63,433 results match your criteria scenario

Improving severity scoring of food-induced allergic reactions: a global "Best-Worst Scaling" exercise.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

National Heart & Lung Institute, Imperial College London, London, UK;. Electronic address:

Background: There is no current consensus on assigning severity to food-induced allergic reactions, for example to assess the efficacy of allergen immunotherapy. Existing severity scores lack the capability to discriminate between non-anaphylaxis reactions of different severities. Attempts are ongoing to develop a more discriminatory score, which should ideally be data-driven and validated in multiple cohorts. Read More

View Article and Full-Text PDF

DoE-Based Analytical-FMCEA for Enhanced AQbD Approach to MEER-RP-HPLC Method for Synchronous Estimation of Fifteen Antihypertensive Pharmaceutical Dosage Forms.

J AOAC Int 2021 Jul 22. Epub 2021 Jul 22.

Department of Quality Assurance, Maliba Pharmacy College, Uka Tarsadia University, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat-394 350, Gujarat, India.

Background: In the recent scenario of green chemistry, the usage of organic solvent should be minimized in the development of the analytical method for the safety of the environment and analysts.

Objective: Hence, the RP-HPLC method has been developed as an economical and eco-friendly alternative to published RP-HPLC methods for the analysis of FDC of anti-hypertensive drugs to save time, resources, cost and organic solvent.

Method: The method has been developed by the implementation of an enhanced AQbD approach based on DoE-based AFMCEA. Read More

View Article and Full-Text PDF

Leadership empowering behaviour as a predictor of employees' psychological well-being: Evidence from a cross-sectional study among secondary school teachers in Kohat Division, Pakistan.

PLoS One 2021 22;16(7):e0254576. Epub 2021 Jul 22.

Elementary & Secondary Education Department, Government of Khyber Pakhtunkhwa, Peshawar, Pakistan.

In this technologically developed scenario, many organizations in developing countries including Pakistan have expanded the enthusiasm for understanding and creating an encouraging administrative and managerial environment. Numerous organizations are struggling for structural changes by deserting the old-fashioned organizational management style and implementing an empowering leadership where leaders give more authority to subordinates in decision making and responsibilities with the aim to increase organizational productivity. Therefore, the study examined the leadership empowering behaviour as a predictor of employees' psychological well-being of the educational institutions at secondary level in Kohat Division, Pakistan. Read More

View Article and Full-Text PDF

Oral immunization of Escherichia albertii strain DM104 induces protective immunity against Shigella dysenteriae type 4 in mouse model.

Acta Microbiol Immunol Hung 2021 Jul 21. Epub 2021 Jul 21.

2Department of Biological Sciences, University of Bergen, Bergen 5020, Norway.

The recent rise of antibiotic resistance and lack of an effective vaccine make the scenario of shigellosis alarming in developing countries like Bangladesh. In recent years, our group reported the vaccine efficacy of a non-pathogenic Escherichia albertii strain DM104 in different animal models, where an ocularly administered vaccine in the guinea pig eye model against Shigella dysenteriae type 4 challenge showed high protective efficacy and also induced a high titer of serum IgG against S. dysenteriae type 4 whole cell lysate (WCL) and LPS. Read More

View Article and Full-Text PDF

User Experiences of the New Zealand COVID Tracer App: Thematic Analysis of Interviews.

JMIR Mhealth Uhealth 2021 Jul 15. Epub 2021 Jul 15.

School of Management, Massey University, Tennent Drive, Palmerston North, NZ.

Background: For mobile app based COVID-19 contact tracing to be fully effective, a large majority of the population needs to be using the app on an on-going basis. However, there is a paucity of studies of users (as opposite to potential adopters) of mobile contact tracing apps and of their experiences. New Zealand, a high-income country with western political culture, was successful in managing the COVID-19 pandemic, and its experience is valuable for informing policy responses in similar contexts. Read More

View Article and Full-Text PDF

Emerging Technologies for In Vitro Inhalation Toxicology.

Adv Healthc Mater 2021 Jul 22:e2100633. Epub 2021 Jul 22.

