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Mild sodium reduction in peritoneal dialysis solution improves hypertension in end stage kidney disease: a case-report study.

BMC Nephrol 2021 May 8;22(1):170. Epub 2021 May 8.

Department of Advanced Medical and Surgical Sciences, Nephrology Unit of University of Campania "Luigi Vanvitelli", Piazza Miraglia, 80138, Naples, Italy.

Introduction: Blood Pressure (BP) control is largely unsatisfied in End Stage Kidney Disease (ESKD) principally due to sodium retention. Peritoneal Dialysis (PD) is the most common type of home dialysis, using a peritoneal membrane to remove sodium, though sodium removal remains challenging.

Methods: This is a case-study reporting two consecutive ESKD patients treated by a novel peritoneal PD solution with a mildly reduced sodium content (130 mmol/L) to treat hypertension. Read More

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Winter warm-up frequency and the degree of temperature fluctuations affect survival outcomes of spotted-wing drosophila winter morphotypes.

J Insect Physiol 2021 Apr 28;131:104246. Epub 2021 Apr 28.

Department of Entomology, Cornell AgriTech, Geneva, NY 14424, USA. Electronic address:

Among overwintering Drosophila suzukii, discrete environmental changes in temperature and photoperiod induce a suite of biochemical changes conferring cold tolerance. However, little is known regarding how temperature fluctuations, which can influence metabolic and cellular repair activity, affect survival outcomes in this species. For that reason, we designed three experiments to test the effects of intermittent warm-up periods and the degree of temperature fluctuation on winter-morphotype (WM) D. Read More

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Exposure to Major Vector-Borne Diseases in Dogs Subjected to Different Preventative Regimens in Endemic Areas of Italy.

Pathogens 2021 Apr 23;10(5). Epub 2021 Apr 23.

Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.

Vector-borne diseases (VBDs) are globally widespread arthropod-transmitted diseases with a significant impact on animal and human health. Many drivers have recently spurred the geographic spread of VBDs in dogs. This study has evaluated the exposure to most important VBDs in dogs under different preventative treatments in different regions of Italy, i. Read More

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An impact of a digitally driven primary care psychiatry program on the integration of psychiatric care in the general practice of primary care doctors.

Indian J Psychiatry 2020 Nov-Dec;62(6):690-696. Epub 2020 Dec 12.

Department of Psychiatry, Tele Medicine Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Introduction: The prevalence of psychiatric disorders among the general population is 10.6%. Primary care doctors (PCDs) are often the first contact for patients with common psychiatric disorders, but the majority of them are ill equipped to handle the same leading to symptomatic treatment. Read More

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December 2020

Effects of an Interprofessional Communication Approach on Support Needs, Quality of Life, and Mood of Patients with Advanced Lung Cancer: A Randomized Trial.

Oncologist 2021 Apr 16. Epub 2021 Apr 16.

Department of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.

Background: To address the support needs of newly diagnosed patients with lung cancer with limited prognosis, the Milestone Communication Approach (MCA) was developed and implemented. The main elements of the MCA are situation-specific conversations along the disease trajectory conducted by an interprofessional tandem of physician and nurse. The aim of the study was to evaluate the effects of MCA on addressing support needs, quality of life, and mood as compared with standard oncological care. Read More

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Time Slotted Channel Hopping and ContikiMAC for IPv6 Multicast-Enabled Wireless Sensor Networks.

Sensors (Basel) 2021 Mar 4;21(5). Epub 2021 Mar 4.

Communications Department, Technical University of Cluj-Napoca, 400027 Cluj-Napoca, Romania.

Smart buildings benefit from IEEE 802.15.4e time slotted channel hopping (TSCH) medium access for creating reliable and power aware wireless sensor and actuator networks (WSANs). Read More

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Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study.

PLoS Med 2021 Apr 1;18(4):e1003587. Epub 2021 Apr 1.

Médecins Sans Frontières, Amsterdam, the Netherlands.

Background: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.

Methods And Findings: Data were collected during mass vaccination campaigns (MVCs), contact tracing activities, and from 9 Diphtheria Treatment Centers (DTCs) operated by national and international organizations. Read More

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Abaloparatide Real-World Patient Experience Study.

JBMR Plus 2021 Mar 4;5(3):e10457. Epub 2021 Feb 4.

Health Economics and Outcomes Research Radius Health, Inc. Waltham, MA USA.

Despite the availability of various osteoporosis treatments, adherence remains suboptimal. One contributing factor may be patient experience with therapy. This US, multicenter, combined retrospective chart review and patient questionnaire study included postmenopausal women at high risk for fracture and is the first study to describe real-world patient experience with abaloparatide (ABL) injection. Read More

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Interviews During the Pandemic: A Thoracic Education Cooperative Group and Surgery Residents Project.

