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Sextant Biopsy-Based Criteria for Clinically Insignificant Prostate Cancer Are Also Valid for the 12-Core Prostate Biopsy Scheme: A Multicenter Study of Urooncology Association, Turkey.

Urol Int 2021 May 5:1-9. Epub 2021 May 5.

Department of Urology, Altunizade Hospital, Mehmet Ali Aydınlar Acıbadem University, Istanbul, Turkey.

Background: Epstein criteria based on sextant biopsy are assumed to be valid for 12-core biopsies. However, very scarce information is present in the current literature to support this view.

Objectives: To investigate the validity of Epstein criteria for clinically insignificant prostate cancer (PCa) in a cohort of the currently utilized 12-core prostate biopsy (TRUS-Bx) scheme in patients with low-risk and intermediate-risk PCa. Read More

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Characterizing the seizure onset zone and epileptic network using EEG-fMRI in a rat seizure model.

Neuroimage 2021 May 2:118133. Epub 2021 May 2.

Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Accurate epileptogenic zone (EZ) or seizure onset zone (SOZ) localization is crucial for epilepsy surgery optimization. Previous animal and human studies on epilepsy have reported that changes in blood oxygen level-dependent (BOLD) signals induced by epileptic events could be used as diagnostic markers for EZ or SOZ localization. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) recording is gaining interest as a non-invasive tool for preoperative epilepsy evaluation. Read More

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A collection of toolkit strains reveals distinct localization and dynamics of membrane-associated transcripts in epithelia.

Cell Rep 2021 May;35(5):109072

Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China. Electronic address:

Visualizing mRNA in real time in vivo at high resolution is critical for a full understanding of the spatiotemporal dynamics of gene regulation and function. Here, using a PP7/PCP-based mRNA-tagging approach, we construct a collection of tissue-specific and differentially expressed toolkit strains for visualizing mRNAs encoding apical, basolateral, and junctional proteins in Caenorhabditis elegans epithelia. We precisely delineate the spatiotemporal organization and dynamics of these transcripts across multiple subcellular compartments and tissues. Read More

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CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.

Immunity 2021 Apr 15. Epub 2021 Apr 15.

Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia; Department of Medicine and Radiology, The University of Melbourne, Parkville, VIC 3000, Australia; Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, VIC 3084, Australia.

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells. By using peptide-human leukocyte antigen (HLA) tetramers for direct ex vivo analysis, we characterized CD8 T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed individuals. Unlike CD8 T cells directed toward subdominant epitopes (B7/N, A2/S, and A24/S) CD8 T cells specific for the immunodominant B7/N epitope were detected at high frequencies in pre-pandemic samples and at increased frequencies during acute COVID-19 and convalescence. Read More

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Anteroinferior Psoas Technique for Oblique Lateral Lumbar Interbody Fusion.

Orthop Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Oblique lateral lumbar interbody fusion (OLIF) has been extensively used, with satisfactory outcomes for the treatment of degenerative lumbar disease. This article aims to demonstrate a modified lateral approach, also known as the anteroinferior psoas (AIP) technique for OLIF, which is expected to enhance security by operating under direct vision. The core procedures of our technique are as follows. Read More

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Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.

PLoS One 2021 5;16(5):e0250586. Epub 2021 May 5.

Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America.

Introduction: Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.

Methods: We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Read More

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Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.

JAMA Psychiatry 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk.

Objective: To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as between participants at CHR who later developed a psychotic disorder (CHR-PS+) and those who did not (CHR-PS-).

Design, Setting, And Participants: In this case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. Read More

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Crystallographic analysis and phasing of iron-assimilating protein 1 (FEA1) from Chlamydomonas reinhardtii.

Acta Crystallogr F Struct Biol Commun 2021 May 28;77(Pt 5):134-139. Epub 2021 Apr 28.

Institute for Protein Research, Osaka University, Yamada-oka 3-2, Suita, Osaka 565-0871, Japan.

As an essential component of protein cofactors, iron is important for all photosynthetic organisms. In Chlamydomonas reinhardtii, iron levels are strictly controlled by proteins such as iron-assimilating protein 1 (FEA1). This periplasmic protein is expressed under conditions of iron deficiency, but its mechanisms of function remain unknown. Read More

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Using network analysis to compare diagnosis-specific and age-specific symptom networks in eating disorders.

Int J Eat Disord 2021 May 5. Epub 2021 May 5.

Department of Psychiatry and Psychotherapy, University Hospital of Munich (LMU), Munich, Germany.

