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Bilateral Thalamic Infarction Secondary to Thrombosis of Artery of Percheron.

Cureus 2021 Mar 4;13(3):e13707. Epub 2021 Mar 4.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

The artery of Percheron (AOP) is a rare anatomical variation emerging from the posterior circulation and supplies both thalami in the brain. As per the literature, the AOP infarction constitutes less than 2% of all stroke cases. AOP infarctions are usually caused by a combination of risk factors and a predisposing vascular territory. Read More

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Risk of Second Primary Malignancies among Patients with Early Gastric Cancer Exposed to Recurrent Computed Tomography Scans.

Cancers (Basel) 2021 Mar 7;13(5). Epub 2021 Mar 7.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Although computed tomography (CT) scans are very useful for identification or surveillance of malignancy, they are also associated with the risk of cancer caused by ionizing radiation. We investigated the risk of second primary malignancies (SPMs) after frequent abdominopelvic CT scans in a cohort of Korean patients with early gastric cancer (EGC). We performed a cohort study of 11,072 patients who underwent resection for EGC at Samsung Medical Center and validated the results using data from 7908 patients in a Korean National Health Insurance Service cohort. Read More

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Second-order nonlinear optical properties of two chalcone derivatives: insights from sum-over-states.

Phys Chem Chem Phys 2021 Mar;23(10):6128-6140

Campus de Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis, GO 75132-903, Brazil. and Universidade Paulista, Goiânia, Goiás 74845-090, Brazil.

In this study, a combined experimental and theoretical study of the nonlinear optical properties (NLO) of two chalcone derivatives, (E)-3-(2-methoxyphenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (MPSP) and (E)-3-(3-nitrophenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (NPSP), in DMSO is reported. The single crystal structures of the compounds, which differ only by the type and position of one substituent, were grown using the slow evaporation technique, and the main structural differences are discussed. The two-photon absorption and first-order hyperpolarizability measurements were performed via the Z-scan technique and hyper-Rayleigh scattering experiment in DMSO. Read More

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Theoretical study of the mixed π-conjugated bridge effect on the nonlinear optical properties of corannulene derivative.

J Mol Model 2021 Feb 2;27(2):66. Epub 2021 Feb 2.

Fujian Provincial Key Laboratory of Advanced Materials Processing and Application, Fuzhou, China.

A new series of corannulene derivatives with two mixed π-conjugated bridge have been theoretically designed and investigated by means of density functional theory. It is found that all molecules exhibit large energy gaps. The holes and electrons analysis show that charge transfer from long-chain connected with NH to long-chain connected with NO. Read More

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February 2021

Prognostic Significance of Pretreatment 18F-FDG PET/CT Volumetric Parameters in Patients With Colorectal Liver Metastasis: A Systematic Review and Meta-analysis.

Clin Nucl Med 2021 03;46(3):206-213

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: Colorectal liver metastasis (CRLM) remains a clinical challenge due to the lack of reliable prognostic parameters. We performed a systematic review and meta-analysis of the prognostic value of pretreatment 18F-FDG PET/CT volumetric parameters for hepatic metastatic lesions (HMLs) in patients with CRLM.

Methods: A systematic search was performed using the following combination of keywords: CRLM, FDG, PET, and prognosis. Read More

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Response evaluation after immunotherapy in NSCLC: Early response assessment using FDG PET/CT.

Medicine (Baltimore) 2020 Dec;99(51):e23815

Center for Lung Cancer.

Abstract: The present study aimed to evaluate the role of early F-18 2-deoxy-2-[fluorine-18] fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT) in non-small cell lung cancer patients undergoing immune checkpoint inhibitor (ICI) treatment.Twenty-four non-small cell lung cancer patients who received nivolumab or pembrolizumab and underwent FDG PET/CT as an interim analysis after 2 or 3 cycles of ICI treatment were retrospectively enrolled. Tumor response was assessed using the PET Response Criteria in Solid Tumors 1. Read More

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December 2020

Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.

Front Oncol 2020 19;10:586192. Epub 2020 Nov 19.

Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Background: The skeleton is a preferred site for prostate cancer metastasis, and once metastases occur, the disease becomes incurable. Increasing evidence indicates the prognostic value of skeletal-related parameters, but remains controversial.

Objective: To perform a systematic review of the existing literature on assessing the prognostic value of alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BSAP), urinary N-telopeptide (uNTx), bone scan index (BSI), and Brief Pain Inventory Short Form (BPI-SF) score in castration-resistant prostate cancer (CRPC) patients with skeleton metastasis. Read More

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November 2020

Prognostic value of F-FDG PET and PET/CT for assessment of treatment response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis.

Breast Cancer Res 2020 10 31;22(1):119. Epub 2020 Oct 31.

