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The Subarachnoid Hemorrhage Early Brain Edema Score (SEBES) as radiographic marker of clinically relevant intracranial hypertension and unfavorable outcome after subarachnoid hemorrhage.

Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery and Spine Surgery, University Hospital of Essen, Germany.

Objective: The severity of early brain edema after aneurysm rupture was reported to be strongly associated with the risk of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Using the recently developed SEBES (Subarachnoid Hemorrhage Early Brain Edema Score), we analyzed the predictors of early brain edema and its impact on the complications related to intracranial pressure (ICP) increase after SAH and poor outcome.

Methods: All consecutive SAH cases treated between January 2003 and June 2016 with assessable SEBES were included (n=745). Read More

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[Translation, Adaptation, Reliability and Validity of the German Version of the Prosthesis Mobility Questionnaire 2.0 (PMQ) on Patients with Major Lower Limb Amputation].

Rehabilitation (Stuttg) 2021 Jul 22. Epub 2021 Jul 22.

Klinik für Rehabilitationsmedizin, Medizinische Hochschule Hannover.

Purpose: The aim of this prospective validation study was to translate the Prosthesis Mobility Questionnaire 2.0 (PMQ) into German based on a guideline, following by psychometric testing for its validity and reliability using classical test theory.

Methods: The PMQ was translated into German according to ISPOR guidelines using double forward and double backward translations, finalized by pilot testing (N=10). Read More

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Long-Term Quality of Life in Patients Following Minimally Invasive Conjunctivodacryocystorhinostomy With StopLoss Jones Tube.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Jozef Strus City Hospital, Poznan, Poland Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To assess the long-term quality of life outcomes of minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes.

Methods: A retrospective interventional case series was performed on all patients diagnosed with proximal bicanalicular obstruction who underwent a minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes over a period of 5 years from October 2014 to September 2019. The procedure was performed as per standard published protocols of minimally invasive conjunctivodacryocystorhinostomy and StopLoss Jones tubes. Read More

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Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

The Pacific Center for Oculofacial and Aesthetic Plastic Surgery, San Francisco, California, U.S.A. California Pacific Medical Center, San Francisco, California, U.S.A. University of California San Francisco, San Francisco, California, U.S.A.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment. Read More

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Validation of the Mini-Addenbrooke's Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers.

Dement Geriatr Cogn Disord 2021 Jul 22:1-5. Epub 2021 Jul 22.

Geriatrics and Gerontology Department, Ain Shams University, Cairo, Egypt.

Introduction: Mild cognitive impairment (MCI) represents a target for early detection and intervention in dementia, yet there is a shortage of validated screening tools in Arabic to diagnose MCI. The mini-Addenbrooke's Cognitive Examination (m-ACE) is a brief cognitive battery that is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition.

Objective: We aimed to validate the m-ACE in Arabic speakers in Egypt with MCI to provide cut-off scores. Read More

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Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer.

Eur J Cancer 2021 Jul 19;154:217-226. Epub 2021 Jul 19.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350007, China. Electronic address:

Purpose: We investigate the prognostic value of tumour-infiltrating lymphocytes (TILs) based on the evaluation of the present frequency in patients with breast cancer rather than that of the density proposed in previous research.

Methods: Multiphoton microscopy (MPM) was introduced to label-freely obtain TIL images from a total of 564 patients, and then TILs were redefined as TILs-1 to TILs-3 from MPM images according to the relative positions between TILs, tumour cells and collagen fibres. More seminally, a new method, which was based on the present frequency of TILs-1 to TILs-3, was presented for assessing the predictive ability of TILs, and then a tumour-infiltrating lymphocytes score (TILs-score) for each patient was obtained by ridge regression analysis. Read More

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Neurological presentations and cognitive outcome in Sturge-Weber syndrome.

Eur J Paediatr Neurol 2021 Jul 9;34:21-32. Epub 2021 Jul 9.

Great Ormond Street Hospital for Children Neurodisability Department, Great Ormond Street, UCL Great Ormond Street Institute of Child Health Clinical Neurosciences, London, United Kingdom.

Introduction: This study of children with Sturge-Weber syndrome (SWS) profiled neurological presentations; compared patients with (+) and without (-) port-wine stain (PWS); and determined risk factors for intellectual and language impairments.

Methods: A retrospective case note review was conducted at a national centre.

Results: This cohort (n = 140, male 72, median follow up 114 months) showed sex parity. Read More

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Effect of Guo Qing Yi Tang combined with Western medicine cluster therapy on acute pancreatitis.