Objective: The network theory of mental disorders conceptualizes eating disorders (EDs) as networks of interacting symptoms. Network analysis studies in EDs mostly have examined transdiagnostic and/or mixed age samples. The aim of our study was to investigate similarities and differences of networks in adolescents and adults with anorexia nervosa (AN) or bulimia nervosa (BN). Read More

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PEG-PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy.

J Mater Chem B 2021 May;9(17):3666-3676

Department of Chemistry, National Institute of Technology Rourkela, Odisha, 769008, India.

A novel hybrid drug carrier has been designed, taking N-doped mesoporous carbon (NMCS) as the core and PEG-PEI as the outer shell. NMCS was functionalized with a photocleavable nitrobenzyl-based linker following a click reaction. Gemcitabine was loaded into NMCS prior to the functionalization via π-π stacking interactions. Read More

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Rationally designed hierarchical C/TiO/Ti multilayer core-sheath wires for high-performance energy storage devices.

Nanoscale 2021 May 4. Epub 2021 May 4.

School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.

Fiber-shaped supercapacitors (FSCs) are promising power sources for wearable electronic devices due to their small size, excellent flexibility and deformability. The performance of FSCs has been severely affected by the framework of the fibrous electrodes and the interface between the electrode materials and current collector. Herein, we propose an ingenious strategy that combines anodizing etching and CVD methods to transform the less-active titanium wires into unique hierarchical carbon/TiO2 nanotube/Ti (CTNT) core-sheath wires, which have high conductivity, good mechanical strength and porous structure on the surface. Read More

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Wavy supramolecular polymers formed by hydrogen-bonded rosettes.

Chem Commun (Camb) 2021 May 4. Epub 2021 May 4.

Institute for Global Prominent Research (IGPR), Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. and Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

A barbiturate-functionalized supramolecular monomer bearing an ester-linked biphenyl and azobenzene π-conjugated core affords wavy supramolecular polymers. The periodic inversion of curvature is due to the conformational rigidity of the monomer and repulsive interactions between rosettes. Photoisomerization of the azobenzene moiety increases the fragility of the main chain without deteriorating its periodic structure. Read More

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Transformations of empty Cu core to CuCuO and CuS cores oxide and sulfide insertions.

Chem Commun (Camb) 2021 May 4. Epub 2021 May 4.

Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

[Cu4(LRh)4]8- ([1]8-; LRh = Δ-[Rh(l-cysteinate)3]3-), with an empty tetrahedral {CuI4}4+ core, was converted to [Cu4O(LRh)4]8- ([2]8-), with a mixed-valent {CuI2CuII2O}4+ core, in aqueous NaOH. A solid sample of the latter compound was converted back to [1]8- by heating under vacuum, while treatment of [1]8- with aqueous NaSH caused conversion to [Cu6S(LRh)4]8- ([3]8-), with a stable octahedral {CuI6S}4+ core. Read More

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Enhanced NO-induced angiogenesis NO/HS co-delivery from self-assembled nanoparticles.

Biomater Sci 2021 May 5. Epub 2021 May 5.

Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.

Nitric oxide (NO) and hydrogen sulfide (H2S) have been the focus of research as therapeutic agents because of their biological functions. The controlled release of NO and H2S can enhance NO-induced angiogenesis by H2S inhibiting PDE5A. Polymeric carriers have been researched to deliver gasotransmitters and used as therapeutic agents because of their important ability to help control the concentration of NO and H2S. Read More

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Fabrication and application of a novel electrochemical biosensor based on a mesoporous carbon sphere@UiO-66-NH/Lac complex enzyme for tetracycline detection.

Analyst 2021 May;146(9):2825-2833

School of Life and Environmental Science, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, PR China.

The overuse of tetracycline results in a threat to human, poultry and livestock health. An enzymatic electrochemical biosensor is an ideal alternative method for accurate and rapid tetracycline detection, while the unstable and easily deactivated nature of the enzyme limits its development. To overcome these limitations, a highly sensitive enzymatic electrochemical biosensor for the determination of tetracycline is developed in this work based on a complex enzyme which was constructed using a mesoporous carbon sphere@UiO-66-NH2 (MCS@UiO-66-NH2) core-shell composite with embedded laccase (Lac). Read More

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Modification of boron-doped diamond electrodes with gold-palladium nanoparticles for an oxygen sensor.

Analyst 2021 May;146(9):2842-2850

Dept. of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Yokohama 223-8522, Japan.

