cerebral Venous Sinus Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 5;30(7):105845. Epub 2021 May 5.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, P R China. Electronic address:

Purpose: This study aims to test the validity of a new quantitative scoring instrument-the Venous Occlusion Image Score (VOIS), and assess the diagnostic and prognostic value of VOIS for cerebral venous sinus thrombosis (CVST).

Methods: The VOIS divided the major cerebral venous sinuses and internal jugular veins into nine parts of interest. CT venography and DSA source images and reconstruction were extracted from the database, then interpreted and scored independently according to VOIS by a panel of three reviewers. Read More

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Pediatric home confinement due to COVID-19: Somatic and anxiety spectrum consequences.

J Clin Nurs 2021 May 6. Epub 2021 May 6.

Department of Paediatrics, HM Hospitals, Madrid, Spain.

Aims And Objectives: We aimed to determine the impact of COVID-19 related home confinement on the paediatric population by focusing on anxiety, behavioural disturbances and somatic symptoms.

Background: To limit the spread of the COVID-19 outbreak, governments have imposed nationwide lockdowns to prevent direct contact; this has affected everyday lives and activities such as attending school classes. Such isolation may have impacted children's anxiety levels. Read More

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Reliability and minimal detectable change of the , an advanced motor skills test for children with cerebral palsy, Danish version.

Disabil Rehabil 2021 May 6:1-8. Epub 2021 May 6.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Purpose: To translate and cross-culturally adapt the , and investigate the reliability and minimal detectable change (MDC) of the Danish in children with cerebral palsy (CP).

Materials And Methods: A Danish version of the was created through a standardized translation process. Four physiotherapists evaluated face validity. Read More

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Evaluation of rapid drug safety communication materials for patients in Japan.

Drug Discov Ther 2021 Apr 30. Epub 2021 Apr 30.

Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Since 2011, pharmaceutical companies in Japan have been required to issue two types of documents regarding severe adverse drug reactions reported post-marketing, namely the Rapid Safety Communication Materials for Patients and the Related Materials. However, the adequacy of these documents has not yet been systematically assessed. The aim of this study was to evaluate the adequacy of these two types of materials. Read More

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Face-to-face panel meetings versus remote evaluation of fellowship applications: simulation study at the Swiss National Science Foundation.

BMJ Open 2021 May 5;11(5):e047386. Epub 2021 May 5.

Institute of Social & Preventive Medicine, University of Bern, Bern, Switzerland.

Objectives: To trial a simplified, time and cost-saving method for remote evaluation of fellowship applications and compare this with existing panel review processes by analysing concordance between funding decisions, and the use of a lottery-based decision method for proposals of similar quality.

Design: The study involved 134 junior fellowship proposals for postdoctoral research ('Postdoc.Mobility'). Read More

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Aligning community-engaged research competencies with online training resources across the Clinical and Translational Science Award Consortium.

J Clin Transl Sci 2020 Sep 11;5(1):e45. Epub 2020 Sep 11.

School of Nursing, Johns Hopkins University, Baltimore, MD, USA.

Introduction: The extent to which Clinical and Translational Science Award (CTSA) programs offer publicly accessible online resources for training in community-engaged research (CEnR) core competencies is unknown. This study cataloged publicly accessible online CEnR resources from CTSAs and mapped resources to CEnR core competency domains.

Methods: Following a search and review of the current literature regarding CEnR competencies, CEnR core competency domains were identified and defined. Read More

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September 2020

US LI-RADS Visualization Score: Interobserver Variability and Association With Cause of Liver Disease, Sex, and Body Mass Index.

Can Assoc Radiol J 2021 May 3:8465371211012104. Epub 2021 May 3.

Department of Radiology, 3688Dalhousie University, Halifax, Nova Scotia, Canada.

Objectives: To evaluate the interobserver agreement between radiologists using the Ultrasound Liver Reporting And Data System (US LI-RADS) visualization score and assess association between visualization score and cause of liver disease, sex, and body mass index (BMI).

Methods: This retrospective, single institution, cross-sectional study evaluated 237 consecutive hepatocellular carcinoma surveillance US examinations between March 4, 2017 and September 4, 2017. Five abdominal radiologists independently assigned a US LI-RADS visualization score (A, no or minimal limitations; B, moderate limitations; C, severe limitations). Read More

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Evaluation of a High Stakes Physician Competency Assessment: Lessons for Assessor Training, Program Accountability, and Continuous Improvement.