Department of Chemical Engineering, Rayen School of Engineering, Youngstown State University, Youngstown, OH, 44555, USA.

Respiratory toxicology remains a major research area in the 21st century since current scenario of airborne viral infection transmission and pollutant inhalation is expected to raise the annual morbidity beyond 2 million. Clinical and epidemiological research connecting human exposure to air contaminants to understand adverse pulmonary health outcomes is, therefore, an immediate subject of human health assessment. Important observations in defining systemic effects of environmental contaminants on inhalation metabolic dysfunction, liver health, and gastrointestinal tract have been well explored with in vivo models. Read More

View Article and Full-Text PDF

Direct and Indirect Costs of Influenza-Like Illness Treated with and Without Oseltamivir in 15 European Countries: A Descriptive Analysis Alongside the Randomised Controlled ALICE Trial.

Clin Drug Investig 2021 Jul 22. Epub 2021 Jul 22.

Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.

Background And Objective: Influenza-like illness (ILI) leads to a substantial disease burden every winter in Europe; however, oseltamivir is not frequently prescribed to ILI patients in the primary-care setting. An open-label, multi-country, multi-season, randomised controlled trial investigated the effectiveness of oseltamivir for treating ILI in 15 European countries. We aimed to evaluate whether patients presenting with ILI in primary care and being managed with the addition of oseltamivir to usual care had lower average direct and indirect costs compared to patients with usual care alone. Read More

View Article and Full-Text PDF

Google trends in "anatomy": pre-pandemic versus during COVID-19 pandemic.

Surg Radiol Anat 2021 Jul 22. Epub 2021 Jul 22.

Department of Internal Medicine, Cleveland Clinic, Cleveland, OHIO, USA.

Purpose: The purpose of the present study was to assess the online search behavior for the keyword "anatomy" worldwide and to compare the pre-pandemic and during COVID-19 pandemic scenario for the same.

Methods: Google trends tool was used for the assessment of the search behavior for the term "anatomy". The data, i. Read More

View Article and Full-Text PDF

Mitochondrial dysfunction: A hidden trigger of autism?

Genes Dis 2021 Sep 16;8(5):629-639. Epub 2020 Jul 16.

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu 641043, India.

Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. Read More

View Article and Full-Text PDF
September 2021

Enzymatic approaches in the bioprocessing of shellfish wastes.

3 Biotech 2021 Aug 6;11(8):367. Epub 2021 Jul 6.

Center for Innovation and Translational Research, CSIR- Indian Institute of Toxicology Research (CSIR-IITR), 31 MG Marg, Lucknow, 226001 India.

Several tonnes of shellfish wastes are generated globally due to the mass consumption of shellfish meat from crustaceans like prawn, shrimp, lobster, crab, Antarctic krill, etc. These shellfish wastes are a reservoir of valuable by-products like chitin, protein, calcium carbonate, and pigments. In the present scenario, these wastes are treated chemically to recover chitin by the chitin and chitosan industries, using hazardous chemicals like HCl and NaOH. Read More

View Article and Full-Text PDF

No Effects of Mental Fatigue and Cerebral Stimulation on Physical Performance of Master Swimmers.

Front Psychol 2021 5;12:656499. Epub 2021 Jul 5.

LAFISE - Laboratório de Fisiologia do Exercício, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Mental fatigue is a psychobiological state caused by extended periods of cognitive effort, and evidence suggests that mentally fatigued athletes present impaired physical performance. Different ergogenic aids have been proposed to counteract the deleterious effects of mental fatigue, but whether brain stimulation can counteract mental fatigue is still unknown. This scenario is even more obscure considering the effects of these interventions (mental fatigue induction and brain stimulation) in a very experienced population consisting of master athletes. Read More

View Article and Full-Text PDF

Organic chemistry as representation.

Eamonn F Healy

Found Chem 2021 Apr 6;23(1):59-68. Epub 2020 Jul 6.

Department of Chemistry, St. Edward's University, Austin, TX 78704, USA.

