901 results match your criteria scheimpflug imaging


Imaging Fuchs Endothelial Corneal Dystrophy in Clinical Practice and Clinical Trials.

Authors:
Sanjay V Patel

Cornea 2021 Jun 1. Epub 2021 Jun 1.

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Abstract: Corneal tomography has an emerging role in the assessment of Fuchs endothelial corneal dystrophy (FECD) in clinical practice and potentially for future clinical trials. Posterior elevation and pachymetry maps derived from elevation based Scheimpflug tomography can detect early corneal edema, even at a subclinical stage, enabling clinicians to better counsel patients about their vision and the risk of disease progression with and without cataract surgery. Tomographic imaging provides a functional assessment of corneal endothelial health, and could enable objective assessment of FECD progression, or regression, in response to novel therapeutic interventions. Read More

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Anterior Chamber Characteristics, Endothelial Parameters, and Corneal Densitometry After Descemet Stripping Automated Endothelial Keratoplasty in Patients With Fuchs Dystrophy.

J Ophthalmic Vis Res 2021 Apr-Jun;16(2):158-164. Epub 2021 Apr 29.

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA.

Purpose: To compare anterior segment parameters in patients with Fuchs endothelial dystrophy (FED) who underwent Descemet stripping automated endothelial keratoplasty (DSAEK) in one eye and no corneal surgery in the fellow eye.

Methods: This prospective study was conducted on 28 eyes of 14 patients with FED who underwent DSAEK in one eye at least one year prior (DSAEK group) and no corneal surgery in the fellow eye (control group). Each eye was analyzed with the anterior segment optical coherence tomography, specular microscopy, and Scheimpflug imaging systems. Read More

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Comparison of total keratometry with corneal power measured by optical low-coherence reflectometry and placido-dual Scheimpflug system.

Eur J Ophthalmol 2021 May 29:11206721211020633. Epub 2021 May 29.

Cataract and Refractive Surgery Services, Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To compare the total keratometry (TK) and astigmatism measurements in eyes with cataract using automated keratometry of sweptsource optical coherence tomography (ss-OCT), optical low-coherence reflectometry (OLCR), simulated keratometry (SimK), and total corneal power (TCP) of combined placidodual Scheimpflug imaging system.

Setting: The study was conducted at LV Prasad Eye Institute, Hyderabad, India.

Design: Retrospective evaluation of electronic medical records of patients who were evaluated for cataract surgery. Read More

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Effects of hormone replacement therapy on lens opacity, serum inflammatory cytokines, and antioxidant levels.

Ann Med 2021 Dec;53(1):707-714

Department of Ophthalmology, The Catholic University of Korea, Seoul, Korea.

Purpose: To evaluate the effect of hormone replacement therapy (HRT) on lens opacity as measured by Scheimpflug densitometry, serum inflammatory cytokines, and antioxidant levels.

Methods: A total of 264 women who were at least five years beyond menopause were included. The control group of 128 patients (Group 1) did not use HRT at any time after menopause. Read More

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December 2021

Radiation-Induced Lens Opacity and Cataractogenesis: A Lifetime Study Using Mice of Varying Genetic Backgrounds.

Radiat Res 2021 May 13. Epub 2021 May 13.

Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, United Kingdom.

Recent epidemiological findings and reanalysis of historical data suggest lens opacities resulting from ionizing radiation exposures are likely induced at lower doses than previously thought. These observations have led to ICRP recommendations for a reduction in the occupational dose limits for the eye lens, as well as subsequent implementation in EU member states. The EU CONCERT LDLensRad project was initiated to further understand the effects of ionizing radiation on the lens and identify the mechanism(s) involved in radiation-induced cataract, as well as the impact of dose and dose-rate. Read More

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A risk prediction model for endothelial keratoplasty after uncomplicated cataract surgery in Fuchs endothelial corneal dystrophy.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

Cornea Unit, Department of Ophthalmology, Ramón y Cajal University Hospital, IRYCIS, Madrid (Spain).

Purpose: To develop a risk prediction model for endothelial keratoplasty (EK) after uncomplicated cataract surgery in Fuchs endothelial corneal dystrophy (FECD) using Scheimpflug imaging.

Design: Prospective, observational cohort study.

Methods: The study was conducted at the Ramón y Cajal University Hospital (Madrid, Spain) on 127 eyes from 93 consecutive patients with vision loss, FECD, and cataracts. Read More

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Hyperosmolar eye drops for diurnal corneal edema in Fuchs' endothelial dystrophy: a double-blind randomized-controlled trial.