Department of Nuclear Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: We performed a systematic review and meta-analysis to evaluate the prognostic significance of F-FDG PET and PET/CT for evaluation of responses to neoadjuvant chemotherapy (NAC) in breast cancer patients.

Methods: We searched PubMed, Embase, and the Cochrane Library databases until June 2020 to identify studies that assessed the prognostic value of F-FDG PET scans during or after NAC with regard to overall (OS) and disease-free survival (DFS). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were pooled meta-analytically using a random-effects model. Read More

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October 2020

Volumetric parameters derived from FLT-PET performed at completion of treatment predict efficacy of Carbon-ion Radiotherapy in patients with locally recurrent Nasopharyngeal Carcinoma.

J Cancer 2020 17;11(23):7073-7080. Epub 2020 Oct 17.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China.

The purpose of this study was to investigate the role of 3'-deoxy-3'-[F]fluorothymidine (FLT)-PET for predicting the outcome of patients with locally recurrent nasopharyngeal carcinoma (LR-NPC) treated by carbon-ion radiotherapy (CIRT). Patients received FLT-PET/CT scan one-week prior to or after completion of CIRT were enrolled in the study. All patients were from prospective trials or treated using a standardized protocol. Read More

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October 2020

Prognostic value of F-fluorodeoxyglucose positron emission tomography/computed tomography in newly diagnosed multiple myeloma: a systematic review and meta-analysis.

Eur Radiol 2021 Jan 18;31(1):152-162. Epub 2020 Aug 18.

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Objectives: We performed a systematic review and meta-analysis on the prognostic values of F-FDG PET/CT in patients with newly diagnosed multiple myeloma (MM).

Methods: PubMed and Embase were searched until July 10, 2019, for studies that reported the prognostic significance of F-FDG PET in patients with newly diagnosed MM, with overall (OS) and progression-free survival (PFS) included as outcomes. Hazard ratios (HRs) and their 95% confidence intervals (CIs) were meta-analytically pooled using a random-effects model. Read More

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January 2021

Early F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.

Int J Radiat Oncol Biol Phys 2020 11 13;108(4):969-976. Epub 2020 Aug 13.

Department of Radiation Oncology, Duke Cancer Institute, Duke University School of Medicine, Durham, North Carolina; Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, Durham, North Carolina.

Purpose: Early indication of treatment outcome may guide therapeutic de-escalation strategies in patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC). This study investigated the relationships between tumor volume and F-fluorodeoxyglucose positron emission tomography (PET) parameters before and during definitive radiation therapy with treatment outcomes.

Methods And Materials: Patients undergoing definitive (chemo)radiation for HPV-related/p16-positive OPC were prospectively enrolled on an institutional review board-approved study. Read More

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November 2020

Adipose tissue density on CT as a prognostic factor in patients with cancer: a systematic review.

Acta Oncol 2020 Dec 30;59(12):1488-1495. Epub 2020 Jul 30.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital - Harvard Medical School, Boston, MA, USA.

Background: Predicting oncologic outcomes is essential for optimizing the treatment for patients with cancer. This review examines the feasibility of using Computed Tomography (CT) images of fat density as a prognostic factor in patients with cancer.

Methods: A systematic literature search was performed in PubMed, Embase and Cochrane up to March 2020. Read More

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December 2020

Prognostic value of maximum standard uptake value, metabolic tumor volume, and total lesion glycolysis of 18F-FDG PET/CT in patients with renal carcinoma: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 May;99(20):e19988

Department of Pathology, Yanbian University hospital, Yanji, Jilin Province, China.

Purpose: We present a comprehensive systematic review of the documented literature on parameters derived from F-fluorodeoxyglucose positron emission tomography (F-FDG PET) and meta-analysis of the prognostic value of maximal standard uptake value (SUVmax), metabolic tumor volume (MTV) and total lesional glycolysis (TLG) in patients with renal carcinoma (RCC).

Patients And Methods: Relevant articles in English from PubMed, EMBASE, and the Cochrane Library were retrieved. Pooled hazard ratio (HR) values were used to assess the prognostic value of SUVmax, MTV, and TLG. Read More

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Is the achievement of 85% of age-predicted heart ratemax at exercise test sufficient to make diagnosis of myocardial ischemia in athletes?