Electron redistribution is the cornerstone of our understanding of chemical reactivity. For the vast majority of organic reactions electrons are assumed to move in pairs providing explanatory mechanisms through the generation of intermediate structures. But for many transformations these discrete steps are idealized constructs, involving intermediates assumed but not empirically justified. Read More

View Article and Full-Text PDF

DEELIG: A Deep Learning Approach to Predict Protein-Ligand Binding Affinity.

Bioinform Biol Insights 2021 7;15:11779322211030364. Epub 2021 Jul 7.

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.

Protein-ligand binding prediction has extensive biological significance. Binding affinity helps in understanding the degree of protein-ligand interactions and is a useful measure in drug design. Protein-ligand docking using virtual screening and molecular dynamic simulations are required to predict the binding affinity of a ligand to its cognate receptor. Read More

View Article and Full-Text PDF

Visual attention during pediatric resuscitation with feedback devices: a randomized simulation study.

Pediatr Res 2021 Jul 21. Epub 2021 Jul 21.

Divison of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Background: The aim of this study was to investigate the effect of feedback devices on visual attention and the quality of pediatric resuscitation.

Methods: This was a randomized cross-over simulation study at the Medical University of Vienna. Participants were students and neonatal providers performing four resuscitation scenarios with the support of feedback devices randomized. Read More

View Article and Full-Text PDF

Cost-Effectiveness Analysis of Michigan's School-Wide Sexually Transmitted Disease Screening Program in Four Detroit High Schools.

J Adolesc Health 2021 Jul 18. Epub 2021 Jul 18.

Division of Adolescent and School Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

Purpose: The Michigan Department of Health and Human Services, in collaboration with St. John Providence Health System, initiated voluntary school-wide sexually transmitted disease (STD) screenings in four Detroit public high schools. We sought to assess the cost-effectiveness of the STD screening program from 2010 to 2015, with a focus on chlamydia. Read More

View Article and Full-Text PDF

Lenvatinib: Established and Promising Drug for the Treatment of Advanced Hepatocellular Carcinoma.

Expert Rev Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Health Sciences, University of Florence, 50139, Florence, Italy.

Introduction: : The evolving therapeutic landscape of advanced hepatocellular carcinoma (HCC) includes the increasing implementation of target-therapy and immunotherapy. Lenvatinib, a multi-target tyrosine kinase inhibitor (TKI), is an emerging first-line therapy for hepatocellular carcinoma. Its approval has changed the scenario of first-line therapies for advanced HCC, where just sorafenib proved clinical efficacy for over a decade. Read More

View Article and Full-Text PDF

Poultry litter stabilization by two-stage composting-vermicomposting process: Environmental, energetic and economic performance.

Chemosphere 2021 Oct 15;281:130872. Epub 2021 May 15.

Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET), Güemes N(◦) 3450, Santa Fe, S3000GLN, Argentina; Facultad de Ingeniería y Ciencias Hídricas, Universidad Nacional del Litoral, Ruta Nacional N° 168 Km 472.4, 3000, Santa Fe, Argentina.

Poultry litter (PL) is a heterogeneous mixture that contains bedding materials, antibiotics, dead skin, feed scraps, water, feathers and the resulting microbiota from poultry production cycle. Although its treatment does not receive attention, it is an important organic resource generated in the north-east region of Santa Fe Province since animal primary production is one of the main economic activities there and in the whole country. The objective of this work was to analyse the economic and energy aspects and the environmental impact of two scenarios corresponding to treat two different mixtures of organic wastes: Eucalyptus sp. Read More

View Article and Full-Text PDF
October 2021

Global assessment of marine and freshwater recreational fish reveals mismatch in climate change vulnerability and conservation effort.

Glob Chang Biol 2021 Jul 21. Epub 2021 Jul 21.

Department of Biology, Carleton University, Ottawa, Ontario, Canada.

Recreational fisheries contribute substantially to the sociocultural and economic well-being of coastal and riparian regions worldwide, but climate change threatens their sustainability. Fishery managers require information on how climate change will impact key recreational species; however, the absence of a global assessment hinders both directed and widespread conservation efforts. In this study, we present the first global climate change vulnerability assessment of recreationally targeted fish species from marine and freshwater environments (including diadromous fishes). Read More

View Article and Full-Text PDF

Interdependence between lignocellulosic biomasses, enzymatic hydrolysis and yeast cell factories in biorefineries.