Modification of boron-doped diamond (BDD) with gold-palladium nanoparticles (Au@PdNPs) was successfully performed. Prior to the modification, BDD was modified with allylamine to provide active sites for the attachment of nanoparticles, while the synthesis of Au@PdNPs was performed by chemical reduction of a palladium salt solution in a colloidal solution of gold nanoparticles. Characterization using TEM images showed that by controlling the palladium concentration, flower and core-shell shaped Au@PdNPs can be prepared. Read More

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Critically ill patients' experience of agitation: A qualitative meta-synthesis.

Nurs Crit Care 2021 May 4. Epub 2021 May 4.

Division of Nursing, Midwifery and Social Work, School of Health Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Acute episodes of agitation are frequently experienced by patients during critical illness, yet what is not understood is the experience of agitation from the patient and family perspectives.

Aims And Objectives: To search existing literature, appraise it and then provide a synthesized interpretation to broaden the understanding of patients' and their families' experience of agitation during an adult critical care admission.

Design: Qualitative meta-synthesis. Read More

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Costunolide suppresses melanoma growth via the AKT/mTOR pathway and .

Am J Cancer Res 2021 15;11(4):1410-1427. Epub 2021 Apr 15.

Department of Animal Science and Biotechnology, Kyungpook National University Sangju-si, Gyeongsang buk-do 37224, Republic of Korea.

Melanoma is the most common type of skin cancer and its incidence is rapidly increasing. AKT, and its related signaling pathways, are highly activated in many cancers including lung, colon, and esophageal cancers. Costunolide (CTD) is a sesquiterpene lactone that has been reported to possess neuroprotective, anti-inflammatory, and anti-cancer properties. Read More

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Using attendance data for social network analysis of a community-engaged research partnership.

J Clin Transl Sci 2020 Dec 21;5(1):e75. Epub 2020 Dec 21.

Community and Collaboration Core, The Rockefeller University, Center for Clinical and Translational Science, New York, NY, USA.

Background: The Rockefeller University Center for Clinical and Translational Science (RU-CCTS) and Clinical Directors Network (CDN), a Practice-Based Research Network (PBRN), fostered a community-academic research partnership involving Community Health Center (CHCs) clinicians, laboratory scientists, clinical researchers, community, and patient partners. From 2011 to 2018, the partnership designed and completed Community-Associated Methicillin-Resistant Project (CAMP1), an observational study funded by the National Center for Advancing Translational Sciences (NCATS), and CAMP2, a Comparative Effectiveness Research Study funded by the Patient-Centered Outcomes Research Institute (PCORI). We conducted a social network analysis (SNA) to characterize this Community-Engaged Research (CEnR) partnership. Read More

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December 2020

Aligning community-engaged research competencies with online training resources across the Clinical and Translational Science Award Consortium.

J Clin Transl Sci 2020 Sep 11;5(1):e45. Epub 2020 Sep 11.

School of Nursing, Johns Hopkins University, Baltimore, MD, USA.

Introduction: The extent to which Clinical and Translational Science Award (CTSA) programs offer publicly accessible online resources for training in community-engaged research (CEnR) core competencies is unknown. This study cataloged publicly accessible online CEnR resources from CTSAs and mapped resources to CEnR core competency domains.

Methods: Following a search and review of the current literature regarding CEnR competencies, CEnR core competency domains were identified and defined. Read More

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September 2020

Development of an electronic health records datamart to support clinical and population health research.

J Clin Transl Sci 2020 Jun 23;5(1):e13. Epub 2020 Jun 23.

Duke Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Introduction: Electronic health record (EHR) data have emerged as an important resource for population health and clinical research. There have been significant efforts to leverage EHR data for research; however, given data security concerns and the complexity of the data, EHR data are frequently difficult to access and use for clinical studies. We describe the development of a Clinical Research Datamart (CRDM) that was developed to provide well-curated and easily accessible EHR data to Duke University investigators. Read More

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Lessons learned about harmonizing survey measures for the CSER consortium.

J Clin Transl Sci 2020 Apr 24;4(6):537-546. Epub 2020 Apr 24.

Division of Ethics, Department of Medical Humanities and Ethics, Columbia University, New York, NY, USA.

