42,074 results match your criteria sciatic nerve

Protective and therapeutic effect of (S)-ginsenoside F1 on peripheral nerve degeneration targeting Schwann cells: a pharmaco-neuroanatomical approach.

Anat Sci Int 2021 Sep 17. Epub 2021 Sep 17.

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea.

Damaged peripheral nerves undergo peripheral neurodegenerative processes that are essential for the nerve regeneration. Peripheral neurodegenerative diseases, including diabetic peripheral neuropathy, are induced by irreversible nerve damage caused by abnormal peripheral nerve degeneration. However, until now, there have been no effective therapeutic treatments for these diseases. Read More

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September 2021

LncRNA SNHG16 promotes Schwann cell proliferation and migration to repair sciatic nerve injury.

Ann Transl Med 2021 Aug;9(16):1349

Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: To investigate the expression of long non-coding RNA (lncRNA) Snorna hostgene16 (SNHG16) in sciatic nerve injury tissues and cells. The molecular mechanism of SNHG16 regulating signal activator of transcription 3 (STAT3) expression through "sponge" adsorption of miR-93-5p was also studied.

Methods: A rat model of sciatic nerve injury was established, and primary Schwann cells (SCs) were extracted. Read More

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(leaves) supplementation exerts curative effects on promoting functional recovery in a mouse model of peripheral nerve injury.

Food Sci Nutr 2021 Sep 9;9(9):5016-5027. Epub 2021 Jul 9.

Institute of Nutrition and Food Science University of Dhaka Dhaka Bangladesh.

Peripheral nerve injuries are among those complicated medical conditions, which are still waiting for their highly effective first-line therapies. In this study, the role of crude leaves was evaluated at different doses for their effectiveness in improving functional recovery following sciatic nerve injury-induced in the mouse model. Thirty-two healthy albino mice were divided into four groups as Normal chow group (control,  = 8) and chow groups (50 mg/kg ( = 8), 100 mg/kg ( = 8) and 200 mg/kg ( = 8)). Read More

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September 2021

Neuroprotective effect of -theanine in a rat model of chronic constriction injury of sciatic nerve-induced neuropathic pain.

J Formos Med Assoc 2021 Sep 13. Epub 2021 Sep 13.

Department of Neurosurgery, Mackay Memorial Hospital, Taipei, 10449, Taiwan, ROC; Department of Medicine, Mackay Medical College, New Taipei City, 252, Taiwan, ROC. Electronic address:

Background/purpose: We investigated the protective efficacy of -theanine (LT), the major amino acid components of green tea, on chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain (NP) development and neuronal functional changes in rats.

Methods: Rats with NP induced by CCI of the left sciatic nerve and sham-operated rats received LT or saline solution, with pain sensitive tests of thermal hyperalgesia and mechanical allodynia. Motor and sensory nerve conduction velocities were measured after surgery. Read More

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September 2021

Successful use of ultrasound-guided peripheral nerve block for lower limb surgery in a patient with heart failure with reduced ejection fraction: a case report.

J Int Med Res 2021 Sep;49(9):3000605211045230

Department of Anaesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.

The number of patients with heart failure with reduced ejection fraction (HFrEF) is increasing. These patients have a reduced cardiorespiratory reserve. Therefore, preoperative evaluation is essential to determine the best type of anaesthesia to use in patients with HFrEF. Read More

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September 2021

Tuberculosis Presenting as an Inflammatory Pseudotumor of the Sciatic Nerve in a Rheumatoid Arthritis Patient Taking Etanercept.

J Rheumatol 2021 Sep 15. Epub 2021 Sep 15.

Bruno Miguel Fernandes, MD, Rheumatology Department, Centro Hospitalar Universitário São João; José Miguel Pereira, MD, Radiology Department, Centro Hospitalar Universitário São João; Pedro Rodrigues Pereira, MD, Pathology Department, Centro Hospitalar Universitário São João; Miguel Bernardes, MD, PhD, Rheumatology Department, Centro Hospitalar Universitário São João, Porto, Portugal. Address correspondence to Dr. B.M. Fernandes, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. Email: The authors declare no conflicts of interest relevant to this article. Ethics approval was granted by the authors' institution and the patient's informed consent was obtained.

Active tuberculosis (TB) in patients treated with anti-tumor necrosis factor-α (TNF-α) agents usually results from the reactivation of a latent infection. A 46-year-old woman with rheumatoid arthritis in Disease Activity Score in 28 joints remission who was taking etanercept (ETN) was admitted in our hospital due to a 4-month history of progressive hypoesthesia and paresthesia, initially on her left foot and later with extension up to the left knee. Read More

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September 2021

Kinetic analysis of pathogenicity and tissue tropism of gyrovirus 3 in experimentally infected chickens.

