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Public perceptions of transoral endocrine surgery and their influence on choice of operative approach.

J Surg Res 2021 Jun 12;267:56-62. Epub 2021 Jun 12.

Harvard Medical School, Boston, MA; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address:

Background: Transoral Endocrine Surgery (TES) represents an alternative to the open approach with no visible scar. Studies have shown TES has a safety profile similar to the open approach, but adoption has been limited. Public perception and preference for TES are factors associated with adoption that have not been explored. Read More

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Salvage Oblique Lateral Interbody Fusion for Pseudarthrosis after Posterior/Transforaminal Lumbar Interbody Fusion: A Technical Note.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objective: This study aims to demonstrate the efficacy of salvage oblique lumbar interbody fusion (OLIF) surgery for pseudarthrosis after posterior/transforaminal lumbar interbody fusion (PLIF/TLIF).

Methods: The subjects consist of the patients with leg or back pain induced by pseudarthrosis after PLIF/TLIF. These patients underwent salvage OLIF surgeries in our institutions between Jul 2015 to Oct 2019. Read More

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Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Duke University, Durham, North Carolina, USA.

Dermal scarring from motor vehicle accidents, severe burns, military blasts, etc. is a major problem affecting over 80 million people worldwide annually, many of whom suffer from debilitating hypertrophic scar contractures. These stiff, shrunken scars limit mobility, impact quality of life, and cost millions of dollars each year in surgical treatment and physical therapy. Read More

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Chronic itch in African Americans: an unmet need.

Arch Dermatol Res 2021 Jun 15. Epub 2021 Jun 15.

Dr. Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, FL, USA.

Chronic pruritus carries a significant burden of disease and is associated with a negative impact on quality of life. African Americans are disproportionately burdened by chronic pruritic disorders, including but not limited to atopic dermatitis, prurigo nodularis, inflammatory scalp dermatoses, pathologic scarring, and HIV-related dermatoses. Racial differences in skin structure and function may contribute to the pathogenesis of itch in African Americans. Read More

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A Leep1 into migration and macropinocytosis.

J Cell Biol 2021 Jul 15;220(7). Epub 2021 Jun 15.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Actin organization underpins conserved functions at the leading edge of cells. In this issue, Yang et al. (2021. Read More

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Botulinum Toxin to Improve Lower Blepharoplasty Scar: A Double-Blinded, Randomized, Vehicle-Controlled Clinical Trial.

Aesthet Surg J 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical and Materials Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan.

Background: Lower blepharoplasty is a common cosmetic operation that relies on minimal postoperative scarring, but Asian patients are at higher risk than Caucasians for hypertrophic and/or widened scars. Botulinum toxin type A (BTX) injections are widely employed to alleviate dynamic facial rhytids and also can improve scar quality by reducing scar tension. The authors assessed whether simultaneous transcutaneous lower blepharoplasty and BTX injections could improve subciliary scar quality. Read More

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Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing.

Carbohydr Polym 2021 Sep 21;268:118239. Epub 2021 May 21.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:

Composite dressing composed of Rhizochitosan and Regenplex™ to promote wound healing were assessed. Rhizochitosan was fabricated by deacetylation of Rhizochitin, which obtained by simply depigmenting sporangium-free mycelial mattress produced from Rhizopus stolonifer F6. Physicochemical characterizations of Rhizochitosan demonstrated that it contained 13. Read More

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September 2021

Identifying Phenotypically Distinct Fibroblast Subsets in Type 2 Diabetes-Associated Iatrogenic Laryngotracheal Stenosis.

Otolaryngol Head Neck Surg 2021 Jun 15:1945998211014790. Epub 2021 Jun 15.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Objective: Iatrogenic laryngotracheal stenosis (iLTS) is the pathologic narrowing of the glottis, subglottis, and/or trachea secondary to intubation or tracheostomy related injury. Patients with type 2 diabetes mellitus (T2DM) are more likely to develop iLTS. To date, the metabolomics and phenotypic expression of cell markers in fibroblasts derived from patients with T2DM and iLTS are largely unknown. Read More

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[Radiofrequency catheter ablation of ventricular tachycardia in patients post surgical repair of tetralogy of Fallot].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):615-620

Cardiac Arrhythmia Center, National Center of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To investigate the clinical and electrophysiological features of ventricular tachycardia (VT) in tetralogy of Fallot (TOF) patients post surgical repair (rTOF) and to analyze the therapeutic effect and prognosis of radiofrequency ablation of rTOF-VT. This is a retrospective study. Consecutive patients with rTOF-VT, who were treated in Fuwai Hospital from January 2015 to March 2020, were enrolled. Read More

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A case report reappraising the usefulness of Valsalva manoeuvre in drug-refractory ventricular tachycardia.