Ann Thorac Surg 2021 Mar 24. Epub 2021 Mar 24.

Division of Cardiothoracic Surgery, University of Texas Medical Branch, Galveston, TX. Electronic address:

Background: The 2020 interview cycle for cardiothoracic fellowships was affected by the coronavirus-19 pandemic. Many programs shifted from in-person to virtual interviews. We evaluated applicant perceptions of the various formats. Read More

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Pediatric routine vaccinations in the COVID 19 lockdown period: the survey of the Italian Pediatric Society.

Ital J Pediatr 2021 Mar 24;47(1):72. Epub 2021 Mar 24.

Pediatric and Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome-The Italian Pediatric Society, Rome, Italy.

Background: COVID-19 pandemic was responsible for disrupting routine immunization activities all over the world. Aim of the study was to investigate the reduced adherence to the national children vaccination schedule during the lockdown period in Italy.

Materials And Methods: Through social channels, the Italian Pediatric Society conducted a survey among Italian families on children vaccination during lockdown period. Read More

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Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.

Allergol Select 2021 11;5:128-132. Epub 2021 Mar 11.

Interdisciplinary Allergy Outpatient Clinic, Department of Pneumology, University of Luebeck.

Background: Systemic reactions and anaphylaxis due to Hymenoptera venoms occur in up to 7.5% of the European population. Fatal sting reactions are very rare. Read More

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Adapting World Health Organization Disability Assessment Schedule 2.0 for Nepal.

BMC Psychol 2021 Mar 17;9(1):45. Epub 2021 Mar 17.

Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.

Background: Disability is a vital public health issue for health care programs. Affluent countries usually prioritize disability-related research, while often it remains neglected in resource-poor countries like Nepal. The aim of this study was to make available a translated and culturally adapted version of the World Health Organization Disability Assessment Schedule 2. Read More

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Are Esophagectomy Board Requirements Achievable? A Multi-Institutional Analysis.

Semin Thorac Cardiovasc Surg 2021 Mar 9. Epub 2021 Mar 9.

Thoracic Education Cooperative Group, Thoracic Surgical Directors Association, Chicago, Illionis; Department of Thoracic and Cardiovascular Surgery, UT MD Anderson Cancer Center, Houston, Texas; Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California. Electronic address:

Duty-hour restrictions have implications on trainee operative exposure necessary to meet minimum case-volume requirements. We utilized a previously validated simulation model to evaluate the effect of program volume, trainee numbers and complement, and rotation schedule on the probability of achieving adequate esophagectomy case numbers for cardiothoracic surgery trainees. A ProModel simulator centered on probabilistic distributions of operative cases was utilized. Read More

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Continuum of care for non-communicable diseases during COVID-19 pandemic in rural India: A mixed methods study.

J Family Med Prim Care 2020 Dec 31;9(12):6012-6017. Epub 2020 Dec 31.

George Institute for Global Health, UNSW, New Delhi, India.

Background: COVID-19 pandemic has resulted in disruption to routine health services delivery as strict lockdowns were implemented in India and health workforce redeployed for COVID-19 focused responses. We assess the perceptions about COVID-19, the impact of the lockdown on access to health services and continuum of care for Non-communicable diseases (NCDs) among a cohort of adults in rural India.

Methodology: Since 2018, we have been following up a cohort of persons with non-communicable diseases in a high NCD burden region in Srikakulam District of Andhra Pradesh under the STOP CKDu study. Read More

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December 2020

Vaccination of immune compromised children-an overview for physicians.

Eur J Pediatr 2021 Mar 5. Epub 2021 Mar 5.

Unit of Pediatric Infectious Diseases, Division of General Pediatrics, Department of Pediatrics, Gynecology & Obstetrics, Children's Hospital, University Hospitals of Geneva, 6 Rue Willy Donzé, 1211, Geneva, Switzerland.

Immune compromised children are threatened by a higher risk of infections; some of these are preventable by vaccination. Primary care physicians play a fundamental role in optimising vaccination status. In this narrative review, we present the evidence on vaccine safety and immunogenicity in immune compromised children and discuss in which conditions live-attenuated vaccines can possibly be used. Read More

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Contemporary Challenges for Veterinary Medical Education: Examining the State of Inter-Professional Education in Veterinary Medicine.

J Vet Med Educ 2021 Mar 4:e20200066. Epub 2021 Mar 4.

All four authors contributed equally to this work.