Am J Emerg Med 2021 Jul 8;50:66-70. Epub 2021 Jul 8.

Department of Critical Care Medicine, Jinjiang Hospital of Traditional Chinese Medicine, Jinjiang 362200, Fujian province, People's Republic of China.

Background: This study evaluated the effect of Guo Qing Yi Tang (GQYT) combined with Western medicine cluster therapy on acute pancreatitis (AP).

Methods: A total of 138 AP patients were recruited and divided into the observation group (68 patients) and control group (70 patients). The control group was treated with cluster therapy alone, while the observation group was treated with trans-jejunum feeding of GQYT combined with cluster therapy. Read More

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The efficacy of acoustic therapy versus oral medication for chronic tinnitus: A meta-analysis.

Am J Otolaryngol 2021 Jun 18;42(6):103116. Epub 2021 Jun 18.

Department of Otorhinolaryngology-Head and Neck Surgery, The first hospital of Jilin University, Changchun, Jilin 130021, PR China.

Purpose: To compare the efficacy of acoustic therapy (AT) and drug therapy (DT) for chronic tinnitus.

Methods: We searched Pubmed, ScienceDirect, Chinese Journal Full-text Database (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), Embase, and Cochrane Library from the establishment of the database to December 2019. Meta-analysis was performed on the Tinnitus Handicap Inventory (THI) score and Visual Analogue Scale (VAS) with included literature using Revman 5. Read More

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The Impact of Incorporating Evidence-based Guidelines for Lumbar Fusion Surgery in Neurosurgical Resident Education.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania.

Background: Instrumented fusion procedures are essential in the treatment of degenerative lumbar spine disease to alleviate pain and improve neurologic function, but are being performed with increasing incidence and variability.

Objective: We implemented a training module for neurosurgery residents that is based on evidence-based criteria for lumbar fusion surgery and measured its effectiveness in the residents' decision making regarding whether patients should or should not undergo instrumented fusion.

Methods: The study design is a pretest versus posttest experiment conducted from September 2019 until July 2020 to measure improvement after formalized instruction on evidence-based guidelines. Read More

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Metformin use and risk of asthma exacerbation among asthma patients with glycemic dysfunction.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland. Electronic address:

Background: Diabetes is associated with worse asthma morbidity. Metformin, which treats diabetes, may have a role among patients with asthma and glycemic dysfunction.

Objective: To determine the association between metformin use and asthma exacerbations among patients with diabetes. Read More

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Improving severity scoring of food-induced allergic reactions: a global "Best-Worst Scaling" exercise.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

National Heart & Lung Institute, Imperial College London, London, UK;. Electronic address:

Background: There is no current consensus on assigning severity to food-induced allergic reactions, for example to assess the efficacy of allergen immunotherapy. Existing severity scores lack the capability to discriminate between non-anaphylaxis reactions of different severities. Attempts are ongoing to develop a more discriminatory score, which should ideally be data-driven and validated in multiple cohorts. Read More

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Penicillin allergy label increases risk of worse clinical outcomes in COVID-19.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Division of Gastroenterology and Hepatology, Pennsylvania State University College of Medicine, Hershey, PA, USA.

Background: Coronavirus disease-2019 (COVID-19) ranges from asymptomatic to severe. Several co-morbidities are associated with worse clinical outcomes. Antibiotic use is common in COVID-19 and penicillin (PCN) allergy can impact antibiotic choice and may influence COVID-19 outcomes. Read More

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The birth trauma psychological therapy service: An audit of outcomes.

Midwifery 2021 Jul 13;102:103099. Epub 2021 Jul 13.

Institute of Psychology, Health and Society, University of Liverpool, Liverpool, United Kingdom and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom. Electronic address:

Objective: To evaluate routinely collected service data from a 'Birth Trauma' psychology clinic integrated into maternity services, in order to review effectiveness for women with symptoms of Post-Traumatic Stress Disorder (PTSD) following childbirth.

Background: Prevalence of PTSD after child-birth has been estimated to be around 3% for women meeting full diagnostic criteria and up to 9% for sub-threshold symptoms. This can occur even in response to deliveries considered to be medically straightforward. Read More

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Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach.

Gene 2021 Jul 19:145856. Epub 2021 Jul 19.

Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India. Electronic address:

Epidemiological studies have established that untreated hypertension (HTN) is a major independent risk factor for developing cardiovascular diseases (CVD), stroke, renal failure, and other conditions. Several important studies have been published to prevent and manage HTN; however, antihypertensive agents' optimal choice remains controversial. Therefore, the present study is undertaken to update our knowledge in the primary treatment of HTN, specifically in the setting of other three important diseases. Read More

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Pregnancy influences the selection of appropriate reference genes in mouse tissue: Determination of appropriate reference genes for quantitative reverse transcription PCR studies in tissues from the female mouse reproductive axis.

Gene 2021 Jul 19:145855. Epub 2021 Jul 19.

University of Westminster, School of Life Sciences, 115 New Cavendish Street, London, W1W 6UW, United Kingdom. Electronic address:

Selecting stably expressed reference genes which are not affected by physiological or pathophysiological conditions is crucial for reliable quantification in gene expression studies. This study examined the expression stability of a panel of twelve reference genes in tissues from the female mouse reproductive axis and the uterus. Gene expression studies were carried out using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). Read More

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Combined transarterial embolization, and percutaneous sclerotherapy as treatment for refractory and non resectable aneurysmal bone cysts.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Radiology, University Hospital Muenster, Muenster, Germany; Department of Radiology, University Hospital LMU Munich, Germany.

Purpose: To evaluate safety and effectiveness of combined transarterial embolization and percutaneous sclerotherapy in treatment for refractory and non-resectable aneurysmal bone cysts (ABCs) as assessed by imaging and clinical outcomes.

Materials And Methods: This retrospective single center study included n=16 consecutive patients (f=9, m=7; age: median 17 (6-25) years) undergoing combined transarterial embolization (using ethylene vinyl alcohol) and percutaneous sclerotherapy (ethanol-gel and polidocanol) for refractory and non-resectable ABCs. Median follow-up was 27. Read More

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Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

J Shoulder Elbow Surg 2021 Jul 19. Epub 2021 Jul 19.

Division of Upper Extremity Surgery, Department of Orthopaedic Surgery, Director of Upper Extremity Surgery Research, Emory University 59 Executive Park South, Atlanta, GA 30329, USA.

Background: While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulder osteoarthritis can present with alterations in glenoid morphology which have contributed to inconsistent outcomes in anatomic shoulder replacement. A predominance of these arthroplasty complications is due to the glenoid component. Read More

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Pan-cancer analysis reveals that neurotrophin signaling correlates positively with anti-tumor immunity, clinical outcomes, and response to targeted therapies and immunotherapies in cancer.

Life Sci 2021 Jul 19:119848. Epub 2021 Jul 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Aims: The crosstalk between cancer cells and nerves plays an important role in tumor biology. However, the correlation between the neurotrophin signaling (NS) and anti-tumor immunity and immunotherapy response in cancer remains unexplored.

Materials And Methods: We analyzed associations of NS with anti-tumor immune signatures, tumor immunity-related molecular and genomic features, and clinical features in 33 TCGA cancer types. Read More

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Dietary quality modifies the association between multimorbidity and change in mobility limitations among older Americans.

Prev Med 2021 Jul 19:106721. Epub 2021 Jul 19.

Department of Oncology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.

To identify potentially modifiable risk-factors in the age-related disablement process, we examined the association between change in mobility limitations and multimorbidity and how dietary quality moderates this association. Information from 3320 adults aged 65 and older in 2012 was drawn from the Health and Retirement Study and the Health Care and Nutrition Study. Mobility limitations reported in 2012 and change in mobility limitations from 2012 to 2014 were regressed on multimorbidity measured as number of chronic conditions in 2012, dietary quality measured in 2013 using the Alternative Healthy Eating Index-2010 (AHEI-2010), and their interaction term using Poisson regression. Read More

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Sex Specific Long-Term Height and BMI Trajectories of Stimulant Treated Children Diagnosed with Attention-Deficit/Hyperactivity Disorder.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv. Electronic address:

Objectives: To evaluate the sex-specific effects of stimulants in children with Attention-Deficit/Hyperactivity Disorder (ADHD) on body mass index (BMI)-Z and Height-Z trajectories.

Study Design: A retrospective cohort study utilizing the database of Israel Clalit Health Services. Participants included 5-18-year-old insureds with documentation of at least two consecutive prescriptions of stimulant drugs for ADHD. Read More

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Cross-Sectional Analysis of Quality of Life in Pediatric Patients with Inflammatory Bowel Disease in British Columbia, Canada.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, British Columbia Children's Hospital, University of British Columbia, B.C., Canada; British Columbia Children Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, B.C., Canada. Electronic address:

Objectives: To evaluate Quality of Life (QoL) in a large cohort of pediatric patients with Inflammatory Bowel Disease (IBD) and to identify the clinical factors that influence QoL.