Ophthalmology 2021 Apr 20. Epub 2021 Apr 20.

Eye Center, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Purpose: The Eye Drops for Early Morning-Associated Swelling (EDEMAS) trial assessed the efficacy of hyperosmolar eye drops on corneal edema resolution.

Design: Double-blind randomized-controlled trial of hyperosmolar eye drops vs. placebo. Read More

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Corneal Biomechanical Assessment with Ultra-High-Speed Scheimpflug Imaging During Non-Contact Tonometry: A Prospective Review.

Clin Ophthalmol 2021 6;15:1409-1423. Epub 2021 Apr 6.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Background: In recent years, increasing interest has arisen in the application of data from corneal biomechanics in many areas of ophthalmology, particularly to assist in the detection of early corneal ectasia or ectasia susceptibility, to predict corneal response to surgical or therapeutic interventions and in glaucoma management. Technology has evolved and, recently, the Scheimpflug principle was associated with a non-contact air-puff tonometer, allowing a thorough analysis of corneal biomechanics and a biomechanically corrected intraocular pressure assessment, opening up new perspectives both in ophthalmology and in other medical areas. Data from corneal biomechanics assessment are being integrated in artificial intelligence models in order to increase its value in clinical practice. Read More

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Terahertz scanning of the rabbit cornea with experimental UVB-induced damage: in vivo assessment of hydration and its verification.

J Biomed Opt 2021 Apr;26(4)

Moscow Pedagogical State University, Department of Physics, Moscow, Russia.

Significance: Water content plays a vital role in the normally functioning visual system; even a minor disruption in the water balance may be harmful. Today, no direct method exists for corneal hydration assessment, while it could be instrumental in early diagnosis and control of a variety of eye diseases. The use of terahertz (THz) radiation, which is highly sensitive to water content, appears to be very promising. Read More

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How direct measurements on worker eyes with Scheimpflug camera can affect lens dose conversion coefficients in interventional radiology.

J Radiol Prot 2021 Apr 7. Epub 2021 Apr 7.

Industrial Engineering - Montecuccolino Laboratory, University of Bologna, Via dei Colli 16, 40136 Bologna, Italy, Bologna, BO, 40136, ITALY.

The Directive 2013/59/Euratom established a reduction of the occupational exposure limits to the lens. Since it is become crucial to estimate the lens absorbed dose, the individual variability of exposed worker's ocular conformations with respect to the data estimated with their personal dosimetry has been studied. The anterior eye conformation of 45 exposed workers was acquired with Scheimpflug imaging and classified according to eye vision conditions (emmetropia, myopia or hypermetropia). Read More

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Influence of rebubbling on anterior segment parameters and refractive outcomes in eyes with DMEK for Fuchs endothelial dystrophy.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 6. Epub 2021 Apr 6.

Department of Ophthalmology, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Purpose: To evaluate the potential impact of rebubbling on the anterior segment parameters and refractive outcomes in patients with graft detachment following uneventful DMEK for Fuchs endothelial dystrophy (FED).

Methods: Retrospective institutional cohort study of comparing 34 eyes of 31 patients with rebubbling for graft detachment following Descemet membrane endothelial keratoplasty (DMEK) to 33 eyes of 28 patients with uneventful DMEK. Main outcome parameters were various corneal parameters obtained by Scheimpflug imaging, refractive outcome, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). Read More

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Corneal Densitometry Assessed With Scheimpflug Camera in Healthy Corneas and Correlation With Specular Microscopy Values and Age.

Cornea 2021 Apr 1. Epub 2021 Apr 1.

Ophthalmology Department, Hellenic Air Force General Hospital, Athens, Greece; Ophthalmology Department, Hellenic Air Force General Hospital and Attikon University Hospital, Athens, Greece; and Ophthalmology Department, Hellenic Army General Hospital, Athens, Greece.

Purpose: To investigate correlations between specular microscopy endothelial parameters and age with corneal densitometry values, as they are presented from a Scheimpflug device, in different levels of the cornea.

Methods: Two hundred eighty-four eyes of 142 healthy subjects were included in this observational, prospective study. Corneal densitometry was evaluated with Scheimpflug imaging system in the central 0- to 2-mm annular zone of the cornea, whereas the endothelial cell properties were assessed with the use of a noncontact specular microscope. Read More

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Anterior chamber morphology changes in eyes with narrow angles by Scheimpflug imaging: Pilocarpine versus laser peripheral iridotomy.