J Contin Educ Health Prof 2021 Apr 22. Epub 2021 Apr 22.

Dr. Wenghofer: Full Professor, School of Rural and Northern Health, Laurentian University, Sudbury, Ontario, Canada. Dr. Steele: Medical Director of Knowledge, Skills, Training, Assessment, and Training (KSTAR) Physician Programs, A&M Rural and Community Health Institute, Texas A&M University Health Science Center, College Station, TX. Dr. Christiansen: Professor of Medicine, Department of Medicine, University of Illinois College of Medicine, Rockford, IL. Dr. Carter: Clinical Assistant Professor of primary care medicine, Primary Care and Population Health, Texas A&M University Health Science Center, College Station, TX.

Introduction: There is a dearth of evidence evaluating postlicensure high-stakes physician competency assessment programs. Our purpose was to contribute to this evidence by evaluating a high-stakes assessment for assessor inter-rater reliability and the relationship between performance on individual assessment components and overall performance. We did so to determine if the assessment tools identify specific competency needs of the assessed physicians and contribute to our understanding of physician dyscompetence more broadly. Read More

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Towards computer-aided severity assessment via deep neural networks for geographic and opacity extent scoring of SARS-CoV-2 chest X-rays.

Sci Rep 2021 04 29;11(1):9315. Epub 2021 Apr 29.

Department of Radiology, Stony Brook School of Medicine, Stony Brook, NY, USA.

A critical step in effective care and treatment planning for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause for the coronavirus disease 2019 (COVID-19) pandemic, is the assessment of the severity of disease progression. Chest x-rays (CXRs) are often used to assess SARS-CoV-2 severity, with two important assessment metrics being extent of lung involvement and degree of opacity. In this proof-of-concept study, we assess the feasibility of computer-aided scoring of CXRs of SARS-CoV-2 lung disease severity using a deep learning system. Read More

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Burnout Status of Italian Healthcare Workers during the First COVID-19 Pandemic Peak Period.

Healthcare (Basel) 2021 Apr 28;9(5). Epub 2021 Apr 28.

Department of Psychological, Health, and Territorial Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.

The pandemic of 2019 coronavirus disease (COVID-19) has burdened extraordinary psychological stress on the healthcare workforce. The present survey aimed to examine the personal resources and psychological symptoms associated with burnout in 933 healthcare workers in Italy during the COVID-19 outbreak period. Sociodemographic and occupational data, depression, anxiety, burnout, and post-traumatic symptoms, as well as psychological well-being, were cross-sectional assessed through an online questionnaire. Read More

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Histological Features of Sporadic and Familial Testicular Germ Cell Tumors Compared and Analysis of Age-Related Changes of Histology.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.

This study aimed to compare histological features of familial and sporadic testicular germ cell tumors (TGCTs) and surrounding parenchyma, since discriminating features might be etiologically relevant and clinically useful. The study of parenchyma was prompted by reports claiming a higher prevalence of testicular microlithiasis in familial cases. Histological features of TGCTs and surrounding parenchyma of 296 sporadic and 305 familial cases were compared. Read More

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Measuring the Quality of Clinical Skills Mobile Apps for Student Learning: Systematic Search, Analysis, and Comparison of Two Measurement Scales.

JMIR Mhealth Uhealth 2021 Apr 23;9(4):e25377. Epub 2021 Apr 23.

Education Unit, University of Otago Wellington, Wellington, New Zealand.

Background: Mobile apps are widely used in health professions, which increases the need for simple methods to determine the quality of apps. In particular, teachers need the ability to curate high-quality mobile apps for student learning.

Objective: This study aims to systematically search for and evaluate the quality of clinical skills mobile apps as learning tools. Read More

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Patient, clinician and independent observer perspectives of shared decision making in adult orthodontics.

J Orthod 2021 Apr 22:14653125211007504. Epub 2021 Apr 22.

Orthodontics, UCL Eastman Dental Institute, London, UK.

Objectives: To investigate and compare the extent of shared decision making (SDM) in orthodontics from the perspective of patients, clinicians and independent observers.

Design: A cross-sectional, observational study.

Setting: NHS teaching hospital. Read More

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Development of a brief, generic, modular resource-use measure (ModRUM): cognitive interviews with patients.

BMC Health Serv Res 2021 Apr 21;21(1):371. Epub 2021 Apr 21.