Eur Heart J Case Rep 2021 May 5;5(5):ytab171. Epub 2021 May 5.

Department of Cardiology, Glenfield Hospital, University of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, UK.

Background: Ventricular tachycardia (VT) is often misdiagnosed as supraventricular tachycardia with aberrancy. Twelve-lead electrocardiogram remains a key diagnostic tool to differentiate them while providing insights to aid localization of VT. The use of Valsalva manoeuvre (VM) in terminating VT is not conventionally recommended due to lack of robust evidence of its effectiveness and poor understanding of its mechanism in terminating VT. Read More

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Bullet-associated ventricular tachycardia: a case report.

Eur Heart J Case Rep 2021 Apr 26;5(4):ytab101. Epub 2021 Apr 26.

Department of Cardiology II (Electrophysiology), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.

Background: The majority of ventricular tachycardias (VTs) occurs in patients with structural heart disease and is associated with an increased risk of sudden cardiac death. These VT are scar-related and may develop in patients with ischaemic or non-ischaemic cardiomyopathies.

Case Summary: We describe a 44-year-old patient without any pre-existing cardiovascular disease, presenting with the first documentation of a haemodynamically unstable sustained fast VT with a cycle length of 250 ms. Read More

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Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction.

Front Cell Dev Biol 2021 26;9:662415. Epub 2021 May 26.

Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, United States.

Stem/progenitor cells are usually cultured at atmospheric O tension (21%); however, since physiologic O tension in the heart is ∼5%, using 21% O may cause oxidative stress and toxicity. Cardiac mesenchymal cells (CMCs), a newly discovered and promising type of progenitor cells, are effective in improving left ventricle (LV) function after myocardial infarction (MI). We have previously shown that, compared with 21% O, culture at 5% O increases CMC proliferation, telomerase activity, telomere length, and resistance to severe hypoxia . Read More

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Aesthetic Outcomes of Perineal Reconstruction with the Lotus Petal Flap.

Plast Reconstr Surg Glob Open 2021 Jun 10;9(6):e3621. Epub 2021 Jun 10.

Department of Plastic Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

The lotus petal flap can be applied for reconstruction of extensive defects in the vulvoperineal area. Studies on aesthetic outcomes are lacking. This study aimed to fill this gap. Read More

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FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis.

Dermatol Pract Concept 2021 May 20;11(3):e2021057. Epub 2021 May 20.

Department of Dermatology, S N Medical College, Bagalkot, Karnataka, India.

Background: Primary localized cutaneous amyloidosis (PLCA) causes extracellular proteinaceous deposits in skin. It is clinically divided into macular amyloidosis, lichen amyloidosis and nodular amyloidosis. Atypical presentations of PLCA make the diagnosis challenging, requiring biopsy to confirm amyloid deposition in the upper papillary dermis. Read More

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Impact of GBBS algorithm on post-mastectomy scar boost irradiation of breast using catheter flap.

J Contemp Brachytherapy 2021 Jun 24;13(3):310-317. Epub 2021 May 24.

Department of Radiation Oncology, Regional Cancer Centre, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Purpose: Post-mastectomy radiation therapy significantly reduces locoregional recurrence rates, which can be achieved with external beam radiotherapy delivered to chest wall, followed by scar irradiation either by electron or high-dose-rate (HDR) mould brachytherapy. The present study evaluates dosimetric advantage of Acuros BV, a TG-186 MBDCA, over TG-43 formalism using Ir source for HDR brachytherapy in chest wall scar boost using catheter flap.

Material And Methods: A total of 25 patients, free of cardiac and pulmonary co-morbidities, who met the inclusion criteria were involved in the study. Read More

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Scar Revisions.

Semin Plast Surg 2021 May 8;35(2):130-138. Epub 2021 Jun 8.