Vet Res 2021 Sep 15;52(1):120. Epub 2021 Sep 15.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, 271018, China.

Gyrovirus 3 (GyV3), the third novel emerging species of the genus Gyrovirus of the Anelloviridae family, has been described in multiple hosts. Epidemiologically, there are suggestions that GyV3 is associated with diarrhea/proventriculitis, however, no direct causal evidence exists between GyV3 infection and specific clinical diseases. Herein, we infected special pathogen-free (SPF) chickens with GyV3, and then assessed the pathogenicity and tissue tropism. Read More

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September 2021

The anterior cingulate cortex projection to the dorsomedial striatum modulates hyperalgesia in a chronic constriction injury mouse model.

Arch Med Sci 2021 15;17(5):1388-1399. Epub 2019 May 15.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.

Introduction: The aim of the study was to study the role of the anterior cingulate cortex (ACC)-dorsal midbrain striatum (DMS) in neuropathic pain in mice.

Material And Methods: Optogenetics has been increasingly used in neuroscience research to selectively and precisely control the activity of a defined group of central neurons to determine their roles in behavioral functions in animals. The most important opsins are blue-sensitive ChR2 and yellow-sensitive NpHR. Read More

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An injectable mesoporous silica-based analgesic delivery system prolongs the duration of sciatic nerve block in mice with minimal toxicity.

Acta Biomater 2021 Sep 11. Epub 2021 Sep 11.

All the authors are from Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233, China. Electronic address:

The major limitation of traditional local anesthetics is the finite duration of a single injection. The present study developed two kinds of novel injectable anesthetic nanocomposites based on mesoporous silica, and evaluated their long-lasting analgesic effect and biosafety. The nanoparticulate carriers, mesoporous silica nanoparticles (MSNs) and mesoporous silica-coated gold nanorods ([email protected]), were firstly constructed using the oil-water biphase reaction approach and then ropivacaine (RPC), a local anesthetic, was loaded into the mesoporous carriers by vacuum suction. Read More

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September 2021

ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair.

Stem Cells Transl Med 2021 Sep 14. Epub 2021 Sep 14.

Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, People's Republic of China.

Cutaneous wound healing requires intricate synchronization of several key processes. Among them, local nerve regeneration is known to be vitally important for proper repair. However, the underlying mechanisms of local nerve regeneration are still unclear. Read More

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September 2021

Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel.

Nat Biomed Eng 2021 Sep 13. Epub 2021 Sep 13.

Laboratory for Biomaterials and Drug Delivery, Department of Anaesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

Site-1 sodium channel blockers (S1SCBs) act as potent local anaesthetics, but they can cause severe systemic toxicity. Delivery systems can be used to reduce the toxicity, but the hydrophilicity of S1SCBs makes their encapsulation challenging. Here, we report a self-assembling delivery system for S1SCBs whose design is inspired by the specific interactions of S1SCBs with two peptide sequences on the sodium channel. Read More

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September 2021

Measuring the Appropriateness of Spinal Manipulation for Chronic Low Back and Chronic Neck Pain in Chiropractic Patients.

Spine (Phila Pa 1976) 2021 Oct;46(19):1344-1353

RAND Corporation, Santa Monica, CA.

Study Design: RAND/UCLA Appropriateness Method (RUAM) applied to chiropractic manipulation for patients with chronic low-back pain (CLBP) and chronic neck pain (CNP).

Objective: Determine the rate of appropriate care provided by US chiropractors.

Summary Of Background Data: Spinal manipulation has been shown effective for CLBP and CNP but may not be appropriate for all patients with these conditions. Read More

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October 2021

The influence of age on the anatomical variability of sciatic nerve divisions in the thigh: an ultrasound study.

Surg Radiol Anat 2021 Sep 13. Epub 2021 Sep 13.

IdiPaz, Research Institute, Madrid, Spain.

Purpose: The Sciatic Nerve Division (SND) into the Common Peroneal Nerve and Tibial Nerve presents a great anatomical variability in its location in the thigh, but the influence of age on it has not been fully addressed.

Methods: Anatomical distances from greater trochanter to SND and from SND to popliteal crease were obtained by ultrasound examination in 60 children (age 1-12 years) and 60 adult patients (age 13-80 years) who were scheduled for programmed surgery. A sciatic nerve/thigh coefficient [Greater Trochanter-SND/(Greater Trochanter-popliteal crease)*100] and its coefficient of variation (standard deviation/mean*100) were calculated. Read More

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September 2021

Ultrasonography Findings in the Proximal Sciatic Nerve and Deep Gluteal Muscles in 29 Dogs With Suspected Sciatic Neuritis.

Front Vet Sci 2021 27;8:704904. Epub 2021 Aug 27.