Int Ophthalmol 2021 Jun 24;41(6):2099-2108. Epub 2021 Mar 24.

Department of Clinical Research, C L Gupta Eye Institute, Ram Ganga Vihar, Phase 2(Ext), Moradabad, 244001, India.

Purpose: To evaluate morphometric variables, like anterior chamber angle (ACA), anterior chamber volume (ACV) and central anterior chamber depth (CACD) after pilocarpine administration and after prophylactic laser peripheral iridotomy (LPI) in eyes with primary angle-closure disease (PACD).

Design: Prospective cohort study METHODS: Ninety-one eyes of 91 patients with narrow angles were consecutively enrolled in this prospective interventional study. All patients were classified into primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG). Read More

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Clinical Characteristics of Highly Myopic Patients With Asymmetric Myopic Atrophic Maculopathy-Analysis Using Multimodal Imaging.

Invest Ophthalmol Vis Sci 2021 Mar;62(3):21

Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Purpose: To evaluate the factors associated with asymmetric myopic atrophic maculopathy (MAM) in highly myopic patients.

Methods: We enrolled highly myopic patients with asymmetric MAM according to the atrophy, traction, and neovascularization (ATN) classification. The results of color fundus photography, optical coherence tomography (OCT), OCT angiography, and corneal visualization Scheimpflug technology (Corvis ST tonometry) were reviewed. Read More

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Partial corneal recovery following selective trabeculoplasty-induced keratopathy: Longitudinal analysis through scheimpflug imaging.

Am J Ophthalmol Case Rep 2021 Jun 26;22:101062. Epub 2021 Feb 26.

Glaucoma Unit, Hospital Medicina dos Olhos, 207, Salem Bechara Street, Osasco, São Paulo, 06018-180, Brazil.

Purpose: To report an uncommon case of hyperopic shift and corneal haze, flattening and thinning following a single session of selective laser trabeculoplasty (SLT), and provide longitudinal clinical data and serial analyses of corneal profile through Scheimpflug imaging. Furthermore, a careful literature review was undertaken to determine possible risk factors for this complication.

Observations: A 47-year-old woman presented with blurred vision and mild corneal edema and haze three days following routine SLT. Read More

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Distribution of Eccentricity in Children Aged 6-12 Years.

Semin Ophthalmol 2021 Mar 9:1-5. Epub 2021 Mar 9.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To determine the distribution of eccentricity and its association with some biometric and demographic parameters.

Methods: In this cross-sectional study, the target population was primary school children aged 6 to 12 years from Shahroud, northeast Iran. Scheimpflug imaging was done using the Pentacam. Read More

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Refractive Outcomes and Anterior Chamber Depth after Cataract Surgery in Eyes with and without Previous Pars Plana Vitrectomy.

Curr Eye Res 2021 Mar 5:1-8. Epub 2021 Mar 5.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

To compare the differences in refractive outcome and anterior chamber depth (ACD) after phacoemulsification between eyes with and without previous pars plana vitrectomy (PPV). Patients who had significant cataracts after PPV were included in the study group, and patients with a matched axial length (AL) who had cataracts without PPV were selected as the control group. The performance of new generation intraocular lens (IOL) power calculation formulas (Barrett Universal II, Kane, Ladas Super formulas), and the traditional formulas (SRK/T, Holladay 1, Hoffer Q, Haigis) with and without the Wang-Koch (WK) AL adjustment were compared between the two groups. Read More

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Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses.

Quant Imaging Med Surg 2021 Mar;11(3):983-997

Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.

Background: Conventional light sheet fluorescence microscopy (LSFM), or selective plane illumination microscopy (SPIM), enables high-resolution 3D imaging over a large volume by using two orthogonally aligned objective lenses to decouple excitation and emission. The recent development of oblique plane microscopy (OPM) simplifies LSFM design with only one single objective lens, by using off-axis excitation and remote focusing. However, most reports on OPM have a limited microscopic field of view (FOV), typically within 1×1 mm. Read More

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The Role of Corneal Biomechanics in the Assessment of Ectasia Susceptibility Before Laser Vision Correction.