Study Design: This cross-sectional study analyzes a quality improvement initiative in 351 pediatric patients with IBD in British Columbia, Canada using the self-reported PedsQL 4.0 generic scale. Read More

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DNA methylation array identifies golli-MBP as a biomarker for the disease severity in childhood atopic dermatitis.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 83301; Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. 83301. Electronic address:

In this study, we investigated the changes in the global methylation status and its functional relevance in childhood atopic dermatitis (AD). Differences in epigenome-scale methylation events in peripheral blood associated with childhood AD were screened using DNA methylation arrays of 24 AD patients compared to 24 control subjects (C). Of the 16,840 differentially methylated CpG regions between AD and C, > 97% CpG loci revealed hypomethylation in childhood AD patients. Read More

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Neonatal lung ultrasound and surfactant administration: a pragmatic, multicenter study.

Chest 2021 Jul 19. Epub 2021 Jul 19.

Neonatal Intensive Care Unit, Vittore Buzzi Children's Hospital, Milan, Italy.

Background: Previous research shows that a lung ultrasound score (LUS) can anticipate CPAP failure in neonatal respiratory distress syndrome.

Research Question: Can LUS also predict the need for surfactant replacement?

Study Design And Methods: Multicenter, pragmatic study on preterm neonates who underwent lung ultrasound at birth and those given surfactant by masked physicians were also scanned within 24 hours from administration. Clinical data and respiratory support variables were recorded. Read More

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Anti-microbial antibody response is associated with future onset of Crohn's disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk.

Gastroenterology 2021 Jul 19. Epub 2021 Jul 19.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: /Aim: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDR) of CD patients is an independent risk factor for future CD development.

Methods: We measured host serum antibody response to six microbial antigens at enrollment (Prometheus ELISA test: ASCA IgA/IgG, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS). Read More

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The effect of esketamine in patients with treatment-resistant depression with and without comorbid anxiety symptoms or disorder.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Department of Neuroscience, Janssen Research & Development, LLC, San Diego, California, USA.

Background: Comorbid anxiety is generally associated with poorer response to antidepressant treatment. This post hoc analysis explored the efficacy of esketamine plus an antidepressant in patients with treatment-resistant depression (TRD) with or without comorbid anxiety.

Methods: TRANSFORM-2, a double-blind, flexible-dose, 4-week study (NCT02418585), randomized adults with TRD to placebo or esketamine nasal spray, each with a newly-initiated oral antidepressant. Read More

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Associations of genetically predicted circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with bladder cancer risk.

Mol Carcinog 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Insulin-like growth factors (IGF) play important roles in carcinogenesis. The associations of circulating IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3) with the risks of bladder cancer remain unclear. In this large case control study of 2011 bladder cancer cases and 2369 heathy controls, we assessed the associations of circulating IGF-1 and IGFBP-3 with bladder cancer risks using a Mendelian randomization approach, which uses genetic variants as instruments to study causal relationship between risk factors and diseases. Read More

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Discriminatory capacity of obesity indicators as predictors of high liver fat in US adolescents.

Eur J Clin Invest 2021 Jul 22:e13654. Epub 2021 Jul 22.

Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IDISNA, 31008, Pamplona, Spain.

Background: The aims of this study was to assess the potential of sixteen anthropometric, body composition and endocrine indexes as predictors of high liver fat and determine the most appropriate cutoff points in US adolescents.

Methods: A cross-sectional study was conducted on a population of 816 adolescents aged 12-17years. The FibroScan®502V2 device was used to estimate the controlled attenuation parameter (CAP). Read More

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Does Variceal Drainage Affect Arteriovenous Malformation Obliteration and Hemorrhage Rates After Stereotactic Radiosurgery? A Case-Matched Analysis.

Neurosurgery 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Stereotactic radiosurgery (SRS) is widely accepted as a minimally invasive alternative to surgery in the management of arteriovenous malformations (AVMs). Dilated AVM outflow veins or varices may be caused by high-flow or partial outflow obstruction, which may increase the risk of a hemorrhage before or after SRS.

Objective: To compare the obliteration and hemorrhage risks in patients with and without AVM varices (AVMv). Read More

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