Microb Biotechnol 2021 Jul 21. Epub 2021 Jul 21.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milano, 20126, Italy.

Biorefineries have a pivotal role in the bioeconomy scenario for the transition from fossil-based processes towards more sustainable ones relying on renewable resources. Lignocellulose is a prominent feedstock since its abundance and relatively low cost. Microorganisms are often protagonists of biorefineries, as they contribute both to the enzymatic degradation of lignocellulose complex polymers and to the fermentative conversion of the hydrolyzed biomasses into fine and bulk chemicals. Read More

View Article and Full-Text PDF

Matrigel® enhances 3T3-L1 cell differentiation.

Adipocyte 2021 Dec;10(1):361-377

Department of Pediatrics and the Graduate Program in Medical Sciences, McMaster University, Hamilton, ON, Canada.

Culturing cells on bio-gels are believed to provide a more -like extracellular matrix. 3T3-L1 cells cultured on Matrigel® significantly alteregd their proliferation and differentiation as compared to growth on tissue culture-coated polystyrene surfaces. Growth on a 250-μm thick layer of Matrigel® facilitated the formation of cellular aggregates of 3T3-L1 cells. Read More

View Article and Full-Text PDF
December 2021

Redox Isomerism in the S3 State of the Oxygen-Evolving Complex Resolved by Coupled Cluster Theory.

Chemistry 2021 Jul 19. Epub 2021 Jul 19.

Max-Planck-Institut für Kohlenforschung, Molecular Theory and Spectroscopy, Kaiser-Wilhelm-Platz 1, 45470, Muelheim an der Ruhr, GERMANY.

The electronic and geometric structures of the water oxidizing complex of Photosystem II in the steps of the catalytic cycle that precede dioxygen evolution remain hotly debated. Recent structural and spectroscopic investigations support contradictory redox formulations for the active-site Mn4CaO x cofactor in the final metastable S3 state. These range from the widely accepted Mn(IV)4 oxo-hydroxo model, which presumes O-O bond formation to occur in the ultimate transient intermediate (S4) of the catalytic cycle, to a Mn(III)2Mn(IV)2 peroxo model representative of the contrasting "early-onset" O-O bond formation hypothesis. Read More

View Article and Full-Text PDF

Impact of the GeneXpert® MTB/RIF rapid molecular test on tuberculosis detection: temporal trends and vulnerable territories.

Rev Lat Am Enfermagem 2021 19;29:e3441. Epub 2021 Jul 19.

Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, PAHO/WHO Collaborating Centre for Nursing Research Development, Ribeirão Preto, SP, Brazil.

Objective: to assess the impact of the GeneXpert® MTB/RIF rapid molecular test on tuberculosis detection, to analyze the temporal trend of the event and to identify vulnerable territories in a Brazilian municipality.

Method: an ecological study carried out in Ribeirão Preto, São Paulo, Brazil, a municipality considered a priority in tuberculosis control due to the high number of cases. To classify the temporal trend, the Prais-Winsten method and the Interrupted Time Series were used to identify changes in the disease incidence. Read More

View Article and Full-Text PDF

Mechanistic underpinning of cell aspect ratio-dependent emergent collective motions in swarming bacteria.

Soft Matter 2021 Jul 21. Epub 2021 Jul 21.

Tata Institute of Fundamental Research Hyderabad, Telangana 500046, India.

Self-propelled bacteria can exhibit a large variety of non-equilibrium self-organized phenomena. Swarming is one such fascinating dynamical scenario where a number of motile individuals group into dynamical clusters and move in synchronized flows and vortices. While precedent investigations into rod-like particles confirm that an increased aspect-ratio promotes alignment and order, recent experimental studies in bacteria Bacillus subtilis show a non-monotonic dependence of the cell-aspect ratio on their swarming motion. Read More

View Article and Full-Text PDF

[Effects of climate changes on the distribution of in China].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Jun;33(3):267-273

School of Public Health, Weifang Medical University, Weifang 261053, China.

Objective: To identify the environmental factors affecting the geographical distribution of in China, and to examine the impact of climate changes on the distribution of in China.