Clin Ophthalmol 2021 19;15:745-758. Epub 2021 Feb 19.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Purpose: To describe the tomographic and corneal biomechanical status of a sample of eyes excluded from LVC and to present the differences in biomechanical behavior in relation to cutoffs of clinical- and tomography-based screening methods used in clinical practice.

Patients And Methods: Observational cross-sectional study including 61 eyes from 32 consecutive patients who were excluded from LVC in our department. Clinical and demographic data were collected from the patients' clinical records. Read More

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February 2021

The use of infrared thermal imaging in tonometry with a Scheimpflug camera.

J Therm Biol 2021 Feb 20;96:102823. Epub 2021 Jan 20.

Institute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia in Katowice, ul. Będzińska 39, Sosnowiec 41-200, Poland; Department of Ophthalmology, District Railway Hospital, Panewnicka 65, 40-760, Katowice, Poland. Electronic address:

Infrared thermal imaging is currently used in almost every field of medicine. This paper presents the novel use of thermography in ophthalmology - using a thermal camera to assess correct intraocular pressure measurement depending on the position of the patient's head during non-contact tonometry. For the analysed group of 10 healthy subjects, thermographic images of the face were recorded before and after intraocular pressure testing. Read More

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February 2021

Predicting Edema Resolution After Descemet Membrane Endothelial Keratoplasty for Fuchs Dystrophy Using Scheimpflug Tomography.

JAMA Ophthalmol 2021 Apr;139(4):423-430

Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Importance: Predicting the extent of corneal edema resolution after Descemet membrane endothelial keratoplasty (DMEK) may help in preoperative decision-making by identifying patients who may benefit from restoring endothelial function.

Objective: To develop and validate a predictive model for edema resolution after DMEK using Scheimpflug tomographic imaging.

Design, Setting, And Participants: Two prospective studies recruited participants with advanced Fuchs dystrophy at a university-based tertiary referral center between July 1, 2017, and August 31, 2019. Read More

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The impact of celiac disease and duration of gluten free diet on anterior and posterior ocular structures: Ocular imaging based study.

Photodiagnosis Photodyn Ther 2021 Feb 12;34:102214. Epub 2021 Feb 12.

Ophthalmology Department, Istanbul Kartal Doctor Lütfi Kırdar City Hospital, Istanbul, Turkey. Electronic address:

Purpose: To evaluate the eyes of adult celiac disease (CD) patients and investigate the association between these ocular parameters with celiac specific antibodies and duration of gluten free diet (GFD).

Methods: This cross-sectional study included 72 eyes of 36 CD patients (18-51 years of age) and 70 eyes of 35 age- and sex-matched healthy controls. In addition to a complete ophthalmologic examination, all patients were scanned by a Scheimpflug camera, specular microscopy and spectral domain optical coherence tomography. Read More

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February 2021

Intracorneal circular ring implant with femtosecond laser: Pocket versus tunnel.

Eur J Ophthalmol 2021 Feb 12:1120672121994729. Epub 2021 Feb 12.

Research Department, Oftalmosalud Institute of Eyes, Lima, Peru.

Purpose: To evaluate and compare visual and refractive outcomes after implantation of the intracorneal continuous ring 360° arc (ICCR) versus the intracorneal ring segment 340° arc (ICRS) using femtosecond laser for central keratoconus.

Setting: Research Department, Oftalmosalud, Instituto de Ojos, Lima, Peru.

Methods: Randomized study that included 40 eyes of 32 patients diagnosed with central keratoconus between November 2014 and March 2015. Read More

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February 2021

Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma.

Can J Ophthalmol 2021 Feb 10. Epub 2021 Feb 10.

Ophthalmology Unit, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid, Spain.

Objective: To describe corneal densitometry, topographic measurements, and biomechanical properties in patients with primary congenital glaucoma (PCG) and healthy patients. To examine correlations between variables and determine their glaucoma diagnostic capacity.

Methods: This was a cross-sectional, case-control study conducted in 50 eyes of 50 patients with PCG (G1) and 40 eyes of 40 healthy patients (G2). Read More

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February 2021

Topographic, elevation, and keratoconus indices for diagnosis of keratoconus by a combined Placido and Scheimpflug topography system.

Eur J Ophthalmol 2021 Feb 7:1120672121991725. Epub 2021 Feb 7.

Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Purpose: To determine the accuracy of various corneal parameters in keratoconus diagnosis using Scheimpflug camera combined with Placido disk corneal topography (Sirius, CSO).