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Scars pose a complex challenge to the reconstructive surgeon in the variability of their presentation and their effect on cosmesis and function. Numerous surgical and nonsurgical options exist for scar management, each with their respective advantages and disadvantages. Each treatment modality should be tailored to the patient to ensure enhanced outcomes. Read More

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Macula hole as a sequelae of presumed ocular toxoplasmosis, an incidental finding in a female Nigerian: Case report and review of literature.

Authors:
Y O Babalola

Niger J Clin Pract 2021 Jun;24(6):959-963

Department of Ophthalmology, University College Hospital/University of Ibadan, Ibadan, Nigeria.

A 39-year-old Nigerian woman presented to the eye clinic for a new pair of spectacles on account of a two-week history of headaches and bilateral eye ache. She was a known spectacle wearer for the past nine years. The presenting visual acuity was 6/6 and 6/36, respectively, in the right and left eye. Read More

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Video-Endoscopic Mobilization of the Gracilis Muscle for Rectourinary Fistula Repair.

Urol Int 2021 Jun 11:1-5. Epub 2021 Jun 11.

Laboratório de Investigação Médica-Urologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Introduction: Transposition of the gracilis has been used in a large number of reconstructive procedures. Its advantage is its proximity to these defects and a good blood supply. Traditionally, the gracilis mobilization is performed by open surgery with one or more incisions. Read More

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Application of lateral supraclavicular incision in unilateral thyroid papillary carcinoma surgery.

Braz J Otorhinolaryngol 2021 Apr 20. Epub 2021 Apr 20.

Kunming Medical University, Third Affiliated Hospital, Kunming, Yunnan Province, China. Electronic address:

Introduction: The standard approach to thyroidectomy is a collar incision via the anterior neck, and the neck scar has always been a source of worry for patients. Acceptable wound cosmetology has become a focus for thyroid surgeons.

Objective: To verify the effectiveness and cosmetic results of thyroidectomy through a lateral supraclavicular incision. Read More

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β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275.

Cell Mol Biol Lett 2021 Jun 12;26(1):28. Epub 2021 Jun 12.

Department of Pulmonary and Critical Care Medicine, Respiratory Medicine Center of Fujian Province, The Second Affiliated Hospital of Fujian Medical University, Zhongshan North Road No.34, Licheng District, Quanzhou, Fujian, China.

Background: We have previously found that β-elemene could inhibit the viability of airway granulation fibroblasts and prevent airway hyperplastic stenosis. This study aimed to elucidate the underlying mechanism and protective efficacy of β-elemene in vitro and in vivo.

Methods: Microarray and bioinformatic analysis were used to identify altered pathways related to cell viability in a β-elemene-treated primary cell model and to construct a β-elemene-altered ceRNA network modulating the target pathway. Read More

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Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.

J Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Odense University Hospital, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Background & Aims: Alcohol is the most common cause of liver-related mortality and morbidity. We therefore aimed to assess and compare the prognostic performance of elastography and blood-based markers to predict time to the first liver-related event, severe infection, and all-cause mortality in patients with a history of excess drinking.

Methods: Prospective cohort study of patients with early, compensated alcohol-related liver disease. Read More

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Ultrastructural Alterations of Grafted Corneal Buttons: The Anatomic Basis for Stromal Peeling along a Natural Plane of Separation.

Am J Ophthalmol 2021 Jun 9. Epub 2021 Jun 9.

University of Ferrara, Department of Translational Medicine, Ferrara, Italy; Ospedali Privati Forlì "Villa Igea", Department of Ophthalmology, Forlì, Italy; Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy.

Purpose: To examine the ultrastructure of the natural plane of separation in grafted corneas and evaluate the outcomes of stromal peeling.

Design: Interventional case series METHODS: In this multicenter study, stromal peeling was attempted in 96 consecutive eyes with unsatisfactory vision following penetrating keratoplasty (PK) for keratoconus(n=79), herpetic keratitis(n=11) and granular dystrophy(n=6). Stromal exchange was performed by: 1) 9mm partial-thickness trephination; 2) creation of a corneal flap across the PK wound; 3) opening of the stromal component of the PK wound until a smooth, translucent natural plane was identified; 4) severing the attachment of the PK scar; 5) stromal peeling along the identified plane; 6) suturing of donor lamella. Read More

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Engineered Microenvironment for the Study of Myofibroblast Mechanobiology.

Wound Repair Regen 2021 Jun 12. Epub 2021 Jun 12.

Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA.