Health Economics at Bristol, Population Health Sciences, Bristol Medical School, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.

Background: Self-report resource-use measures (RUMs) are often used to collect healthcare use data from participants in healthcare studies. However, RUMs are typically adapted from existing measures on a study-by-study basis, resulting in a lack of standardisation which limits comparability across studies. Psychometric testing of RUMs is rarely conducted. Read More

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Current progress and quality of radiomic studies for predicting EGFR mutation in patients with non-small cell lung cancer using PET/CT images: a systematic review.

Br J Radiol 2021 May 12:20201272. Epub 2021 May 12.

Department of Radiology, The First People's Hospital of Kashi Area, Kashi, Xinjiang, China.

Objectives: To assess the methodological quality of radiomic studies based on positron emission tomography/computed tomography (PET/CT) images predicting epidermal growth factor receptor (EGFR) mutation status in patients with non-small cell lung cancer (NSCLC).

Methods: We systematically searched for eligible studies in the PubMed and Web of Science datasets using the terms "radiomics", "PET/CT", "NSCLC", and "EGFR". The included studies were screened by two reviewers independently. Read More

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Comparison of prostate imaging reporting and data system v2.1 and 2 in transition and peripheral zones: evaluation of interreader agreement and diagnostic performance in detecting clinically significant prostate cancer.

Br J Radiol 2021 Apr 21:20201434. Epub 2021 Apr 21.

Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the interreader agreement and diagnostic performance of the Prostate Imaging Reporting and Data System (PI-RADS) v2.1, in comparison with v2.

Methods: Institutional review board approval was obtained for this retrospective study. Read More

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T-staging of rectal cancer: Utility of single-shot turbo spin-echo diffusion-weighted imaging with T2-weighted images and fusion images.

PLoS One 2021 21;16(4):e0249433. Epub 2021 Apr 21.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Purpose: The purpose of this study was to evaluate the usefulness of turbo spin-echo (TSE) DWI with fusion images in the T-staging compared with T2-weighted imaging (T2WI) alone and conventional echo-planner imaging (EPI) DWI.

Methods: In this prospective study, 4-mm-thick axial EPI-DWI, TSE-DWI, and T2WI were performed with the same slice locations for 20 patients with rectal cancer. Fusion images of DWI and T2WI were created for both EPI-DWI and TSE-DWI. Read More

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Clinical Effects of Baduanjin Qigong Exercise on Cancer Patients: A Systematic Review and Meta-Analysis on Randomized Controlled Trials.

Evid Based Complement Alternat Med 2021 8;2021:6651238. Epub 2021 Apr 8.

Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.

Objective: Baduanjin is a traditional Chinese Qigong exercise for health improvement. However, a few studies were examining the association between Baduanjin Qigong exercise and cancer patients. This study is conducted to explore the clinical effects of the Baduanjin Qigong exercise among cancer patients. Read More

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Four-dimensional Multiphase Steady-State MRI with Ferumoxytol Enhancement: Early Multicenter Feasibility in Pediatric Congenital Heart Disease.

Radiology 2021 Apr 20:203696. Epub 2021 Apr 20.

From the Diagnostic Cardiovascular Imaging Laboratory, Department of Radiological Sciences (K.L.N., T.Y., A.B., P.H., J.P.F.), and Division of Cardiology (K.L.N.), David Geffen School of Medicine at UCLA, 300 Medical Plaza, B119, Los Angeles, CA 90095; VA Greater Los Angeles Healthcare System, Los Angeles, Calif (K.L.N.); Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pa (R.M.G., M.A.F., K.K.W.); Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital, Chicago, Ill (L.M.G., C.K.R.); and Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.M.G., C.K.R.).

Background The value of MRI in pediatric congenital heart disease (CHD) is well recognized; however, the requirement for expert oversight impedes its widespread use. Four-dimensional (4D) multiphase steady-state imaging with contrast enhancement (MUSIC) is a cardiovascular MRI technique that uses ferumoxytol and captures all anatomic features dynamically. Purpose To evaluate multicenter feasibility of 4D MUSIC MRI in pediatric CHD. Read More

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Impact of structured curriculum with simulation on bronchoscopy.

Respirology 2021 Apr 19. Epub 2021 Apr 19.

Division of Respiratory and Critical Care Medicine, National University Hospital, Singapore.