Veterinary Orthopedic and Sports Medicine Group, Annapolis Junction, MD, United States.

The present study aimed to describe the ultrasonography technique and analyze the ultrasonographic findings of the proximal sciatic nerve and deep gluteal muscles in dogs with suspected sciatic neuritis. The records of 29 dogs that underwent musculoskeletal ultrasound of the sciatic nerve and deep gluteal muscles were retrospectively evaluated. Both right and left sides were evaluated. Read More

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Elevated Expression and Activity of Sodium Leak Channel Contributes to Neuronal Sensitization of Inflammatory Pain in Rats.

Front Mol Neurosci 2021 27;14:723395. Epub 2021 Aug 27.

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Inflammatory pain encompasses many clinical symptoms, and there is no satisfactory therapeutic target. Neuronal hyperexcitability and/or sensitization of the primary nociceptive neurons in the dorsal root ganglion (DRG) and spinal dorsal horn are critical to the development and maintenance of inflammatory pain. The sodium leak channel (NALCN), a non-selective cation channel, mediates the background Na leak conductance and controls neuronal excitability. Read More

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MRI DTI and PDFF as Biomarkers for Lower Motor Neuron Degeneration in ALS.

Front Neurosci 2021 26;15:682126. Epub 2021 Aug 26.

Department of Neuroradiology, Center Hospital Luxembourg, Luxembourg City, Luxembourg.

Objective: To evaluate the utility of nerve magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and muscle MRI multi-echo Dixon for assessing lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS).

Methods: In this prospective observational cohort study, 14 patients with ALS and 13 healthy controls underwent a multiparametric MRI protocol, including DTI of the sciatic nerve and assessment of muscle proton density fat fraction of the biceps femoris and the quadriceps femoris muscles by a multi-echo Dixon sequence.

Results: In ALS patients, mean fractional anisotropy values of the sciatic nerve were significantly lower than those of healthy controls. Read More

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Elastin-like Proteins to Support Peripheral Nerve Regeneration in Guidance Conduits.

ACS Biomater Sci Eng 2021 09 4;7(9):4209-4220. Epub 2020 Nov 4.

Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States.

Synthetic nerve guidance conduits (NGCs) offer an alternative to harvested nerve grafts for treating peripheral nerve injury (PNI). NGCs have been made from both naturally derived and synthesized materials. While naturally derived materials typically have an increased capacity for bioactivity, synthesized materials have better material control, including tunability and reproducibility. Read More

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September 2021

Lactate administration does not affect denervation-induced loss of mitochondrial content and muscle mass in mice.

FEBS Open Bio 2021 Sep 12. Epub 2021 Sep 12.

Department of Sports Sciences, The University of Tokyo, Tokyo, Japan.

Lactate is considered to be a signaling molecule that induces mitochondrial adaptation and muscle hypertrophy. The purpose of this study was to examine whether lactate administration attenuates denervation-induced loss of mitochondrial content and muscle mass. Eight-week-old male Institute of Cancer Research (ICR) mice underwent unilateral sciatic nerve transection surgery. Read More

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September 2021

Comparing axon regeneration in male and female mice after peripheral nerve injury.

J Neurosci Res 2021 Sep 12. Epub 2021 Sep 12.

Laboratory of Neuroscience, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.

Axons in the adult mammalian central nervous system fail to regenerate after injury. By contrast, spontaneous axon regeneration occurs in the peripheral nervous system (PNS) due to a supportive PNS environment and an increase in the intrinsic growth potential induced by injury via cooperative activation of multifaceted biological pathways. This study compared axon regeneration and injury responses in C57BL/6 male and female mice after sciatic nerve crush (SNC) injury. Read More

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September 2021

Metabolic control of sensory neuron survival by the p75 neurotrophin receptor in Schwann cells.

J Neurosci 2021 Sep 7. Epub 2021 Sep 7.

Department of Biological Chemistry and Pharmacology, Ohio State University, Columbus, OH, USA

We report that the neurotrophin receptor p75 contributes to sensory neuron survival through the regulation of cholesterol metabolism in Schwann cells. Selective deletion of p75 in mouse Schwann cells of either sex resulted in a 30% loss of dorsal root ganglia (DRG) neurons and diminished thermal sensitivity. P75 regulates Schwann cell cholesterol biosynthesis in response to BDNF, forming a co-receptor complex with ErbB2 and activating ErbB2-mediated stimulation of SREBP2, a master regulator of cholesterol synthesis. Read More

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September 2021

Sciatic Nerve Hematoma - Case Report.