Minerva Cardioangiol 2020 Apr;68(2):67-71

Specialization School in Sports Medicine and Exercise, Tor Vergata University, Rome, Italy -

Background: Exercise test (ET) is a validated tool for the identification of coronary artery disease (CAD) even among athletes. A "cut-off" of 85% HRmax is often chosen as an "end point" although it has been shown that this percentage is far from a maximal effort and might be insufficient to evaluate athletes who often reach HRs close to 100% of the theoretical HRmax during sport activity. The aim of this study was to identify the percentage of theoretical HRmax (% HRmax) at which ST segment depression due to a coronary insufficiency on ECG at ET became significant and how much this value would be different from the "cut-off" of 85% of the theoretical HRmax. Read More

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Pattern and Outcome of Pediatric Traumatic Brain Injury at Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia: Observational Cross-Sectional Study.

Emerg Med Int 2020 29;2020:1965231. Epub 2020 Jan 29.

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Traumatic brain injury (TBI) is the most common cause of death/disability in children. The Glasgow coma scale and other parameters are used for treatment/follow-up of TBI. Childhood TBI data are scarce from sub-Saharan Africa. Read More

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January 2020

Skeletal muscle mass as a prognostic indicator of outcomes in ovarian cancer: a systematic review and meta-analysis.

Int J Gynecol Cancer 2020 05 2;30(5):654-663. Epub 2020 Apr 2.

Dipartimento di Medicina e chirurgia traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Muscle mass plays a key role in predicting clinical outcomes in cancer. This systematic review and meta-analysis aimed to evaluate whether computed tomography (CT) scan indexes of muscle mass quantity and quality could be used as prognostic factors in ovarian cancer.

Methods: Three electronic bibliographic databases (MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials) were used to conduct a systematic literature search from inception to January 2020. Read More

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Prognostic value of the bone scan index in patients with metastatic castration-resistant prostate cancer: a systematic review and meta-analysis.

BMC Cancer 2020 Mar 20;20(1):238. Epub 2020 Mar 20.

Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing, 100034, China.

Background: Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis.

Methods: The PubMed, Cochrane, and Embase databases were searched systematically for relevant articles published before September 1, 2019. Read More

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Contemporary treatment options for a classical disease: Advanced Hodgkin lymphoma.

Crit Rev Oncol Hematol 2020 Apr 13;148:102897. Epub 2020 Feb 13.

Department of Pharmacy Services and Clinical Pharmacy, Michigan Medicine and the University of Michigan College of Pharmacy, 1540 E. Hospital Drive, CW 7-251B, Ann Arbor, MI 48109, United States. Electronic address:

Advanced classical Hodgkin lymphoma (cHL) is a rare lymphoid disease characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells. Each year, cHL accounts for 0.5% of all new cancer diagnoses and about 80% are diagnosed with advanced stage disease. Read More

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Successful Cerebral Hemorrhage Control with Prothrombin Complex Concentrate in a Patient on Edoxaban Therapy: A Case Report.

J Blood Med 2020 30;11:35-38. Epub 2020 Jan 30.

Emergency Department, Policlinico San Marco, Zingonia, BG, Italy.

Direct oral anticoagulants (DOACs) have demonstrated safety and efficacy in stroke prevention in patients with non-valvular atrial fibrillation (NVAF). In terms of safety, there was a significant reduction of intracranial hemorrhages (ICH) in patients treated with DOACs over warfarin. To date, a specific antidote for edoxaban is not yet available. Read More

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January 2020

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model.

Sci Rep 2020 02 21;10(1):3130. Epub 2020 Feb 21.

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, NY, New York, NY, USA.

Vascular changes occur early in the development of obstructive airways disease. However, the vascular remodeling and dysfunction due to World Trade Center-Particulate Matter (WTC-PM) exposure are not well described and are therefore the focus of this investigation. C57Bl/6 female mice oropharyngeally aspirated 200 µg of WTC-PM or phosphate-buffered saline (PBS) (controls). Read More

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February 2020

Serum Cleaved Tau Protein and Clinical Outcome in Patients with Minor Head Trauma.

Open Access Emerg Med 2020 20;12:7-12. Epub 2020 Jan 20.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Minor head trauma is due to the transfer of a mechanical energy to the brain caused by a traumatic event. The present study was accomplished aiming to investigate the cleaved tau protein (CTP) as a brain injury biomarker among patients with minor head trauma.

Patients And Methods: This observational study was performed on patients with minor head trauma in 2017 who referred to emergency department of Imam Khomeini Hospital and Golestan Hospital of Ahvaz, Iran. Read More

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January 2020

The Diagnostic Value of Neuron-Specific Enolase in Children with Mild Blunt Trauma Requiring Cranial CT Scan.

Open Access Emerg Med 2020 13;12:1-5. Epub 2020 Jan 13.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: The present study was conducted to investigate the relationship between serum levels of enolase and pathological findings obtained from CT scans of the brain in children with mild blunt brain trauma and help with a more accurate diagnosis of brain injuries.