Background And Objective: Simulation enhances a physician's competency in procedural skills by accelerating ascent of the learning curve. Training programmes are moving away from the Halstedian model of 'see one, do one, teach one', also referred as medical apprenticeship. We aimed to determine if a 3-month structured bronchoscopy curriculum that incorporated simulator training could improve bronchoscopy competency among pulmonary medicine trainees. Read More

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Accomplishment of instrumental activities of daily living and its relationship with cognitive functions in adults with myotonic dystrophy type 1 childhood phenotype: an exploratory study.

BMC Psychol 2021 Apr 17;9(1):56. Epub 2021 Apr 17.

Groupe de Recherche Interdisciplinaire Sur Les Maladies Neuromusculaires (GRIMN), Centre Intégré Universitaire de Santé Et de Services Sociaux du Saguenay-Lac-St-Jean, Québec, Canada.

Background: The childhood phenotype of myotonic dystrophy type 1 (DM1) involves impaired cognitive functioning starting in infancy, which may compromise later on their ability to carry out instrumental activities of daily living (IADLs) necessary for living independently. The current study aims to document the ability to perform IADLs among adults with the childhood phenotype of DM1 and to explore its links to cognitive functioning.

Methods: This cross-sectional exploratory study was conducted among 11 individuals living with DM1. Read More

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Appraisal of the current guidelines for the management of diverticular disease using the Appraisal of Guidelines Research and Evaluation II (AGREE II) instrument.

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Cambridge University Hospitals NHS Foundation Trust, UK.

Introduction: Diverticular disease is one of the most frequent reasons for attending emergency departments and surgical causes of hospital admission. In the past decade, many surgical and gastroenterological societies have published guidelines for the management of diverticular disease. The aim of the present study was to appraise the methodological quality of these guidelines using the Appraisal of Guidelines Research and Evaluation II (AGREE II) tool. Read More

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Validating scoring systems for fracture healing in infants and young children: pilot study.

Pediatr Radiol 2021 Apr 13. Epub 2021 Apr 13.

The University of Sheffield, Western Bank, Sheffield, South Yorkshire, S10 2TN, UK.

Background: Recent studies have analysed birth-related clavicular fractures to propose time frames for healing that could be applied to dating of all fractures in cases of suspected child abuse.

Objective: To assess differences in healing rates between femoral fractures and birth-related clavicular fractures in infants and young children.

Materials And Methods: A retrospective 5-year pilot study of femoral fractures in children younger than 3 years of age was performed. Read More

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Usefulness of sleep events detection using a wrist worn peripheral arterial tone signal device (WatchPAT™) in a population at low risk of obstructive sleep apnea.

J Sleep Res 2021 Apr 12:e13352. Epub 2021 Apr 12.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Due to the high prevalence of obstructive sleep apnea (OSA), it is recommended to use in-laboratory polysomnography (PSG) or a home sleep apnea test (HSAT) in uncomplicated adult subjects at high risk of OSA. The aims of the present study were to compare a HSAT device, a wrist worn peripheral arterial tone signal device (WatchPAT™-200 [WP]) with PSG and respiratory polygraphy (RP) in a low-risk population of OSA. A total of 47 adult subjects at low risk of OSA were simultaneously examined with the three different approaches in a single night. Read More

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Reliability of the Cutting Alignment Scoring Tool (CAST) to Assess Trunk and Limb Alignment During a 45-Degree Side-Step Cut.

Int J Sports Phys Ther 2021 Apr 1;16(2):312-321. Epub 2021 Apr 1.

The Micheli Center for Sports Injury Prevention; Waseda University.

Background: Three-dimensional (3D) motion analysis is considered the gold standard for evaluating human movement. However, its clinical utility is limited due to cost, operating expertise, and lengthy data processing time. Numerous qualitative scoring systems have been introduced to assess trunk and lower extremity biomechanics during functional tasks. Read More

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Evaluation of failure modes and effect analysis for routine risk assessment of lung radiotherapy at a UK center.

J Appl Clin Med Phys 2021 Apr 9. Epub 2021 Apr 9.

Medical Physics, Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral, UK.

Purpose: Explore the feasibility of adopting failure modes and effects analysis (FMEA) for risk assessment of a high volume clinical service at a UK radiotherapy center. Compare hypothetical failure modes to locally reported incidents.

Method: An FMEA for a lung radiotherapy service was conducted at a hospital that treats ~ 350 lung cancer patients annually with radical radiotherapy. Read More

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