Methods: The national and international publications pertaining to the geographical distribution of in China were retrieved, and the geographical location was extracted. The suitable habitats of and the dominant environmental factors affecting the distribution of suitable habitats of were predicted in China based on the geographical data and environmental variables using the ArcGIS 10. Read More

View Article and Full-Text PDF

Postoperative radiotherapy after upfront radical prostatectomy: debated issues at a turning point-a survey exploring management trends on behalf of AIRO (Italian Association of Radiotherapy and Clinical Oncology).

Clin Transl Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Radiation Oncology, School of Medicine and Surgery, University of Milan Bicocca, Milan, Italy.

Objectives: Postoperative prostate cancer patients are a heterogeneous population, and many prognostic factors (e.g., local staging, PSA kinetics, margin status, histopathological features) may influence their clinical management. Read More

View Article and Full-Text PDF

Mechanistic aspects of plant-based silver nanoparticles against multi-drug resistant bacteria.

Heliyon 2021 Jul 1;7(7):e07448. Epub 2021 Jul 1.

Department of Biology, University of North Carolina at Greensboro, NC, United States.

Resistance among pathogenic bacteria to the existing antibiotics is one of the most alarming problems of the modern world. Alongwith reducing the use of antibiotics, and antibiotic stewardship, an alternative to antibiotics is much needed in the current scenario to combact infectious diseases. One alternative is to produce nanomaterials, especially, silver nanoparticles (AgNPs) against antibiotic-resistant bacteria. Read More

View Article and Full-Text PDF

Using the Apriori Algorithm to Explore Caregivers' Depression by the Combination of the Patients with Dementia and Their Caregivers.

Risk Manag Healthc Policy 2021 12;14:2953-2963. Epub 2021 Jul 12.

Department of Business Administration, National Changhua University of Education, Changhua, Taiwan.

Purpose: The purpose of this study was to identify the caring scenarios that result in severe depression in caregivers caring for dementia patients.

Patients And Methods: A cross-sectional study with 1111 dementia patients and their caregivers in Taiwan from October 2015 to January 2020 was conducted. Gender, age, type of dementia, clinical dementia rating, walking ability, mood symptoms, behavioral symptoms, and psychological symptoms were the variables from the dementia patients. Read More

View Article and Full-Text PDF

Step-Up and Step-Down Treatment Approaches for COPD: A Holistic View of Progressive Therapies.

Int J Chron Obstruct Pulmon Dis 2021 12;16:2065-2076. Epub 2021 Jul 12.

Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain.

Recent advances in inhaled drugs and a clearer definition of the disease have made the task of managing COPD more complex. Different proposals have been put forward which combine all the available treatments and the different clinical presentations in an effort to select the best therapeutic options for each clinical context. As COPD is a chronic progressive disease, the escalation of therapy has traditionally been considered the most natural way to tackle it. Read More

View Article and Full-Text PDF

Syncing sustainable urban mobility with public transit policy trends based on global data analysis.

Sci Rep 2021 07 20;11(1):14597. Epub 2021 Jul 20.

Civil and Environmental Engineering, Technion-Israel Institute of Technology, Haifa, Israel.

Unforeseeable developments will accompany progressive COVID-19 recovery globally. Similarly, science will inform changes amidst its own progress. Social isolation and distancing imposed by the pandemic are likely to result in changed habits, behavior, and thinking paradigms. Read More

View Article and Full-Text PDF

An integrated primary care workforce planning toolkit at the regional level (part 1): qualitative tools compiled for decision-makers in Toronto, Canada.

Hum Resour Health 2021 Jul 21;19(1):85. Epub 2021 Jul 21.

University of Ottawa and Canadian Health Workforce Network, Ottawa, Canada.

Background: A regional health authority in Toronto, Canada, identified health workforce planning as an essential input to the implementation of their comprehensive Primary Care Strategy. The goal of this project was to develop an evidence-informed toolkit for integrated, multi-professional, needs-based primary care workforce planning for the region. This article presents the qualitative workforce planning processes included in the toolkit. Read More

View Article and Full-Text PDF