Educational training in professional programs forms the foundation for how a person problem-solves throughout their career. However, training focused on only one profession ignores the value realized through collaborations among multiple professions for solving health-related problems. This is at the core of inter-professional education (IPE). Read More

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Physical activity, screen time and the COVID-19 school closures in Europe - An observational study in 10 countries.

Eur J Sport Sci 2021 Mar 29:1-10. Epub 2021 Mar 29.

Early Start and Illawarra Health & Medical Research Institute, University of Wollongong, Keiraville, Australia.

To date, few data on how the COVID-19 pandemic and restrictions affected children's physical activity in Europe have been published. This study examined the prevalence and correlates of physical activity and screen time from a large sample of European children during the COVID-19 pandemic to inform strategies and provide adequate mitigation measures. An online survey was conducted using convenience sampling from 15 May to 22 June, 2020. Read More

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Working Time Characteristics and Mental Health among Corrections and Transportation Workers.

Ann Work Expo Health 2021 May;65(4):432-445

Department of Medicine, UConn School of Medicine, Division of Occupational and Environmental Medicine, S7313, Farmington, CT, USA.

Objectives: Mental health disorders are a leading cause of work disability and while the psychosocial workplace environment plays a critical role, working time characteristics are also implicated. We sought to examine the association between working time characteristics and mental health in a cohort of two unionized, full-time worker populations, correctional supervisors, and transportation maintainers.

Methods: Using a cross-sectional study design, we surveyed workers on working time characteristics across seven domains including length of the shift, the intensity or proximity of sequential shifts, the time of day, and social aspects of work hours including predictability, variability, control, and free time. Read More

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Systematic review of stereotactic body radiotherapy in stage III non-small cell lung cancer.

Transl Lung Cancer Res 2021 Jan;10(1):529-538

Department of Radiation Oncology, Catalan Institute of Oncology, L'Hospitalet, Barcelona, Spain.

Despite adequate treatment, 50% of stage III locally advanced inoperable non-small cell lung cancer (NSCLC) patients have a locoregional relapse. Local control on early stages on the contrary, is as high as 85-90% with stereotactic body radiotherapy (SBRT). The addition of SBRT to conventional chemoradiation or its use in monotherapy in stage III NSCLC is a novel strategy to decrease local failure that has been explored by various authors. Read More

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January 2021

Enhancing SDN WISE with Slicing Over TSCH.

Sensors (Basel) 2021 Feb 4;21(4). Epub 2021 Feb 4.

Instituto Tecnológico de Informática (ITI), 46022 Valencia, Spain.

IWSNs (Industrial Wireless Sensor Networks) have become the next step in the evolution of WSN (Wireless Sensor Networks) due to the nature and demands of modern industry. With this type of network, flexible and scalable architectures can be created that simultaneously support traffic sources with different characteristics. Due to the great diversity of application scenarios, there is a need to implement additional capabilities that can guarantee an adequate level of reliability and that can adapt to the dynamic behavior of the applications in use. Read More

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February 2021

A phase 1 trial of 4-(N-(S-penicillaminylacetyl)amino)-phenylarsonous acid (PENAO) in patients with advanced solid tumours.

Cancer Chemother Pharmacol 2021 May 26;87(5):613-620. Epub 2021 Jan 26.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Purpose: This phase I study was conducted to evaluate the safety and Maximum Tolerated Dose of PENAO (4-(N-(S-penicillaminylacetyl)amino)-phenylarsonous acid), a second-generation organic arsenical with anti-mitochondrial activity, when given as a continuous intravenous infusion (CIVI), in patients with advanced solid tumours.

Methods: Eligibility criteria for this trial included age ≥ 18 years, advanced solid tumour, ECOG Performance Status ≤ 1 and adequate organ function. PENAO was administered by CIVI, with dose levels initially increased by infusion duration in a 21-day cycle at a fixed daily dose and then increased daily dose. Read More

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Effect of Text Messaging on Bowel Preparation and Appointment Attendance for Outpatient Colonoscopy: A Randomized Clinical Trial.

JAMA Netw Open 2021 01 4;4(1):e2034553. Epub 2021 Jan 4.

Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: Outpatient colonoscopy is important for colorectal cancer screening. However, nonadherence and poor bowel preparation are common.

Objective: To determine if an automated text messaging intervention with a focus on informational and reminder functions could improve attendance rates and bowel preparation quality for outpatient colonoscopy. Read More

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January 2021

Immunogenicity after pre- and post-exposure rabies vaccination: A systematic review and dose-response meta-analysis.

Vaccine 2021 Feb 18;39(7):1044-1050. Epub 2021 Jan 18.