Neurol India 2021 Jul-Aug;69(4):1043-1044

Department of Radiology and Imaging Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Hemorrhagic neuropathy is an extremely rare condition. This condition refers to bleed into or around a peripheral nerve, causing either an extra neural or an intraneural hematoma. When they do occur, it is usually due to iatrogenic/inherited coagulopathies or as a consequence of injections targeting nerves. Read More

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September 2021

Nerve conduction assessment and magnetic resonance imaging for the diagnosis of localized hypertrophic neuropathy of the sciatic nerve and the lumbo-sacral plexus.

Clin Neurol Neurosurg 2021 Aug 28;209:106917. Epub 2021 Aug 28.

Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Localized hypertrophic neuropathy (LHN) are slowly growing nerve lesions causing progressive nerve deficit and weakness. We present the case of a 32-year old woman with long history of motor and sensory deficit complains along the sciatic nerve territory. The muscles involved were featured by delay in F waves at nerve conduction assessment. Read More

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Exosomes Secreted by Adipose-Derived Stem Cells Following FK506 Stimulation Reduce Autophagy of Macrophages in Spine after Nerve Crush Injury.

Int J Mol Sci 2021 Sep 6;22(17). Epub 2021 Sep 6.

Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Macrophages emerge in the milieu around innervated neurons after nerve injuries. Following nerve injury, autophagy is induced in macrophages and affects the regulation of inflammatory responses. It is closely linked to neuroinflammation, while the immunosuppressive drug tacrolimus (FK506) enhances nerve regeneration following nerve crush injury and nerve allotransplantation with additional neuroprotective and neurotrophic functions. Read More

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September 2021

Exercise, but Not Metformin Prevents Loss of Muscle Function Due to Doxorubicin in Mice Using an In Situ Method.

Int J Mol Sci 2021 Aug 25;22(17). Epub 2021 Aug 25.

Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT 84602, USA.

Though effective in treating various types of cancer, the chemotherapeutic doxorubicin (DOX) is associated with skeletal muscle wasting and fatigue. The purpose of this study was to assess muscle function in situ following DOX administration in mice. Furthermore, pre-treatments with exercise (EX) or metformin (MET) were used in an attempt to preserve muscle function following DOX. Read More

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In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Laboratory of Veterinary Toxicology, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.

Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Read More

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Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.

Clin Neurol Neurosurg 2021 Aug 28;209:106920. Epub 2021 Aug 28.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background And Aims: Nerve capping treatment using bioabsorbable nerve conduits has recently been introduced for painful amputation neuroma. However, no clinical or experimental data are available for comparing nerve conduits with open distal ends and closed distal ends. Here, we investigated the nerve conduit with open or closed distal ends as the superior capping device, using a commercially available polyglycolic acid (PGA) nerve conduit in a rat sciatic nerve amputation model. Read More

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Conductive conduit based on electrospun poly (l-lactide-co-D, l-lactide) nanofibers containing 4-aminopyridine-loaded molecularly imprinted poly (methacrylic acid) nanoparticles used for peripheral nerve regeneration.

Int J Biol Macromol 2021 Sep 7;190:499-507. Epub 2021 Sep 7.

Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box: 11155-4563, Tehran, Iran.

Using biocompatible polymer nanofibrous conduits with a controlled drug delivery have attracted much attention for peripheral nerve regeneration. This work was aimed at preparing electrospun poly (l-lactide-co-D, l-lactide) (PLDLLA) containing multi-walled carbon nanotubes (MWCNTs) and 4-aminopyridine (4-AP)-loaded molecularly imprinted nanoparticles (MIP) as well as evaluating their performance in in vitro and in vivo assessments. After synthesis of MIP based on poly (methacrylic acid) with imprinting factor of 1. Read More

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September 2021

The co-administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens.

Vet Med Sci 2021 Sep 8. Epub 2021 Sep 8.

Department of Food Science and Technology, Ardestan Branch, Islamic Azad University, Ardestan, Iran.

The study aimed to examine the effect of simultaneous application of florfenicol and lasalocid on the performance and vital organ function of chickens. For this, 300 chicks were divided into four groups. Group one to three received florfenicol, lasalocid and lasalocid plus florfenicol, respectively. Read More

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September 2021

Effects of the addition of dexamethasone on postoperative analgesia after anterior cruciate ligament reconstruction surgery under quadruple nerve blocks.

BMC Anesthesiol 2021 09 8;21(1):218. Epub 2021 Sep 8.

Department of Anesthesiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo City, Shimane, 693-8501, Japan.

Background: Anterior cruciate ligament (ACL) reconstruction is an invasive surgical procedure for the knee. Quadruple nerve blocks including continuous femoral nerve block and single-injection sciatic, obturator, and lateral femoral cutaneous nerve blocks can provide effective intraoperative anesthesia and analgesia in the early postoperative period. However, severe pain often appears after the effect of single-injection nerve blocks resolves and that is why we conducted two studies. Read More

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September 2021