Methods: The present observational study was conducted on children presenting with head traumas to the emergency department (ED) of Golestan Hospital in Ahvaz, Iran in 2016. A venous blood sample was immediately taken by the ward nurse from all the eligible patients within 6 hrs of the incident after obtaining their information, performing initial examinations and their initial stabilization. Read More

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January 2020

BIGDOSE: software for 3D personalized targeted radionuclide therapy dosimetry.

Quant Imaging Med Surg 2020 Jan;10(1):160-170

Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, University of Macau, Macau SAR, China.

Background: Advance 3D quantitative radionuclide imaging techniques boost the accuracy of targeted radionuclide therapy (TRT) dosimetry to voxel level. The goal of this work is to develop a comprehensive 3D dosimetric software, BIGDOSE, with new features of image registration and virtual CT for patient-specific dosimetry.

Methods: BIGDOSE includes a portable graphical user interface written in Python, integrating (I) input of sequential ECT/CT images; (II) segmentation; (III) non-rigid image registration; (IV) curve fitting and voxel-based integration; (V) dose conversion and (VI) 3D dose analysis. Read More

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January 2020

Application of an Imaging-Based Sum Score for Cerebral Amyloid Angiopathy to the General Population: Risk of Major Neurological Diseases and Mortality.

Front Neurol 2019 6;10:1276. Epub 2019 Dec 6.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.

To assess the relation between a sum score of imaging markers indicative of cerebral amyloid angiopathy (CAA) and cognitive impairment, stroke, dementia, and mortality in a general population. One thousand six hundred twenty-two stroke-free and dementia-free participants of the population-based Rotterdam Study (mean age 73.1 years, 54. Read More

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December 2019

Prognostic value of maximum standard uptake value, metabolic tumor volume, and total lesion glycolysis of positron emission tomography/computed tomography in patients with breast cancer: A systematic review and meta-analysis.

PLoS One 2019 11;14(12):e0225959. Epub 2019 Dec 11.

Center of Morphological Experiment, Medical College of Yanbian University, Yanji, Jilin Province, China.

Purpose: A comprehensive systematic review of the literature was conducted on parameters from 18 F-FDG PET and a meta-analysis of the prognostic value of the maximal standard uptake value (SUVmax), metabolic tumor volume (MTV) and total lesional glycolysis (TLG) in patients with breast cancer (BC).

Patients And Methods: Relevant English articles from PubMed, EMBASE, and the Cochrane Library were retrieved. Pooled hazard ratios (HRs) were used to assess the prognostic value of SUVmax, MTV, and TLG. Read More

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High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma.

Eur J Nucl Med Mol Imaging 2020 05 13;47(5):1039-1045. Epub 2019 Nov 13.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: The purpose of this study was to investigate if FDG uptake metrics in primary tumor and lymph node metastases in patients with oropharyngeal squamous cell carcinoma (OPSCC) has a prognostic value beyond UICC8 staging in a multiple endpoint model.

Methods: Patients with OPSCC treated with primary radiotherapy at Rigshospitalet in the period 2010-2017 were included. All patients had a pretreatment FDG PET/CT scan performed. Read More

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Chalcone-based molecules: Experimental and theoretical studies on the two-photon absorption and molecular first hyperpolarizability.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Feb 6;227:117772. Epub 2019 Nov 6.

Departamento de Física, Universidade Federal de Sergipe, 49100-000 São Cristovão, SE, Brazil.

Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1. The aldehydes used were benzaldehyde, anisaldehyde, and β-naphthaldehyde, while the used ketones were acetophenone, p-methoxyacetophenone, and 3,4-methylenedioxyacetophenone. Z-scan and hyper-Rayleigh scattering techniques were used to study the nonlinear optical properties of these compounds in dichloromethane medium. Read More

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February 2020

How often suspected pulmonary embolism is diagnosed and its main diagnostic characteristics, in an emergency nuclear medicine service? Four years experience.

Hell J Nucl Med 2019 Sep-Dec;22(3):187-193. Epub 2019 Oct 7.

Nuclear Medicine Department, University of Bari "Aldo Moro", Bari, Italy.

Objective: Acute pulmonary embolism (APE) is an emergency condition and its treatment must be immediate. Nevertheless, the diagnosis of APE is diffcult because its symptoms and risk factors are not specific. We present our 4 years experience on this subject. Read More

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Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction.

Clin Epidemiol 2019 25;11:901-910. Epub 2019 Sep 25.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Comorbidity is common among patients with myocardial infarction (MI). We examined whether comorbidity level modified the single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)-based prediction of 5-year risk of MI and all-cause death in patients with MI.

Methods: This cohort study included patients with prior MI having a SPECT MPI at Aarhus University Hospital, Denmark, 1999-2011. Read More

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September 2019