Methods: One hundred and fifteen keratoconic eyes (group1) and a 111 normal eyes (group2) were assessed prospectively between March 2018 and July 2019 for: corneal keratometric indices (K1, K2, sim K, apex curvature) at different corneal rings of both corneal surfaces, central corneal thickness (CCT), thinnest corneal thickness (TL), corneal asphericity (Q), elevation at thinnest point, root mean square (RMS), and root mean square per area (RMS/A) in spherical, aspheric and aspherotoric reference for both corneal surfaces and keratoconus summary parameters; surface asymmetry index of front and back (SIf, SIb respectively), elevation at keratoconus vertex front and back (KVf, KVb respectively), Baiocchi Calossi Versaci front and back index (BCVf, BCVb) and its vector summation (BCV) and convergence radius and cutoff value for each was calculated.

Results: All studied indices were significantly different between the two groups. Read More

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February 2021

Atypical presentation of peripheral posterior lenticonus and role of multi-modal ocular imaging in its diagnosis and management.

BMJ Case Rep 2021 Feb 5;14(2). Epub 2021 Feb 5.

Ophthalmology, All India Institute of Medical Sciences, New Delhi, India

A 6-year-old systemically healthy child presented with visual acuity of 1/60, N18 oculusdextrus (OD), and 6/18, N6 oculus sinister (OS). Slit-lamp biomicroscopy revealed suspicious bilateral inferotemporal pigmented ciliary body (CB) tumour, protruding posterior capsule and temporal posterior subcapsular cataract oculus uterque. Anterior segment optical coherence tomography, ultrasonography, ultrasonic biomicroscopy and Scheimpflug imaging revealed protruding posterior capsule and cortex abutting but not arising from CB suggestive of peripheral pigmented posterior lenticonus with hypermetropia (axial length 20. Read More

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February 2021

Agreement of keratometric readings measured using rotating Scheimpflug imaging, auto-refractokeratometer, and biograph in eyes with keratoconus.

Int Ophthalmol 2021 May 5;41(5):1659-1669. Epub 2021 Feb 5.

Department of Ophthalmology, Hisar Intercontinental Hospital, 34768, Istanbul, Turkey.

Aim: To determine agreement in keratometric readings obtained using rotating Scheimpflug imaging with Pentacam, biograph with Lenstar LS900, and Topcon KR-8100P auto-keratorefractometer in eyes with different stages of keratoconus.

Methods: A total of 89 eyes of 58 patients with keratoconus were examined in this study, retrospectively. The eyes were divided into two groups: mild group (group 1: 42 eyes) (Amsler-Krumeich stage 1) and moderate-to-severe group (group 2: 47 eyes) (Amsler-Krumeich stage 2, 3, 4). Read More

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Visual outcomes of surgical and conservative treatment in children with small posterior polar cataracts and posterior lenticonus.

Int J Ophthalmol 2021 18;14(1):64-71. Epub 2021 Jan 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.

Aim: To compare the visual outcomes of children with small (≤3 mm) posterior polar cataracts (PPC) and posterior lenticonus who had cataract extraction surgery with the visual outcomes of those who were managed conservatively.

Methods: Children who initially had small PPC and posterior lenticonus who were followed up over 1-year period were retrospective reviewed in the study. Patients receiving surgery were compared with those receiving conservative therapy. Read More

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January 2021

Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice.

Int J Radiat Biol 2021 1;97(4):529-540. Epub 2021 Mar 1.

Institute of Developmental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany.

Purpose: The long-term effect of low and moderate doses of ionizing radiation on the lens is still a matter of debate and needs to be evaluated in more detail.

Material And Methods: We conducted a detailed histological analysis of eyes from B6C3F1 mice cohorts after acute gamma irradiation (Co source; 0.063 Gy/min) at young adult age of 10 weeks with doses of 0. Read More

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Ionising radiation causes vision impairment in neonatal B6C3F1 mice.

Exp Eye Res 2021 Mar 14;204:108432. Epub 2021 Jan 14.

Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany. Electronic address:

Ionising radiation interacts with lenses and retinae differently. In human lenses, posterior subcapsular cataracts are the predominant observation, whereas retinae of adults are comparably resistant to even relatively high doses. In this study, we demonstrate the effects of 2 Gy of low linear energy transfer ionising radiation on eyes of B6C3F1 mice aged postnatal day 2. Read More

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