Introduction: Implementation of genome-scale sequencing in clinical care has significant challenges: the technology is highly dimensional with many kinds of potential results, results interpretation and delivery require expertise and coordination across multiple medical specialties, clinical utility may be uncertain, and there may be broader familial or societal implications beyond the individual participant. Transdisciplinary consortia and collaborative team science are well poised to address these challenges. However, understanding the complex web of organizational, institutional, physical, environmental, technologic, and other political and societal factors that influence the effectiveness of consortia is understudied. Read More

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The DIAMOND portal: An innovative platform for sharing translational research workforce training and assessment resources.

J Clin Transl Sci 2020 Jul 6;4(6):480-484. Epub 2020 Jul 6.

Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, USA.

Although several initiatives have produced core competency domains for training the translational science workforce, training resources to help clinical research professionals advance these skills reside primarily within local departments or institutions. The Development, Implementation, and AssessMent of Novel Training in Domain (DIAMOND) project was designed to make this training more readily and publicly available. DIAMOND includes a digital portal to catalog publicly available educational resources and an ePortfolio to document professional development. Read More

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Clinical use and implications of sexual devices and sexually explicit media.

Nat Rev Urol 2021 May 4. Epub 2021 May 4.

Flare-Health, Amstelveen, Netherlands.

Given that sexual pleasure is a core component of sexual health, devices that are designed to enhance and diversify sexual pleasure are particularly useful in clinical practice. Despite their growing popularity and widespread use in various biopsychosocial circumstances, many taboos still seem to exist, as indicated by the paucity of scientific literature on the prevalence, application and effectiveness of sexual devices for therapeutic use. However, sex toys and sexual devices are commonly used and have a variety of indications to expand individual and partnered sexuality and to treat sexual difficulties. Read More

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Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study.

Sci Rep 2021 May 4;11(1):9452. Epub 2021 May 4.

Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei, 23142, Taiwan.

The diagnostic peripheral biomarkers are still lacking for the bipolar II disorder (BD-II). We used isobaric tags for relative and absolute quantification technology to identify five upregulated candidate proteins [matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)] for the diagnosis of BD-II. We analysed the differences in the plasma levels of these candidate proteins between BD-II patients and controls (BD-II, n = 185; Controls, n = 186) using ELISA. Read More

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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.

Science 2021 May 4. Epub 2021 May 4.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor-binding domain (RBD). In one subject, just four IgG lineages accounted for 93. Read More

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Cognitive control and emotional response in attention-deficit/ hyperactivity disorder comorbidity with disruptive, impulse-control, and conduct disorders.

BMC Psychiatry 2021 05 4;21(1):232. Epub 2021 May 4.

Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.

Background: This study investigated cognitive and emotional functioning in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and disruptive, impulse-control, and conduct disorders (DICCD).

Methods: Thirty patients with ADHD, 26 with DICCD, 22 with ADHD+DICCD were recruited from the outpatient department of Shanghai Changning Mental Health Center, plus 20 healthy controls (HC). Differences between the groups in cognitive and emotional functioning were examined using Golden's Stroop and Emotional Stroop tests. Read More

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Clinical significance and risk factors of International Society of Urological Pathology (ISUP) grade upgrading in prostate cancer patients undergoing robot-assisted radical prostatectomy.

BMC Cancer 2021 May 4;21(1):501. Epub 2021 May 4.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Hongo7-3-1, Bunkyo-Ku, Tokyo, Japan.

Background: The objective of this study is to investigate the clinical significance and risk factors of upgrading in the International Society of Urological Pathology (ISUP) Grade Group System in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer.

Methods: A total of 583 patients diagnosed with prostate cancer by systematic biopsy were treated with RARP without neoadjuvant therapy from November 2011 to December 2018. Clinicopathological data were obtained from our clinical records. Read More

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Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).

BMC Microbiol 2021 May 4;21(1):138. Epub 2021 May 4.

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease, Kunming, Yunnan, China.

Background: Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Read More

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Linkage Isomers of 4-Methylimidazolate Mn(II) Porphyrinates: Hindered or Unhindered?

Inorg Chem 2021 May 5. Epub 2021 May 5.

The University of Chinese Academy of Sciences, Beijing 100049, China.

Three different manganese(II) porphyrins have been exploited to react with 4-methylimidazolate (4-MeIm), and the five-coordinate products are characterized by ultraviolet-visible, single-crystal X-ray, and electronic paramagnetic resonance spectroscopies. Interestingly, 4-MeIm is found to bond to the metal center through either of the two N atoms (N1 or N3), which yielded two linkage isomers with either an unhindered or a hindered ligand conformation, respectively. Investigations revealed it is the large metal out-of-plane displacements (Δ and Δ ≥ 0. Read More

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