Research School of Population Health, Australian National University, Canberra, Australia. Electronic address:

Background: There are a myriad of vaccine schedules for rabies pre- (PrEP) and post-exposure prophylaxis (PEP) that differ in the number and timedoses, number of visits, length of schedule, and route of administration. The objective of this study was to systematically review the evidence and investigate how thedifferences in schedules influence titres over time.

Methods: Four databaseswere searched from inception to January 2020 for rabies PrEP and PEP studies. Read More

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February 2021

An Examination of Work Characteristics, Fatigue, and Recovery Among Acute Care Nurses.

Authors:
Karen R Cochran

J Nurs Adm 2021 Feb;51(2):89-94

Author Affiliation: Grant Evaluation Specialist, Western Carolina University, Asheville, North Carolina.

Objective: To examine self-perceived fatigue among nurses and to quantify levels of fatigue and the ability to recover from fatigue between worked shifts across various work characteristics.

Background: Fatigue is associated with working long hours, disruption of sleep, and inadequate time to recover between shifts. Fatigue degrades the nurses' performance leading to poorer patient outcomes and increased occupational injuries. Read More

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February 2021

Emotional Impact of COVID-19 Lockdown Among the Spanish Population.

Front Psychol 2020 17;11:616978. Epub 2020 Dec 17.

Department of Psychology, Comillas Pontifical University, Madrid, Spain.

Background: The COVID-19 pandemic has resulted in some populations being confined to their homes as part of infection control measures. This situation can be hard to cope with due to separation from loved ones, prohibition of regular activities, fear of infection, loss of freedom, and so on. These negative impacts cause considerable psychological stress, and all the more so when the situation continues for an extended period, as was the case in Spain. Read More

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December 2020

Intermittent Administration of Nitroglycerin Sublingual Powder Compared with Placebo in Outpatients with Peripheral Artery Disease: Results of a Randomised Proof of Concept Study.

Eur J Vasc Endovasc Surg 2021 03 23;61(3):457-465. Epub 2020 Dec 23.

G. Pohl-Boskamp GmbH & Co. KG, Hohenlockstedt, Germany.

Objective: Treatment of peripheral artery disease (PAD), Fontaine Stage IIb with vasoactive substances is of limited efficacy and does not last beyond the active treatment. Glyceryl trinitrate (GTN) is a vasodilating agent that relaxes vascular smooth muscle cells. The aim was to prove the concept that GTN sublingual powder has sustained clinical efficacy and adequate safety in these patients. Read More

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Benzodiazepines: Thinking outside the black box.

J Clin Pharm Ther 2020 Dec 21. Epub 2020 Dec 21.

Neumentum Inc., Summit, NJ, USA.

What Is Known And Objective: The United States Food and Drug Administration (FDA) recently issued a Drug Safety Communication requiring Boxed Warning updating and other changes in order to improve the safe use of the benzodiazepine drug class. These changes were prompted because 'The current prescribing information for benzodiazepines does not provide adequate warnings about [the] serious risks and harms associated with these medicines so they may be prescribed and used inappropriately'.

Comment: The FDA Communication points out that benzodiazepines can be an important option for treating disorders for which these drugs are indicated. Read More

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December 2020

Cultural adaptation of the ing program for the treatment of depression in the Ecuadorian public health care system: A study protocol for a randomized controlled trial.

Internet Interv 2021 Mar 28;23:100352. Epub 2020 Nov 28.

Department of Personality, Evaluation and Psychological Treatments, University of Valencia, Valencia, Spain.

Background: Depression is one of the world's major health problems. Due to its high prevalence, it constitutes the first cause of disability among the Americas, where only a very low percentage of the population receives the adequate evidence-based psychological treatment. Internet-Based Interventions (IBIs) are a great alternative to reduce the treatment gap for mental disorders. Read More

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Vaccination perception and coverage among healthcare students in France in 2019.

BMC Med Educ 2020 Dec 14;20(1):508. Epub 2020 Dec 14.

Department of Infectious Diseases, CHU de Caen, Avenue de la Côte de Nacre, F-14000, Caen, France.

Background: Vaccine hesitancy in healthcare workers has been increasing especially in France while they are the cornerstone of vaccination programs. Greater understanding of healthcare students (HCS) vaccine knowledge, attitudes and beliefs is necessary to provide an adequate vaccination education to better equip them to promote vaccination in their future careers. The aim of this study was to assess vaccination perception (VP) (perception of benefits and risks of vaccines) and its impact on vaccination coverage (VC) for mandatory and recommended vaccines among HCS. Read More

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December 2020