Myofibroblasts are mechanosensitive cells and a variety of their behaviors including differentiation, migration, force production and biosynthesis are regulated by the surrounding microenvironment. Engineered cell culture models have been developed to examine the effect of microenvironmental factors such as the substrate stiffness, the topography and strain of the extracellular matrix (ECM) and the shear stress on myofibroblast biology. These engineered models provide well-mimicked, pathophysiologically-relavent experimental conditions that are superior to those enabled by the conventional 2D culture models. Read More

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Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.

Adv Sci (Weinh) 2021 Jun 12:e2100446. Epub 2021 Jun 12.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, 11794, USA.

Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early-stage response to tissue damages. These cells break down extracellular matrix, clear debris, and secret cytokines to orchestrate regeneration. However, the immune response can also lead to abnormal tissue healing or scar formation if not well directed. Read More

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595-nm pulsed dye laser combined with fractional CO laser reduces hypertrophic scar through down-regulating TGFβ1 and PCNA.

Lasers Med Sci 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.

595-nm pulsed dye laser and fractional CO laser have been demonstrated effective to treat hypertrophic scar. The underlying mechanism may involve transforming growth factor-beta1 (TGFβ1) and proliferating cell nuclear antigen (PCNA), but remains to be clarified. Our study was performed to investigate how 595-nm pulsed dye laser combined with fractional CO laser treats hypertrophic scars in a rabbit model through regulating the expression of TGFβ1 and PCNA. Read More

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Scientific validation of three-dimensional stereophotogrammetry compared to the IGAIS clinical scale for assessing wrinkles and scars after laser treatment.

Sci Rep 2021 Jun 11;11(1):12385. Epub 2021 Jun 11.

Pharmaceutical Research Group, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK.

Measuring outcomes from treatments to the skin is either reliant upon patient's subjective feedback or scale-based peer assessments. Three-Dimensional stereophotogrammetry intend to accurately quantify skin microtopography before and after treatments. The objective of this study is comparing the accuracy of stereophotogrammetry with a scale-based peer evaluation in assessing topographical changes to skin surface following laser treatment. Read More

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Segmental strain analysis for the detection of chronic ischemic scars in non-contrast cardiac MRI cine images.

Sci Rep 2021 Jun 11;11(1):12376. Epub 2021 Jun 11.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Cardiac magnetic resonance imaging (MRI) with late gadolinium enhancement (LGE) is considered the gold standard for scar detection after myocardial infarction. In times of increasing skepticism about gadolinium depositions in brain tissue and contraindications of gadolinium administration in some patient groups, tissue strain-based techniques for detecting ischemic scars should be further developed as part of clinical protocols. Therefore, the objective of the present work was to investigate whether segmental strain is noticeably affected in chronic infarcts and thus can be potentially used for infarct detection based on routinely acquired non-contrast cine images in patients with known coronary artery disease (CAD). Read More

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Surgical repair of a cesarean scar defect using a vaginal approach.

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Objective: To discuss the signs and symptoms of a cesarean section (C-section) scar defect, and to describe the techniques to repair the defect using a vaginal approach.

Design: A video review of a 32-year-old woman with abnormal bleeding and a C-section scar defect managed surgically by vaginal repair. The patient provided consent for video recording and publication. Read More

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Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.

Dermatol Ther (Heidelb) 2021 Jun 11. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

Previous approaches to acne management have focused on the four main factors implicated in acne, namely, androgen-mediated sebogenesis (considered integral to acne), hyperkeratinization, colonization with Cutibacterium acnes, and inflammation related to both innate and adaptive mechanisms. Recent advances have facilitated potential novel approaches to acne management, as the pathophysiology and the immunological aspects related to acne and wound healing have evolved. Particular targets that have been shown to be closely involved in acne pathophysiology and wound healing include interleukin (IL)-1β, IL-17, IL-23, and tumor necrosis factor alpha (TNFα). Read More

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Postoperative incision scars and cosmetic satisfaction of living liver donors.

Medicine (Baltimore) 2021 Jun;100(23):e26187

Department of General Surgery, Changhua Christian Hospital, Changhua.

Abstract: Cosmetic appearance is a major concern for living donors. However, little is known about the impact of a surgical scar on body image changes in living liver donors. The aim of this study was to identify potential factors that cause displeasing upper midline incision scar, and to evaluate the overall satisfaction regarding body image and scarring after living donor hepatectomy. Read More

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